Details of the Target

General Information of Target

Target ID LDTP11081
Target Name NAD-capped RNA hydrolase NUDT12 (NUDT12)
Gene Name NUDT12
Gene ID 83594
Synonyms
NAD-capped RNA hydrolase NUDT12; DeNADding enzyme NUDT12; EC 3.6.1.-; NADH pyrophosphatase NUDT12; EC 3.6.1.22; Nucleoside diphosphate-linked moiety X motif 12; Nudix motif 12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGDYEDDLCRRALILVSDLCARVRDADTNDRCQEFNDRIRGYPRGPDADISVSLLSVIV
TFCGIVLLGVSLFVSWKLCWVPWRDKGGSAVGGGPLRKDLGPGVGLAGLVGGGGHHLAAG
LGGHPLLGGPHHHAHAAHHPPFAELLEPGSLGGSDTPEPSYLDMDSYPEAAAAAVAAGVK
PSQTSPELPSEGGAGSGLLLLPPSGGGLPSAQSHQQVTSLAPTTRYPALPRPLTQQTLTS
QPDPSSEERPPALPLPLPGGEEKAKLIGQIKPELYQGTGPGGRRSGGGPGSGEAGTGAPC
GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTL
NPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWR
DIVEGGSEKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGR
RLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPD
AADPHGREHWAEMLANPRKPVEHWHQLVEEKTVTSFTKGSKGLSEKENSE
Target Bioclass
Enzyme
Family
Nudix hydrolase family, NudC subfamily
Subcellular location
Cytoplasm
Function
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to nutrient stress. Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver.
Uniprot ID
Q9BQG2
Ensemble ID
ENST00000230792.7
HGNC ID
HGNC:18826

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.G164D DBIA    Probe Info 
DETROIT562 SNV: p.K132R .
HT SNV: p.N461T .
LNCaP clone FGC SNV: p.A82V .
LUDLU1 SNV: p.F121V .
MFE319 SNV: p.E220K .
RL952 SNV: p.T316I .
SH4 SNV: p.P460S DBIA    Probe Info 
WM1552C SNV: p.K193N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C117(2.27)  LDD0168  [1]
HHS-475
 Probe Info  		Y52(0.79)  LDD0264  [2]
DBIA
 Probe Info  		C117(1.35)  LDD0080  [3]
IA-alkyne
 Probe Info  		C177(0.00); C117(0.00)  LDD0162  [4]
IPM
 Probe Info  		C18(0.00); C117(0.00)  LDD0005  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
HHS-465
 Probe Info  		N.A.  LDD2240  [8]
PAL-AfBPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C053
 Probe Info  		5.13  LDD1751  [9]
C161
 Probe Info  		16.91  LDD1841  [9]
C169
 Probe Info  		21.26  LDD1849  [9]
C191
 Probe Info  		61.39  LDD1868  [9]
C194
 Probe Info  		9.99  LDD1870  [9]
C213
 Probe Info  		17.03  LDD1887  [9]
C238
 Probe Info  		12.38  LDD1911  [9]
C240
 Probe Info  		15.78  LDD1913  [9]
C246
 Probe Info  		14.62  LDD1919  [9]
C284
 Probe Info  		33.36  LDD1954  [9]
C293
 Probe Info  		18.90  LDD1963  [9]
C296
 Probe Info  		15.56  LDD1966  [9]
C297
 Probe Info  		8.94  LDD1967  [9]
C305
 Probe Info  		21.71  LDD1974  [9]
C314
 Probe Info  		15.35  LDD1981  [9]
C344
 Probe Info  		5.70  LDD2006  [9]
C348
 Probe Info  		10.93  LDD2009  [9]
C353
 Probe Info  		20.25  LDD2014  [9]
C361
 Probe Info  		26.17  LDD2022  [9]
C376
 Probe Info  		7.67  LDD2036  [9]
C382
 Probe Info  		13.55  LDD2041  [9]
C383
 Probe Info  		10.85  LDD2042  [9]
C389
 Probe Info  		9.38  LDD2048  [9]
C399
 Probe Info  		21.26  LDD2058  [9]
C405
 Probe Info  		6.92  LDD2063  [9]
C413
 Probe Info  		11.00  LDD2069  [9]
C420
 Probe Info  		36.25  LDD2075  [9]
C431
 Probe Info  		20.97  LDD2086  [9]
FFF probe13
 Probe Info  		20.00  LDD0475  [10]
FFF probe15
 Probe Info  		10.78  LDD0478  [10]
FFF probe6
 Probe Info  		20.00  LDD0467  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C117(2.27)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA HEK-293T C18(2.24); C117(4.24)  LDD0169  [1]
 LDCM0214  AC1 HCT 116 C117(0.73)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C117(0.98)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C284(0.64); C287(0.64)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C284(0.71); C287(0.71)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C284(0.74); C287(0.74)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C284(0.65); C287(0.65)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C284(0.90); C287(0.90)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C284(0.69); C287(0.69)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C284(0.62); C287(0.62)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C284(0.67); C287(0.67)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C284(0.68); C287(0.68)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C284(1.05); C287(1.05)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C117(1.06)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C284(0.69); C287(0.69)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C284(0.75); C287(0.75)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C284(0.75); C287(0.75)  LDD0546  [3]
 LDCM0230  AC113 HEK-293T C117(1.05)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C117(1.09)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C117(0.97)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C117(1.06)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C117(1.09)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C117(1.02)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C117(1.05)  LDD0834  [3]
 LDCM0237  AC12 HCT 116 C117(0.98)  LDD0554  [3]
 LDCM0238  AC120 HEK-293T C117(1.08)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C117(1.10)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C117(1.13)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C117(1.21)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C117(1.05)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C117(1.12)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C117(1.18)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C117(1.28)  LDD0843  [3]
 LDCM0246  AC128 HCT 116 C284(1.30); C287(1.30)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C284(0.99); C287(0.99)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C284(0.88); C287(0.88)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C284(1.03); C287(1.03)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C284(0.82); C287(0.82)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C284(0.90); C287(0.90)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C284(0.84); C287(0.84)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C284(0.97); C287(0.97)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C284(0.82); C287(0.82)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C284(0.84); C287(0.84)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C284(0.69); C287(0.69)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C284(0.76); C287(0.76)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C117(1.12)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C284(0.75); C287(0.75)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C284(0.71); C287(0.71)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C284(0.95); C287(0.95)  LDD0579  [3]
 LDCM0263  AC143 HEK-293T C284(1.05)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C284(1.36)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C284(1.59)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C284(1.43)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C284(1.51)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C284(1.20)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C284(0.73)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C117(1.18)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C284(1.32)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C284(1.32)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C284(1.49)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C284(1.35)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C284(0.90)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C284(1.34)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C284(2.26)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C284(1.70)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C117(1.00)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C117(3.28)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C117(1.13)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C117(0.91)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C117(1.20)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C117(1.25)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C117(1.13)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C117(1.02)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C117(0.92)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C117(1.40)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C117(1.11)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C117(1.74)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C117(1.65)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C117(1.24)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C117(0.85)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C117(1.46)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C117(1.32)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C117(1.47)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C117(1.59)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C117(1.61)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C284(1.27); C287(1.27)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C284(0.93); C287(0.93)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C284(1.23); C287(1.23)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C284(0.91); C287(0.91)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C284(0.97); C287(0.97)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C117(0.75)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C284(0.94); C287(0.94)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C284(1.04); C287(1.04)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C284(1.04); C287(1.04)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C284(0.89); C287(0.89)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C284(1.28); C287(1.28)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C284(1.38); C287(1.38)  LDD0624  [3]
 LDCM0308  AC46 HEK-293T C117(0.78)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C117(1.06)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C117(0.93)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C117(1.07)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C117(0.84)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C117(1.01)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C117(1.15)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C117(0.77)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C117(0.82)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C117(0.81)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C117(1.10)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C117(0.88)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C284(0.52)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C284(0.46)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C284(0.64)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C117(1.29)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C284(0.49)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C284(0.57)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C284(0.64)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C284(0.64)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C284(0.57)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C284(0.47)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C284(0.54)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C284(0.57)  LDD0648  [3]
 LDCM0332  AC68 HEK-293T C284(0.94)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C284(0.91)  LDD0931  [3]
 LDCM0334  AC7 HCT 116 C117(1.04)  LDD0651  [3]
 LDCM0335  AC70 HEK-293T C284(0.96)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C284(0.98)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C284(1.06)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C284(0.98)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C284(0.79)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C284(0.97)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C284(0.90)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C284(0.87)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C284(0.88)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C284(0.90)  LDD0942  [3]
 LDCM0345  AC8 HCT 116 C117(1.17)  LDD0662  [3]
 LDCM0346  AC80 HEK-293T C284(1.05)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C284(0.84)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C284(1.00)  LDD0946  [3]
 LDCM0349  AC83 HCT 116 C284(0.68); C287(0.68)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C284(0.70); C287(0.70)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C284(0.81); C287(0.81)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C284(1.07); C287(1.07)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C284(0.88); C287(0.88)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C284(1.14); C287(1.14)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C284(0.87); C287(0.87)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C284(1.21); C287(1.21)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C284(0.87); C287(0.87)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C284(0.89); C287(0.89)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C284(0.98); C287(0.98)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C284(0.81); C287(0.81)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C284(0.67); C287(0.67)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C284(0.70); C287(0.70)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C284(0.86); C287(0.86)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C284(0.61); C287(0.61)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C284(0.60); C287(0.60)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C117(1.03)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C117(0.98)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C117(1.55)  LDD0592  [3]
 LDCM0630  CCW28-3 231MFP C117(1.31)  LDD2214  [11]
 LDCM0367  CL1 HCT 116 C284(0.83); C287(0.83)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C284(0.53); C287(0.53)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C117(0.74)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C117(1.20)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C117(1.18)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C117(1.01)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C117(1.01)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C117(1.60)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C117(1.92)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C117(1.34)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C117(1.35)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C117(1.32)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C284(0.53); C287(0.53)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C117(1.56)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C117(1.61)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C117(1.19)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C117(1.24)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C117(1.04)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C117(1.64)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C117(1.42)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C284(0.80); C287(0.80)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C284(0.96); C287(0.96)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C284(1.01); C287(1.01)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C284(0.71); C287(0.71)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C284(0.85); C287(0.85)  LDD0708  [3]
 LDCM0392  CL121 HEK-293T C117(0.90)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C117(0.98)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C117(1.20)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C117(1.02)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C284(0.67)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C284(0.83)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C284(0.63)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C284(0.66)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C284(0.59); C287(0.59)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C284(0.81); C287(0.81)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C284(0.64); C287(0.64)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C284(0.95); C287(0.95)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C284(0.52); C287(0.52)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C284(0.37); C287(0.37)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C284(0.61); C287(0.61)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C284(0.81); C287(0.81)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C284(0.76); C287(0.76)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C284(0.48); C287(0.48)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C284(0.46); C287(0.46)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C284(0.72); C287(0.72)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C284(0.57); C287(0.57)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C284(0.57); C287(0.57)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C284(0.76); C287(0.76)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C284(0.88); C287(0.88)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C284(0.59); C287(0.59)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C284(0.67); C287(0.67)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C284(0.98); C287(0.98)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C284(0.71); C287(0.71)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C117(0.86)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C117(0.85)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C117(0.92)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C117(1.05)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C117(0.97)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C117(1.10)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C117(0.81)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C117(0.87)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C284(0.94); C287(0.94)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C117(0.92)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C117(0.91)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C117(0.82)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C117(0.81)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C117(0.97)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C117(0.87)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C117(1.03)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C117(0.95)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C117(0.87)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C117(1.03)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C284(0.92); C287(0.92)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C117(0.86)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C117(1.04)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C117(1.09)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C117(1.03)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C117(0.71)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C117(0.80)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C117(1.06)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C117(1.21)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C117(0.85)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C117(0.82)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C284(0.53); C287(0.53)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C117(1.10)  LDD0769  [3]
 LDCM0453  CL61 HEK-293T C18(1.14); C247(1.00); C117(0.88)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C18(1.00); C247(1.10); C117(1.05); C177(1.13)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C247(1.32); C117(1.01); C287(0.81)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C247(1.01); C117(1.01); C352(1.22); C287(1.11)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C18(1.02); C247(1.15); C117(0.91)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C18(1.12); C247(0.89); C117(0.97); C352(1.21)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C18(1.12); C247(1.11); C117(0.91); C287(1.14)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C18(0.86); C247(1.20); C117(0.93); C287(0.96)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C18(0.85); C247(1.17); C117(0.99); C287(1.08)  LDD1664  [12]
 LDCM0462  CL7 HCT 116 C284(0.67); C287(0.67)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C18(1.23); C247(1.35); C117(0.86); C287(1.27)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C18(1.01); C247(0.95); C117(0.86); C284(1.09)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C18(1.02); C247(1.07); C117(1.00); C352(0.89)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C18(1.02); C247(1.27); C117(0.84)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C18(0.90); C247(0.94); C117(1.08); C177(1.18)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C247(0.94); C117(1.01); C352(1.06); C287(1.22)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C18(1.12); C247(1.14); C117(1.04)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C18(1.16); C247(1.01); C117(1.00); C352(1.17)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C18(1.07); C247(1.14); C117(0.94); C287(1.15)  LDD1675  [12]
 LDCM0473  CL8 HCT 116 C284(0.61); C287(0.61)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C18(1.01); C247(0.95); C117(1.00); C287(1.04)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C18(1.10); C247(1.23); C117(1.04); C287(1.44)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C18(1.05); C247(1.29); C117(0.97); C287(1.24)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C18(0.99); C247(1.12); C117(0.85); C284(1.00)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C18(0.93); C247(1.05); C117(1.06); C352(0.90)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C18(1.01); C247(1.02); C117(0.85)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C18(0.89); C247(1.07); C117(1.00); C177(1.09)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C247(1.11); C117(1.01); C287(0.89)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C247(1.05); C117(1.00); C352(0.87); C287(1.53)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C18(1.00); C247(1.18); C117(0.95)  LDD1686  [12]
 LDCM0484  CL9 HCT 116 C284(0.85); C287(0.85)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C18(0.93); C247(0.96); C117(0.85); C352(0.99)  LDD1688  [12]
 LDCM0486  CL91 HCT 116 C117(0.98)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C117(1.05)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C117(0.97)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C117(0.83)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C117(0.91)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C117(0.84)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C117(1.17)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C117(0.77)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C117(0.75)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C247(1.15); C117(1.05); C287(0.84)  LDD1698  [12]
 LDCM0468  Fragment33 HEK-293T C247(1.10); C117(1.03); C287(0.78)  LDD1671  [12]
 LDCM0427  Fragment51 HCT 116 C117(0.84)  LDD0744  [3]
 LDCM0116  HHS-0101 DM93 Y52(0.79)  LDD0264  [2]
 LDCM0117  HHS-0201 DM93 Y52(0.96)  LDD0265  [2]
 LDCM0118  HHS-0301 DM93 Y52(1.05)  LDD0266  [2]
 LDCM0119  HHS-0401 DM93 Y52(0.78)  LDD0267  [2]
 LDCM0120  HHS-0701 DM93 Y52(0.89)  LDD0268  [2]
 LDCM0022  KB02 HCT 116 C117(1.35)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C117(1.20)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C117(3.05)  LDD0082  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C117(1.34)  LDD2207  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bleomycin hydrolase (BLMH) Peptidase C1 family Q13867

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
11 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.