Details of the Target

General Information of Target

Target ID LDTP15714
Target Name Mdm2-binding protein (MTBP)
Gene Name MTBP
Gene ID 27085
Synonyms
Mdm2-binding protein; hMTBP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALDILAMAPLYQAPAINRIGPKTDPSKRPADPLKPLVLSRTKLTTIEAKRIMSILDEAI
YKVELVTLLSYVASNREDMEGMLGEDVMRAVREHEDLCQVLLENVRCLKEKERQLQEQKE
AEEEGWLRDRLLSIELQKSSLSPLMQQIKDSTKNVLRLLLSNPQAARLLQMQTQGRSAEA
QNFIDSLIELRGFLFEKLLTSPMEARDKAQFLQDISRQNSNNQQIIDTLEKELAERMKNR
NAEVEKENFVIQELKNHLHQVLKFSENSLVRTKQEAEKQQKADFRASQARVAKIQQEILQ
LQSQFYNLVMENREAEQALRKKKYKVETEIENWIQKYDTEMGEKQEELEDLDAVHREEKI
SLEELRRRHKVLVGEFAQIREEREINSKKRMEAEQEMVRMVRAATLIQALWKGYLVRSLL
RSKKKRGKGKAKDKEKGKQKGKEKGKGKK
Target Bioclass
Other
Family
MTBP family
Function
Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
Uniprot ID
Q96DY7
Ensemble ID
ENST00000305949.6
HGNC ID
HGNC:7417

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1806 Insertion: p.L587SfsTer19 .
HCC44 SNV: p.D228E .
HT115 SNV: p.D107Y .
LNCaP clone FGC SNV: p.P624Q .
MDAMB231 SNV: p.S63N .
OV56 SNV: p.I291M .
PC9 Substitution: p.T571K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Johansson_61
 Probe Info  		_(11.90)  LDD1490  [1]
AHL-Pu-1
 Probe Info  		C789(3.12)  LDD0173  [2]
DBIA
 Probe Info  		C789(5.43); C797(5.43)  LDD0080  [3]
IPM
 Probe Info  		C789(0.00); C691(0.00); C347(0.00); C481(0.00)  LDD2156  [4]
VSF
 Probe Info  		N.A.  LDD0007  [5]
W1
 Probe Info  		D234(0.00); E237(0.00)  LDD0236  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
PAL-AfBPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		5.78  LDD1725  [8]
C095
 Probe Info  		4.99  LDD1786  [8]
C102
 Probe Info  		8.88  LDD1790  [8]
C140
 Probe Info  		7.78  LDD1822  [8]
C145
 Probe Info  		13.93  LDD1827  [8]
C176
 Probe Info  		5.66  LDD1855  [8]
C177
 Probe Info  		9.85  LDD1856  [8]
C182
 Probe Info  		7.84  LDD1860  [8]
C260
 Probe Info  		5.86  LDD1932  [8]
C286
 Probe Info  		5.24  LDD1956  [8]
C288
 Probe Info  		6.36  LDD1958  [8]
C290
 Probe Info  		7.11  LDD1960  [8]
C297
 Probe Info  		6.02  LDD1967  [8]
C303
 Probe Info  		6.82  LDD1972  [8]
C342
 Probe Info  		7.89  LDD2004  [8]
C347
 Probe Info  		7.41  LDD2008  [8]
C353
 Probe Info  		10.06  LDD2014  [8]
C354
 Probe Info  		9.71  LDD2015  [8]
C418
 Probe Info  		10.70  LDD2073  [8]
C419
 Probe Info  		13.93  LDD2074  [8]
C420
 Probe Info  		21.56  LDD2075  [8]
C429
 Probe Info  		16.11  LDD2084  [8]
C430
 Probe Info  		5.58  LDD2085  [8]
C431
 Probe Info  		16.00  LDD2086  [8]
C433
 Probe Info  		11.16  LDD2088  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C789(3.12)  LDD0173  [2]
 LDCM0214  AC1 HCT 116 C691(0.88); C743(0.89); C789(0.95); C797(0.95)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C691(0.84); C743(0.95); C789(0.97); C797(0.97)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C208(0.91); C212(0.91); C691(1.24); C743(0.84)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C208(0.97); C212(0.97); C691(0.84); C743(1.44)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C208(0.90); C212(0.90); C691(1.10); C743(1.19)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C208(0.84); C212(0.84); C691(1.18); C743(1.40)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C208(0.88); C212(0.88); C691(1.23); C743(1.23)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C208(1.09); C212(1.09); C691(1.18); C743(1.59)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C208(1.05); C212(1.05); C691(1.47); C743(1.16)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C208(0.70); C212(1.00); C691(0.83); C743(1.59)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C208(1.38); C212(0.92); C691(1.19); C743(0.76)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C208(1.41); C212(0.94); C691(1.07); C743(1.10)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C691(1.04); C743(0.83); C789(1.33); C797(1.33)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C208(1.16); C212(1.03); C691(1.42); C743(1.25)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C208(1.11); C212(0.80); C691(1.30); C743(1.51)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C208(0.83); C212(0.85); C691(1.00); C743(1.20)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C208(1.03); C212(1.03); C398(1.02); C691(0.83)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C208(1.29); C212(1.29); C398(0.80); C691(1.10)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C208(1.30); C212(1.30); C398(1.01); C691(1.03)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C208(1.30); C212(1.30); C398(1.04); C691(1.24)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C208(1.13); C212(1.13); C398(1.10); C691(1.38)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C208(1.05); C212(1.05); C398(1.03); C691(1.04)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C208(1.19); C212(1.19); C398(0.95); C691(1.04)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C691(0.98); C743(0.89); C789(1.11); C797(1.11)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C208(1.41); C212(1.41); C398(1.17); C691(1.18)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C208(1.19); C212(1.19); C398(1.10); C691(1.08)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C208(1.24); C212(1.24); C398(1.20); C691(1.04)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C208(1.08); C212(1.08); C398(1.04); C691(1.19)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C208(1.07); C212(1.07); C398(0.86); C691(1.27)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C208(0.99); C212(0.99); C398(1.19); C691(1.20)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C208(1.13); C212(1.13); C398(1.06); C691(1.25)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C208(1.25); C212(1.25); C398(1.08); C691(1.39)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C789(1.08); C797(1.08)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C789(0.99); C797(0.99)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C789(1.31); C797(1.31)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C789(1.11); C797(1.11)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C789(0.82); C797(0.82)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C789(1.13); C797(1.13)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C789(1.02); C797(1.02)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C789(0.98); C797(0.98)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C789(0.97); C797(0.97)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C789(0.85); C797(0.85)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C789(1.11); C797(1.11)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C789(1.07); C797(1.07)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C691(1.00); C743(0.81); C789(0.70); C797(0.70)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C789(1.08); C797(1.08)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C789(1.05); C797(1.05)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C789(0.93); C797(0.93)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C853(0.92); C857(0.92); C789(0.93); C797(0.93)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C691(0.84); C789(1.10); C797(1.10); C853(1.12)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C691(0.81); C789(1.02); C797(1.02); C853(1.62)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C691(0.87); C789(1.33); C797(1.33); C853(1.40)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C691(0.95); C789(1.12); C797(1.12); C853(1.20)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C691(0.79); C853(1.41); C857(1.41); C789(1.54)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C691(0.68); C853(1.03); C857(1.03); C789(1.29)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C743(0.75); C691(0.98); C789(1.05); C797(1.05)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C691(0.83); C789(0.95); C797(0.95); C853(1.04)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C789(0.88); C797(0.88); C691(1.20); C853(1.43)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C691(1.01); C789(1.19); C797(1.19); C853(1.69)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C691(0.67); C853(1.47); C857(1.47); C789(1.62)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C691(1.05); C789(1.46); C797(1.46); C853(1.23)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C691(0.80); C789(1.25); C797(1.25); C853(1.14)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C691(0.93); C789(1.25); C797(1.25); C853(1.19)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C691(0.82); C789(1.10); C797(1.10); C853(1.55)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C398(0.72)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C398(0.91)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C398(0.72)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C789(0.68); C797(0.68); C691(0.85); C743(0.92)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C398(0.67)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C398(0.83)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C398(0.73)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C398(0.75)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C398(0.73)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C398(0.83)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C398(0.75)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C398(0.96)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C398(0.67)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C398(1.12)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C789(0.72); C797(0.72); C743(0.88); C691(1.04)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C398(0.86)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C398(0.70)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C398(0.57)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C398(0.77)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C398(1.40)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C691(1.64); C853(1.30); C857(0.96)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C691(1.73); C853(1.25); C857(0.77)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C691(1.44); C853(1.15); C857(0.87)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C691(1.11); C853(1.19); C857(1.27)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C691(1.31); C853(1.31); C857(1.31)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C789(0.74); C797(0.74); C743(0.86); C691(1.02)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C691(0.73); C853(0.73); C857(0.72)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C691(0.95); C853(0.88); C857(0.81)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C691(1.35); C853(1.09); C857(0.83)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C691(1.16); C853(1.13); C857(1.10)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C691(1.15); C853(1.05); C857(0.95)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C691(1.83); C853(1.31); C857(0.80)  LDD0905  [3]
 LDCM0308  AC46 HCT 116 C398(0.95); C691(0.98); C208(0.99); C212(0.99)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C398(0.85); C691(0.97); C208(1.07); C212(1.07)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C208(1.07); C212(1.07); C691(1.10); C398(1.14)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C208(0.59); C212(0.59); C691(0.99); C398(2.48)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C789(0.61); C797(0.61); C691(0.94); C743(0.95)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C208(0.76); C212(0.76); C691(0.99); C398(1.34)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C691(0.99); C208(1.00); C212(1.00); C398(1.61)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C208(0.94); C212(0.94); C691(1.13); C398(1.48)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C208(0.97); C212(0.97); C691(1.05); C398(1.18)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C208(0.96); C212(0.96); C398(1.06); C691(1.14)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C398(0.89); C691(1.11); C208(1.11); C212(1.11)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C208(0.80); C212(0.80); C691(0.95); C398(1.52)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C208(1.01); C789(1.04); C797(1.04); C212(1.07)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C789(0.74); C797(0.74); C691(1.07); C208(1.07)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C789(0.99); C797(0.99); C691(1.17); C208(1.26)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C743(0.84); C691(0.98); C789(0.99); C797(0.99)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C789(0.85); C797(0.85); C212(1.16); C208(1.20)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C789(0.73); C797(0.73); C691(1.01); C208(1.06)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C789(0.68); C797(0.68); C691(1.02); C212(1.05)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C789(0.79); C797(0.79); C212(1.06); C208(1.13)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C789(0.56); C797(0.56); C691(1.12); C208(1.60)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C789(0.33); C797(0.33); C691(1.09); C208(1.30)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C789(0.34); C797(0.34); C691(1.03); C208(1.08)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C789(0.37); C797(0.37); C691(1.15); C208(1.42)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C789(1.08); C797(1.08); C853(1.13); C857(1.13)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C853(0.97); C857(0.97); C789(1.09); C797(1.09)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C743(0.80); C789(0.91); C797(0.91); C691(1.01)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C743(0.87); C789(0.99); C797(0.99); C691(1.13)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C743(0.97); C853(1.04); C857(1.04); C789(1.07)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C691(1.21); C853(1.21); C857(1.21); C789(1.29)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C853(1.31); C857(1.31); C789(1.55); C797(1.55)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C789(1.56); C797(1.56); C853(1.57); C857(1.57)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C853(1.58); C857(1.58); C789(1.89); C797(1.89)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C853(0.87); C857(0.87); C789(1.15); C797(1.15)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C789(1.22); C797(1.22); C853(1.26); C857(1.26)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C853(1.05); C857(1.05); C691(1.10); C789(1.15)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C743(0.98); C853(1.19); C857(1.19); C789(1.20)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C743(0.83); C691(0.96); C789(1.03); C797(1.03)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C853(0.79); C857(0.79); C789(1.19); C797(1.19)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C853(0.63); C857(0.63); C789(0.65); C797(0.65)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C853(1.39); C857(1.39); C789(1.52); C797(1.52)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C853(0.82); C857(0.82); C208(1.05); C212(1.05)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C853(0.82); C857(0.82); C208(1.04); C212(1.04)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C208(0.85); C212(0.85); C853(0.91); C857(0.91)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C853(0.79); C857(0.79); C789(1.05); C797(1.05)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C208(0.86); C212(0.86); C853(1.03); C857(1.03)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C853(0.89); C857(0.89); C208(1.00); C212(1.00)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C853(0.82); C857(0.82); C208(0.98); C212(0.98)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C789(0.78); C797(0.78); C853(0.84); C857(0.84)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C853(0.81); C857(0.81); C208(1.14); C212(1.14)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C853(0.78); C857(0.78); C208(1.18); C212(1.18)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C853(0.86); C857(0.86); C208(1.01); C212(1.01)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C208(0.86); C212(0.86); C853(0.97); C857(0.97)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C208(0.75); C212(0.75); C789(1.12); C797(1.12)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C208(0.95); C212(0.95); C853(1.25); C857(1.25)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C853(0.73); C857(0.73); C208(1.04); C212(1.04)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C853(0.79); C857(0.79); C208(0.91); C212(0.91)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C853(0.74); C857(0.74); C789(0.76); C797(0.76)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C691(1.02); C743(0.99); C789(0.94); C797(0.94)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C743(0.84); C789(0.86); C797(0.86); C691(1.02)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C743(0.80); C691(0.97); C789(1.28); C797(1.28)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C743(1.17)  LDD2171  [3]
 LDCM0367  CL1 HCT 116 C853(0.84); C857(0.84); C743(1.02); C691(1.62)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C743(0.89); C853(1.00); C857(1.00); C691(1.47)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C691(0.84); C789(0.90); C797(0.90); C743(0.95)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C743(0.76); C691(0.92); C789(0.96); C797(0.96)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C691(0.73); C743(0.84); C789(0.91); C797(0.91)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C743(0.83); C691(0.96); C789(1.54); C797(1.54)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C743(0.76); C789(1.00); C797(1.00); C691(1.34)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C398(0.76)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C398(0.90)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C398(0.93)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C398(0.83)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C398(0.72)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C743(0.89); C691(1.17); C853(1.19); C857(1.19)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C398(0.66)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C398(0.83)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C398(1.01)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C398(1.13)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C398(1.52)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C398(1.37)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C398(0.92)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C691(1.73); C853(1.30); C857(0.86)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C691(1.25); C853(1.04); C857(0.84)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C691(0.95); C853(0.84); C857(0.74)  LDD0987  [3]
 LDCM0390  CL12 HCT 116 C743(0.93); C853(1.14); C857(1.14); C691(1.72)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C691(1.69); C853(1.24); C857(0.78)  LDD0989  [3]
 LDCM0392  CL121 HCT 116 C208(0.84); C212(0.84); C398(0.98); C691(1.05)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C208(0.80); C212(0.80); C691(0.96); C398(1.50)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C208(0.93); C212(0.93); C691(0.95); C398(1.09)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C208(0.85); C212(0.85); C691(1.18); C398(1.21)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C789(0.72); C797(0.72); C212(0.77); C691(0.83)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C789(0.67); C797(0.67); C691(0.93); C208(1.85)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C691(0.93); C789(0.93); C797(0.93); C208(1.19)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C789(0.77); C797(0.77); C691(1.06); C208(1.16)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C743(0.96); C853(1.08); C857(1.08); C691(1.30)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C853(0.89); C857(0.89); C743(0.93); C691(1.09)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C743(0.97); C691(1.02); C853(1.23); C857(1.23)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C691(1.00); C208(2.30); C212(2.30)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C208(0.76); C212(0.76)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C208(0.80); C212(0.80)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C208(0.85); C212(0.85)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C853(0.84); C857(0.84); C743(0.96); C691(1.44)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C208(0.90); C212(0.90)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C208(0.88); C212(0.88)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C208(1.58); C212(1.58)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C208(0.70); C212(0.70)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C208(1.16); C212(1.16)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C208(1.81); C212(1.81)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C208(1.20); C212(1.20)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C208(0.83); C212(0.83)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C208(1.65); C212(1.65)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C208(0.93); C212(0.93)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C691(1.35); C743(1.06); C853(1.00); C857(1.00)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C208(0.75); C212(0.75)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C208(1.25); C691(1.16)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C208(1.04); C691(1.21)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C208(1.02); C691(1.20)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C208(1.34); C691(1.10)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C208(1.08); C691(1.22)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C208(1.11); C691(0.95)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C208(0.85); C691(1.18)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C208(0.84); C691(1.17)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C691(1.19); C743(0.98); C853(0.94); C857(0.94)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C208(1.32); C691(0.92)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C208(0.99); C691(1.00)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C208(0.96); C691(1.30)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C208(0.90); C691(1.30)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C208(1.06); C691(1.26)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C208(1.35); C691(1.19)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C208(1.10); C743(1.11); C789(1.03); C797(1.03)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C208(1.27); C743(0.91); C789(0.98); C797(0.98)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C208(0.99); C743(0.92); C789(0.94); C797(0.94)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C208(0.87); C743(1.03); C789(0.93); C797(0.93)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C691(0.89); C743(0.87); C853(0.84); C857(0.84)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C208(0.98); C743(1.06); C789(0.88); C797(0.88)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C208(1.42); C743(1.07); C789(1.05); C797(1.05)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C208(1.22); C743(0.85); C789(1.11); C797(1.11)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C208(1.01); C743(0.70); C789(1.00); C797(1.00)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C208(0.95); C743(0.93); C789(1.42); C797(1.42)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C208(0.86); C743(0.99); C789(0.99); C797(0.99)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C208(0.91); C743(0.88); C789(1.02); C797(1.02)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C208(1.10); C743(1.00); C789(1.17); C797(1.17)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C208(1.07); C743(0.79); C789(1.08); C797(1.08)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C208(0.75); C743(1.25); C789(1.11); C797(1.11)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C691(1.14); C743(1.02); C853(0.91); C857(0.91)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C208(1.03); C743(0.98); C789(1.11); C797(1.11)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C691(1.15); C743(0.96)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C691(0.78); C743(1.02)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C691(1.22); C743(0.87)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C691(0.98); C743(0.71)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C691(1.25); C743(0.93)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C691(1.14); C743(1.03)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C691(0.94); C743(0.99)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C691(0.90); C743(0.88)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C691(1.04); C743(1.11)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C691(1.25); C743(0.81); C853(1.18); C857(1.18)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C691(0.94); C743(0.90)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C691(1.06); C743(0.99)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C691(1.31); C743(0.93)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C691(1.08); C743(0.84)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C691(1.28); C743(0.87)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C208(0.74); C212(0.74); C691(0.95); C743(1.02)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C208(0.52); C212(0.52); C691(0.57); C743(0.98)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C208(0.98); C212(0.98); C691(1.11); C743(1.23)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C208(1.06); C212(1.06); C691(0.77); C743(1.43)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C691(1.55); C743(1.32); C853(1.26); C857(1.26)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C208(1.01); C212(1.01); C691(1.07); C743(1.41)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C208(1.72); C212(1.72); C691(1.18); C743(1.47)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C208(0.98); C212(0.98); C691(1.01); C743(1.25)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C208(0.92); C212(0.92); C691(1.27); C743(0.68)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C208(0.96); C212(0.96); C691(0.85); C743(1.14)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C208(0.83); C212(0.83); C691(1.08); C743(1.29)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C208(0.68); C212(0.68); C691(0.98); C743(0.85)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C208(0.76); C212(0.76); C691(1.13); C743(0.78)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C208(0.62); C212(0.62); C691(0.95); C743(0.94)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C208(0.87); C212(0.87); C691(1.21); C743(1.39)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C691(1.30); C743(0.97); C853(0.87); C857(0.87)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C208(0.80); C212(0.80); C691(0.82); C743(1.07)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C691(0.76); C743(0.87); C789(0.92); C797(0.92)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C691(0.83); C743(0.84); C789(0.97); C797(0.97)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C691(0.85); C743(1.00); C789(1.00); C797(1.00)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C691(0.87); C743(0.85); C789(1.20); C797(1.20)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C691(0.83); C743(0.90); C789(0.97); C797(0.97)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C691(0.84); C743(0.79); C789(1.06); C797(1.06)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C691(0.78); C743(0.90); C789(0.68); C797(0.68)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C691(0.94); C743(0.64); C789(0.64); C797(0.64)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C691(1.03); C743(0.85); C789(0.77); C797(0.77)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C347(1.05); C317(0.97); C481(0.94); C789(1.34)  LDD1698  [9]
 LDCM0468  Fragment33 HCT 116 C691(0.95); C743(0.91)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C208(1.13); C691(1.11)  LDD0744  [3]
 LDCM0617  Fragment63-S Jurkat _(11.90)  LDD1490  [1]
 LDCM0022  KB02 HCT 116 C789(5.43); C797(5.43)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C789(5.39); C797(5.39)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C789(4.72); C797(4.72)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C743(1.17)  LDD2173  [3]

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402