Details of the Target

General Information of Target

Target ID LDTP14059
Target Name Insulin receptor substrate 2 (IRS2)
Gene Name IRS2
Gene ID 8660
Synonyms
Insulin receptor substrate 2; IRS-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKPLAIPANHGVMGQQEKHSLPADFTKLHLTDSLHPQVTHVSSSHSGCSITSDSGSSSLS
DIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERASDPLMSRDIVRDCLEKDPIDRTD
DDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGS
VEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEK
NMQKVEEEGEIVMVKEHRELDRTGTRKGHIVIKGTSERLTMHLVEEHSVVDPTFIEDFLL
TYRTFLSSPMEVGKKLLEWFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMTRFLEEFENN
LEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDSVDSGS
KATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTRLSEE
KRNGAPHLPKIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT
RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPTALPVSGTLSSSNPDLLQSHHRILDFS
ATPDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPDQYSLCEVSVTPE
GVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQISLLQLSTVE
VATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEILRETN
QLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDL
QDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMI
AKEIRHVGRMASVNMDPALMFRTRKKKWRSLGSLSQGSTNATVLDVAQTGGHKKRVRRSS
FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPATNTLPKNPGDKKPVKSE
TSPVAPRAGSQQKAQSLPQPQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINS
PQALKKILSLSEEGSLERHKKQAEDTISNASSQLSSPPTSPQSSPRKGYTLAPSGTVDNF
SDSGHSEISSRSSIVSNSSFDSVPVSLHDERRQRHSVSIVETNLGMGRMERRTMIEPDQY
SLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRASLDAADSGRGSWTSCSSGSHDNI
QTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDHSTKYNRQNQSRESLEQA
QSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEETKPVPMPAHIAV
ASSTTKGLIARKEGRYREPPPTPPGYIGIPITDFPEGHSHPARKPPDYNVALQRSRMVAR
SSDTAGPSSVQQPHGHPTSSRPVNKPQWHKPNESDPRLAPYQSQGFSTEEDEDEQVSAV
Target Type
Clinical trial
Target Bioclass
Other
Subcellular location
Cytoplasm, cytosol
Function May mediate the control of various cellular processes by insulin.
TTD ID
T06128
Uniprot ID
Q9Y4H2
DrugMap ID
TTF95B8
Ensemble ID
ENST00000375856.5
HGNC ID
HGNC:6126

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K205(3.68)  LDD0277  [1]
BTD
 Probe Info  		C409(1.49)  LDD2091  [2]
AHL-Pu-1
 Probe Info  		C514(2.11)  LDD0170  [3]
EA-probe
 Probe Info  		N.A.  LDD0440  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
DBIA
 Probe Info  		C816(1.30); C801(1.06); C802(1.06)  LDD0078  [6]
IA-alkyne
 Probe Info  		C409(0.00); C514(0.00)  LDD0162  [7]
NAIA_4
 Probe Info  		C409(0.00); C552(0.00); C816(0.00)  LDD2226  [8]
NAIA_5
 Probe Info  		N.A.  LDD2225  [8]
TFBX
 Probe Info  		C613(0.00); C616(0.00); C802(0.00); C801(0.00)  LDD0027  [9]
IPM
 Probe Info  		C409(0.00); C514(0.00); C816(0.00)  LDD0147  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [5]
AOyne
 Probe Info  		15.00  LDD0443  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C514(2.11)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C514(2.84); C409(9.79)  LDD0171  [3]
 LDCM0563  Abegg_cp(+)-11 HeLa C409(2.45)  LDD0314  [9]
 LDCM0214  AC1 HEK-293T C248(1.27); C613(1.11)  LDD1507  [11]
 LDCM0215  AC10 HCT 116 C97(1.26); C98(1.26)  LDD0532  [6]
 LDCM0216  AC100 PaTu 8988t C97(0.82); C98(0.82)  LDD1095  [6]
 LDCM0217  AC101 PaTu 8988t C97(0.87); C98(0.87)  LDD1096  [6]
 LDCM0218  AC102 PaTu 8988t C97(0.80); C98(0.80)  LDD1097  [6]
 LDCM0219  AC103 PaTu 8988t C97(0.89); C98(0.89)  LDD1098  [6]
 LDCM0220  AC104 PaTu 8988t C97(1.01); C98(1.01)  LDD1099  [6]
 LDCM0221  AC105 PaTu 8988t C97(0.96); C98(0.96)  LDD1100  [6]
 LDCM0222  AC106 PaTu 8988t C97(1.06); C98(1.06)  LDD1101  [6]
 LDCM0223  AC107 PaTu 8988t C97(1.02); C98(1.02)  LDD1102  [6]
 LDCM0224  AC108 PaTu 8988t C97(0.95); C98(0.95)  LDD1103  [6]
 LDCM0225  AC109 PaTu 8988t C97(0.90); C98(0.90)  LDD1104  [6]
 LDCM0226  AC11 HCT 116 C97(1.11); C98(1.11)  LDD0543  [6]
 LDCM0227  AC110 PaTu 8988t C97(0.93); C98(0.93)  LDD1106  [6]
 LDCM0228  AC111 PaTu 8988t C97(0.98); C98(0.98)  LDD1107  [6]
 LDCM0229  AC112 PaTu 8988t C97(1.01); C98(1.01)  LDD1108  [6]
 LDCM0237  AC12 HCT 116 C97(0.97); C98(0.97)  LDD0554  [6]
 LDCM0246  AC128 HCT 116 C801(0.83); C802(0.83); C97(1.10); C98(1.10)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C801(0.78); C802(0.78); C97(0.91); C98(0.91)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C801(0.71); C802(0.71); C97(1.13); C98(1.13)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C801(0.78); C802(0.78); C97(0.91); C98(0.91)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C801(0.78); C802(0.78); C97(1.04); C98(1.04)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C801(0.84); C802(0.84); C97(1.13); C98(1.13)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C801(1.07); C802(1.07); C97(1.13); C98(1.13)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C801(0.75); C802(0.75); C97(1.11); C98(1.11)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C801(0.99); C802(0.99); C97(1.10); C98(1.10)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C801(0.86); C802(0.86); C97(1.00); C98(1.00)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C801(0.93); C802(0.93); C97(0.98); C98(0.98)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C801(1.10); C802(1.10); C97(1.12); C98(1.12)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C97(1.28); C98(1.28)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C801(0.95); C802(0.95); C97(1.06); C98(1.06)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C801(0.92); C802(0.92); C97(1.03); C98(1.03)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C801(0.85); C802(0.85); C97(0.91); C98(0.91)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C613(0.98); C616(0.98); C97(1.02); C98(1.02)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C801(0.89); C802(0.89); C97(1.09); C98(1.09)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C801(0.83); C802(0.83); C97(1.05); C98(1.05)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C801(0.95); C802(0.95); C97(1.08); C98(1.08)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C801(0.98); C802(0.98); C613(1.04); C616(1.13)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C801(0.97); C802(0.97); C616(1.39); C97(1.44)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C801(1.18); C802(1.18); C97(1.20); C98(1.20)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C97(1.30); C98(1.30)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C801(0.90); C802(0.90); C97(1.12); C98(1.12)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C801(0.77); C802(0.77); C97(0.97); C98(0.97)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C801(0.88); C802(0.88); C97(1.13); C98(1.13)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C801(0.76); C802(0.76); C97(1.38); C98(1.38)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C613(1.29); C616(1.39); C801(0.77); C802(0.77)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C613(1.71); C616(1.60); C801(0.78); C802(0.78)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C613(1.34); C616(1.41); C801(0.77); C802(0.77)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C613(1.49); C616(1.33); C801(0.64); C802(0.64)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C801(0.87); C802(0.87)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C801(0.72); C802(0.72)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C801(0.71); C802(0.71)  LDD0595  [6]
 LDCM0279  AC2 HEK-293T C248(1.26)  LDD1518  [11]
 LDCM0280  AC20 HCT 116 C801(0.62); C802(0.62)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C801(0.83); C802(0.83)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C801(0.83); C802(0.83)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C801(0.77); C802(0.77)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C801(0.79); C802(0.79)  LDD0601  [6]
 LDCM0285  AC25 PaTu 8988t C97(1.07); C98(1.07)  LDD1164  [6]
 LDCM0286  AC26 PaTu 8988t C97(1.14); C98(1.14)  LDD1165  [6]
 LDCM0287  AC27 PaTu 8988t C97(1.32); C98(1.32)  LDD1166  [6]
 LDCM0288  AC28 PaTu 8988t C97(1.60); C98(1.60)  LDD1167  [6]
 LDCM0289  AC29 PaTu 8988t C97(1.26); C98(1.26)  LDD1168  [6]
 LDCM0290  AC3 HEK-293T C248(0.98)  LDD1529  [11]
 LDCM0291  AC30 PaTu 8988t C97(1.20); C98(1.20)  LDD1170  [6]
 LDCM0292  AC31 PaTu 8988t C97(1.12); C98(1.12)  LDD1171  [6]
 LDCM0293  AC32 PaTu 8988t C97(1.19); C98(1.19)  LDD1172  [6]
 LDCM0294  AC33 PaTu 8988t C97(1.53); C98(1.53)  LDD1173  [6]
 LDCM0295  AC34 PaTu 8988t C97(1.11); C98(1.11)  LDD1174  [6]
 LDCM0296  AC35 HEK-293T C248(0.97)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C248(1.17); C409(0.83)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C248(1.00); C409(1.19); C616(1.08)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C248(1.05); C613(1.12)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C248(1.24); C613(1.05); C616(1.19)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C248(0.91); C409(0.85)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C248(1.03); C409(0.94); C616(1.08)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C248(1.02); C613(1.07)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C248(1.04)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C248(0.94)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C248(0.92); C409(0.92)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C248(1.05); C409(1.11); C616(1.12)  LDD1546  [11]
 LDCM0308  AC46 PaTu 8988t C97(1.03); C98(1.03)  LDD1187  [6]
 LDCM0309  AC47 PaTu 8988t C97(0.91); C98(0.91)  LDD1188  [6]
 LDCM0310  AC48 PaTu 8988t C97(0.92); C98(0.92)  LDD1189  [6]
 LDCM0311  AC49 PaTu 8988t C97(0.97); C98(0.97)  LDD1190  [6]
 LDCM0312  AC5 HEK-293T C248(1.02); C409(0.92); C616(1.02)  LDD1551  [11]
 LDCM0313  AC50 PaTu 8988t C97(1.07); C98(1.07)  LDD1192  [6]
 LDCM0314  AC51 PaTu 8988t C97(0.94); C98(0.94)  LDD1193  [6]
 LDCM0315  AC52 PaTu 8988t C97(1.07); C98(1.07)  LDD1194  [6]
 LDCM0316  AC53 PaTu 8988t C97(1.06); C98(1.06)  LDD1195  [6]
 LDCM0317  AC54 PaTu 8988t C97(1.23); C98(1.23)  LDD1196  [6]
 LDCM0318  AC55 PaTu 8988t C97(0.95); C98(0.95)  LDD1197  [6]
 LDCM0319  AC56 PaTu 8988t C97(0.88); C98(0.88)  LDD1198  [6]
 LDCM0320  AC57 HCT 116 C97(1.31); C98(1.31)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C97(1.23); C98(1.23)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C97(1.42); C98(1.42)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C97(1.10); C98(1.10)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C97(1.21); C98(1.21)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C97(1.12); C98(1.12)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C97(1.29); C98(1.29)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C97(1.31); C98(1.31)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C97(1.43); C98(1.43)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C97(1.81); C98(1.81)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C97(1.71); C98(1.71)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C97(1.88); C98(1.88)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C801(0.79); C802(0.79)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C801(1.01); C802(1.01)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C97(1.00); C98(1.00)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C801(0.86); C802(0.86)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C801(0.93); C802(0.93)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C801(1.25); C802(1.25)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C801(2.08); C802(2.08)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C801(1.04); C802(1.04)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C801(1.46); C802(1.46)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C801(0.91); C802(0.91)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C801(1.06); C802(1.06)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C801(0.90); C802(0.90)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C801(0.86); C802(0.86)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C97(1.05); C98(1.05)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C801(0.96); C802(0.96)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C801(0.91); C802(0.91)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C801(1.59); C802(1.59)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C801(0.51); C802(0.51)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C801(0.39); C802(0.39)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C801(0.40); C802(0.40)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C801(0.42); C802(0.42)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C801(0.44); C802(0.44)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C801(0.49); C802(0.49)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C801(0.44); C802(0.44)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C801(0.66); C802(0.66)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C801(0.47); C802(0.47)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C801(0.42); C802(0.42)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C801(0.50); C802(0.50)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C801(0.36); C802(0.36)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C801(0.46); C802(0.46)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C801(0.35); C802(0.35)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C801(0.59); C802(0.59)  LDD0681  [6]
 LDCM0365  AC98 PaTu 8988t C97(0.82); C98(0.82)  LDD1244  [6]
 LDCM0366  AC99 PaTu 8988t C97(0.96); C98(0.96)  LDD1245  [6]
 LDCM0248  AKOS034007472 HCT 116 C97(1.08); C98(1.08)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C97(1.10); C98(1.10)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C97(1.47); C98(1.47)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C816(1.30); C801(1.06); C802(1.06)  LDD0078  [6]
 LDCM0498  BS-3668 MDA-MB-231 C409(1.49)  LDD2091  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0632  CL-Sc Hep-G2 C409(1.03)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C97(0.89); C98(0.89); C801(1.08); C802(1.08)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C801(0.91); C802(0.91); C97(1.04); C98(1.04)  LDD0685  [6]
 LDCM0369  CL100 HEK-293T C248(1.03)  LDD1573  [11]
 LDCM0370  CL101 HCT 116 C97(1.43); C98(1.43)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C97(1.06); C98(1.06)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C97(1.06); C98(1.06)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C97(1.04); C98(1.04)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C801(0.78); C802(0.78)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C801(0.66); C802(0.66)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C801(0.69); C802(0.69)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C801(0.71); C802(0.71)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C801(0.78); C802(0.78)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C801(1.04); C802(1.04); C97(1.29); C98(1.29)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C801(0.64); C802(0.64)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C801(0.66); C802(0.66)  LDD0698  [6]
 LDCM0382  CL112 PaTu 8988t C97(1.20); C98(1.20)  LDD1261  [6]
 LDCM0383  CL113 PaTu 8988t C97(1.34); C98(1.34)  LDD1262  [6]
 LDCM0384  CL114 PaTu 8988t C97(1.07); C98(1.07)  LDD1263  [6]
 LDCM0385  CL115 PaTu 8988t C97(1.24); C98(1.24)  LDD1264  [6]
 LDCM0386  CL116 PaTu 8988t C97(1.19); C98(1.19)  LDD1265  [6]
 LDCM0387  CL117 HEK-293T C248(0.85); C552(1.02); C616(1.13); C613(0.95)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C248(1.01)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C248(0.77)  LDD1593  [11]
 LDCM0390  CL12 HCT 116 C801(0.89); C802(0.89); C97(1.27); C98(1.27)  LDD0707  [6]
 LDCM0391  CL120 HEK-293T C248(0.88)  LDD1595  [11]
 LDCM0392  CL121 PaTu 8988t C97(0.84); C98(0.84)  LDD1271  [6]
 LDCM0393  CL122 PaTu 8988t C97(0.75); C98(0.75)  LDD1272  [6]
 LDCM0394  CL123 PaTu 8988t C97(1.20); C98(1.20)  LDD1273  [6]
 LDCM0395  CL124 PaTu 8988t C97(0.96); C98(0.96)  LDD1274  [6]
 LDCM0396  CL125 HCT 116 C97(0.96); C98(0.96)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C97(1.00); C98(1.00)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C97(1.05); C98(1.05)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C97(1.36); C98(1.36)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C801(0.97); C802(0.97); C97(1.08); C98(1.08)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C801(0.95); C802(0.95); C97(1.01); C98(1.01)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C97(0.97); C98(0.97); C801(1.25); C802(1.25)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C613(0.97); C616(0.97); C97(1.11); C98(1.11)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C613(0.81); C616(0.81); C97(0.89); C98(0.89)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C613(0.94); C616(0.94); C97(1.03); C98(1.03)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C613(0.82); C616(0.82); C97(1.12); C98(1.12)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C97(0.83); C98(0.83); C801(1.00); C802(1.00)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C613(0.87); C616(0.87); C97(1.16); C98(1.16)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C613(0.82); C616(0.82); C97(1.15); C98(1.15)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C613(0.58); C616(0.58); C97(1.62); C98(1.62)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C613(0.91); C616(0.91); C97(1.04); C98(1.04)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C613(0.97); C616(0.97); C97(1.42); C98(1.42)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C613(1.05); C616(1.05); C97(1.35); C98(1.35)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C613(0.86); C616(0.86); C97(1.12); C98(1.12)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C613(0.86); C616(0.86); C97(1.23); C98(1.23)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C613(0.80); C616(0.80); C97(1.28); C98(1.28)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C613(0.96); C616(0.96); C97(1.41); C98(1.41)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C801(0.90); C802(0.90); C97(0.85); C98(0.85)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C613(0.94); C616(0.94); C97(1.31); C98(1.31)  LDD0736  [6]
 LDCM0420  CL31 PaTu 8988t C97(1.15); C98(1.15)  LDD1299  [6]
 LDCM0421  CL32 HCT 116 C97(1.19); C98(1.19)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C97(0.87); C98(0.87)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C97(1.06); C98(1.06)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C97(1.15); C98(1.15)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C97(0.84); C98(0.84)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C97(1.11); C98(1.11)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C97(1.03); C98(1.03)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C801(1.12); C802(1.12); C97(0.97); C98(0.97)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C97(1.04); C98(1.04)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C97(0.85); C98(0.85)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C97(1.00); C98(1.00)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C97(1.14); C98(1.14)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C97(0.99); C98(0.99)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C97(1.11); C98(1.11)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C801(0.67); C802(0.67); C97(0.95); C98(0.95)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C801(0.82); C802(0.82); C97(0.82); C98(0.82)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C801(0.70); C802(0.70); C97(0.83); C98(0.83)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C801(0.61); C802(0.61); C97(0.99); C98(0.99)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C801(1.18); C802(1.18); C97(1.02); C98(1.02)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C801(0.80); C802(0.80); C97(1.00); C98(1.00)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C801(0.69); C802(0.69); C97(0.95); C98(0.95)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C801(1.26); C802(1.26); C97(0.86); C98(0.86)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C801(0.92); C802(0.92); C97(0.86); C98(0.86)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C801(1.02); C802(1.02); C97(0.91); C98(0.91)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C801(0.80); C802(0.80); C97(0.80); C98(0.80)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C801(0.78); C802(0.78); C97(0.91); C98(0.91)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C801(0.85); C802(0.85); C97(0.77); C98(0.77)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C801(1.00); C802(1.00); C97(0.81); C98(0.81)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C801(0.79); C802(0.79); C97(0.93); C98(0.93)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C801(1.19); C802(1.19); C97(0.93); C98(0.93)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C801(0.82); C802(0.82); C97(0.90); C98(0.90)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C613(1.03); C616(1.03); C97(1.02); C98(1.02)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C613(1.28); C616(1.28); C97(1.04); C98(1.04)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C613(0.78); C616(0.78); C97(1.12); C98(1.12)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C613(0.77); C616(0.77); C97(1.11); C98(1.11)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C613(0.77); C616(0.77); C97(1.03); C98(1.03)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C613(0.80); C616(0.80); C97(1.38); C98(1.38)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C613(0.84); C616(0.84); C97(1.21); C98(1.21)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C613(0.76); C616(0.76); C97(1.13); C98(1.13)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C613(1.00); C616(1.00); C97(0.89); C98(0.89)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C801(0.86); C802(0.86); C97(1.28); C98(1.28)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C613(0.86); C616(0.86); C97(0.97); C98(0.97)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C613(0.96); C616(0.96); C97(1.10); C98(1.10)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C613(0.93); C616(0.93); C97(1.00); C98(1.00)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C613(0.86); C616(0.86); C97(1.03); C98(1.03)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C613(0.97); C616(0.97); C97(1.00); C98(1.00)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C613(0.62); C616(0.62)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C613(0.57); C616(0.57)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C613(0.67); C616(0.67)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C613(0.65); C616(0.65)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C801(0.93); C802(0.93); C97(1.10); C98(1.10)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C613(0.71); C616(0.71)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C613(0.54); C616(0.54)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C613(0.48); C616(0.48)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C613(0.71); C616(0.71)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C613(0.67); C616(0.67)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C613(0.73); C616(0.73)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C613(0.64); C616(0.64)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C613(0.50); C616(0.50)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C613(0.59); C616(0.59)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C613(0.58); C616(0.58)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C801(0.79); C802(0.79); C97(1.08); C98(1.08)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C613(0.69); C616(0.69)  LDD0802  [6]
 LDCM0486  CL91 HEK-293T C248(0.99)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C248(0.90); C409(1.02)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C248(1.06); C409(0.90); C616(1.09)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C248(1.26); C613(1.18)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C248(1.41); C613(0.99); C616(1.11)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C248(1.26); C409(1.08); C616(1.30)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C248(1.03); C552(1.06); C616(1.08); C613(1.14)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C248(0.98)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C248(1.03)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C248(0.99)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C514(2.31); C409(1.15)  LDD1702  [2]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [4]
 LDCM0468  Fragment33 HCT 116 C613(0.91); C616(0.91); C97(1.03); C98(1.03)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C97(0.97); C98(0.97)  LDD0744  [6]
 LDCM0022  KB02 HCT 116 C613(13.02); C616(13.02)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C613(2.95); C616(2.95)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C613(5.18); C616(5.18)  LDD0082  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C409(0.77)  LDD2127  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C220(1.31)  LDD2141  [2]
 LDCM0021  THZ1 HCT 116 C801(1.30); C802(1.30)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) Sirtuin family Q96EB6
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) PI3K p85 subunit family P27986

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nt219 Small molecular drug DUI59O

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402