Details of the Target

General Information of Target

Target ID LDTP07872
Target Name Intermembrane lipid transfer protein VPS13C (VPS13C)
Gene Name VPS13C
Gene ID 54832
Synonyms
KIAA1421; Intermembrane lipid transfer protein VPS13C; Vacuolar protein sorting-associated protein 13C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLESVVADLLNRFLGDYVENLNKSQLKLGIWGGNVALDNLQIKENALSELDVPFKVKAG
QIDKLTLKIPWKNLYGEAVVATLEGLYLLVVPGASIKYDAVKEEKSLQDVKQKELSRIEE
ALQKAAEKGTHSGEFIYGLENFVYKDIKPGRKRKKHKKHFKKPFKGLDRSKDKPKEAKKD
TFVEKLATQVIKNVQVKITDIHIKYEDDVTDPKRPLSFGVTLGELSLLTANEHWTPCILN
EADKIIYKLIRLDSLSAYWNVNCSMSYQRSREQILDQLKNEILTSGNIPPNYQYIFQPIS
ASAKLYMNPYAESELKTPKLDCNIEIQNIAIELTKPQYLSMIDLLESVDYMVRNAPYRKY
KPYLPLHTNGRRWWKYAIDSVLEVHIRRYTQMWSWSNIKKHRQLLKSYKIAYKNKLTQSK
VSEEIQKEIQDLEKTLDVFNIILARQQAQVEVIRSGQKLRKKSADTGEKRGGWFSGLWGK
KESKKKDEESLIPETIDDLMTPEEKDKLFTAIGYSESTHNLTLPKQYVAHIMTLKLVSTS
VTIRENKNIPEILKIQIIGLGTQVSQRPGAQALKVEAKLEHWYITGLRQQDIVPSLVASI
GDTTSSLLKIKFETNPEDSPADQTLIVQSQPVEVIYDAKTVNAVVEFFQSNKGLDLEQIT
SATLMKLEEIKERTATGLTHIIETRKVLDLRINLKPSYLVVPQTGFHHEKSDLLILDFGT
FQLNSKDQGLQKTTNSSLEEIMDKAYDKFDVEIKNVQLLFARAEETWKKCRFQHPSTMHI
LQPMDIHVELAKAMVEKDIRMARFKVSGGLPLMHVRISDQKMKDVLYLMNSIPLPQKSSA
QSPERQVSSIPIISGGTKGLLGTSLLLDTVESESDDEYFDAEDGEPQTCKSMKGSELKKA
AEVPNEELINLLLKFEIKEVILEFTKQQKEEDTILVFNVTQLGTEATMRTFDLTVVSYLK
KISLDYHEIEGSKRKPLHLISSSDKPGLDLLKVEYIKADKNGPSFQTAFGKTEQTVKVAF
SSLNLLLQTQALVASINYLTTIIPSDDQSISVAKEVQISTEKQQKNSTLPKAIVSSRDSD
IIDFRLFAKLNAFCVIVCNEKNNIAEIKIQGLDSSLSLQSRKQSLFARLENIIVTDVDPK
TVHKKAVSIMGNEVFRFNLDLYPDATEGDLYTDMSKVDGVLSLNVGCIQIVYLHKFLMSL
LNFLNNFQTAKESLSAATAQAAERAATSVKDLAQRSFRVSINIDLKAPVIVIPQSSISTN
AVVVDLGLIRVHNQFSLVSDEDYLNPPVIDRMDVQLTKLTLYRTVIQPGIYHPDIQLLHP
INLEFLVNRNLAASWYHKVPVVEIKGHLDSMNVSLNQEDLNLLFRILTENLCEGTEDLDK
VKPRVQETGEIKEPLEISISQDVHDSKNTLTTGVEEIRSVDIINMLLNFEIKEVVVTLMK
KSEKKGRPLHELNVLQLGMEAKVKTYDMTAKAYLKKISMQCFDFTDSKGEPLHIINSSNV
TDEPLLKMLLTKADSDGPEFKTIHDSTKQRLKVSFASLDLVLHLEALLSFMDFLSSAAPF
SEPSSSEKESELKPLVGESRSIAVKAVSSNISQKDVFDLKITAELNAFNVFVCDQKCNIA
DIKIHGMDASISVKPKQTDVFARLKDIIVMNVDLQSIHKKAVSILGDEVFRFQLTLYPDA
TEGEAYADMSKVDGKLSFKVGCIQIVYVHKFFMSLLNFLNNFQTAKEALSTATVQAAERA
ASSMKDLAQKSFRLLMDINLKAPVIIIPQSSVSPNAVIADLGLIRVENKFSLVPMEHYSL
PPVIDKMNIELTQLKLSRTILQASLPQNDIEILKPVNMLLSIQRNLAAAWYVQIPGMEIK
GKLKPMQVALSEDDLTVLMKILLENLGEASSQPSPTQSVQETVRVRKVDVSSVPDHLKEQ
EDWTDSKLSMNQIVSLQFDFHFESLSIILYNNDINQESGVAFHNDSFQLGELRLHLMASS
GKMFKDGSMNVSVKLKTCTLDDLREGIERATSRMIDRKNDQDNNSSMIDISYKQDKNGSQ
IDAVLDKLYVCASVEFLMTVADFFIKAVPQSPENVAKETQILPRQTATGKVKIEKDDSVR
PNMTLKAMITDPEVVFVASLTKADAPALTASFQCNLSLSTSKLEQMMEASVRDLKVLACP
FLREKRGKNITTVLQPCSLFMEKCTWASGKQNINIMVKEFIIKISPIILNTVLTIMAALS
PKTKEDGSKDTSKEMENLWGIKSINDYNTWFLGVDTATEITESFKGIEHSLIEENCGVVV
ESIQVTLECGLGHRTVPLLLAESKFSGNIKNWTSLMAAVADVTLQVHYYNEIHAVWEPLI
ERVEGKRQWNLRLDVKKNPVQDKSLLPGDDFIPEPQMAIHISSGNTMNITISKSCLNVFN
NLAKGFSEGTASTFDYSLKDRAPFTVKNAVGVPIKVKPNCNLRVMGFPEKSDIFDVDAGQ
NLELEYASMVPSSQGNLSILSRQESSFFTLTIVPHGYTEVANIPVARPGRRLYNVRNPNA
SHSDSVLVQIDATEGNKVITLRSPLQIKNHFSIAFIIYKFVKNVKLLERIGIARPEEEFH
VPLDSYRCQLFIQPAGILEHQYKESTTYISWKEELHRSREVRCMLQCPSVEVSFLPLIVN
TVALPDELSYICTHGEDWDVAYIIHLYPSLTLRNLLPYSLRYLLEGTAETHELAEGSTAD
VLHSRISGEIMELVLVKYQGKNWNGHFRIRDTLPEFFPVCFSSDSTEVTTVDLSVHVRRI
GSRMVLSVFSPYWLINKTTRVLQYRSEDIHVKHPADFRDIILFSFKKKNIFTKNKVQLKI
STSAWSSSFSLDTVGSYGCVKCPANNMEYLVGVSIKMSSFNLSRIVTLTPFCTIANKSSL
ELEVGEIASDGSMPTNKWNYIASSECLPFWPESLSGKLCVRVVGCEGSSKPFFYNRQDNG
TLLSLEDLNGGILVDVNTAEHSTVITFSDYHEGSAPALIMNHTPWDILTYKQSGSPEEMV
LLPRQARLFAWADPTGTRKLTWTYAANVGEHDLLKDGCGQFPYDANIQIHWVSFLDGRQR
VLLFTDDVALVSKALQAEEMEQADYEITLSLHSLGLSLVNNESKQEVSYIGITSSGVVWE
VKPKQKWKPFSQKQIILLEQSYQKHQISRDHGWIKLDNNFEVNFDKDPMEMRLPIRSPIK
RDFLSGIQIEFKQSSHQRSLRARLYWLQVDNQLPGAMFPVVFHPVAPPKSIALDSEPKPF
IDVSVITRFNEYSKVLQFKYFMVLIQEMALKIDQGFLGAIIALFTPTTDPEAERRRTKLI
QQDIDALNAELMETSMTDMSILSFFEHFHISPVKLHLSLSLGSGGEESDKEKQEMFAVHS
VNLLLKSIGATLTDVDDLIFKLAYYEIRYQFYKRDQLIWSVVRHYSEQFLKQMYVLVLGL
DVLGNPFGLIRGLSEGVEALFYEPFQGAVQGPEEFAEGLVIGVRSLFGHTVGGAAGVVSR
ITGSVGKGLAAITMDKEYQQKRREELSRQPRDFGDSLARGGKGFLRGVVGGVTGIITKPV
EGAKKEGAAGFFKGIGKGLVGAVARPTGGIVDMASSTFQGIQRAAESTEEVSSLRPPRLI
HEDGIIRPYDRQESEGSDLLENHIKKLEGETYRYHCAIPGSKKTILMVTNRRVLCIKEVE
ILGLMCVDWQCPFEDFVFPPSVSENVLKISVKEQGLFHKKDSANQGCVRKVYLKDTATAE
RACNAIEDAQSTRQQQKLMKQSSVRLLRPQLPS
Target Bioclass
Other
Family
VPS13 family
Subcellular location
Mitochondrion outer membrane
Function
Mediates the transfer of lipids between membranes at organelle contact sites. Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization.
Uniprot ID
Q709C8
Ensemble ID
ENST00000249837.7
HGNC ID
HGNC:23594

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.H2495R DBIA    Probe Info 
A431 SNV: p.L935V DBIA    Probe Info 
AN3CA SNV: p.R3526Ter DBIA    Probe Info 
CHL1 SNV: p.V438I DBIA    Probe Info 
COLO320 SNV: p.S1824N DBIA    Probe Info 
DOTC24510 SNV: p.L699V DBIA    Probe Info 
DU145 SNV: p.D2046N DBIA    Probe Info 
ECC2 Deletion: p.W32GfsTer7; p.G33AfsTer6 DBIA    Probe Info 
HCT15 SNV: p.Y878H DBIA    Probe Info 
HEP3B217 SNV: p.S2012T .
HT115 SNV: p.E2604Ter; p.K3019T .
IPC298 SNV: p.P904S DBIA    Probe Info 
KMRC1 SNV: p.D1169G DBIA    Probe Info 
KNS81FD SNV: p.T3716P DBIA    Probe Info 
LN229 SNV: p.V3220I .
LNCaP clone FGC SNV: p.L1427M DBIA    Probe Info 
MCC13 SNV: p.Q3301Ter DBIA    Probe Info 
MDAMB468 SNV: p.S2742A DBIA    Probe Info 
MDST8 Substitution: p.P212L DBIA    Probe Info 
MEWO SNV: p.L1197F; p.G2089R; p.G3451S DBIA    Probe Info 
NCIH1299 SNV: p.L1193I .
NCIH1703 SNV: p.R1235S DBIA    Probe Info 
NCIH1944 SNV: p.G3561A DBIA    Probe Info 
NCIH2052 SNV: p.I1310V DBIA    Probe Info 
NCIH2286 SNV: p.I741V .
OVK18 SNV: p.M1983V DBIA    Probe Info 
PC14 SNV: p.F3261V DBIA    Probe Info 
PC9 SNV: p.F3261V .
REH SNV: p.E765K DBIA    Probe Info 
RKO SNV: p.V183A DBIA    Probe Info 
SG231 SNV: p.R3598L .
SKMEL5 SNV: p.P3672S DBIA    Probe Info 
SNU1196 SNV: p.H1194L DBIA    Probe Info 
SW480 SNV: p.G3521R .
SW756 SNV: p.S1021L DBIA    Probe Info 
SW948 SNV: p.G1010E DBIA    Probe Info 
UMUC3 SNV: p.P2423S DBIA    Probe Info 
WM1552C SNV: p.M2624R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.55  LDD0402  [1]
TH211
 Probe Info  		Y2032(20.00); Y995(9.45)  LDD0260  [2]
TH216
 Probe Info  		Y2032(20.00)  LDD0259  [2]
BTD
 Probe Info  		C2440(0.44)  LDD2089  [3]
Acrolein
 Probe Info  		N.A.  LDD0231  [4]
DBIA
 Probe Info  		C1094(1.07); C1098(1.07)  LDD0078  [5]
ATP probe
 Probe Info  		K1616(0.00); K1623(0.00)  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C3723(0.00); C2588(0.00); C2184(0.00); C1372(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C3723(0.00); C2588(0.00); C3707(0.00); C1372(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C3723(0.00); C2588(0.00); C2184(0.00); C2395(0.00)  LDD0037  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [10]
IPM
 Probe Info  		N.A.  LDD0005  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C2440(0.99)  LDD2152  [3]
 LDCM0562  Abegg_cp(-)-11 HeLa C2159(2.68)  LDD0313  [8]
 LDCM0214  AC1 HCT 116 C2395(1.00); C2159(1.02); C2184(0.83); C3707(1.09)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C2395(0.95); C1998(1.40); C2159(1.05); C3707(1.47)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C2395(1.06); C2159(0.92); C2177(0.57); C3707(1.00)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C2395(1.05); C2159(1.00); C2177(0.63); C3707(1.09)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C2395(1.02); C2159(0.98); C2177(0.63); C3707(0.96)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C2395(1.00); C2159(0.95); C2177(0.74); C3707(1.14)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C2395(0.85); C2159(1.08); C2177(0.69); C3707(1.03)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C2395(1.00); C2159(0.80); C2177(0.64); C3707(1.09)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C2395(1.04); C2159(0.91); C2177(0.70); C3707(1.28)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C2395(0.92); C2159(0.81); C2177(0.57); C3707(0.88)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C2395(0.96); C2159(0.93); C2177(0.89); C3707(0.86)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C2395(0.99); C2159(1.11); C2177(0.80); C3707(0.83)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C2395(0.94); C1998(1.48); C2159(1.02); C3707(1.32)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C2395(1.02); C2159(0.99); C2177(0.77); C3707(0.79)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C2395(0.99); C2159(0.91); C2177(0.90); C3707(0.88)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C2395(0.98); C2159(0.96); C2177(0.62); C3707(1.06)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C2159(1.04); C2184(0.86); C3707(1.11)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C2159(1.01); C2184(1.03); C3707(1.22)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C2159(1.03); C2184(0.74); C3707(1.24)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C2159(1.12); C2184(0.74); C3707(1.10)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C2159(1.19); C2184(0.71); C3707(0.91)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C2159(1.23); C2184(0.63); C3707(1.11)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C2159(1.76); C2184(0.60); C3707(1.03)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C2395(0.91); C1998(1.15); C2159(1.26); C3707(0.97)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C2159(0.77); C2184(0.48); C3707(1.12)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C2159(0.76); C2184(0.65); C3707(0.83)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C2159(1.25); C2184(0.77); C3707(1.12)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C2159(0.82); C2184(0.59); C3707(1.11)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C2159(1.11); C2184(0.58); C3707(0.99)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C2159(0.83); C2184(0.57); C3707(1.01)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C2159(1.06); C2184(0.73); C3707(0.98)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C2159(1.04); C2184(0.65); C3707(1.07)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C2159(1.48); C3707(0.92)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C2159(1.03); C3707(0.85)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C2159(1.39); C3707(0.90)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C2159(0.92); C3707(1.21)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C2159(0.80); C3707(0.97)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C2159(1.12); C3707(0.99)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C2159(1.36); C3707(0.91)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C2159(1.39); C3707(1.00)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C2159(1.15); C3707(0.99)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C2159(0.99); C3707(0.80)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C2159(0.84); C3707(0.96)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C2159(1.09); C3707(0.82)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C2395(0.94); C1998(1.13); C2159(1.08); C3707(1.17)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C2159(1.14); C3707(0.89)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C2159(1.39); C3707(1.08)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C2159(1.17); C3707(1.43)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C2395(0.92); C2159(0.94); C2184(1.22); C3707(1.99)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C3707(0.93); C2395(1.01); C2159(1.13); C2184(1.54)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C2395(0.85); C3707(0.96); C2159(1.04); C2184(1.21)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C2395(0.92); C2159(1.12); C3707(1.14); C2184(1.54)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C2395(0.97); C2159(1.05); C3707(1.20); C2184(1.58)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C2395(0.96); C3707(1.29); C2159(1.66); C2184(1.91)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C3707(0.88); C2395(0.91); C2159(1.39); C2184(1.68)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C2395(1.01); C2159(1.06); C3707(1.09); C1998(1.09)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C2395(0.93); C3707(1.23); C2159(1.23); C2184(1.52)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C2395(0.86); C3707(0.92); C2159(0.99); C2184(1.16)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C2395(0.89); C2159(1.22); C3707(1.43); C2184(1.47)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C3707(0.60); C2395(1.03); C2159(1.28); C2184(2.18)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C2395(0.83); C2159(1.12); C2184(1.46); C3707(0.84)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C2395(0.94); C2159(1.19); C2184(1.24); C3707(0.76)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C2395(0.89); C2159(1.28); C2184(1.32); C3707(0.92)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C2395(0.91); C2159(1.12); C2184(0.96); C3707(0.86)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C1998(0.95); C3707(0.96); C2395(1.00); C2177(1.01)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C2395(0.89); C2177(0.93); C2159(0.95); C1998(1.06)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C2395(0.90); C2177(1.02); C2159(1.07); C1998(1.16)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C2184(0.74); C3707(0.95); C2159(1.00); C2395(1.07)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C1998(0.68); C2395(0.96); C2177(0.99); C2159(1.05)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C2395(0.87); C2177(0.95); C1998(1.09); C2159(1.09)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C1998(0.81); C2177(0.90); C2395(0.94); C3707(1.05)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C2395(0.83); C1998(0.90); C2177(0.98); C2184(1.11)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C1998(0.83); C3707(0.84); C2184(0.96); C2159(0.99)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C2184(1.18); C1998(1.21); C3707(1.24); C2159(1.28)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C2159(1.00); C1998(1.02); C2184(1.20); C3707(1.41)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C3707(1.00); C2184(1.20); C1998(1.29); C2159(1.29)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C2159(1.01); C1998(1.15); C2184(1.40); C3707(1.41)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C1998(1.00); C2159(1.26); C2184(1.34); C3707(1.60)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C3707(0.78); C2184(0.90); C2395(1.03); C2159(1.05)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C1998(0.95); C2184(1.23); C3707(1.29); C2159(1.32)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C3707(0.99); C2184(1.20); C1998(1.21); C2159(1.26)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C1998(0.92); C2159(1.00); C2184(1.26); C3707(1.27)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C1998(0.90); C3707(0.96); C2159(1.09); C2184(1.16)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C1998(0.94); C3707(0.94); C2184(1.05); C2159(1.17)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C2184(0.89); C2159(0.93); C3707(1.10); C1998(1.20)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C2159(0.87); C3707(0.94); C1998(0.99); C2184(0.99)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C2159(0.88); C2184(0.95); C1998(1.31); C3707(1.33)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C2184(0.94); C2159(0.95); C3707(1.04); C1998(1.19)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C1998(0.98); C2159(1.07); C3707(1.14); C2184(1.16)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C2184(0.82); C3707(1.04); C2395(1.06); C2159(1.12)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C2159(1.01); C2184(1.20); C3707(1.26); C1998(1.38)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C2159(0.98); C3707(1.18); C1998(1.19); C2184(1.24)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C2159(1.02); C1998(1.11); C2184(1.13); C3707(1.35)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C2159(0.88); C2184(1.02); C3707(1.04); C1998(1.42)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C2159(0.84); C2184(1.07); C1998(1.16); C3707(1.27)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C2159(0.87); C2184(1.15); C1998(1.29); C3707(1.35)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C1998(0.86); C2159(1.07); C2395(1.15); C2440(1.15)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C1998(0.85); C2440(0.94); C2159(1.15); C2395(1.24)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C1998(0.97); C2440(1.05); C2159(1.05); C2395(1.16)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C2159(1.04); C2440(1.10); C1998(1.14); C3707(1.21)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C2184(0.89); C2395(1.06); C2159(1.07); C3707(1.08)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C2159(0.99); C1998(1.11); C2440(1.11); C2395(1.11)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C1998(0.89); C2159(1.01); C3707(1.04); C2440(1.15)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C1998(0.79); C2159(0.95); C2440(1.11); C3707(1.21)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C2440(0.69); C1998(0.96); C3707(1.02); C2395(1.18)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C3707(0.98); C2440(0.99); C1998(1.10); C2395(1.21)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C2440(0.76); C1998(1.06); C2159(1.15); C2395(1.19)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C2440(0.88); C2159(1.02); C2395(1.17); C1998(1.26)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C1998(0.66); C3707(1.04); C2395(1.05); C2177(1.12)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C3707(0.65); C1998(1.01); C2159(1.02); C2395(1.07)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C3707(0.88); C1998(0.91); C2395(1.05); C2177(1.09)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C2395(0.96); C1998(1.06); C2159(1.11); C3707(1.24)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C2159(0.92); C3707(0.95); C1998(0.96); C2395(0.97)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C1998(0.81); C3707(0.86); C2177(0.96); C2395(1.09)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C1998(0.93); C2159(1.01); C2395(1.10); C2177(1.20)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C3707(0.78); C1998(1.01); C2395(1.02); C2177(1.04)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C3707(0.86); C2159(0.97); C1998(0.98); C2395(1.07)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C3707(0.77); C1998(1.07); C2159(1.11); C2395(1.19)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C1998(1.06); C3707(1.08); C2159(1.12); C2177(1.21)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C1998(0.74); C3707(0.99); C2159(1.00); C2395(1.15)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C1998(0.93); C2395(1.08); C2184(1.10); C2159(1.16)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C2159(0.94); C2395(1.04); C2184(1.06); C1998(1.16)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C2159(0.93); C2395(1.02); C1998(1.31); C3707(1.61)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C2159(1.07); C1998(1.15); C2395(1.20); C2184(1.33)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C2184(1.06); C1998(1.17); C2395(1.23); C2159(1.24)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C2184(1.14); C2395(1.17); C2159(1.22); C1998(1.26)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C2395(1.32); C1998(1.05); C2184(1.32); C2159(1.38)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C1998(1.12); C2184(1.18); C2159(1.26); C2395(1.35)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C1998(1.08); C2159(1.09); C2184(1.41); C2395(1.43)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C1998(1.09); C2395(1.21); C2184(1.22); C2159(1.37)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C1998(0.88); C2159(1.01); C2184(1.07); C2395(1.14)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C2395(1.02); C2159(1.04); C1998(1.06); C2184(1.28)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C2184(1.09); C1998(1.14); C2395(1.20); C2159(1.25)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C3707(0.97); C2395(0.97); C2159(0.99); C1998(1.10)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C1998(1.10); C2395(1.12); C2159(1.14); C2184(1.27)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C2395(0.95); C2159(1.07); C2184(1.08); C1998(1.24)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C2159(1.17); C1998(1.17); C2184(1.40); C2395(1.51)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C2395(0.99); C2159(1.11); C2184(1.26)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C2395(0.99); C2159(1.00); C2184(1.28)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C2159(0.84); C2395(0.94); C2184(1.10)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C2159(0.94); C2395(0.96); C2184(1.13)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C2395(0.85); C2184(0.95); C2159(1.16)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C2159(0.85); C2395(0.90); C2184(0.93)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C2159(0.81); C2395(0.93); C2184(0.98)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C2395(0.87); C2159(0.94); C2184(1.01)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C2159(0.79); C2395(0.92); C2184(1.10)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C2159(0.83); C2395(1.02); C2184(1.10)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C2184(0.90); C2395(0.92); C2159(1.06)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C2184(0.89); C2395(0.89); C2159(1.05)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C2395(0.80); C2184(0.87); C2159(0.89)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C2395(0.83); C2184(0.92); C2159(0.99)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C2395(0.88); C2159(0.91); C2184(1.01)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C2177(0.75); C2159(0.94); C2395(1.04); C3707(1.16)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C2177(0.70); C2395(0.94); C2159(1.08); C3707(1.09)  LDD0683  [5]
 LDCM0545  Acetamide MDA-MB-231 C2440(0.26)  LDD2138  [3]
 LDCM0248  AKOS034007472 HCT 116 C2395(1.01); C1998(1.35); C2159(1.08); C3707(1.58)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C3707(0.94); C2395(1.04); C2159(1.11); C1998(1.53)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C3707(1.12); C1998(1.12); C2395(1.14); C2159(1.26)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C1094(1.07); C1098(1.07)  LDD0078  [5]
 LDCM0367  CL1 HCT 116 C2440(0.83); C1998(0.89); C2177(0.91); C2159(1.10)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C2440(0.61); C1998(0.89); C2177(0.95); C2395(1.12)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C3707(0.75); C2184(0.80); C2395(1.07); C2159(1.13)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C3707(0.79); C2159(0.98); C2395(1.00); C1998(1.11)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C2395(1.05); C3707(1.18); C1998(1.22); C2159(1.27)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C2395(0.91); C3707(1.07); C2159(1.16); C1998(1.36)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C2159(0.93); C2395(0.93); C3707(1.13); C1998(1.28)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C2177(0.88); C2395(0.93); C2159(1.18); C2184(1.20)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C1998(0.94); C2177(0.95); C2395(0.98); C2184(1.24)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C2395(0.93); C1998(0.99); C2177(1.04); C3707(1.22)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C2159(1.02); C1998(1.10); C3707(1.10); C2395(1.12)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C1998(0.82); C2395(0.89); C2177(0.93); C3707(1.13)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C2440(0.55); C2159(1.00); C1998(1.01); C2177(1.13)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C1998(0.77); C2395(0.96); C2177(0.97); C2184(1.20)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C2395(0.87); C2177(0.90); C1998(0.94); C2159(1.03)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C1998(0.89); C2159(1.22); C3707(1.24); C2184(1.34)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C1998(0.90); C3707(1.06); C2184(1.16); C2159(1.18)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C1998(0.81); C2159(1.02); C3707(1.14); C2184(1.15)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C3707(0.95); C1998(0.97); C2184(0.99); C2159(1.33)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C1998(0.90); C3707(0.91); C2184(1.08); C2159(1.62)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C2159(1.08); C1998(1.16); C3707(1.39); C2184(1.47)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C2159(0.97); C2184(1.07); C3707(1.23); C1998(1.33)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C2159(0.83); C2184(1.09); C1998(1.11); C3707(1.12)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C2440(0.58); C2395(1.00); C1998(1.01); C3707(1.04)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C2159(0.89); C1998(1.09); C2184(1.13); C3707(1.24)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C2440(0.90); C3707(0.96); C2159(1.07); C1998(1.13)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C1998(0.87); C2440(1.04); C2159(1.14); C2395(1.26)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C1998(0.97); C2440(1.08); C2159(1.09); C2395(1.14)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C2159(0.98); C2440(1.01); C3707(1.06); C1998(1.16)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C1998(0.75); C2177(1.00); C3707(1.07); C2395(1.08)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C1998(0.67); C3707(0.91); C2177(0.96); C2395(1.04)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C3707(0.77); C2159(0.84); C1998(0.87); C2395(1.02)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C3707(0.79); C2159(0.95); C1998(1.00); C2395(1.05)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C2440(0.64); C1998(0.88); C3707(0.91); C2177(1.07)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C2440(0.67); C2177(0.94); C3707(0.96); C1998(1.05)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C2440(0.67); C2177(0.98); C3707(1.13); C2159(1.16)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C3707(0.77); C2395(0.79); C2177(0.83); C2159(0.85)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C2395(0.72); C2159(0.82); C2184(0.85); C3707(0.87)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C2395(0.78); C2177(0.80); C2159(0.85); C1998(1.06)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C3707(0.79); C2395(0.82); C2177(0.88); C1998(0.88)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C2440(0.88); C2177(0.96); C1998(1.04); C2159(1.11)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C3707(0.78); C2395(0.86); C2159(0.91); C2177(1.03)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C3707(0.68); C2395(0.91); C2159(0.96); C1998(0.98)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C3707(0.68); C2184(0.83); C2159(0.98); C2395(1.01)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C2159(0.79); C2395(0.83); C3707(0.91); C1998(1.07)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C2395(0.86); C1998(1.24); C2159(0.88); C2177(1.00)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C2395(0.89); C1998(0.84); C2159(0.83); C2177(1.16)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C2395(0.78); C1998(1.02); C2159(0.94); C2177(0.89)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C2395(0.80); C1998(1.17); C2159(0.84); C2177(0.95)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C2395(0.82); C1998(0.92); C2159(0.87); C2177(0.99)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C2395(0.89); C1998(1.01); C2159(0.92); C2177(1.00)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C2395(1.17); C1998(0.87); C2159(1.06); C2177(1.01)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C2395(0.82); C1998(0.74); C2159(0.94); C2177(0.96)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C2395(1.12); C2184(0.98); C2440(0.36); C3707(0.96)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C2395(1.12); C2159(1.21); C2440(0.94); C3707(1.03)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C2395(1.07); C2159(1.17); C2440(1.03); C3707(1.14)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C2395(1.17); C2159(1.07); C2440(0.84); C3707(1.23)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C2395(0.95); C2159(1.57); C2440(1.05); C3707(1.13)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C2395(0.97); C2159(0.62); C2440(0.95); C3707(1.44)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C2395(1.03); C2159(1.30); C2440(0.86); C3707(1.07)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C2395(1.06); C2159(1.35); C2440(0.88); C3707(1.08)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C2395(1.35); C1998(0.82); C2159(1.10); C2177(0.85)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C2395(1.19); C2159(0.85); C2440(0.89); C3707(1.06)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C2395(1.18); C2159(0.79); C2440(0.83); C3707(1.25)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C2395(0.97); C2159(0.81); C2440(0.78); C3707(1.20)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C2395(1.12); C2159(1.16); C2440(0.83); C3707(0.95)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C2395(1.12); C2159(1.05); C2440(0.83); C3707(1.16)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C2395(1.26); C2159(1.09); C2440(0.87); C3707(1.18)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C2395(1.02); C1998(1.10); C2177(1.03); C2184(1.17)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C2395(1.44); C1998(0.76); C2177(0.88); C2184(1.13)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C2395(0.88); C1998(0.95); C2177(1.27); C2184(1.11)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C2395(1.29); C1998(1.29); C2177(1.22); C2184(1.23)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C2395(1.24); C1998(1.08); C2159(1.19); C2177(1.11)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C2395(0.99); C1998(1.08); C2177(0.89); C2184(1.14)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C2395(1.00); C1998(1.10); C2177(0.87); C2184(1.25)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C2395(0.96); C1998(1.00); C2177(0.86); C2184(1.27)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C2395(1.12); C1998(0.84); C2177(1.01); C2184(0.89)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C2395(0.95); C1998(1.25); C2177(1.03); C2184(1.22)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C2395(1.22); C1998(1.16); C2177(1.07); C2184(1.21)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C2395(1.71); C1998(0.94); C2177(0.86); C2184(1.18)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C2395(1.05); C1998(0.91); C2177(0.95); C2184(1.00)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C2395(1.28); C1998(0.97); C2177(0.99); C2184(1.19)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C2395(1.22); C1998(0.96); C2177(0.99); C2184(1.16)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C2395(1.53); C1998(1.12); C2159(1.14); C2177(1.07)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C2395(0.98); C1998(1.12); C2177(1.07); C2184(1.21)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C2395(0.90); C1998(0.89); C2159(0.96); C2177(0.90)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C2395(0.91); C1998(0.99); C2159(1.08); C2177(0.92)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C2395(0.85); C1998(1.15); C2159(1.27); C2177(0.92)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C2395(0.98); C1998(0.99); C2159(1.26); C2177(0.97)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C2395(0.98); C1998(1.07); C2159(1.48); C2177(0.86)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C2395(0.98); C1998(0.99); C2159(1.30); C2177(1.04)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C2395(0.96); C1998(0.82); C2159(1.50); C2177(1.01)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C2395(0.88); C1998(0.89); C2159(1.37); C2177(0.93)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C2395(0.83); C1998(0.62); C2159(1.02); C2177(0.84)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C2395(1.45); C1998(1.10); C2159(1.23); C2177(1.18)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C2395(0.81); C1998(0.80); C2159(1.08); C2177(0.85)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C2395(0.90); C1998(0.98); C2159(1.05); C2177(0.98)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C2395(1.03); C1998(1.03); C2159(1.30); C2177(0.96)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C2395(0.96); C1998(0.73); C2159(1.29); C2177(1.34)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C2395(0.93); C1998(0.85); C2159(1.28); C2177(1.03)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C2395(1.31); C1998(1.03); C2159(1.42); C2177(1.01)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C2395(20.00); C1998(0.82); C2159(1.42); C2177(1.65)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C2395(1.25); C1998(0.94); C2159(1.04); C2177(0.97)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C2395(1.64); C1998(1.02); C2159(1.16); C2177(1.15)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C2395(1.20); C1998(0.95); C2159(1.22); C2177(1.36)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C2395(1.25); C1998(1.04); C2159(1.12); C2177(1.05)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C2395(1.15); C1998(0.98); C2159(1.19); C2177(1.11)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C2395(1.01); C1998(1.07); C2159(1.04); C2177(1.20)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C2395(1.01); C1998(1.00); C2159(1.31); C2177(1.29)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C2395(1.24); C1998(0.95); C2159(1.04); C2177(1.36)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C2395(1.44); C1998(0.93); C2159(1.12); C2177(1.10)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C2395(1.07); C1998(0.88); C2159(1.05); C2177(1.06)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C2395(1.93); C1998(0.89); C2159(1.26); C2177(1.15)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C2395(1.68); C1998(0.92); C2159(1.28); C2177(1.24)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C2395(1.21); C1998(1.06); C2159(1.21); C2177(1.43)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C2395(1.24); C1998(1.05); C2159(1.21); C2177(1.17)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C2395(0.87); C1998(0.96); C2159(1.27); C2177(1.07)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C2395(1.03); C2159(0.93); C2184(0.89); C3707(0.81)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C2395(0.95); C2159(0.92); C2184(1.06); C3707(0.68)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C2395(0.96); C2159(1.05); C2184(0.87); C3707(0.90)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C2395(1.02); C2159(0.99); C2184(0.87); C3707(0.92)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C2395(0.95); C2159(1.02); C2184(0.80); C3707(1.08)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C2395(0.92); C2159(1.05); C2184(0.82); C3707(0.72)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C2395(1.05); C2159(1.06); C2184(0.81); C3707(0.78)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C2395(1.05); C2159(1.04); C2184(0.71); C3707(1.03)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C2395(1.03); C2159(0.97); C2184(0.87); C3707(0.81)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C3707(0.99); C2440(0.82); C1998(0.96); C1617(1.03)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C2440(1.08)  LDD1702  [3]
 LDCM0625  F8 Ramos C3707(1.58); C2588(1.23); C1372(1.95)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C3707(1.01); C2588(2.49)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C3707(2.63); C1372(3.60); C1481(2.69)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C3707(1.21); C2588(1.30)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C3707(0.92); C2588(1.49)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C3707(0.79); C2588(1.21); C1372(1.09); C1481(0.96)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C3707(0.75); C2588(2.37)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C3707(0.94); C2588(1.11)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C3707(1.39); C2588(1.71)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C3707(1.08); C2588(6.81)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C3707(0.61); C2588(0.97)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C3707(1.55); C2588(1.32)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C3707(1.13); C2588(1.18)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C3707(1.74); C2588(1.58)  LDD2201  [14]
 LDCM0468  Fragment33 HCT 116 C2395(0.89); C1998(1.07); C2159(1.12); C2177(0.89)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C3707(1.10); C2588(0.95)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C3707(0.79); C2588(0.73); C1372(0.84); C1481(0.95)  LDD2184  [14]
 LDCM0427  Fragment51 HCT 116 C2395(1.45); C2159(1.38); C2440(0.92); C3707(0.87)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C3707(1.51)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C3707(2.72); C2588(1.35)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C3707(0.80); C1372(1.38); C1481(0.93)  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C3707(0.87); C2588(0.96)  LDD2188  [14]
 LDCM0022  KB02 HCT 116 C2184(1.59)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C2184(1.68)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C2184(1.76)  LDD0082  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C2440(0.42)  LDD2121  [3]
 LDCM0109  NEM HeLa N.A.  LDD0231  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C2440(0.44)  LDD2089  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C2440(0.94)  LDD2093  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C2440(0.96)  LDD2099  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C2440(0.87)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C2440(1.34)  LDD2111  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C2440(2.03)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C2440(0.67)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C2440(1.13)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C2440(1.15)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C2440(0.81)  LDD2129  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C2440(5.04)  LDD2135  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C2440(0.91)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C2440(4.39)  LDD2140  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C2440(4.21)  LDD2146  [3]
 LDCM0131  RA190 MM1.R C1481(1.21)  LDD0304  [15]
 LDCM0021  THZ1 HCT 116 C2184(1.14)  LDD2173  [5]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.