Details of the Target

General Information of Target

Target ID LDTP02922
Target Name CTP synthase 1 (CTPS1)
Gene Name CTPS1
Gene ID 1503
Synonyms
CTPS; CTP synthase 1; EC 6.3.4.2; CTP synthetase 1; UTP--ammonia ligase 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFV
LDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDA
IQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHV
SLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQ
VICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCS
IALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSADLEPITSQEEPVRYHEAWQK
LCSAHGVLVPGGFGVRGTEGKIQAIAWARNQKKPFLGVCLGMQLAVVEFSRNVLGWQDAN
STEFDPTTSHPVVVDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDADYLEERHRH
RFEVNPVWKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPY
FGLLLASVGRLSHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSINHD
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
CTP synthase family
Subcellular location
Cytoplasm, cytosol
Function
This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.
TTD ID
T70101
Uniprot ID
P17812
DrugMap ID
TTN12BZ
Ensemble ID
ENST00000372616.1
HGNC ID
HGNC:2519

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.P351L DBIA    Probe Info 
CORL23 SNV: p.A120V DBIA    Probe Info 
EFO27 Deletion: p.L396WfsTer5 DBIA    Probe Info 
K562 SNV: p.H116L FFF probe13    Probe Info 
MFE319 SNV: p.M464T DBIA    Probe Info 
NCIH1155 SNV: p.R205K DBIA    Probe Info 
PF382 SNV: p.W387R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 49 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.16  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y96(20.00); Y336(13.85); Y106(13.42); Y473(11.88)  LDD0257  [4]
TH214
 Probe Info  		Y554(20.00)  LDD0258  [4]
TH216
 Probe Info  		Y473(20.00); Y554(20.00); Y94(20.00); Y96(20.00)  LDD0259  [4]
AZ-9
 Probe Info  		E505(10.00)  LDD2208  [5]
ONAyne
 Probe Info  		N.A.  LDD0273  [6]
Probe 1
 Probe Info  		Y94(24.69); Y106(95.04); Y292(30.29); Y314(40.90)  LDD3495  [7]
THZ1-DTB
 Probe Info  		C216(0.94)  LDD0460  [8]
DA-P3
 Probe Info  		21.69  LDD0183  [9]
AHL-Pu-1
 Probe Info  		C491(3.32)  LDD0168  [10]
HHS-482
 Probe Info  		Y354(0.61); Y468(0.88); Y554(1.04)  LDD0285  [11]
HHS-475
 Probe Info  		Y554(0.62); Y96(0.89); Y354(0.90); Y473(0.98)  LDD0264  [12]
HHS-465
 Probe Info  		Y354(10.00); Y473(10.00); Y554(10.00); Y96(5.64)  LDD2237  [13]
DBIA
 Probe Info  		C362(1.26); C218(1.04); C299(1.04); C234(1.04)  LDD0078  [14]
5E-2FA
 Probe Info  		H235(0.00); H365(0.00)  LDD2235  [15]
ATP probe
 Probe Info  		K557(0.00); K306(0.00); K309(0.00); K466(0.00)  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C491(0.00); C218(0.00); C176(0.00); C216(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		C216(0.00); C362(0.00); C299(0.00); C234(0.00)  LDD0032  [18]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [19]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [19]
Lodoacetamide azide
 Probe Info  		C491(0.00); C218(0.00); C176(0.00); C216(0.00)  LDD0037  [17]
ATP probe
 Probe Info  		N.A.  LDD0035  [20]
BTD
 Probe Info  		C491(0.00); C362(0.00)  LDD0004  [21]
JW-RF-010
 Probe Info  		C299(0.00); C491(0.00); C218(0.00); C216(0.00)  LDD0026  [22]
NAIA_4
 Probe Info  		C216(0.00); C218(0.00); C491(0.00)  LDD2226  [23]
TFBX
 Probe Info  		C491(0.00); C216(0.00); C299(0.00); C218(0.00)  LDD0027  [22]
WYneN
 Probe Info  		C218(0.00); C216(0.00)  LDD0021  [21]
WYneO
 Probe Info  		N.A.  LDD0022  [21]
Compound 10
 Probe Info  		N.A.  LDD2216  [24]
ENE
 Probe Info  		N.A.  LDD0006  [21]
IPM
 Probe Info  		C216(0.00); C30(0.00); C362(0.00)  LDD0005  [21]
NHS
 Probe Info  		N.A.  LDD0010  [21]
NPM
 Probe Info  		C218(0.00); C491(0.00)  LDD0016  [21]
PF-06672131
 Probe Info  		C216(0.00); C362(0.00)  LDD0017  [25]
SF
 Probe Info  		Y96(0.00); Y554(0.00); Y473(0.00)  LDD0028  [26]
STPyne
 Probe Info  		K193(0.00); K557(0.00)  LDD0009  [21]
VSF
 Probe Info  		C218(0.00); C491(0.00); C362(0.00)  LDD0007  [21]
Phosphinate-6
 Probe Info  		C491(0.00); C559(0.00)  LDD0018  [27]
1c-yne
 Probe Info  		N.A.  LDD0228  [28]
1d-yne
 Probe Info  		N.A.  LDD0357  [28]
Acrolein
 Probe Info  		C299(0.00); C30(0.00); H553(0.00); C234(0.00)  LDD0217  [29]
Methacrolein
 Probe Info  		C362(0.00); C299(0.00); C216(0.00); C30(0.00)  LDD0218  [29]
W1
 Probe Info  		N.A.  LDD0236  [30]
AOyne
 Probe Info  		15.00  LDD0443  [31]
NAIA_5
 Probe Info  		C491(0.00); C218(0.00); C216(0.00); C362(0.00)  LDD2223  [23]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C191
 Probe Info  		12.21  LDD1868  [32]
C246
 Probe Info  		28.64  LDD1919  [32]
FFF probe11
 Probe Info  		8.04  LDD0472  [33]
FFF probe12
 Probe Info  		6.16  LDD0473  [33]
FFF probe13
 Probe Info  		9.63  LDD0475  [33]
FFF probe2
 Probe Info  		5.00  LDD0463  [33]
FFF probe3
 Probe Info  		5.20  LDD0464  [33]
STS-1
 Probe Info  		N.A.  LDD0136  [34]
STS-2
 Probe Info  		N.A.  LDD0138  [34]
VE-P
 Probe Info  		N.A.  LDD0396  [35]
DA-2
 Probe Info  		N.A.  LDD0071  [36]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C30(1.01); C491(0.74)  LDD2142  [37]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C30(0.87); C491(1.03)  LDD2112  [37]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C30(0.82); C491(0.64); C362(0.54)  LDD2095  [37]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C30(0.67); C491(1.08)  LDD2130  [37]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C30(1.14); C491(1.07); C362(1.30); C299(1.17)  LDD2117  [37]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C30(1.39); C491(1.22)  LDD2152  [37]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C30(0.93); C491(0.96)  LDD2103  [37]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C30(0.69); C491(0.58); C299(0.78)  LDD2132  [37]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C30(0.55); C491(0.74)  LDD2131  [37]
 LDCM0025  4SU-RNA HEK-293T C491(3.32)  LDD0168  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C491(7.21); C362(2.17)  LDD0169  [10]
 LDCM0563  Abegg_cp(+)-11 HeLa C362(2.43)  LDD0314  [22]
 LDCM0214  AC1 HCT 116 C216(1.26); C218(1.54); C299(1.46); C362(1.01)  LDD0531  [14]
 LDCM0215  AC10 HCT 116 C216(0.96); C218(1.11); C362(0.71); C491(1.40)  LDD0532  [14]
 LDCM0216  AC100 HCT 116 C216(1.12); C218(0.90); C491(1.23)  LDD0533  [14]
 LDCM0217  AC101 HCT 116 C216(0.79); C218(0.89); C491(1.14)  LDD0534  [14]
 LDCM0218  AC102 HCT 116 C216(0.99); C218(1.05); C491(1.09)  LDD0535  [14]
 LDCM0219  AC103 HCT 116 C216(0.94); C218(0.88); C491(1.29)  LDD0536  [14]
 LDCM0220  AC104 HCT 116 C216(0.97); C218(0.83); C491(1.01)  LDD0537  [14]
 LDCM0221  AC105 HCT 116 C216(0.88); C218(0.95); C491(1.17)  LDD0538  [14]
 LDCM0222  AC106 HCT 116 C216(1.09); C218(0.90); C491(1.24)  LDD0539  [14]
 LDCM0223  AC107 HCT 116 C216(1.07); C218(0.91); C491(1.14)  LDD0540  [14]
 LDCM0224  AC108 HCT 116 C216(0.90); C218(0.92); C491(1.33)  LDD0541  [14]
 LDCM0225  AC109 HCT 116 C216(1.17); C218(0.92); C491(1.07)  LDD0542  [14]
 LDCM0226  AC11 HCT 116 C216(0.87); C218(1.36); C362(0.58); C491(1.15)  LDD0543  [14]
 LDCM0227  AC110 HCT 116 C216(0.90); C218(0.91); C491(1.29)  LDD0544  [14]
 LDCM0228  AC111 HCT 116 C216(0.66); C218(0.91); C491(1.29)  LDD0545  [14]
 LDCM0229  AC112 HCT 116 C216(0.75); C218(0.89); C491(1.29)  LDD0546  [14]
 LDCM0230  AC113 HCT 116 C216(1.04); C218(1.15); C234(0.84); C243(0.84)  LDD0547  [14]
 LDCM0231  AC114 HCT 116 C216(0.85); C218(0.96); C234(0.85); C243(0.80)  LDD0548  [14]
 LDCM0232  AC115 HCT 116 C216(0.95); C218(0.93); C234(1.02); C243(0.84)  LDD0549  [14]
 LDCM0233  AC116 HCT 116 C216(0.84); C218(1.03); C234(0.95); C243(0.77)  LDD0550  [14]
 LDCM0234  AC117 HCT 116 C216(0.98); C218(1.32); C234(0.99); C243(0.91)  LDD0551  [14]
 LDCM0235  AC118 HCT 116 C216(0.91); C218(1.04); C234(0.79); C243(0.77)  LDD0552  [14]
 LDCM0236  AC119 HCT 116 C216(0.99); C218(1.15); C234(0.87); C243(0.72)  LDD0553  [14]
 LDCM0237  AC12 HCT 116 C216(1.12); C218(1.28); C362(0.83); C491(1.14)  LDD0554  [14]
 LDCM0238  AC120 HCT 116 C216(1.03); C218(0.83); C234(0.85); C243(0.85)  LDD0555  [14]
 LDCM0239  AC121 HCT 116 C216(1.35); C218(1.26); C234(1.07); C243(0.64)  LDD0556  [14]
 LDCM0240  AC122 HCT 116 C216(0.93); C218(1.07); C234(0.92); C243(0.80)  LDD0557  [14]
 LDCM0241  AC123 HCT 116 C216(0.91); C218(0.90); C234(0.82); C243(0.72)  LDD0558  [14]
 LDCM0242  AC124 HCT 116 C216(1.07); C218(1.10); C234(0.91); C243(0.69)  LDD0559  [14]
 LDCM0243  AC125 HCT 116 C216(1.13); C218(1.02); C234(0.91); C243(0.86)  LDD0560  [14]
 LDCM0244  AC126 HCT 116 C216(0.85); C218(1.06); C234(0.74); C243(0.84)  LDD0561  [14]
 LDCM0245  AC127 HCT 116 C216(0.89); C218(1.12); C234(0.86); C243(0.86)  LDD0562  [14]
 LDCM0246  AC128 HCT 116 C216(1.11); C218(0.75); C234(2.27); C243(2.27)  LDD0563  [14]
 LDCM0247  AC129 HCT 116 C216(0.87); C218(0.72); C234(1.20); C243(1.20)  LDD0564  [14]
 LDCM0249  AC130 HCT 116 C216(0.71); C218(0.95); C234(1.06); C243(1.06)  LDD0566  [14]
 LDCM0250  AC131 HCT 116 C216(0.76); C218(0.80); C234(1.55); C243(1.55)  LDD0567  [14]
 LDCM0251  AC132 HCT 116 C216(0.50); C218(0.95); C234(0.72); C243(0.72)  LDD0568  [14]
 LDCM0252  AC133 HCT 116 C216(0.61); C218(0.87); C234(1.08); C243(1.08)  LDD0569  [14]
 LDCM0253  AC134 HCT 116 C216(0.52); C218(0.87); C234(1.01); C243(1.01)  LDD0570  [14]
 LDCM0254  AC135 HCT 116 C216(0.54); C218(0.88); C234(0.90); C243(0.90)  LDD0571  [14]
 LDCM0255  AC136 HCT 116 C216(0.46); C218(0.90); C234(0.95); C243(0.95)  LDD0572  [14]
 LDCM0256  AC137 HCT 116 C216(0.58); C218(0.86); C234(0.86); C243(0.86)  LDD0573  [14]
 LDCM0257  AC138 HCT 116 C216(0.38); C218(0.85); C234(1.04); C243(1.04)  LDD0574  [14]
 LDCM0258  AC139 HCT 116 C216(0.39); C218(0.91); C234(0.68); C243(0.68)  LDD0575  [14]
 LDCM0259  AC14 HCT 116 C216(0.83); C218(1.11); C362(0.92); C491(1.15)  LDD0576  [14]
 LDCM0260  AC140 HCT 116 C216(0.37); C218(0.84); C234(0.81); C243(0.81)  LDD0577  [14]
 LDCM0261  AC141 HCT 116 C216(0.38); C218(0.85); C234(0.76); C243(0.76)  LDD0578  [14]
 LDCM0262  AC142 HCT 116 C216(0.46); C218(0.86); C234(0.80); C243(0.80)  LDD0579  [14]
 LDCM0263  AC143 HCT 116 C216(0.67); C218(0.99); C362(1.07); C491(1.12)  LDD0580  [14]
 LDCM0264  AC144 HCT 116 C216(0.87); C491(1.20); C218(1.23); C362(1.25)  LDD0581  [14]
 LDCM0265  AC145 HCT 116 C218(1.03); C491(1.11); C216(1.11); C362(1.25)  LDD0582  [14]
 LDCM0266  AC146 HCT 116 C216(0.67); C491(1.06); C362(1.10); C218(1.14)  LDD0583  [14]
 LDCM0267  AC147 HCT 116 C216(1.11); C218(1.25); C491(1.27); C362(1.48)  LDD0584  [14]
 LDCM0268  AC148 HCT 116 C216(0.75); C218(1.37); C491(1.41); C362(1.60)  LDD0585  [14]
 LDCM0269  AC149 HCT 116 C216(0.82); C218(1.25); C491(1.27); C362(1.31)  LDD0586  [14]
 LDCM0270  AC15 HCT 116 C362(0.86); C216(0.96); C218(1.11); C491(1.24)  LDD0587  [14]
 LDCM0271  AC150 HCT 116 C216(0.75); C491(1.04); C218(1.09); C362(1.34)  LDD0588  [14]
 LDCM0272  AC151 HCT 116 C216(0.61); C491(0.98); C362(1.07); C218(1.29)  LDD0589  [14]
 LDCM0273  AC152 HCT 116 C216(0.60); C491(1.22); C218(1.31); C362(1.63)  LDD0590  [14]
 LDCM0274  AC153 HCT 116 C216(0.38); C218(1.45); C362(1.47); C491(1.67)  LDD0591  [14]
 LDCM0621  AC154 HCT 116 C216(0.64); C218(1.13); C362(1.60); C491(1.10)  LDD2158  [14]
 LDCM0622  AC155 HCT 116 C216(0.42); C218(1.19); C362(1.15); C491(1.09)  LDD2159  [14]
 LDCM0623  AC156 HCT 116 C216(0.70); C218(1.15); C362(1.15); C491(0.93)  LDD2160  [14]
 LDCM0624  AC157 HCT 116 C216(0.55); C218(1.13); C362(0.89); C491(0.93)  LDD2161  [14]
 LDCM0276  AC17 HCT 116 C362(0.89); C491(0.97); C216(1.00); C299(1.04)  LDD0593  [14]
 LDCM0277  AC18 HCT 116 C299(0.63); C216(0.77); C362(0.92); C491(0.97)  LDD0594  [14]
 LDCM0278  AC19 HCT 116 C362(0.84); C491(0.93); C216(0.95); C299(0.98)  LDD0595  [14]
 LDCM0279  AC2 HCT 116 C362(0.75); C299(0.90); C216(1.00); C218(1.13)  LDD0596  [14]
 LDCM0280  AC20 HCT 116 C362(0.94); C216(0.98); C218(0.99); C299(1.04)  LDD0597  [14]
 LDCM0281  AC21 HCT 116 C299(0.81); C491(0.87); C362(0.89); C216(0.98)  LDD0598  [14]
 LDCM0282  AC22 HCT 116 C299(0.89); C362(0.90); C218(1.02); C216(1.07)  LDD0599  [14]
 LDCM0283  AC23 HCT 116 C216(0.90); C299(0.95); C491(0.99); C218(1.02)  LDD0600  [14]
 LDCM0284  AC24 HCT 116 C362(0.74); C218(0.90); C491(0.99); C216(1.00)  LDD0601  [14]
 LDCM0285  AC25 HCT 116 C491(0.74); C234(0.87); C243(0.87); C216(0.91)  LDD0602  [14]
 LDCM0286  AC26 HCT 116 C234(0.58); C243(0.58); C216(0.74); C491(0.85)  LDD0603  [14]
 LDCM0287  AC27 HCT 116 C234(0.66); C243(0.66); C216(0.73); C491(0.83)  LDD0604  [14]
 LDCM0288  AC28 HCT 116 C234(0.61); C243(0.61); C216(0.64); C299(0.83)  LDD0605  [14]
 LDCM0289  AC29 HCT 116 C216(0.57); C234(0.57); C243(0.57); C491(0.86)  LDD0606  [14]
 LDCM0290  AC3 HCT 116 C362(0.93); C299(1.09); C218(1.18); C491(1.19)  LDD0607  [14]
 LDCM0291  AC30 HCT 116 C216(0.54); C234(0.57); C243(0.57); C491(0.87)  LDD0608  [14]
 LDCM0292  AC31 HCT 116 C216(0.51); C299(0.76); C234(0.81); C243(0.81)  LDD0609  [14]
 LDCM0293  AC32 HCT 116 C216(0.47); C234(0.55); C243(0.55); C299(0.66)  LDD0610  [14]
 LDCM0294  AC33 HCT 116 C216(0.68); C299(0.71); C491(0.83); C234(0.90)  LDD0611  [14]
 LDCM0295  AC34 HCT 116 C299(0.64); C216(0.64); C234(0.84); C243(0.84)  LDD0612  [14]
 LDCM0296  AC35 HCT 116 C491(0.82); C218(0.84); C216(1.29)  LDD0613  [14]
 LDCM0297  AC36 HCT 116 C218(0.89); C491(0.89); C216(1.03)  LDD0614  [14]
 LDCM0298  AC37 HCT 116 C491(0.86); C218(1.06); C216(1.24)  LDD0615  [14]
 LDCM0299  AC38 HCT 116 C218(0.85); C491(0.97); C216(1.01)  LDD0616  [14]
 LDCM0300  AC39 HCT 116 C218(0.91); C491(1.04); C216(1.24)  LDD0617  [14]
 LDCM0301  AC4 HCT 116 C362(0.81); C299(1.21); C491(1.31); C218(1.32)  LDD0618  [14]
 LDCM0302  AC40 HCT 116 C218(0.93); C491(1.09); C216(1.22)  LDD0619  [14]
 LDCM0303  AC41 HCT 116 C218(0.86); C216(0.87); C491(1.02)  LDD0620  [14]
 LDCM0304  AC42 HCT 116 C218(0.92); C491(1.04); C216(1.05)  LDD0621  [14]
 LDCM0305  AC43 HCT 116 C216(0.88); C218(1.01); C491(1.08)  LDD0622  [14]
 LDCM0306  AC44 HCT 116 C218(1.02); C491(1.05); C216(1.19)  LDD0623  [14]
 LDCM0307  AC45 HCT 116 C491(1.10); C216(1.11); C218(1.28)  LDD0624  [14]
 LDCM0308  AC46 HCT 116 C216(0.68); C299(1.00); C234(1.01); C243(1.01)  LDD0625  [14]
 LDCM0309  AC47 HCT 116 C216(0.83); C234(0.92); C243(0.92); C299(0.95)  LDD0626  [14]
 LDCM0310  AC48 HCT 116 C234(0.80); C243(0.80); C299(0.82); C216(0.90)  LDD0627  [14]
 LDCM0311  AC49 HCT 116 C299(0.73); C216(0.83); C218(1.03); C491(1.29)  LDD0628  [14]
 LDCM0312  AC5 HCT 116 C362(1.01); C299(1.14); C491(1.35); C218(1.37)  LDD0629  [14]
 LDCM0313  AC50 HCT 116 C299(0.76); C216(0.98); C234(1.04); C243(1.04)  LDD0630  [14]
 LDCM0314  AC51 HCT 116 C216(0.94); C299(1.06); C491(1.20); C218(1.24)  LDD0631  [14]
 LDCM0315  AC52 HCT 116 C299(0.90); C216(1.02); C218(1.08); C234(1.13)  LDD0632  [14]
 LDCM0316  AC53 HCT 116 C299(0.76); C216(0.84); C234(0.91); C243(0.91)  LDD0633  [14]
 LDCM0317  AC54 HCT 116 C299(0.98); C218(1.03); C234(1.07); C243(1.07)  LDD0634  [14]
 LDCM0318  AC55 HCT 116 C216(0.57); C299(0.75); C234(0.88); C243(0.88)  LDD0635  [14]
 LDCM0319  AC56 HCT 116 C299(0.58); C216(0.83); C234(1.11); C243(1.11)  LDD0636  [14]
 LDCM0320  AC57 HCT 116 C299(0.51); C362(0.67); C491(1.33); C218(1.36)  LDD0637  [14]
 LDCM0321  AC58 HCT 116 C299(0.43); C362(1.06); C218(1.18); C491(1.35)  LDD0638  [14]
 LDCM0322  AC59 HCT 116 C299(0.44); C362(0.82); C491(1.43); C218(1.53)  LDD0639  [14]
 LDCM0323  AC6 HCT 116 C216(0.84); C218(1.10); C362(1.13); C491(1.18)  LDD0640  [14]
 LDCM0324  AC60 HCT 116 C299(0.37); C362(0.96); C491(1.26); C218(1.29)  LDD0641  [14]
 LDCM0325  AC61 HCT 116 C299(0.35); C362(1.02); C491(1.29); C218(1.34)  LDD0642  [14]
 LDCM0326  AC62 HCT 116 C299(0.41); C362(0.87); C218(1.29); C491(1.72)  LDD0643  [14]
 LDCM0327  AC63 HCT 116 C299(0.42); C362(1.01); C218(1.26); C491(1.30)  LDD0644  [14]
 LDCM0328  AC64 HCT 116 C299(0.39); C362(0.96); C218(1.27); C491(1.52)  LDD0645  [14]
 LDCM0329  AC65 HCT 116 C299(0.60); C362(0.91); C218(1.42); C491(1.61)  LDD0646  [14]
 LDCM0330  AC66 HCT 116 C299(0.58); C362(0.91); C218(1.36); C491(1.41)  LDD0647  [14]
 LDCM0331  AC67 HCT 116 C299(0.27); C362(0.90); C218(1.21); C491(1.79)  LDD0648  [14]
 LDCM0332  AC68 HCT 116 C218(0.82); C491(0.88); C234(0.96); C243(0.96)  LDD0649  [14]
 LDCM0333  AC69 HCT 116 C491(0.81); C218(0.83); C234(0.86); C243(0.86)  LDD0650  [14]
 LDCM0334  AC7 HCT 116 C216(0.86); C362(0.98); C491(1.07); C218(1.11)  LDD0651  [14]
 LDCM0335  AC70 HCT 116 C218(0.77); C362(0.81); C234(0.93); C243(0.93)  LDD0652  [14]
 LDCM0336  AC71 HCT 116 C491(0.82); C218(0.89); C362(0.90); C234(1.09)  LDD0653  [14]
 LDCM0337  AC72 HCT 116 C218(0.74); C362(0.93); C491(0.95); C234(0.96)  LDD0654  [14]
 LDCM0338  AC73 HCT 116 C218(0.76); C362(0.87); C234(0.89); C243(0.89)  LDD0655  [14]
 LDCM0339  AC74 HCT 116 C491(0.84); C218(0.92); C362(0.94); C234(1.08)  LDD0656  [14]
 LDCM0340  AC75 HCT 116 C218(0.78); C362(0.83); C234(0.96); C243(0.96)  LDD0657  [14]
 LDCM0341  AC76 HCT 116 C491(0.82); C362(0.85); C218(0.89); C234(1.04)  LDD0658  [14]
 LDCM0342  AC77 HCT 116 C218(0.79); C491(0.90); C234(0.90); C243(0.90)  LDD0659  [14]
 LDCM0343  AC78 HCT 116 C491(0.87); C218(0.88); C234(0.91); C243(0.91)  LDD0660  [14]
 LDCM0344  AC79 HCT 116 C218(0.72); C362(0.91); C491(0.96); C234(1.02)  LDD0661  [14]
 LDCM0345  AC8 HCT 116 C216(0.81); C362(1.04); C491(1.17); C218(1.20)  LDD0662  [14]
 LDCM0346  AC80 HCT 116 C491(0.89); C234(0.93); C243(0.93); C218(0.97)  LDD0663  [14]
 LDCM0347  AC81 HCT 116 C218(0.81); C491(0.95); C362(0.97); C234(1.08)  LDD0664  [14]
 LDCM0348  AC82 HCT 116 C362(0.89); C491(0.89); C218(0.91); C234(1.03)  LDD0665  [14]
 LDCM0349  AC83 HCT 116 C216(0.87); C218(1.14); C362(1.23); C491(1.58)  LDD0666  [14]
 LDCM0350  AC84 HCT 116 C216(0.88); C218(1.04); C362(1.32); C491(1.48)  LDD0667  [14]
 LDCM0351  AC85 HCT 116 C216(0.91); C218(1.01); C362(1.24); C491(1.26)  LDD0668  [14]
 LDCM0352  AC86 HCT 116 C216(0.66); C362(1.08); C218(1.15); C491(1.21)  LDD0669  [14]
 LDCM0353  AC87 HCT 116 C216(0.70); C218(1.01); C491(1.04); C362(1.06)  LDD0670  [14]
 LDCM0354  AC88 HCT 116 C216(0.60); C218(1.06); C491(1.14); C362(1.21)  LDD0671  [14]
 LDCM0355  AC89 HCT 116 C216(0.70); C218(1.02); C362(1.12); C491(1.25)  LDD0672  [14]
 LDCM0357  AC90 HCT 116 C216(0.62); C362(0.82); C491(1.08); C218(1.35)  LDD0674  [14]
 LDCM0358  AC91 HCT 116 C216(1.05); C362(1.09); C218(1.23); C491(1.50)  LDD0675  [14]
 LDCM0359  AC92 HCT 116 C216(0.97); C362(1.11); C218(1.29); C491(1.42)  LDD0676  [14]
 LDCM0360  AC93 HCT 116 C216(0.86); C218(1.05); C491(1.14); C362(1.17)  LDD0677  [14]
 LDCM0361  AC94 HCT 116 C218(0.87); C491(1.11); C362(1.24); C216(1.44)  LDD0678  [14]
 LDCM0362  AC95 HCT 116 C216(0.65); C362(0.86); C218(1.01); C491(1.15)  LDD0679  [14]
 LDCM0363  AC96 HCT 116 C362(0.99); C218(1.17); C491(1.21); C216(1.33)  LDD0680  [14]
 LDCM0364  AC97 HCT 116 C216(0.61); C362(1.11); C218(1.14); C491(1.32)  LDD0681  [14]
 LDCM0365  AC98 HCT 116 C216(0.67); C218(0.92); C491(1.38)  LDD0682  [14]
 LDCM0366  AC99 HCT 116 C218(0.86); C216(0.86); C491(1.26)  LDD0683  [14]
 LDCM0545  Acetamide MDA-MB-231 C30(0.42); C491(0.51)  LDD2138  [37]
 LDCM0520  AKOS000195272 MDA-MB-231 C30(0.96); C491(0.71); C362(0.96)  LDD2113  [37]
 LDCM0248  AKOS034007472 HCT 116 C216(1.06); C218(1.12); C362(0.63); C491(1.10)  LDD0565  [14]
 LDCM0356  AKOS034007680 HCT 116 C362(0.91); C216(0.92); C491(1.19); C218(1.19)  LDD0673  [14]
 LDCM0275  AKOS034007705 HCT 116 C216(0.74); C218(1.11); C362(1.14); C491(1.49)  LDD0592  [14]
 LDCM0156  Aniline NCI-H1299 11.56  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C362(1.26); C218(1.04); C299(1.04); C234(1.04)  LDD0078  [14]
 LDCM0498  BS-3668 MDA-MB-231 C30(0.56); C491(0.53); C299(1.00)  LDD2091  [37]
 LDCM0108  Chloroacetamide HeLa C176(0.00); C299(0.00); C362(0.00); C30(0.00)  LDD0222  [29]
 LDCM0632  CL-Sc Hep-G2 C218(20.00); C216(20.00); C218(2.82); C362(1.75)  LDD2227  [23]
 LDCM0367  CL1 HCT 116 C218(0.86); C491(0.94); C216(1.03); C299(1.11)  LDD0684  [14]
 LDCM0368  CL10 HCT 116 C216(0.64); C218(0.96); C491(1.19); C299(1.23)  LDD0685  [14]
 LDCM0369  CL100 HCT 116 C362(0.94); C216(1.13); C218(1.25); C491(1.26)  LDD0686  [14]
 LDCM0370  CL101 HCT 116 C216(0.91); C362(0.98); C218(1.06); C491(1.27)  LDD0687  [14]
 LDCM0371  CL102 HCT 116 C362(0.82); C491(1.04); C218(1.06); C216(1.10)  LDD0688  [14]
 LDCM0372  CL103 HCT 116 C362(0.76); C491(1.05); C216(1.06); C218(1.19)  LDD0689  [14]
 LDCM0373  CL104 HCT 116 C362(0.91); C216(0.97); C491(0.99); C218(1.18)  LDD0690  [14]
 LDCM0374  CL105 HCT 116 C299(0.77); C216(0.88); C362(1.00); C218(1.06)  LDD0691  [14]
 LDCM0375  CL106 HCT 116 C299(0.44); C216(0.66); C218(1.12); C362(1.16)  LDD0692  [14]
 LDCM0376  CL107 HCT 116 C299(0.65); C216(0.79); C218(1.00); C362(1.10)  LDD0693  [14]
 LDCM0377  CL108 HCT 116 C299(0.62); C216(0.80); C218(1.05); C362(1.07)  LDD0694  [14]
 LDCM0378  CL109 HCT 116 C299(0.79); C216(0.81); C362(0.89); C218(0.91)  LDD0695  [14]
 LDCM0379  CL11 HCT 116 C216(0.80); C218(0.86); C491(1.17); C299(1.22)  LDD0696  [14]
 LDCM0380  CL110 HCT 116 C299(0.65); C216(0.81); C362(0.94); C218(1.15)  LDD0697  [14]
 LDCM0381  CL111 HCT 116 C216(0.75); C299(0.81); C362(0.99); C218(1.05)  LDD0698  [14]
 LDCM0382  CL112 HCT 116 C216(0.69); C491(0.74); C234(0.90); C243(0.90)  LDD0699  [14]
 LDCM0383  CL113 HCT 116 C216(0.53); C234(0.62); C243(0.62); C299(0.75)  LDD0700  [14]
 LDCM0384  CL114 HCT 116 C216(0.46); C234(0.79); C243(0.79); C491(0.83)  LDD0701  [14]
 LDCM0385  CL115 HCT 116 C216(0.63); C491(0.79); C234(0.81); C243(0.81)  LDD0702  [14]
 LDCM0386  CL116 HCT 116 C216(0.77); C299(0.85); C234(0.85); C243(0.85)  LDD0703  [14]
 LDCM0387  CL117 HCT 116 C218(0.94); C216(0.99); C491(1.35)  LDD0704  [14]
 LDCM0388  CL118 HCT 116 C216(0.88); C218(0.93); C491(1.04)  LDD0705  [14]
 LDCM0389  CL119 HCT 116 C216(0.91); C218(1.02); C491(1.06)  LDD0706  [14]
 LDCM0390  CL12 HCT 116 C216(0.80); C218(1.10); C299(1.18); C491(1.36)  LDD0707  [14]
 LDCM0391  CL120 HCT 116 C216(0.85); C218(0.87); C491(1.03)  LDD0708  [14]
 LDCM0392  CL121 HCT 116 C216(0.71); C234(0.93); C243(0.93); C299(0.97)  LDD0709  [14]
 LDCM0393  CL122 HCT 116 C299(0.73); C218(0.86); C216(0.86); C234(1.02)  LDD0710  [14]
 LDCM0394  CL123 HCT 116 C234(0.77); C243(0.77); C299(0.79); C491(1.03)  LDD0711  [14]
 LDCM0395  CL124 HCT 116 C299(0.75); C234(0.89); C243(0.89); C216(1.06)  LDD0712  [14]
 LDCM0396  CL125 HCT 116 C362(0.92); C299(0.94); C491(1.11); C218(1.31)  LDD0713  [14]
 LDCM0397  CL126 HCT 116 C299(0.64); C362(1.03); C218(1.13); C491(1.19)  LDD0714  [14]
 LDCM0398  CL127 HCT 116 C299(0.74); C362(0.94); C491(1.10); C218(1.20)  LDD0715  [14]
 LDCM0399  CL128 HCT 116 C299(0.52); C362(0.77); C491(1.24); C218(1.38)  LDD0716  [14]
 LDCM0400  CL13 HCT 116 C216(0.75); C218(0.85); C299(1.17); C491(1.18)  LDD0717  [14]
 LDCM0401  CL14 HCT 116 C216(0.87); C218(0.94); C491(1.02); C299(1.32)  LDD0718  [14]
 LDCM0402  CL15 HCT 116 C216(0.71); C218(0.87); C491(1.14); C299(1.50)  LDD0719  [14]
 LDCM0403  CL16 HCT 116 C216(0.67); C299(0.70); C218(1.00); C491(1.20)  LDD0720  [14]
 LDCM0404  CL17 HCT 116 C299(0.68); C216(0.87); C362(0.97); C218(0.99)  LDD0721  [14]
 LDCM0405  CL18 HCT 116 C299(0.46); C216(0.64); C218(0.93); C362(1.02)  LDD0722  [14]
 LDCM0406  CL19 HCT 116 C299(0.65); C216(0.76); C362(0.95); C218(0.99)  LDD0723  [14]
 LDCM0407  CL2 HCT 116 C218(0.88); C491(0.96); C216(1.01); C299(1.09)  LDD0724  [14]
 LDCM0408  CL20 HCT 116 C299(0.63); C216(0.84); C218(1.18); C362(1.24)  LDD0725  [14]
 LDCM0409  CL21 HCT 116 C299(0.45); C216(0.80); C362(0.90); C218(1.14)  LDD0726  [14]
 LDCM0410  CL22 HCT 116 C299(0.44); C216(0.70); C218(1.15); C362(1.36)  LDD0727  [14]
 LDCM0411  CL23 HCT 116 C216(0.72); C299(0.77); C218(1.09); C362(1.11)  LDD0728  [14]
 LDCM0412  CL24 HCT 116 C299(0.53); C216(0.67); C362(1.01); C218(1.15)  LDD0729  [14]
 LDCM0413  CL25 HCT 116 C216(0.66); C218(1.17); C299(0.53); C362(1.19)  LDD0730  [14]
 LDCM0414  CL26 HCT 116 C216(0.65); C218(1.05); C299(0.79); C362(1.20)  LDD0731  [14]
 LDCM0415  CL27 HCT 116 C216(0.88); C218(1.14); C299(0.70); C362(1.02)  LDD0732  [14]
 LDCM0416  CL28 HCT 116 C216(0.66); C218(1.09); C299(0.60); C362(1.00)  LDD0733  [14]
 LDCM0417  CL29 HCT 116 C216(0.77); C218(1.14); C299(0.58); C362(1.07)  LDD0734  [14]
 LDCM0418  CL3 HCT 116 C216(0.98); C218(0.88); C299(1.32); C491(1.02)  LDD0735  [14]
 LDCM0419  CL30 HCT 116 C216(0.73); C218(0.92); C299(0.68); C362(1.03)  LDD0736  [14]
 LDCM0420  CL31 HCT 116 C216(0.79); C218(0.96); C234(1.05); C243(1.05)  LDD0737  [14]
 LDCM0421  CL32 HCT 116 C216(0.50); C218(0.96); C234(0.68); C243(0.68)  LDD0738  [14]
 LDCM0422  CL33 HCT 116 C216(0.57); C218(0.91); C234(0.75); C243(0.75)  LDD0739  [14]
 LDCM0423  CL34 HCT 116 C216(0.63); C218(0.99); C234(0.69); C243(0.69)  LDD0740  [14]
 LDCM0424  CL35 HCT 116 C216(0.68); C218(1.04); C234(0.96); C243(0.96)  LDD0741  [14]
 LDCM0425  CL36 HCT 116 C216(0.74); C218(1.08); C234(0.86); C243(0.86)  LDD0742  [14]
 LDCM0426  CL37 HCT 116 C216(0.73); C218(1.01); C234(0.76); C243(0.76)  LDD0743  [14]
 LDCM0428  CL39 HCT 116 C216(0.68); C218(0.97); C234(0.73); C243(0.73)  LDD0745  [14]
 LDCM0429  CL4 HCT 116 C216(1.02); C218(0.86); C299(0.84); C491(1.00)  LDD0746  [14]
 LDCM0430  CL40 HCT 116 C216(0.73); C218(1.08); C234(0.84); C243(0.84)  LDD0747  [14]
 LDCM0431  CL41 HCT 116 C216(0.67); C218(1.01); C234(0.90); C243(0.90)  LDD0748  [14]
 LDCM0432  CL42 HCT 116 C216(0.61); C218(1.06); C234(0.69); C243(0.69)  LDD0749  [14]
 LDCM0433  CL43 HCT 116 C216(0.58); C218(0.88); C234(0.81); C243(0.81)  LDD0750  [14]
 LDCM0434  CL44 HCT 116 C216(0.66); C218(0.89); C234(0.70); C243(0.70)  LDD0751  [14]
 LDCM0435  CL45 HCT 116 C216(0.64); C218(1.00); C234(0.57); C243(0.57)  LDD0752  [14]
 LDCM0436  CL46 HCT 116 C216(0.89); C218(1.01); C491(0.82)  LDD0753  [14]
 LDCM0437  CL47 HCT 116 C216(1.01); C218(0.95); C491(0.90)  LDD0754  [14]
 LDCM0438  CL48 HCT 116 C216(0.81); C218(0.92); C491(0.81)  LDD0755  [14]
 LDCM0439  CL49 HCT 116 C216(1.14); C218(0.96); C491(0.88)  LDD0756  [14]
 LDCM0440  CL5 HCT 116 C216(0.98); C218(0.87); C299(1.15); C491(1.04)  LDD0757  [14]
 LDCM0441  CL50 HCT 116 C216(0.96); C218(1.05); C491(0.88)  LDD0758  [14]
 LDCM0442  CL51 HCT 116 C216(1.00); C218(1.19); C491(0.89)  LDD0759  [14]
 LDCM0443  CL52 HCT 116 C216(0.68); C218(1.52); C491(0.94)  LDD0760  [14]
 LDCM0444  CL53 HCT 116 C216(0.85); C218(1.02); C491(0.81)  LDD0761  [14]
 LDCM0445  CL54 HCT 116 C216(0.90); C218(1.04); C491(0.86)  LDD0762  [14]
 LDCM0446  CL55 HCT 116 C216(1.13); C218(0.97); C491(0.81)  LDD0763  [14]
 LDCM0447  CL56 HCT 116 C216(0.96); C218(1.09); C491(0.97)  LDD0764  [14]
 LDCM0448  CL57 HCT 116 C216(1.42); C218(1.04); C491(0.92)  LDD0765  [14]
 LDCM0449  CL58 HCT 116 C216(0.79); C218(0.99); C491(0.83)  LDD0766  [14]
 LDCM0450  CL59 HCT 116 C216(1.04); C218(1.01); C491(0.94)  LDD0767  [14]
 LDCM0451  CL6 HCT 116 C216(0.65); C218(0.93); C299(1.14); C491(1.09)  LDD0768  [14]
 LDCM0452  CL60 HCT 116 C216(0.79); C218(0.86); C491(0.90)  LDD0769  [14]
 LDCM0453  CL61 HCT 116 C216(1.05); C218(1.11); C362(0.98); C491(1.01)  LDD0770  [14]
 LDCM0454  CL62 HCT 116 C216(1.00); C218(1.16); C362(0.76); C491(0.93)  LDD0771  [14]
 LDCM0455  CL63 HCT 116 C216(0.98); C218(1.07); C362(0.90); C491(1.02)  LDD0772  [14]
 LDCM0456  CL64 HCT 116 C216(0.98); C218(1.12); C362(0.74); C491(0.91)  LDD0773  [14]
 LDCM0457  CL65 HCT 116 C216(1.02); C218(0.89); C362(0.92); C491(0.89)  LDD0774  [14]
 LDCM0458  CL66 HCT 116 C216(0.92); C218(1.13); C362(0.75); C491(0.90)  LDD0775  [14]
 LDCM0459  CL67 HCT 116 C216(1.01); C218(1.19); C362(0.98); C491(0.89)  LDD0776  [14]
 LDCM0460  CL68 HCT 116 C216(0.73); C218(1.07); C362(2.09); C491(0.95)  LDD0777  [14]
 LDCM0461  CL69 HCT 116 C216(0.71); C218(0.82); C362(0.80); C491(1.12)  LDD0778  [14]
 LDCM0462  CL7 HCT 116 C216(0.81); C218(1.01); C299(1.32); C491(1.22)  LDD0779  [14]
 LDCM0463  CL70 HCT 116 C216(0.73); C218(0.97); C362(1.08); C491(1.06)  LDD0780  [14]
 LDCM0464  CL71 HCT 116 C216(0.84); C218(1.00); C362(0.96); C491(1.09)  LDD0781  [14]
 LDCM0465  CL72 HCT 116 C216(0.90); C218(0.99); C362(1.05); C491(1.11)  LDD0782  [14]
 LDCM0466  CL73 HCT 116 C216(0.85); C218(1.05); C362(0.96); C491(0.96)  LDD0783  [14]
 LDCM0467  CL74 HCT 116 C216(0.87); C218(1.00); C362(1.03); C491(1.00)  LDD0784  [14]
 LDCM0469  CL76 HCT 116 C216(1.09); C218(1.03); C299(0.71); C362(1.38)  LDD0786  [14]
 LDCM0470  CL77 HCT 116 C216(1.33); C218(0.96); C299(0.74); C362(0.90)  LDD0787  [14]
 LDCM0471  CL78 HCT 116 C216(0.86); C218(1.23); C299(0.77); C362(1.26)  LDD0788  [14]
 LDCM0472  CL79 HCT 116 C216(1.44); C218(1.07); C299(0.68); C362(1.46)  LDD0789  [14]
 LDCM0473  CL8 HCT 116 C216(0.69); C218(0.79); C299(1.14); C491(1.32)  LDD0790  [14]
 LDCM0474  CL80 HCT 116 C216(1.44); C218(0.78); C299(0.64); C362(0.83)  LDD0791  [14]
 LDCM0475  CL81 HCT 116 C216(1.42); C218(1.05); C299(0.75); C362(1.22)  LDD0792  [14]
 LDCM0476  CL82 HCT 116 C216(1.56); C218(1.04); C299(0.53); C362(1.31)  LDD0793  [14]
 LDCM0477  CL83 HCT 116 C216(1.41); C218(1.14); C299(0.60); C362(1.71)  LDD0794  [14]
 LDCM0478  CL84 HCT 116 C216(1.42); C218(1.13); C299(0.51); C362(1.58)  LDD0795  [14]
 LDCM0479  CL85 HCT 116 C216(1.09); C218(1.07); C299(0.81); C362(1.42)  LDD0796  [14]
 LDCM0480  CL86 HCT 116 C216(1.14); C218(1.09); C299(1.01); C362(1.33)  LDD0797  [14]
 LDCM0481  CL87 HCT 116 C216(1.54); C218(1.13); C299(0.82); C362(1.56)  LDD0798  [14]
 LDCM0482  CL88 HCT 116 C216(1.82); C218(1.08); C299(0.62); C362(1.95)  LDD0799  [14]
 LDCM0483  CL89 HCT 116 C216(1.20); C218(1.03); C299(0.48); C362(1.44)  LDD0800  [14]
 LDCM0484  CL9 HCT 116 C216(0.88); C218(0.87); C299(1.24); C491(1.11)  LDD0801  [14]
 LDCM0485  CL90 HCT 116 C216(1.40); C218(0.79); C299(0.96); C362(1.15)  LDD0802  [14]
 LDCM0486  CL91 HCT 116 C216(0.92); C218(1.16); C299(0.74); C362(1.31)  LDD0803  [14]
 LDCM0487  CL92 HCT 116 C216(1.07); C218(1.07); C299(0.82); C362(0.84)  LDD0804  [14]
 LDCM0488  CL93 HCT 116 C216(1.26); C218(1.18); C299(1.16); C362(0.92)  LDD0805  [14]
 LDCM0489  CL94 HCT 116 C216(1.29); C218(1.27); C299(1.60); C362(0.89)  LDD0806  [14]
 LDCM0490  CL95 HCT 116 C216(1.16); C218(1.25); C299(0.86); C362(0.92)  LDD0807  [14]
 LDCM0491  CL96 HCT 116 C216(1.18); C218(1.24); C299(0.86); C362(0.97)  LDD0808  [14]
 LDCM0492  CL97 HCT 116 C216(1.05); C218(1.03); C299(0.79); C362(0.97)  LDD0809  [14]
 LDCM0493  CL98 HCT 116 C216(0.96); C218(1.26); C299(1.03); C362(0.96)  LDD0810  [14]
 LDCM0494  CL99 HCT 116 C216(1.22); C218(1.29); C299(1.25); C362(1.02)  LDD0811  [14]
 LDCM0634  CY-0357 Hep-G2 C218(1.04)  LDD2228  [23]
 LDCM0495  E2913 HEK-293T C30(1.05); C491(1.02); C362(1.02); C176(1.18)  LDD1698  [38]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C30(1.10); C362(1.01); C299(0.91)  LDD1702  [37]
 LDCM0031  Epigallocatechin gallate HEK-293T 21.69  LDD0183  [9]
 LDCM0625  F8 Ramos C491(1.43); C30(0.43); C218(1.08); C216(0.96)  LDD2187  [39]
 LDCM0572  Fragment10 Ramos C491(1.80); C30(0.26); C218(0.39); C216(0.26)  LDD2189  [39]
 LDCM0573  Fragment11 Ramos C491(1.01); C30(0.05); C218(0.16); C216(3.45)  LDD2190  [39]
 LDCM0574  Fragment12 Ramos C491(1.19); C30(0.48); C218(0.61); C216(0.47)  LDD2191  [39]
 LDCM0575  Fragment13 Ramos C491(1.25); C30(0.82); C218(0.98); C216(0.94)  LDD2192  [39]
 LDCM0576  Fragment14 Ramos C491(0.86); C30(0.32); C218(0.24); C216(0.33)  LDD2193  [39]
 LDCM0579  Fragment20 Ramos C491(1.23); C30(0.31); C218(0.51); C216(0.31)  LDD2194  [39]
 LDCM0580  Fragment21 Ramos C491(1.13); C30(0.64); C218(0.66); C216(0.76)  LDD2195  [39]
 LDCM0582  Fragment23 Ramos C491(1.56); C30(0.51); C218(0.33); C216(0.34)  LDD2196  [39]
 LDCM0578  Fragment27 Ramos C491(1.37); C30(0.72); C218(0.90); C216(0.95)  LDD2197  [39]
 LDCM0586  Fragment28 Ramos C491(0.69); C30(0.48); C218(0.53); C216(0.84)  LDD2198  [39]
 LDCM0588  Fragment30 Ramos C491(1.45); C30(0.86); C218(1.15); C216(0.87)  LDD2199  [39]
 LDCM0589  Fragment31 Ramos C491(0.97); C30(0.63); C218(0.84); C216(0.79)  LDD2200  [39]
 LDCM0590  Fragment32 Ramos C491(1.09); C30(0.38); C218(0.49); C216(0.31)  LDD2201  [39]
 LDCM0468  Fragment33 HCT 116 C216(0.89); C218(1.09); C362(0.89); C491(1.06)  LDD0785  [14]
 LDCM0596  Fragment38 Ramos C491(1.26); C30(0.57); C218(1.01); C216(0.77)  LDD2203  [39]
 LDCM0566  Fragment4 Ramos C491(0.94); C30(0.42); C218(0.83); C216(0.76)  LDD2184  [39]
 LDCM0427  Fragment51 HCT 116 C216(0.67); C218(0.83); C234(0.80); C243(0.80)  LDD0744  [14]
 LDCM0610  Fragment52 Ramos C491(1.71); C30(1.03); C218(1.56); C216(0.84)  LDD2204  [39]
 LDCM0614  Fragment56 Ramos C491(1.59); C30(0.87); C218(1.38); C216(1.03)  LDD2205  [39]
 LDCM0569  Fragment7 Ramos C491(1.01); C30(0.25); C218(0.52); C216(0.35)  LDD2186  [39]
 LDCM0571  Fragment9 Ramos C491(1.25); C30(0.27); C218(0.48); C216(0.31)  LDD2188  [39]
 LDCM0116  HHS-0101 DM93 Y554(0.62); Y96(0.89); Y354(0.90); Y473(0.98)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y554(0.57); Y354(0.82); Y96(1.30); Y473(1.59)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y554(0.54); Y354(0.78); Y473(0.89); Y96(1.56)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y554(0.62); Y354(0.86); Y96(0.87); Y473(1.08)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y554(0.50); Y354(0.92); Y473(0.97); Y96(1.20)  LDD0268  [12]
 LDCM0107  IAA HeLa H553(0.00); H365(0.00); H33(0.00); C299(0.00)  LDD0221  [29]
 LDCM0123  JWB131 DM93 Y354(0.61); Y468(0.88); Y554(1.04)  LDD0285  [11]
 LDCM0124  JWB142 DM93 Y354(0.40); Y468(0.33); Y554(0.70)  LDD0286  [11]
 LDCM0125  JWB146 DM93 Y354(1.06); Y468(1.24); Y554(1.09)  LDD0287  [11]
 LDCM0126  JWB150 DM93 Y354(6.27); Y468(3.53); Y554(2.75)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y354(1.67); Y468(3.42); Y554(1.87)  LDD0289  [11]
 LDCM0128  JWB198 DM93 Y354(1.28); Y554(1.49)  LDD0290  [11]
 LDCM0129  JWB202 DM93 Y354(0.20); Y468(0.38); Y554(0.67)  LDD0291  [11]
 LDCM0130  JWB211 DM93 Y354(1.17); Y468(1.23); Y554(1.01)  LDD0292  [11]
 LDCM0022  KB02 HCT 116 C362(1.19); C491(1.32); C216(0.99)  LDD0080  [14]
 LDCM0023  KB03 HCT 116 C362(0.95); C491(1.12); C216(0.81)  LDD0081  [14]
 LDCM0024  KB05 HCT 116 C362(1.20); C491(1.09); C216(0.75)  LDD0082  [14]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C30(0.90); C491(1.17); C362(1.12)  LDD2102  [37]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C491(0.61); C216(1.37)  LDD2121  [37]
 LDCM0109  NEM HeLa H323(0.00); H553(0.00); H330(0.00); H365(0.00)  LDD0223  [29]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C30(0.64); C491(0.94)  LDD2089  [37]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C491(1.50)  LDD2090  [37]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C30(0.95); C491(0.86); C362(0.81)  LDD2092  [37]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C30(1.24); C491(0.98); C362(1.50)  LDD2093  [37]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C491(1.38); C362(1.18)  LDD2094  [37]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C30(0.35); C491(1.00); C176(0.78)  LDD2096  [37]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C30(1.77); C491(0.90)  LDD2097  [37]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C30(1.30); C362(1.09)  LDD2098  [37]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C30(1.34); C491(0.89); C362(1.05); C299(0.93)  LDD2099  [37]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C30(0.98); C491(1.00)  LDD2100  [37]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C30(1.00); C491(0.64)  LDD2101  [37]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C30(0.85); C491(0.77)  LDD2104  [37]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C30(1.00); C491(1.49); C362(0.93)  LDD2105  [37]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C30(0.79); C491(0.92)  LDD2106  [37]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C30(1.00); C491(0.95); C299(1.45); C216(0.80)  LDD2107  [37]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C30(1.01); C491(0.72)  LDD2108  [37]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C30(0.69); C491(0.94); C362(1.07); C299(0.48)  LDD2109  [37]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C491(1.22)  LDD2110  [37]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C30(1.11); C491(0.94); C362(1.21)  LDD2111  [37]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C30(0.81); C491(0.73)  LDD2114  [37]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C30(0.71); C491(0.73); C362(0.75)  LDD2115  [37]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C30(0.73); C491(1.43)  LDD2116  [37]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C30(0.66); C491(1.74)  LDD2118  [37]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C30(1.72); C491(2.72)  LDD2119  [37]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C30(0.61); C491(1.02)  LDD2120  [37]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C30(0.85); C491(4.24); C176(1.60)  LDD2122  [37]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C30(1.00); C491(0.86); C362(1.04); C299(0.86)  LDD2123  [37]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C30(0.41); C491(1.10); C176(0.96)  LDD2124  [37]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C30(0.97); C491(0.87); C362(0.81); C299(0.85)  LDD2125  [37]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C30(0.53); C491(0.95); C176(1.00)  LDD2126  [37]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C30(1.15); C491(1.02); C362(1.27); C299(0.69)  LDD2127  [37]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C30(0.92); C491(1.02)  LDD2128  [37]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C30(1.16); C491(0.84)  LDD2129  [37]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C30(0.72); C491(0.55)  LDD2133  [37]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C30(0.94); C491(0.72); C362(0.80)  LDD2134  [37]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C30(1.42); C491(0.88); C299(1.07)  LDD2135  [37]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C30(1.37); C491(1.29); C362(1.06); C299(1.58)  LDD2136  [37]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C30(1.03); C491(0.94); C362(0.99); C299(0.95)  LDD2137  [37]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C491(3.54); C30(2.47)  LDD1700  [37]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C30(1.01); C491(0.97); C299(0.79)  LDD2140  [37]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C30(0.92); C491(0.70)  LDD2141  [37]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C30(0.70); C491(0.93)  LDD2143  [37]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C30(1.68); C491(2.95); C176(2.03)  LDD2144  [37]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C30(4.80); C491(2.92)  LDD2145  [37]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C30(1.09); C491(0.85); C362(1.38)  LDD2146  [37]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C30(1.59); C491(2.49)  LDD2147  [37]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C30(0.67); C491(0.62)  LDD2148  [37]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C30(0.75); C491(2.03); C176(0.95)  LDD2149  [37]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C30(0.43); C491(0.45); C362(0.42); C299(0.80)  LDD2150  [37]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C491(11.58)  LDD2151  [37]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C30(1.87); C491(1.98)  LDD2153  [37]
 LDCM0627  NUDT7-COV-1 HEK-293T C491(0.97); C299(0.95); C491(0.57)  LDD2206  [40]
 LDCM0032  Oleacein HEK-293T 5.96  LDD0184  [9]
 LDCM0628  OTUB2-COV-1 HEK-293T C491(0.83); C491(0.52)  LDD2207  [40]
 LDCM0131  RA190 MM1.R C30(1.31); C491(1.09)  LDD0304  [41]
 LDCM0021  THZ1 HeLa S3 C216(0.94)  LDD0460  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CTP synthase 1 (CTPS1) CTP synthase family P17812
CTP synthase 2 (CTPS2) CTP synthase family Q9NRF8

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
L-glutamine Small molecular drug DB00130
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cyclopentenylcytosine Small molecular drug D0VW0I
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-methyl-2,4-pentanediol Small molecular drug D06GOK
Carbodine Small molecular drug D0B3MG
Cyclopentylcytosine Small molecular drug D08XAW
Cylopentenyl Cytosine . D0GK2Q
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acivicin Small molecular drug D02JUT

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD022279
25 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
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Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD033004
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD039908 , PXD029761
38 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
39 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
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