Details of the Target

General Information of Target

Target ID LDTP02342
Target Name Dihydropteridine reductase (QDPR)
Gene Name QDPR
Gene ID 5860
Synonyms
DHPR; SDR33C1; Dihydropteridine reductase; EC 1.5.1.34; HDHPR; Quinoid dihydropteridine reductase; Short chain dehydrogenase/reductase family 33C member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSF
TEQADQVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSH
LATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAV
LPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELT
PAYF
Target Bioclass
Enzyme
Family
Short-chain dehydrogenases/reductases (SDR) family
Function Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.
Uniprot ID
P09417
Ensemble ID
ENST00000281243.10
HGNC ID
HGNC:9752
ChEMBL ID
CHEMBL3730

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FADU SNV: p.M147I DBIA    Probe Info 
MEWO SNV: p.V71A DBIA    Probe Info 
NALM6 SNV: p.V13G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
SAA-alkyne
 Probe Info  		1.11  LDD0252  [1]
C-Sul
 Probe Info  		2.72  LDD0066  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K98(4.93)  LDD0277  [4]
IPM
 Probe Info  		N.A.  LDD0241  [5]
BTD
 Probe Info  		C161(1.85)  LDD2093  [6]
HHS-482
 Probe Info  		Y150(0.52)  LDD0285  [7]
HHS-475
 Probe Info  		Y150(1.03)  LDD0264  [8]
DBIA
 Probe Info  		C104(0.28)  LDD0563  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C161(0.00); C104(0.00); C85(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		C161(0.00); C104(0.00); C85(0.00)  LDD0037  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
SF
 Probe Info  		Y150(0.00); K154(0.00)  LDD0028  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
NAIA_5
 Probe Info  		N.A.  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C158
 Probe Info  		11.71  LDD1838  [17]
C187
 Probe Info  		32.00  LDD1865  [17]
C189
 Probe Info  		4.96  LDD1866  [17]
C190
 Probe Info  		5.94  LDD1867  [17]
C191
 Probe Info  		25.99  LDD1868  [17]
C193
 Probe Info  		13.36  LDD1869  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C161(1.63)  LDD2152  [6]
 LDCM0562  Abegg_cp(-)-11 HeLa C161(2.03)  LDD0313  [12]
 LDCM0214  AC1 HEK-293T C161(1.22)  LDD0812  [9]
 LDCM0215  AC10 HEK-293T C161(1.48)  LDD0813  [9]
 LDCM0216  AC100 HEK-293T C161(1.28)  LDD0814  [9]
 LDCM0217  AC101 HEK-293T C161(1.16)  LDD0815  [9]
 LDCM0218  AC102 HEK-293T C161(1.14)  LDD0816  [9]
 LDCM0219  AC103 HEK-293T C161(1.33)  LDD0817  [9]
 LDCM0220  AC104 HEK-293T C161(1.38)  LDD0818  [9]
 LDCM0221  AC105 HEK-293T C161(0.91)  LDD0819  [9]
 LDCM0222  AC106 HEK-293T C161(1.15)  LDD0820  [9]
 LDCM0223  AC107 HEK-293T C161(1.42)  LDD0821  [9]
 LDCM0224  AC108 HEK-293T C161(1.07)  LDD0822  [9]
 LDCM0225  AC109 HEK-293T C161(1.23)  LDD0823  [9]
 LDCM0226  AC11 HEK-293T C161(1.20)  LDD0824  [9]
 LDCM0227  AC110 HEK-293T C161(2.26)  LDD0825  [9]
 LDCM0228  AC111 HEK-293T C161(2.26)  LDD0826  [9]
 LDCM0229  AC112 HEK-293T C161(2.09)  LDD0827  [9]
 LDCM0230  AC113 HEK-293T C161(1.14)  LDD0828  [9]
 LDCM0231  AC114 HEK-293T C161(1.14)  LDD0829  [9]
 LDCM0232  AC115 HEK-293T C161(1.11)  LDD0830  [9]
 LDCM0233  AC116 HEK-293T C161(1.27)  LDD0831  [9]
 LDCM0234  AC117 HEK-293T C161(1.40)  LDD0832  [9]
 LDCM0235  AC118 HEK-293T C161(1.24)  LDD0833  [9]
 LDCM0236  AC119 HEK-293T C161(1.28)  LDD0834  [9]
 LDCM0237  AC12 HEK-293T C161(0.95)  LDD0835  [9]
 LDCM0238  AC120 HEK-293T C161(1.24)  LDD0836  [9]
 LDCM0239  AC121 HEK-293T C161(2.01)  LDD0837  [9]
 LDCM0240  AC122 HEK-293T C161(1.94)  LDD0838  [9]
 LDCM0241  AC123 HEK-293T C161(1.86)  LDD0839  [9]
 LDCM0242  AC124 HEK-293T C161(1.53)  LDD0840  [9]
 LDCM0243  AC125 HEK-293T C161(1.62)  LDD0841  [9]
 LDCM0244  AC126 HEK-293T C161(2.88)  LDD0842  [9]
 LDCM0245  AC127 HEK-293T C161(3.01)  LDD0843  [9]
 LDCM0246  AC128 HCT 116 C104(0.28)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C104(1.22)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C104(0.66)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C104(1.09)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C104(1.14)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C104(0.92)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C104(1.30)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C104(0.82)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C104(1.01)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C104(2.00)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C104(1.20)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C104(1.14)  LDD0575  [9]
 LDCM0259  AC14 HEK-293T C161(1.13)  LDD0857  [9]
 LDCM0260  AC140 HCT 116 C104(1.03)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C104(1.28)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C104(1.33)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C161(1.07)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C161(0.69)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C161(0.98)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C161(0.95)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C161(0.64)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C161(0.11)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C161(0.56)  LDD0586  [9]
 LDCM0270  AC15 HEK-293T C161(1.19)  LDD0868  [9]
 LDCM0271  AC150 HCT 116 C161(1.89)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C161(0.95)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C161(0.44)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C161(0.10)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C161(0.56)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C161(1.19)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C161(0.97)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C161(0.90)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C104(1.31)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C104(0.74)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C104(0.91)  LDD0595  [9]
 LDCM0279  AC2 HEK-293T C161(1.07)  LDD0877  [9]
 LDCM0280  AC20 HCT 116 C104(1.24)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C104(1.05)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C104(1.40)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C104(1.02)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C104(1.38)  LDD0601  [9]
 LDCM0285  AC25 HEK-293T C161(1.14)  LDD0883  [9]
 LDCM0286  AC26 HEK-293T C161(0.96)  LDD0884  [9]
 LDCM0287  AC27 HEK-293T C161(1.01)  LDD0885  [9]
 LDCM0288  AC28 HEK-293T C161(0.65)  LDD0886  [9]
 LDCM0289  AC29 HEK-293T C161(1.08)  LDD0887  [9]
 LDCM0290  AC3 HEK-293T C161(1.03)  LDD0888  [9]
 LDCM0291  AC30 HEK-293T C161(1.10)  LDD0889  [9]
 LDCM0292  AC31 HEK-293T C161(0.89)  LDD0890  [9]
 LDCM0293  AC32 HEK-293T C161(1.01)  LDD0891  [9]
 LDCM0294  AC33 HEK-293T C161(1.05)  LDD0892  [9]
 LDCM0295  AC34 HEK-293T C161(1.12)  LDD0893  [9]
 LDCM0296  AC35 HEK-293T C161(1.00); C85(1.01)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C161(0.97); C85(1.05)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C104(1.05); C85(1.20)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C104(1.20); C161(1.25); C85(1.13)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C85(1.00)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C161(1.21)  LDD0899  [9]
 LDCM0302  AC40 HEK-293T C104(1.07); C161(1.18)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C104(1.01); C161(0.95); C85(0.97)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C161(1.06)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C161(1.09); C85(1.09)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C161(0.93); C85(1.00)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C104(1.12); C85(1.12)  LDD1546  [18]
 LDCM0308  AC46 HCT 116 C104(1.94)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C104(1.18)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C104(1.87)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C104(0.29)  LDD0628  [9]
 LDCM0312  AC5 HEK-293T C161(1.23)  LDD0910  [9]
 LDCM0313  AC50 HCT 116 C104(0.40)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C104(2.72)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C104(1.08)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C104(0.59)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C104(0.55)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C104(0.30)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C104(0.26)  LDD0636  [9]
 LDCM0320  AC57 HEK-293T C161(1.06)  LDD0918  [9]
 LDCM0321  AC58 HEK-293T C161(1.01)  LDD0919  [9]
 LDCM0322  AC59 HEK-293T C161(1.10)  LDD0920  [9]
 LDCM0323  AC6 HEK-293T C161(0.86)  LDD0921  [9]
 LDCM0324  AC60 HEK-293T C161(1.04)  LDD0922  [9]
 LDCM0325  AC61 HEK-293T C161(1.25)  LDD0923  [9]
 LDCM0326  AC62 HEK-293T C161(1.26)  LDD0924  [9]
 LDCM0327  AC63 HEK-293T C161(1.34)  LDD0925  [9]
 LDCM0328  AC64 HEK-293T C161(1.01)  LDD0926  [9]
 LDCM0329  AC65 HEK-293T C161(1.21)  LDD0927  [9]
 LDCM0330  AC66 HEK-293T C161(1.15)  LDD0928  [9]
 LDCM0331  AC67 HEK-293T C161(1.32)  LDD0929  [9]
 LDCM0332  AC68 HCT 116 C161(0.87)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C161(0.66)  LDD0650  [9]
 LDCM0334  AC7 HEK-293T C161(1.19)  LDD0932  [9]
 LDCM0335  AC70 HCT 116 C161(0.22)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C161(1.05)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C161(0.64)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C161(0.14)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C161(0.16)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C161(0.15)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C161(0.49)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C161(0.40)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C161(0.88)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C161(0.89)  LDD0661  [9]
 LDCM0345  AC8 HEK-293T C161(1.06)  LDD0943  [9]
 LDCM0346  AC80 HCT 116 C161(0.50)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C161(0.85)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C161(0.14)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C104(0.22); C161(0.23)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C104(0.34); C161(0.44)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C104(0.77); C161(1.33)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C104(0.70); C161(1.37)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C104(1.06); C161(1.32)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C104(0.65); C161(0.98)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C104(0.49); C161(0.63)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C104(2.15); C161(2.29)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C161(0.18); C104(0.20)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C104(0.27); C161(0.32)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C104(0.81); C161(1.19)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C104(1.12); C161(1.81)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C161(1.11); C104(1.15)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C104(0.60); C161(0.81)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C104(0.45); C161(0.51)  LDD0681  [9]
 LDCM0365  AC98 HEK-293T C161(1.16)  LDD0963  [9]
 LDCM0366  AC99 HEK-293T C161(1.06)  LDD0964  [9]
 LDCM0248  AKOS034007472 HEK-293T C161(0.88)  LDD0846  [9]
 LDCM0356  AKOS034007680 HEK-293T C161(1.11)  LDD0954  [9]
 LDCM0275  AKOS034007705 HEK-293T C161(1.30)  LDD0873  [9]
 LDCM0108  Chloroacetamide HeLa C85(0.00); C161(0.00)  LDD0222  [15]
 LDCM0367  CL1 HCT 116 C104(0.98)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C104(0.49)  LDD0685  [9]
 LDCM0369  CL100 HEK-293T C161(1.39)  LDD0967  [9]
 LDCM0370  CL101 HEK-293T C161(1.34)  LDD0968  [9]
 LDCM0371  CL102 HEK-293T C161(1.17)  LDD0969  [9]
 LDCM0372  CL103 HEK-293T C161(1.51)  LDD0970  [9]
 LDCM0373  CL104 HEK-293T C161(1.14)  LDD0971  [9]
 LDCM0374  CL105 HCT 116 C104(0.78)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C104(0.54)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C104(0.54)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C104(0.30)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C104(0.80)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C104(0.28)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C104(0.57)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C104(0.79)  LDD0698  [9]
 LDCM0382  CL112 HEK-293T C161(1.21)  LDD0980  [9]
 LDCM0383  CL113 HEK-293T C161(0.91)  LDD0981  [9]
 LDCM0384  CL114 HEK-293T C161(1.47)  LDD0982  [9]
 LDCM0385  CL115 HEK-293T C161(1.44)  LDD0983  [9]
 LDCM0386  CL116 HEK-293T C161(1.25)  LDD0984  [9]
 LDCM0387  CL117 HEK-293T C104(1.06); C161(1.09); C85(1.11)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C104(1.28); C161(1.09); C85(1.00)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C104(1.23); C161(1.07); C85(1.13)  LDD1593  [18]
 LDCM0390  CL12 HCT 116 C104(0.24)  LDD0707  [9]
 LDCM0391  CL120 HEK-293T C161(0.97)  LDD1595  [18]
 LDCM0392  CL121 HCT 116 C104(0.53)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C104(0.96)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C104(0.49)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C104(0.39)  LDD0712  [9]
 LDCM0396  CL125 HEK-293T C161(1.02)  LDD0994  [9]
 LDCM0397  CL126 HEK-293T C161(1.05)  LDD0995  [9]
 LDCM0398  CL127 HEK-293T C161(0.82)  LDD0996  [9]
 LDCM0399  CL128 HEK-293T C161(0.82)  LDD0997  [9]
 LDCM0400  CL13 HCT 116 C104(0.57)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C104(1.08)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C104(0.52)  LDD0719  [9]
 LDCM0403  CL16 HEK-293T C161(0.89)  LDD1001  [9]
 LDCM0404  CL17 HEK-293T C161(1.02)  LDD1002  [9]
 LDCM0405  CL18 HEK-293T C161(1.01)  LDD1003  [9]
 LDCM0406  CL19 HEK-293T C161(1.22)  LDD1004  [9]
 LDCM0407  CL2 HCT 116 C104(1.08)  LDD0724  [9]
 LDCM0408  CL20 HEK-293T C161(1.02)  LDD1006  [9]
 LDCM0409  CL21 HEK-293T C161(1.33)  LDD1007  [9]
 LDCM0410  CL22 HEK-293T C161(1.32)  LDD1008  [9]
 LDCM0411  CL23 HEK-293T C161(0.84)  LDD1009  [9]
 LDCM0412  CL24 HEK-293T C161(0.94)  LDD1010  [9]
 LDCM0413  CL25 HEK-293T C161(1.08)  LDD1011  [9]
 LDCM0414  CL26 HEK-293T C161(1.26)  LDD1012  [9]
 LDCM0415  CL27 HEK-293T C161(1.02)  LDD1013  [9]
 LDCM0416  CL28 HEK-293T C161(0.85)  LDD1014  [9]
 LDCM0417  CL29 HEK-293T C161(1.07)  LDD1015  [9]
 LDCM0418  CL3 HCT 116 C104(1.23)  LDD0735  [9]
 LDCM0419  CL30 HEK-293T C161(1.27)  LDD1017  [9]
 LDCM0420  CL31 HEK-293T C161(1.24)  LDD1018  [9]
 LDCM0421  CL32 HEK-293T C161(1.19)  LDD1019  [9]
 LDCM0422  CL33 HEK-293T C161(0.98)  LDD1020  [9]
 LDCM0423  CL34 HEK-293T C161(1.23)  LDD1021  [9]
 LDCM0424  CL35 HEK-293T C161(1.22)  LDD1022  [9]
 LDCM0425  CL36 HEK-293T C161(1.15)  LDD1023  [9]
 LDCM0426  CL37 HEK-293T C161(1.27)  LDD1024  [9]
 LDCM0428  CL39 HEK-293T C161(2.02)  LDD1026  [9]
 LDCM0429  CL4 HCT 116 C104(0.74)  LDD0746  [9]
 LDCM0430  CL40 HEK-293T C161(1.14)  LDD1028  [9]
 LDCM0431  CL41 HEK-293T C161(1.59)  LDD1029  [9]
 LDCM0432  CL42 HEK-293T C161(1.48)  LDD1030  [9]
 LDCM0433  CL43 HEK-293T C161(1.58)  LDD1031  [9]
 LDCM0434  CL44 HEK-293T C161(1.36)  LDD1032  [9]
 LDCM0435  CL45 HEK-293T C161(1.99)  LDD1033  [9]
 LDCM0436  CL46 HEK-293T C161(2.15)  LDD1034  [9]
 LDCM0437  CL47 HEK-293T C161(1.79)  LDD1035  [9]
 LDCM0438  CL48 HEK-293T C161(1.36)  LDD1036  [9]
 LDCM0439  CL49 HEK-293T C161(1.44)  LDD1037  [9]
 LDCM0440  CL5 HCT 116 C104(0.90)  LDD0757  [9]
 LDCM0441  CL50 HEK-293T C161(1.30)  LDD1039  [9]
 LDCM0442  CL51 HEK-293T C161(1.23)  LDD1040  [9]
 LDCM0443  CL52 HEK-293T C161(1.38)  LDD1041  [9]
 LDCM0444  CL53 HEK-293T C161(1.42)  LDD1042  [9]
 LDCM0445  CL54 HEK-293T C161(1.40)  LDD1043  [9]
 LDCM0446  CL55 HEK-293T C161(1.52)  LDD1044  [9]
 LDCM0447  CL56 HEK-293T C161(2.01)  LDD1045  [9]
 LDCM0448  CL57 HEK-293T C161(1.50)  LDD1046  [9]
 LDCM0449  CL58 HEK-293T C161(1.64)  LDD1047  [9]
 LDCM0450  CL59 HEK-293T C161(1.93)  LDD1048  [9]
 LDCM0451  CL6 HCT 116 C104(0.90)  LDD0768  [9]
 LDCM0452  CL60 HEK-293T C161(1.51)  LDD1050  [9]
 LDCM0453  CL61 HEK-293T C161(1.11)  LDD1051  [9]
 LDCM0454  CL62 HEK-293T C161(1.67)  LDD1052  [9]
 LDCM0455  CL63 HEK-293T C161(1.97)  LDD1053  [9]
 LDCM0456  CL64 HEK-293T C161(1.39)  LDD1054  [9]
 LDCM0457  CL65 HEK-293T C161(1.38)  LDD1055  [9]
 LDCM0458  CL66 HEK-293T C161(1.14)  LDD1056  [9]
 LDCM0459  CL67 HEK-293T C161(1.49)  LDD1057  [9]
 LDCM0460  CL68 HEK-293T C161(1.44)  LDD1058  [9]
 LDCM0461  CL69 HEK-293T C161(1.25)  LDD1059  [9]
 LDCM0462  CL7 HCT 116 C104(0.51)  LDD0779  [9]
 LDCM0463  CL70 HEK-293T C161(1.14)  LDD1061  [9]
 LDCM0464  CL71 HEK-293T C161(1.31)  LDD1062  [9]
 LDCM0465  CL72 HEK-293T C161(1.71)  LDD1063  [9]
 LDCM0466  CL73 HEK-293T C161(1.27)  LDD1064  [9]
 LDCM0467  CL74 HEK-293T C161(2.32)  LDD1065  [9]
 LDCM0469  CL76 HCT 116 C161(0.88)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C161(0.83)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C161(1.02)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C161(0.70)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C104(0.22)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C161(1.04)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C161(0.80)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C161(0.34)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C161(0.45)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C161(0.23)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C161(0.91)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C161(1.05)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C161(1.03)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C161(0.55)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C161(0.26)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C104(0.65)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C161(0.88)  LDD0802  [9]
 LDCM0486  CL91 HEK-293T C161(1.51)  LDD1084  [9]
 LDCM0487  CL92 HEK-293T C161(1.09)  LDD1085  [9]
 LDCM0488  CL93 HEK-293T C161(1.25)  LDD1086  [9]
 LDCM0489  CL94 HEK-293T C161(1.43)  LDD1087  [9]
 LDCM0490  CL95 HEK-293T C161(1.36)  LDD1088  [9]
 LDCM0491  CL96 HEK-293T C161(1.04)  LDD1089  [9]
 LDCM0492  CL97 HEK-293T C161(0.80)  LDD1090  [9]
 LDCM0493  CL98 HEK-293T C161(1.27)  LDD1091  [9]
 LDCM0494  CL99 HEK-293T C161(0.97)  LDD1092  [9]
 LDCM0495  E2913 HEK-293T C104(1.09); C161(0.96); C85(0.89)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C26(1.41)  LDD1702  [6]
 LDCM0625  F8 Ramos C104(1.05); C161(1.27)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C161(0.82)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C161(20.00)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C161(0.85)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C161(0.94)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C161(0.45)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C161(0.67)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C161(1.16)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C161(1.24)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C161(1.28)  LDD2197  [19]
 LDCM0588  Fragment30 Ramos C161(1.27)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C161(1.33)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C161(0.83)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C161(1.70)  LDD1066  [9]
 LDCM0596  Fragment38 Ramos C161(1.75)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C104(0.78); C161(1.04)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C161(0.94)  LDD1025  [9]
 LDCM0610  Fragment52 Ramos C161(1.61)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C161(2.00)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C104(0.75); C161(0.94)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C161(0.72)  LDD2188  [19]
 LDCM0116  HHS-0101 DM93 Y150(1.03)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y150(0.89)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y150(1.04)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y150(1.12)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y150(1.92)  LDD0268  [8]
 LDCM0123  JWB131 DM93 Y150(0.52)  LDD0285  [7]
 LDCM0124  JWB142 DM93 Y150(0.77)  LDD0286  [7]
 LDCM0125  JWB146 DM93 Y150(0.56)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y150(1.01)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y150(0.55)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y150(1.31)  LDD0290  [7]
 LDCM0129  JWB202 DM93 Y150(0.21)  LDD0291  [7]
 LDCM0130  JWB211 DM93 Y150(0.46)  LDD0292  [7]
 LDCM0022  KB02 HEK-293T C161(1.10)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C161(0.95)  LDD1497  [18]
 LDCM0024  KB05 IGR37 C161(4.97)  LDD3314  [20]
 LDCM0109  NEM HeLa N.A.  LDD0226  [15]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C161(1.85)  LDD2093  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C161(2.28)  LDD2099  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C161(1.02)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C161(0.98)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C161(1.20)  LDD2111  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C161(0.63)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C161(0.69)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C161(2.45)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C161(0.51)  LDD2120  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C161(2.08)  LDD2123  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C161(1.85)  LDD2129  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C161(1.37)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C161(0.94)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C161(0.88)  LDD2140  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C104(0.72)  LDD2148  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C161(0.77)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C161(0.40)  LDD2151  [6]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-(N-morpholino)Ethanesulfonic Acid Small molecular drug DB03814

References

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2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840