Details of the Target

General Information of Target

Target ID LDTP15328
Target Name Dolichyldiphosphatase 1 (DOLPP1)
Gene Name DOLPP1
Gene ID 57171
Synonyms
LSFR2; Dolichyldiphosphatase 1; EC 3.6.1.43; Dolichyl pyrophosphate phosphatase 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWKLGRGRVLLDEPPEEEDGLRGGPPPAAAAAAQAQVQGASFRGWKEVTSLFNKDDEQHL
LERCKSPKSKGTNLRLKEELKAEKKSGFWDNLVLKQNIQSKKPDEIEGWEPPKLALEDIS
ADPEDTVGGHPSWSGWEDDAKGSTKYTSLASSANSSRWSLRAAGRLVSIRRQSKGHLTDS
PEEAE
Target Bioclass
Enzyme
Family
Dolichyldiphosphatase family
Subcellular location
Endoplasmic reticulum membrane
Function
Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.
Uniprot ID
Q86YN1
Ensemble ID
ENST00000372546.9
HGNC ID
HGNC:29565

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LS123 SNV: p.S8Ter DBIA    Probe Info 
MFE319 SNV: p.C7R .
PC14 SNV: p.L120Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C86(0.97)  LDD0531  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
BTD
 Probe Info  		N.A.  LDD0004  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 90 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		10.93  LDD1728  [8]
C040
 Probe Info  		15.89  LDD1740  [8]
C041
 Probe Info  		6.59  LDD1741  [8]
C049
 Probe Info  		5.62  LDD1747  [8]
C055
 Probe Info  		40.79  LDD1752  [8]
C056
 Probe Info  		98.36  LDD1753  [8]
C063
 Probe Info  		16.80  LDD1760  [8]
C064
 Probe Info  		9.51  LDD1761  [8]
C070
 Probe Info  		13.93  LDD1766  [8]
C072
 Probe Info  		11.31  LDD1768  [8]
C091
 Probe Info  		38.59  LDD1782  [8]
C092
 Probe Info  		55.33  LDD1783  [8]
C094
 Probe Info  		79.89  LDD1785  [8]
C095
 Probe Info  		5.46  LDD1786  [8]
C106
 Probe Info  		46.85  LDD1793  [8]
C107
 Probe Info  		9.51  LDD1794  [8]
C108
 Probe Info  		10.06  LDD1795  [8]
C112
 Probe Info  		47.84  LDD1799  [8]
C130
 Probe Info  		8.17  LDD1812  [8]
C134
 Probe Info  		46.85  LDD1816  [8]
C135
 Probe Info  		15.24  LDD1817  [8]
C139
 Probe Info  		11.39  LDD1821  [8]
C141
 Probe Info  		12.13  LDD1823  [8]
C143
 Probe Info  		18.51  LDD1825  [8]
C153
 Probe Info  		18.00  LDD1834  [8]
C159
 Probe Info  		11.47  LDD1839  [8]
C160
 Probe Info  		11.39  LDD1840  [8]
C161
 Probe Info  		20.25  LDD1841  [8]
C163
 Probe Info  		5.82  LDD1843  [8]
C169
 Probe Info  		58.08  LDD1849  [8]
C178
 Probe Info  		31.34  LDD1857  [8]
C183
 Probe Info  		5.10  LDD1861  [8]
C186
 Probe Info  		13.93  LDD1864  [8]
C201
 Probe Info  		51.98  LDD1877  [8]
C206
 Probe Info  		25.28  LDD1881  [8]
C210
 Probe Info  		68.59  LDD1884  [8]
C218
 Probe Info  		27.10  LDD1892  [8]
C219
 Probe Info  		7.06  LDD1893  [8]
C220
 Probe Info  		31.78  LDD1894  [8]
C225
 Probe Info  		6.59  LDD1898  [8]
C226
 Probe Info  		6.28  LDD1899  [8]
C228
 Probe Info  		60.13  LDD1901  [8]
C229
 Probe Info  		10.63  LDD1902  [8]
C231
 Probe Info  		73.52  LDD1904  [8]
C232
 Probe Info  		67.18  LDD1905  [8]
C233
 Probe Info  		21.26  LDD1906  [8]
C234
 Probe Info  		9.65  LDD1907  [8]
C235
 Probe Info  		64.45  LDD1908  [8]
C238
 Probe Info  		17.88  LDD1911  [8]
C240
 Probe Info  		11.00  LDD1913  [8]
C243
 Probe Info  		20.68  LDD1916  [8]
C244
 Probe Info  		21.26  LDD1917  [8]
C246
 Probe Info  		51.98  LDD1919  [8]
C249
 Probe Info  		15.67  LDD1922  [8]
C252
 Probe Info  		15.24  LDD1925  [8]
C264
 Probe Info  		30.91  LDD1935  [8]
C265
 Probe Info  		18.90  LDD1936  [8]
C270
 Probe Info  		7.62  LDD1940  [8]
C271
 Probe Info  		5.13  LDD1941  [8]
C273
 Probe Info  		8.69  LDD1943  [8]
C277
 Probe Info  		16.91  LDD1947  [8]
C278
 Probe Info  		98.36  LDD1948  [8]
C282
 Probe Info  		22.78  LDD1952  [8]
C284
 Probe Info  		20.97  LDD1954  [8]
C285
 Probe Info  		65.80  LDD1955  [8]
C287
 Probe Info  		31.12  LDD1957  [8]
C288
 Probe Info  		13.36  LDD1958  [8]
C289
 Probe Info  		99.73  LDD1959  [8]
C290
 Probe Info  		6.36  LDD1960  [8]
C292
 Probe Info  		5.78  LDD1962  [8]
C293
 Probe Info  		99.73  LDD1963  [8]
C296
 Probe Info  		56.89  LDD1966  [8]
C297
 Probe Info  		6.92  LDD1967  [8]
C299
 Probe Info  		8.63  LDD1968  [8]
C305
 Probe Info  		15.45  LDD1974  [8]
C314
 Probe Info  		19.84  LDD1981  [8]
C343
 Probe Info  		19.84  LDD2005  [8]
C376
 Probe Info  		7.36  LDD2036  [8]
C382
 Probe Info  		13.45  LDD2041  [8]
C383
 Probe Info  		12.64  LDD2042  [8]
C388
 Probe Info  		99.73  LDD2047  [8]
C390
 Probe Info  		41.64  LDD2049  [8]
C399
 Probe Info  		8.63  LDD2058  [8]
C403
 Probe Info  		21.26  LDD2061  [8]
FFF probe11
 Probe Info  		20.00  LDD0471  [9]
FFF probe13
 Probe Info  		20.00  LDD0475  [9]
FFF probe14
 Probe Info  		17.13  LDD0477  [9]
FFF probe2
 Probe Info  		20.00  LDD0463  [9]
FFF probe3
 Probe Info  		20.00  LDD0464  [9]
OEA-DA
 Probe Info  		16.85  LDD0046  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C86(0.97)  LDD2142  [11]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C86(1.07)  LDD2112  [11]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C86(0.59)  LDD2130  [11]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C86(0.74)  LDD2117  [11]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C86(1.35)  LDD2152  [11]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C86(0.45)  LDD2132  [11]
 LDCM0214  AC1 HCT 116 C86(0.97)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C86(0.92)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C86(1.34)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C86(0.91)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C86(0.74)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C86(0.89)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C86(0.91)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C86(0.87)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C86(1.05)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C86(1.11)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C86(1.82)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C86(0.92)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C86(1.03)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C86(0.93)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C86(0.99)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C86(0.82)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C86(1.16)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C86(1.17)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C86(1.31)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C86(1.00)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C86(0.97)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C86(1.14)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C86(1.23)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C86(1.03)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C86(1.08)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C86(0.85)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C86(0.99)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C86(1.08)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C86(1.05)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C86(1.20)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C86(1.18)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C86(1.33)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C86(1.26)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C86(1.30)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C86(1.42)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C86(1.28)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C86(1.51)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C86(1.21)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C86(1.19)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C86(1.20)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C86(0.94)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C86(1.24)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C86(0.90)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C86(1.13)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C86(0.70)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C86(1.11)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C86(1.23)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C86(1.03)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C86(0.98)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C86(1.04)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C86(0.92)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C86(1.16)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C86(0.88)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C86(1.17)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C86(1.25)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C86(0.81)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C86(1.11)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C86(1.14)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C86(1.09)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C86(1.33)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C86(1.04)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C86(1.15)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C86(1.15)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C86(1.15)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C86(1.34)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C86(1.00)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C86(0.99)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C86(1.08)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C86(0.92)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C86(0.95)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C86(1.04)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C86(1.13)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C86(0.93)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C86(1.25)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C86(1.17)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C86(1.07)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C86(1.61)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C86(1.10)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C86(1.04)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C86(1.00)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C86(1.12)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C86(1.16)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C86(1.11)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C86(0.96)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C86(1.15)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C86(1.09)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C86(1.12)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C86(1.06)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C86(1.11)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C86(1.22)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C86(1.08)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C86(0.96)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C86(1.04)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C86(1.33)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C86(1.00)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C86(0.96)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C86(1.07)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C86(1.16)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C86(1.01)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C86(1.10)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C86(1.11)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C86(1.02)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C86(1.00)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C86(0.93)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C86(1.05)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C86(1.00)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C86(1.08)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C86(1.07)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C86(0.97)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C86(1.09)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C86(0.96)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C86(0.90)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C86(0.88)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C86(0.95)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C86(1.27)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C86(1.05)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C86(1.18)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C86(1.11)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C86(1.18)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C86(1.10)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C86(1.06)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C86(0.94)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C86(1.01)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C86(1.16)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C86(1.16)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C86(1.13)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C86(1.17)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C86(1.04)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C86(1.16)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C86(1.10)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C86(1.10)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C86(1.00)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C86(1.19)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C86(0.96)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C86(1.01)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C86(1.19)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C86(1.25)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C86(1.12)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C86(1.07)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C86(0.97)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C86(1.09)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C86(1.06)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C86(1.04)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C86(0.93)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C86(1.07)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C86(1.00)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C86(1.41)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C86(0.99)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C86(1.09)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C86(1.00)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C86(1.23)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C86(1.10)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C86(1.23)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C86(1.14)  LDD0683  [2]
 LDCM0545  Acetamide MDA-MB-231 C86(0.28)  LDD2138  [11]
 LDCM0520  AKOS000195272 MDA-MB-231 C86(0.77)  LDD2113  [11]
 LDCM0248  AKOS034007472 HCT 116 C86(0.84)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C86(0.91)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C86(0.84)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C86(0.92)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C86(1.09)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C86(1.25)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C86(0.82)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C86(0.76)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C86(0.91)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C86(0.72)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C86(1.23)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C86(1.17)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C86(1.27)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C86(1.18)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C86(0.95)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C86(0.92)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C86(1.23)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C86(1.08)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C86(1.09)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C86(1.10)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C86(1.14)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C86(0.93)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C86(1.02)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C86(1.03)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C86(1.06)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C86(1.10)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C86(1.04)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C86(1.34)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C86(0.88)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C86(0.98)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C86(0.98)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C86(1.06)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C86(1.41)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C86(1.20)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C86(1.15)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C86(1.18)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C86(0.73)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C86(0.77)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C86(0.86)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C86(1.24)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C86(1.67)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C86(1.07)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C86(1.21)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C86(1.06)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C86(1.30)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C86(1.19)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C86(1.25)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C86(1.10)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C86(1.33)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C86(1.45)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C86(1.18)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C86(1.45)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C86(1.40)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C86(2.00)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C86(0.89)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C86(1.38)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C86(0.96)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C86(1.43)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C86(1.17)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C86(1.26)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C86(1.18)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C86(1.01)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C86(1.05)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C86(1.09)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C86(0.72)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C86(0.95)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C86(0.92)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C86(0.95)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C86(1.13)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C86(1.26)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C86(1.20)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C86(1.46)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C86(1.19)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C86(1.21)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C86(1.43)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C86(0.94)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C86(1.19)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C86(1.41)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C86(1.53)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C86(0.81)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C86(1.02)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C86(0.93)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C86(0.78)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C86(0.69)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C86(1.16)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C86(0.95)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C86(0.99)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C86(1.49)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C86(1.55)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C86(1.63)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C86(1.03)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C86(1.15)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C86(1.19)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C86(1.21)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C86(1.24)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C86(1.30)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C86(1.05)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C86(1.25)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C86(1.40)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C86(1.14)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C86(1.03)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C86(0.97)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C86(1.21)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C86(0.92)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C86(0.89)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C86(0.93)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C86(1.01)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C86(0.88)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C86(0.89)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C86(1.04)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C86(1.20)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C86(1.00)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C86(1.11)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C86(1.00)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C86(0.84)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C86(1.06)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C86(1.01)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C86(1.12)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C86(0.88)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C86(0.89)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C86(1.18)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C86(1.25)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C86(1.12)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C86(1.01)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C86(0.98)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C86(1.07)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C86(1.03)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C86(1.35)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C86(1.10)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C86(0.85)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C86(12.58)  LDD1702  [11]
 LDCM0625  F8 Ramos C86(0.98)  LDD2187  [13]
 LDCM0573  Fragment11 Ramos C86(20.00)  LDD2190  [13]
 LDCM0575  Fragment13 Ramos C86(0.99)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C86(1.78)  LDD2193  [13]
 LDCM0580  Fragment21 Ramos C86(1.06)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C86(1.00)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C86(1.09)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C86(0.97)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C86(2.04)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C86(1.12)  LDD2200  [13]
 LDCM0468  Fragment33 HCT 116 C86(1.19)  LDD0785  [2]
 LDCM0596  Fragment38 Ramos C86(2.32)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C86(0.89)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C86(1.05)  LDD0744  [2]
 LDCM0610  Fragment52 Ramos C86(2.21)  LDD2204  [13]
 LDCM0022  KB02 HEK-293T C86(1.00)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C86(0.96)  LDD1497  [12]
 LDCM0024  KB05 COLO792 C86(1.91)  LDD3310  [14]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C86(0.32)  LDD2121  [11]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C86(0.89)  LDD2092  [11]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C86(1.21)  LDD2093  [11]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C86(1.09)  LDD2094  [11]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C86(1.04)  LDD2098  [11]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C86(1.19)  LDD2099  [11]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C86(0.79)  LDD2100  [11]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C86(1.07)  LDD2101  [11]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C86(0.91)  LDD2104  [11]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C86(1.29)  LDD2105  [11]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C86(1.07)  LDD2106  [11]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C86(1.00)  LDD2107  [11]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C86(0.83)  LDD2108  [11]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C86(0.84)  LDD2109  [11]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C86(0.86)  LDD2111  [11]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C86(1.29)  LDD2114  [11]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C86(0.71)  LDD2115  [11]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C86(2.92)  LDD2119  [11]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C86(0.85)  LDD2123  [11]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C86(0.96)  LDD2127  [11]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C86(0.86)  LDD2129  [11]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C86(1.07)  LDD2134  [11]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C86(0.72)  LDD2135  [11]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C86(1.48)  LDD2136  [11]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C86(1.00)  LDD2137  [11]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C86(1.03)  LDD1700  [11]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C86(0.70)  LDD2140  [11]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C86(0.95)  LDD2141  [11]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C86(3.37)  LDD2144  [11]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C86(3.16)  LDD2145  [11]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C86(0.94)  LDD2146  [11]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C86(4.11)  LDD2147  [11]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C86(0.85)  LDD2148  [11]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C86(0.31)  LDD2150  [11]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840