Details of the Target

General Information of Target

Target ID LDTP07462
Target Name MFS-type transporter SLC18B1 (SLC18B1)
Gene Name SLC18B1
Gene ID 116843
Synonyms
C6orf192; MFS-type transporter SLC18B1; Solute carrier family 18 member B1; Vesicular polyamine transporter; VPAT
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEALGDLEGPRAPGGDDPAGSAGETPGWLSREQVFVLISAASVNLGSMMCYSILGPFFPK
EAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVL
DRVPDGPVFIAMCFLVRVMDAVSFAAAMTASSSILAKAFPNNVATVLGSLETFSGLGLIL
GPPVGGFLYQSFGYEVPFIVLGCVVLLMVPLNMYILPNYESDPGEHSFWKLIALPKVGLI
AFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPP
LRKWLLVFGNLITAGCYMLLGPVPILHIKSQLWLLVLILVVSGLSAGMSIIPTFPEILSC
AHENGFEEGLSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISGL
AMGLFYLLEYSRRKRSKSQNILSTEEERTTLLPNET
Target Bioclass
Transporter and channel
Family
Major facilitator superfamily
Subcellular location
Cytoplasmic vesicle, secretory vesicle membrane
Function
Proton-coupled polyamine antiporter involved in the translocation of polyamines from cytosol into secretory vesicles prior to their release via exocytosis. Uses the electrochemical proton gradient generated by a V-type proton-pumping ATPase to couple the efflux of protons with the uptake of a polyamine molecule. Facilitates vesicular storage of spermine and spermidine in astrocytes with an impact on glutamatergic neuronal transmission and memory formation. Upon antigen stimulation, regulates polyamine accumulation and release in mast cell secretory granules, which in turn potentiates mast cell degranulation and histamine secretion.
Uniprot ID
Q6NT16
Ensemble ID
ENST00000275227.9
HGNC ID
HGNC:21573

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P11
 Probe Info  		20.00  LDD0201  [1]
PAL-AfBPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C008
 Probe Info  		5.46  LDD1717  [2]
C011
 Probe Info  		6.11  LDD1720  [2]
C024
 Probe Info  		5.13  LDD1730  [2]
C063
 Probe Info  		19.70  LDD1760  [2]
C229
 Probe Info  		13.09  LDD1902  [2]
C231
 Probe Info  		15.45  LDD1904  [2]
C233
 Probe Info  		14.52  LDD1906  [2]
C234
 Probe Info  		8.34  LDD1907  [2]
C235
 Probe Info  		20.82  LDD1908  [2]
C258
 Probe Info  		7.01  LDD1931  [2]
C260
 Probe Info  		8.94  LDD1932  [2]
C297
 Probe Info  		5.58  LDD1967  [2]
C299
 Probe Info  		6.19  LDD1968  [2]
C339
 Probe Info  		6.82  LDD2002  [2]
C342
 Probe Info  		6.50  LDD2004  [2]
C346
 Probe Info  		15.67  LDD2007  [2]
C347
 Probe Info  		7.06  LDD2008  [2]
C348
 Probe Info  		15.89  LDD2009  [2]
C349
 Probe Info  		13.83  LDD2010  [2]
C350
 Probe Info  		29.45  LDD2011  [2]
C353
 Probe Info  		6.96  LDD2014  [2]
C354
 Probe Info  		11.96  LDD2015  [2]
C376
 Probe Info  		8.22  LDD2036  [2]
C380
 Probe Info  		7.78  LDD2039  [2]
C382
 Probe Info  		10.41  LDD2041  [2]
C413
 Probe Info  		23.59  LDD2069  [2]
C414
 Probe Info  		7.21  LDD2070  [2]
C416
 Probe Info  		7.73  LDD2071  [2]
C418
 Probe Info  		13.09  LDD2073  [2]
C419
 Probe Info  		23.26  LDD2074  [2]
C420
 Probe Info  		27.10  LDD2075  [2]
C429
 Probe Info  		46.21  LDD2084  [2]
C430
 Probe Info  		6.02  LDD2085  [2]
C431
 Probe Info  		40.79  LDD2086  [2]
C432
 Probe Info  		21.11  LDD2087  [2]
C433
 Probe Info  		25.81  LDD2088  [2]
Alk-rapa
 Probe Info  		4.70  LDD0213  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [1]
 LDCM0090  Rapamycin JHH-7 4.70  LDD0213  [3]

References

1 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
3 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.