Details of the Target

General Information of Target

Target ID LDTP14980
Target Name RRP12-like protein (RRP12)
Gene Name RRP12
Gene ID 23223
Synonyms
KIAA0690; RRP12-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYGRPQAEMEQEAGELSRWQAAHQAAQDNENSAPILNMSSSSGSSGVHTSWNQGLPSIQH
FPHSAEMLGSPLVSVEAPGQNVNEGGPQFSMPLPERGMSYCPQATLTPSRMIYCQRMSPP
QQEMTIFSGPQLMPVGEPNIPRVARPFGGNLRMPPNGLPVSASTGIPIMSHTGNPPVPYP
GLSTVPSDETLLGPTVPSTEAQAVLPSMAQMLPPQDAHDLGMPPAESQSLLVLGSQDSLV
SQPDSQEGPFLPEQPGPAPQTVEKNSRPQEGTGRRGSSEARPYCCNYENCGKAYTKRSHL
VSHQRKHTGERPYSCNWESCSWSFFRSDELRRHMRVHTRYRPYKCDQCSREFMRSDHLKQ
HQKTHRPGPSDPQANNNNGEQDSPPAAGP
Target Bioclass
Other
Family
RRP12 family
Subcellular location
Nucleus, nucleolus
Uniprot ID
Q5JTH9
Ensemble ID
ENST00000315563.10
HGNC ID
HGNC:29100

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Insertion: p.L728FfsTer11 DBIA    Probe Info 
COLO792 Substitution: p.R1022E DBIA    Probe Info 
HCT15 SNV: p.P544H DBIA    Probe Info 
IGROV1 SNV: p.T722A DBIA    Probe Info 
KASUMI2 SNV: p.I1254V DBIA    Probe Info 
MFE319 SNV: p.K597Ter DBIA    Probe Info 
NCIH2052 SNV: p.P707R DBIA    Probe Info 
SNGM SNV: p.L513I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.07  LDD0402  [1]
CY-1
 Probe Info  		5.66  LDD0243  [2]
TH216
 Probe Info  		Y779(6.14)  LDD0259  [3]
YN-4
 Probe Info  		100.00  LDD0445  [4]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [5]
BTD
 Probe Info  		C261(2.47); C662(1.20)  LDD1700  [6]
AHL-Pu-1
 Probe Info  		C261(2.26)  LDD0169  [7]
Alkyne-RA190
 Probe Info  		2.05  LDD0299  [8]
EA-probe
 Probe Info  		C763(1.05)  LDD2210  [9]
DBIA
 Probe Info  		C839(4.22)  LDD0080  [10]
ATP probe
 Probe Info  		K6(0.00); K14(0.00); K16(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C317(0.00); C446(0.00); C865(0.00); C125(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C799(0.00); C446(0.00); C423(0.00); C512(0.00)  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C261(0.00); C839(0.00); C317(0.00); C865(0.00)  LDD0037  [12]
JW-RF-010
 Probe Info  		C31(0.00); C102(0.00)  LDD0026  [14]
NAIA_4
 Probe Info  		C31(0.00); C344(0.00)  LDD2226  [15]
TFBX
 Probe Info  		C662(0.00); C102(0.00); C31(0.00); C326(0.00)  LDD0027  [14]
WYneN
 Probe Info  		C317(0.00); C839(0.00); C31(0.00); C102(0.00)  LDD0021  [16]
WYneO
 Probe Info  		C261(0.00); C662(0.00); C31(0.00)  LDD0022  [16]
aHNE
 Probe Info  		N.A.  LDD0001  [16]
1d-yne
 Probe Info  		N.A.  LDD0356  [17]
Compound 10
 Probe Info  		C31(0.00); C423(0.00); C662(0.00); C673(0.00)  LDD2216  [18]
Compound 11
 Probe Info  		C31(0.00); C662(0.00)  LDD2213  [18]
ENE
 Probe Info  		C288(0.00); C261(0.00); C673(0.00); C662(0.00)  LDD0006  [16]
IPM
 Probe Info  		C799(0.00); C662(0.00); C839(0.00); C261(0.00)  LDD0005  [16]
NHS
 Probe Info  		N.A.  LDD0010  [16]
PF-06672131
 Probe Info  		N.A.  LDD0017  [19]
SF
 Probe Info  		Y1251(0.00); Y1253(0.00)  LDD0028  [20]
STPyne
 Probe Info  		K739(0.00); K819(0.00)  LDD0009  [16]
VSF
 Probe Info  		C31(0.00); C446(0.00); C102(0.00)  LDD0007  [16]
Phosphinate-6
 Probe Info  		C839(0.00); C673(0.00); C31(0.00)  LDD0018  [21]
1c-yne
 Probe Info  		K265(0.00); K57(0.00); K852(0.00); K687(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		C102(0.00); H278(0.00); C31(0.00); C317(0.00)  LDD0217  [22]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [22]
Crotonaldehyde
 Probe Info  		H277(0.00); C662(0.00); H59(0.00); H576(0.00)  LDD0219  [22]
Methacrolein
 Probe Info  		C446(0.00); C31(0.00); C662(0.00); C288(0.00)  LDD0218  [22]
W1
 Probe Info  		C31(0.00); C317(0.00); C799(0.00); C662(0.00)  LDD0236  [23]
AOyne
 Probe Info  		5.90  LDD0443  [24]
NAIA_5
 Probe Info  		C261(0.00); C288(0.00); C317(0.00); C673(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		9.21  LDD0475  [25]
FFF probe3
 Probe Info  		12.45  LDD0464  [25]
STS-1
 Probe Info  		N.A.  LDD0137  [26]
STS-2
 Probe Info  		N.A.  LDD0138  [26]
VE-P
 Probe Info  		N.A.  LDD0396  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C673(0.80)  LDD2112  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C261(0.97); C662(0.57)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C261(1.11); C662(1.03)  LDD2152  [6]
 LDCM0025  4SU-RNA DM93 C31(3.19)  LDD0170  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C261(2.26)  LDD0169  [7]
 LDCM0561  Abegg_cp(-)-10 HeLa C839(10.01)  LDD0312  [14]
 LDCM0562  Abegg_cp(-)-11 HeLa C839(12.94)  LDD0313  [14]
 LDCM0214  AC1 HCT 116 C102(1.13); C125(1.18); C261(0.99); C288(1.06)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C102(1.20); C261(0.88); C288(0.95); C326(1.11)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C102(0.93); C261(0.61); C288(0.81); C317(0.51)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C102(1.00); C261(0.63); C288(0.66); C317(0.56)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C102(0.93); C261(0.60); C288(0.70); C317(0.54)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C102(0.95); C261(0.59); C288(0.68); C317(0.53)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C102(0.93); C261(0.70); C288(0.66); C317(0.53)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C102(0.95); C261(0.58); C288(0.68); C317(0.49)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C102(1.00); C261(0.58); C288(0.65); C317(0.50)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C102(0.77); C261(0.62); C288(0.69); C317(0.53)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C102(0.77); C261(0.87); C288(0.75); C317(0.60)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C102(0.82); C261(0.66); C288(0.76); C317(0.62)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C102(1.12); C261(0.74); C288(0.93); C326(1.54)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C102(0.81); C261(0.65); C288(0.71); C317(0.58)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C102(0.78); C261(0.79); C288(0.65); C317(0.54)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C102(0.79); C261(0.62); C288(0.59); C317(0.57)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C102(0.92); C261(0.90); C288(0.92); C512(1.05)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C102(1.02); C261(0.92); C288(0.88); C512(0.99)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C102(1.11); C261(0.92); C288(0.86); C512(0.88)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C102(1.06); C261(0.83); C288(0.91); C512(0.89)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C102(1.09); C261(0.90); C288(0.94); C512(1.02)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C102(0.96); C261(0.90); C288(0.94); C512(1.06)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C102(1.05); C261(0.95); C288(0.89); C512(1.00)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C102(1.02); C261(0.85); C288(1.09); C326(1.37)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C102(1.12); C261(0.96); C288(0.89); C512(0.93)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C102(0.95); C261(0.89); C288(1.01); C512(1.34)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C102(1.01); C261(0.91); C288(0.82); C512(1.04)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C102(1.00); C261(0.90); C288(0.93); C512(1.25)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C102(0.86); C261(0.94); C288(1.02); C512(1.25)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C102(0.99); C261(0.87); C288(0.91); C512(1.11)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C102(1.05); C261(0.93); C288(0.97); C512(1.02)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C102(1.00); C261(0.91); C288(0.97); C512(1.11)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C102(0.99); C261(1.38); C288(1.22); C326(1.17)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C102(1.05); C261(1.40); C288(1.25); C326(1.28)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C102(1.06); C261(1.11); C288(1.11); C326(1.41)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C102(1.02); C261(1.06); C288(1.02); C326(1.34)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C102(1.13); C261(0.99); C288(1.04); C326(1.32)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C102(1.16); C261(1.11); C288(1.17); C326(1.34)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C102(1.15); C261(1.04); C288(1.04); C326(1.79)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C102(1.21); C261(1.09); C288(1.18); C326(1.14)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C102(1.33); C261(0.90); C288(1.11); C326(1.47)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C102(1.11); C261(1.13); C288(1.13); C326(1.27)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C102(1.15); C261(0.97); C288(1.13); C326(1.68)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C102(1.22); C261(0.86); C288(1.12); C326(1.52)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C102(1.16); C261(0.74); C288(0.88); C326(1.17)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C102(1.25); C261(0.89); C288(1.23); C326(1.78)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C102(1.29); C261(0.91); C288(1.11); C326(1.70)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C102(1.07); C261(0.91); C288(1.18); C326(1.61)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C673(0.72); C288(0.89); C865(0.89); C261(0.90)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C673(0.71); C512(0.81); C517(0.82); C288(0.82)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C673(0.67); C261(0.87); C517(0.88); C512(0.90)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C512(0.73); C517(0.76); C288(0.86); C673(0.87)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C673(0.71); C512(0.75); C517(0.76); C288(0.83)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C673(0.76); C512(0.81); C517(0.89); C288(0.89)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C288(0.76); C512(0.78); C673(0.83); C517(0.85)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C261(0.83); C288(0.88); C662(0.99); C512(1.01)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C673(0.85); C512(0.88); C517(0.91); C288(0.91)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C673(0.75); C288(0.85); C865(0.86); C261(0.91)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C673(0.72); C512(0.73); C517(0.73); C261(0.78)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C673(0.88); C261(0.92); C512(0.94); C517(0.99)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C102(1.22); C261(0.73); C288(0.81); C326(1.18)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C102(1.34); C261(0.76); C288(0.83); C326(1.01)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C102(1.03); C261(0.83); C288(0.93); C326(1.09)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C102(1.10); C261(0.79); C288(0.85); C326(1.36)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C512(0.73); C517(0.79); C662(0.93); C865(1.01)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C865(0.48); C512(0.76); C673(0.81); C517(0.89)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C673(0.86); C512(0.87); C517(0.92); C261(0.92)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C512(0.84); C261(0.94); C662(0.96); C865(1.02)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C512(0.79); C517(0.84); C662(0.89); C326(0.89)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C865(0.63); C512(0.94); C662(0.94); C517(0.98)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C865(0.70); C512(0.94); C517(0.95); C662(0.96)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C865(0.71); C512(0.86); C517(0.91); C673(0.95)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C512(0.84); C261(0.90); C662(0.91); C865(0.92)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C865(0.81); C261(0.91); C662(0.93); C512(1.00)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C662(0.79); C865(0.84); C261(0.86); C512(0.89)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C326(0.85); C662(0.86); C261(0.86); C517(0.91)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C673(0.63); C517(0.81); C512(0.82); C865(0.90)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C662(0.76); C326(0.77); C261(0.84); C517(0.86)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C512(0.91); C261(0.97); C865(0.97); C662(1.05)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C326(0.78); C662(0.79); C517(0.80); C512(0.83)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C261(0.86); C512(0.87); C662(0.89); C517(0.89)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C326(0.77); C512(0.80); C517(0.84); C261(0.84)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C517(0.78); C512(0.79); C261(0.80); C662(0.82)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C512(0.75); C517(0.76); C662(0.83); C261(0.84)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C102(0.87); C799(1.02); C125(1.03); C839(1.03)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C799(0.79); C125(0.84); C102(0.93); C839(0.93)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C125(0.86); C839(0.93); C102(0.94); C261(1.02)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C125(0.91); C102(0.96); C839(0.99); C288(1.00)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C839(0.83); C799(0.89); C102(0.97); C261(1.06)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C512(0.89); C865(0.91); C261(1.04); C125(1.08)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C799(0.70); C839(0.86); C125(1.01); C102(1.01)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C839(0.93); C261(0.96); C125(0.99); C288(0.99)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C261(0.96); C102(0.97); C839(0.99); C288(1.00)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C125(0.93); C839(0.95); C261(0.99); C517(0.99)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C839(0.93); C799(0.94); C261(0.99); C102(0.99)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C799(0.84); C839(0.93); C261(1.00); C517(1.04)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C288(0.79); C673(0.80); C326(0.90); C662(0.90)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C326(0.82); C673(0.88); C288(0.97); C799(0.99)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C288(0.78); C673(0.81); C326(0.85); C102(1.03)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C673(0.64); C288(0.72); C326(0.82); C799(0.93)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C512(0.98); C125(1.06); C261(1.07); C288(1.18)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C288(0.72); C673(0.75); C326(0.76); C662(0.98)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C673(0.74); C326(0.76); C288(0.79); C102(0.93)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C799(0.78); C288(0.78); C326(0.83); C673(0.86)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C673(0.78); C288(0.80); C326(0.82); C261(0.91)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C326(0.74); C288(0.76); C673(0.76); C261(0.97)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C288(0.79); C326(0.86); C261(0.97); C673(1.10)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C288(0.64); C673(0.87); C839(0.97); C326(0.98)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C517(0.77); C261(0.81); C662(0.87); C512(0.88)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C517(0.72); C512(0.80); C261(0.86); C326(0.91)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C517(0.70); C261(0.79); C512(0.83); C662(0.87)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C288(0.80); C662(0.85); C839(0.85); C261(0.90)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C512(0.77); C326(0.78); C517(0.80); C261(0.82)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C517(0.84); C326(0.84); C662(0.87); C288(0.91)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C517(0.78); C512(0.79); C261(0.84); C326(0.84)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C512(0.71); C517(0.79); C326(0.88); C261(0.89)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C512(0.76); C517(0.80); C261(0.87); C662(0.96)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C517(0.83); C512(0.87); C261(0.89); C326(0.98)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C512(0.84); C517(0.84); C261(0.88); C326(0.94)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C512(0.79); C517(0.83); C261(0.86); C662(0.94)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C288(0.88); C662(1.00); C102(1.01); C261(1.02)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C662(1.03); C517(1.04); C261(1.04); C512(1.04)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C288(0.84); C261(0.91); C865(0.97); C662(1.01)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C512(0.89); C288(0.90); C517(0.92); C261(0.92)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C102(0.96); C288(1.09); C261(1.16); C512(1.18)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C512(0.91); C517(0.92); C288(0.94); C662(0.98)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C288(0.91); C673(1.06); C512(1.07); C517(1.09)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C512(1.07); C517(1.09); C288(1.11); C261(1.27)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C288(0.84); C517(1.19); C673(1.21); C512(1.21)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C261(0.96); C102(1.04); C662(1.04); C512(1.12)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C261(0.92); C288(0.96); C673(0.97); C662(0.98)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C288(0.82); C839(1.00); C662(1.02); C673(1.05)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C288(0.88); C261(0.98); C673(0.99); C512(1.09)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C839(0.89); C288(0.90); C512(0.91); C517(0.94)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C517(1.00); C261(1.00); C512(1.01); C662(1.06)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C288(0.96); C512(0.99); C517(1.02); C673(1.04)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C288(0.93); C512(1.09); C517(1.14); C261(1.34)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C317(0.78); C512(0.80); C839(0.83); C517(0.88)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C317(0.75); C512(0.84); C326(0.89); C517(0.89)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C317(0.73); C839(0.84); C662(0.84); C288(0.88)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C317(0.77); C839(0.80); C512(0.87); C517(0.89)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C317(0.87); C662(0.89); C261(0.95); C288(0.96)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C317(0.72); C662(0.79); C326(0.80); C261(0.89)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C317(0.71); C662(0.82); C517(0.87); C261(0.88)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C839(0.91); C317(0.95); C102(0.97); C261(1.01)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C317(0.72); C512(0.87); C662(0.87); C839(0.88)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C317(0.67); C517(0.76); C512(0.80); C326(0.82)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C317(0.76); C517(0.82); C662(0.88); C288(0.89)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C512(0.77); C317(0.78); C517(0.80); C326(0.87)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C317(0.77); C261(0.84); C662(0.85); C839(0.86)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C317(0.67); C261(0.91); C517(0.97); C512(0.98)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C317(0.67); C512(0.75); C517(0.78); C839(0.81)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C512(0.52); C517(0.61); C317(0.64); C288(0.66)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C512(0.60); C317(0.61); C662(0.68); C517(0.68)  LDD0683  [10]
 LDCM0545  Acetamide MDA-MB-231 C31(0.46)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C662(1.00)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C102(1.01); C261(0.90); C288(1.01); C326(1.33)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C662(0.87); C261(0.89); C865(0.95); C288(0.95)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C261(0.87); C288(0.91); C512(0.91); C662(0.94)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 11.39  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C662(1.16); C288(1.02); C102(0.97); C839(1.12)  LDD2171  [10]
 LDCM0498  BS-3668 MDA-MB-231 C261(0.51); C662(0.46)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C102(0.00); H278(0.00); H277(0.00); C31(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C673(20.00); C317(0.64)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C839(0.72); C125(0.79); C865(0.85); C662(0.93)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C317(0.82); C261(0.85); C662(0.88); C288(0.94)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C512(0.86); C662(0.95); C865(0.98); C261(0.98)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C261(0.80); C839(0.80); C662(0.82); C288(0.86)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C261(0.88); C288(0.88); C839(0.97); C662(0.98)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C865(0.90); C839(0.92); C261(0.94); C662(0.98)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C261(0.85); C839(0.87); C288(0.88); C865(0.98)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C512(0.77); C662(0.81); C517(0.82); C673(0.87)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C512(0.83); C517(0.88); C673(0.99); C662(1.01)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C512(0.81); C517(0.91); C662(0.93); C326(0.96)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C512(0.74); C517(0.81); C662(0.87); C326(0.93)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C512(0.81); C261(0.82); C517(0.82); C662(0.85)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C662(0.89); C261(0.90); C125(0.91); C839(0.97)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C865(0.77); C261(0.82); C662(0.89); C512(0.89)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C865(0.48); C512(0.81); C673(0.82); C517(0.86)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C662(0.81); C517(0.87); C512(0.88); C865(0.90)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C512(0.75); C517(0.78); C326(0.79); C662(0.80)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C261(0.81); C865(0.82); C662(0.82); C512(0.83)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C517(0.81); C512(0.81); C261(0.82); C662(0.84)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C326(0.83); C865(0.87); C261(0.87); C839(0.89)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C839(0.95); C326(1.08); C288(1.09); C102(1.12)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C799(0.87); C102(0.95); C261(0.95); C517(1.04)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C799(0.91); C261(0.96); C517(0.97); C125(0.97)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C839(0.88); C261(0.91); C512(0.96); C317(0.96)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C125(0.89); C799(0.89); C102(0.93); C261(0.98)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C326(0.72); C662(0.74); C261(0.77); C288(0.77)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C673(0.72); C326(0.75); C288(0.75); C839(0.87)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C673(0.73); C288(0.77); C326(0.82); C662(0.96)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C288(0.72); C673(0.75); C839(0.87); C326(0.91)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C662(0.84); C517(0.85); C865(0.88); C512(0.92)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C326(0.73); C517(0.79); C865(0.87); C261(0.87)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C517(0.76); C512(0.76); C261(0.79); C326(0.80)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C261(0.80); C517(0.80); C288(0.88); C662(0.88)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C261(0.86); C662(0.93); C125(0.94); C839(0.95)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C865(0.74); C261(0.77); C317(0.83); C662(0.84)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C125(0.77); C261(0.83); C662(0.89); C865(0.90)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C261(0.68); C865(0.80); C288(0.82); C326(0.83)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C326(0.59); C865(0.85); C288(0.90); C261(0.90)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C326(0.68); C662(0.72); C261(0.79); C839(0.84)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C662(0.75); C261(0.79); C288(0.86); C839(0.93)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C125(0.77); C839(0.81); C865(0.86); C662(0.90)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C662(0.75); C261(0.79); C799(0.82); C288(0.85)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C662(0.78); C288(0.84); C261(0.86); C839(0.94)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C261(0.92); C662(0.94); C288(1.00); C839(1.05)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C288(0.76); C261(0.78); C662(0.83); C839(0.91)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C102(1.20); C125(1.33); C261(0.78); C288(0.88)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C102(1.24); C125(1.10); C261(0.69); C288(0.82)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C102(1.09); C125(1.00); C261(0.69); C288(0.83)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C102(1.03); C125(0.96); C261(0.73); C288(0.86)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C102(1.12); C125(1.05); C261(0.63); C288(0.80)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C102(1.19); C125(1.18); C261(0.75); C288(0.80)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C102(0.90); C125(0.97); C261(0.98); C288(1.01)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C102(1.15); C125(1.18); C261(0.75); C288(0.77)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C102(1.02); C261(1.00); C288(0.90); C326(1.05)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C102(1.02); C261(0.94); C288(0.89); C326(0.86)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C102(1.03); C261(0.86); C288(0.76); C326(0.85)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C102(1.12); C261(0.88); C288(0.87); C326(0.88)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C102(1.09); C261(0.87); C288(0.74); C326(0.99)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C102(1.00); C261(0.82); C288(0.89); C326(0.94)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C102(1.12); C261(0.90); C288(0.94); C326(1.05)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C102(1.07); C261(0.99); C288(0.79); C326(1.10)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C102(0.98); C125(0.92); C261(0.89); C288(0.95)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C102(1.03); C261(0.80); C288(0.73); C326(0.91)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C102(1.11); C261(0.86); C288(0.84); C326(0.94)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C102(1.30); C261(1.15); C288(1.04); C326(0.71)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C102(1.17); C261(0.95); C288(0.83); C326(1.05)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C102(1.07); C261(0.96); C288(0.86); C326(0.94)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C102(1.12); C261(1.00); C288(0.92); C326(0.95)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C102(0.89); C261(0.93); C288(1.00); C317(0.99)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C102(0.92); C261(0.95); C288(1.00); C317(0.98)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C102(0.85); C261(0.95); C288(0.97); C317(0.94)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C102(0.87); C261(0.94); C288(0.95); C317(0.83)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C102(0.93); C125(0.90); C261(0.94); C288(0.99)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C102(0.84); C261(0.92); C288(1.20); C317(0.84)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C102(0.90); C261(0.92); C288(1.06); C317(0.90)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C102(0.91); C261(0.86); C288(1.12); C317(0.88)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C102(0.85); C261(0.93); C288(0.90); C317(0.79)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C102(1.49); C261(0.95); C288(1.04); C317(1.22)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C102(0.81); C261(0.97); C288(0.94); C317(0.88)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C102(0.95); C261(0.94); C288(1.05); C317(0.85)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C102(0.80); C261(0.86); C288(0.95); C317(0.85)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C102(0.83); C261(0.92); C288(0.95); C317(0.91)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C102(0.89); C261(0.98); C288(0.96); C317(0.88)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C102(1.00); C125(0.85); C261(0.90); C288(0.92)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C102(0.94); C261(0.91); C288(0.85); C317(0.84)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C102(1.06); C261(1.01); C288(0.79); C326(1.37)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C102(1.06); C261(0.99); C288(0.83); C326(0.82)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C102(1.15); C261(1.07); C288(0.74); C326(0.82)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C102(1.08); C261(0.95); C288(0.73); C326(0.91)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C102(1.10); C261(1.03); C288(0.83); C326(0.98)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C102(1.13); C261(1.03); C288(0.75); C326(0.85)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C102(1.16); C261(1.06); C288(0.76); C326(0.98)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C102(1.09); C261(1.03); C288(0.72); C326(0.81)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C102(1.17); C261(0.98); C288(0.79); C326(1.02)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C102(1.05); C125(1.05); C261(1.01); C288(1.03)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C102(1.17); C261(1.06); C288(0.74); C326(0.94)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C102(1.31); C261(1.04); C288(0.64); C326(0.56)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C102(1.13); C261(0.98); C288(0.85); C326(0.82)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C102(1.15); C261(0.96); C288(0.69); C326(0.84)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C102(1.20); C261(0.99); C288(0.70); C326(0.92)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C102(0.87); C261(0.99); C288(0.95); C317(0.87)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C102(0.78); C261(1.05); C288(0.94); C317(0.86)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C102(0.96); C261(0.94); C288(0.99); C317(0.91)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C102(0.98); C261(1.00); C288(0.93); C317(0.82)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C102(1.38); C125(1.19); C261(1.06); C288(0.93)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C102(0.95); C261(1.02); C288(0.97); C317(0.87)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C102(0.77); C261(1.04); C288(1.03); C317(0.82)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C102(0.77); C261(1.13); C288(1.13); C317(0.99)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C102(0.76); C261(1.07); C288(1.04); C317(1.01)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C102(0.81); C261(1.11); C288(1.18); C317(1.11)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C102(0.91); C261(0.98); C288(1.02); C317(0.97)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C102(0.81); C261(1.00); C288(1.08); C317(1.01)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C102(0.74); C261(0.98); C288(1.01); C317(0.97)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C102(0.90); C261(1.03); C288(1.06); C317(0.97)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C102(0.86); C261(1.28); C288(1.29); C317(1.31)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C102(1.08); C125(0.91); C261(0.81); C288(0.91)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C102(0.87); C261(0.99); C288(1.09); C317(1.03)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C102(1.05); C125(1.08); C261(1.00); C288(0.99)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C102(1.07); C125(1.03); C261(1.08); C288(1.02)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C102(1.03); C125(1.20); C261(1.17); C288(1.19)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C102(1.03); C125(1.25); C261(0.93); C288(0.93)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C102(1.22); C125(1.04); C261(0.95); C288(0.90)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C102(1.03); C125(1.12); C261(0.95); C288(0.99)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C102(1.14); C125(0.96); C261(0.89); C288(0.90)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C102(1.25); C125(1.20); C261(0.96); C288(1.01)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C102(1.12); C125(1.10); C261(0.97); C288(1.03)  LDD0811  [10]
 LDCM0634  CY-0357 Hep-G2 C31(0.96)  LDD2228  [15]
 LDCM0495  E2913 HEK-293T C31(1.23); C326(0.99); C261(0.95); C662(0.91)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C662(13.94); C799(3.03); C31(1.70); C517(1.64)  LDD1702  [6]
 LDCM0175  Ethacrynic acid HeLa C763(1.05)  LDD2210  [9]
 LDCM0625  F8 Ramos C673(1.71); C31(2.17); C839(1.48); C288(0.60)  LDD2187  [29]
 LDCM0572  Fragment10 Ramos C673(1.66); C31(0.99); C288(0.51); C326(1.28)  LDD2189  [29]
 LDCM0573  Fragment11 Ramos C673(1.09); C31(0.19); C839(0.27); C326(1.32)  LDD2190  [29]
 LDCM0574  Fragment12 Ramos C673(1.36); C31(1.04); C839(6.20); C288(0.88)  LDD2191  [29]
 LDCM0575  Fragment13 Ramos C673(0.69); C31(0.90); C288(0.56); C326(0.88)  LDD2192  [29]
 LDCM0576  Fragment14 Ramos C673(3.27); C31(1.03); C326(1.89); C662(5.27)  LDD2193  [29]
 LDCM0579  Fragment20 Ramos C673(2.12); C31(0.79); C288(0.87); C326(2.38)  LDD2194  [29]
 LDCM0580  Fragment21 Ramos C673(0.87); C31(0.84); C839(1.07); C288(0.54)  LDD2195  [29]
 LDCM0582  Fragment23 Ramos C673(1.31); C31(0.77); C839(0.81); C288(0.58)  LDD2196  [29]
 LDCM0578  Fragment27 Ramos C673(0.55); C31(0.87); C839(1.23); C288(0.59)  LDD2197  [29]
 LDCM0586  Fragment28 Ramos C673(0.92); C31(0.76); C839(0.98); C288(0.77)  LDD2198  [29]
 LDCM0588  Fragment30 Ramos C673(1.19); C31(1.05); C839(1.89); C288(0.53)  LDD2199  [29]
 LDCM0589  Fragment31 Ramos C673(0.84); C31(0.85); C839(1.46); C288(0.66)  LDD2200  [29]
 LDCM0590  Fragment32 Ramos C673(1.60); C31(1.22); C288(0.72); C326(0.93)  LDD2201  [29]
 LDCM0468  Fragment33 HCT 116 C102(1.16); C261(0.91); C288(0.71); C326(0.78)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C673(1.03); C31(0.96); C288(0.63); C326(1.02)  LDD2203  [29]
 LDCM0566  Fragment4 Ramos C673(3.23); C31(1.16); C839(2.29); C288(0.87)  LDD2184  [29]
 LDCM0427  Fragment51 HCT 116 C102(1.32); C261(1.08); C288(0.97); C326(0.80)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C673(0.96); C31(1.66); C288(0.55); C326(0.80)  LDD2204  [29]
 LDCM0614  Fragment56 Ramos C673(1.00); C31(1.33); C839(0.84); C288(0.59)  LDD2205  [29]
 LDCM0569  Fragment7 Ramos C673(3.03); C31(0.98); C839(1.68); C288(0.90)  LDD2186  [29]
 LDCM0571  Fragment9 Ramos C673(2.00); C31(0.91); C288(0.69); C662(3.22)  LDD2188  [29]
 LDCM0015  HNE MDA-MB-231 C673(1.12)  LDD0346  [29]
 LDCM0107  IAA HeLa H278(0.00); H277(0.00); H22(0.00); H59(0.00)  LDD0221  [22]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [5]
 LDCM0022  KB02 HCT 116 C839(4.22)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C839(3.78)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C839(3.39)  LDD0082  [10]
 LDCM0109  NEM HeLa H277(0.00); H59(0.00); H22(0.00); H278(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C261(0.61)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C662(1.66)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C261(0.87); C512(1.17)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C261(1.29); C673(0.66); C662(0.86)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C261(1.56)  LDD2094  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C662(0.73)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C261(0.92)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C261(1.23); C512(1.41); C673(1.56); C662(0.77)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C288(1.01)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C662(1.31)  LDD2101  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C673(1.01)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C261(1.01); C512(1.06); C662(0.74)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C261(1.05); C673(0.51); C662(0.54); C326(0.96)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C261(1.08); C512(1.08); C673(1.00); C662(0.78)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C673(0.83)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C662(0.80)  LDD2115  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C673(0.60)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C261(1.85)  LDD2119  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C662(0.48)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C261(1.11); C512(0.96); C673(0.87); C662(0.71)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C662(0.49)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C261(0.93); C662(0.58); C799(0.82)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C261(0.96); C662(0.69)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C261(0.71); C512(1.01)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C261(1.05); C512(0.90); C673(0.87); C662(0.83)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C662(0.76)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C662(0.45)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C261(1.14); C673(0.77); C662(1.03)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C261(1.74); C673(1.15); C662(0.93); C326(1.05)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C261(1.05); C662(0.87)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C261(2.47); C662(1.20)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C261(1.06); C673(0.90); C662(0.49); C326(0.73)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C288(0.81)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C261(1.07); C512(1.06)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C261(1.99); C662(2.23)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C261(0.97); C662(0.74)  LDD2146  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C261(0.58); C662(0.66)  LDD2150  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C261(1.93)  LDD2153  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C673(1.05); C288(0.95)  LDD2206  [30]
 LDCM0628  OTUB2-COV-1 HEK-293T C662(0.69); C673(0.69)  LDD2207  [30]
 LDCM0131  RA190 MM1.R 2.05  LDD0299  [8]
 LDCM0021  THZ1 HCT 116 C662(1.16); C288(1.02); C102(0.97); C839(1.12)  LDD2173  [10]
 LDCM0112  W16 Hep-G2 C31(0.63)  LDD0239  [23]
 LDCM0113  W17 Hep-G2 C31(3.22)  LDD0240  [23]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
9 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
19 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
24 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
27 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
30 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.