Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Experiment Method
ISO-TOP ABPP
Competitor Name KB63  Competitor Info 
Competitor Concentration 50 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cells (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 31 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) 20.0
 LDTP06211  Caspase-8 (CASP8) 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 20.0
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) 20.0
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 20.0
 LDTP12784  Pyroglutamyl-peptidase 1 (PGPEP1) 20.0
 LDTP01649  Phosphatidate cytidylyltransferase 2 (CDS2) 19.4
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) 19.2
 LDTP03985  Caspase-2 (CASP2) 16.9
 LDTP00697  Cytochrome b5 type B (CYB5B) 15.0
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) 14.3
 LDTP05893  Baculoviral IAP repeat-containing protein 2 (BIRC2) 13.3
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) 12.3
 LDTP12539  DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) 9.9
 LDTP01141  E3 ubiquitin-protein ligase BRE1B (RNF40) 9.5
 LDTP03458  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) 7.9
 LDTP02852  Methylated-DNA--protein-cysteine methyltransferase (MGMT) 7.6
 LDTP03540  Heme oxygenase 2 (HMOX2) 5.7
 LDTP15370  Pseudouridylate synthase RPUSD2 (RPUSD2) 5.5
 LDTP03656  Cystathionine gamma-lyase (CTH) 5.2
 LDTP12828  Anaphase-promoting complex subunit 11 (ANAPC11) 5.0
 LDTP01776  Superoxide dismutase [Cu-Zn] (SOD1) 4.8
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) 4.6
 LDTP14074  Ribosomal biogenesis protein LAS1L (LAS1L) 4.5
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) 4.4
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) 4.4
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) 4.2
 LDTP08214  N6-adenosine-methyltransferase catalytic subunit (METTL3) 4.1
 LDTP12313  Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (ALG13) 4.1
 LDTP08401  All trans-polyprenyl-diphosphate synthase PDSS2 (PDSS2) 4.1
 LDTP01173  RNA/RNP complex-1-interacting phosphatase (DUSP11) 4.1
Transporter and channel
Click to Show/Hide to Show 9 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04801  Gasdermin-D (GSDMD) 20.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 20.0
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 7.4
 LDTP11397  Solute carrier family 12 member 9 (SLC12A9) 6.7
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) 6.5
 LDTP01060  PRA1 family protein 2 (PRAF2) 5.2
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) 4.5
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 4.2
 LDTP07191  MICOS complex subunit MIC10 (MICOS10) 4.2
Immunoglobulin
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02338  CD48 antigen (CD48) 9.0
 LDTP00671  Tapasin (TAPBP) 7.8
Other
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 20.0
 LDTP12412  Reticulon-4 (RTN4) 10.7
 LDTP06193  Raftlin (RFTN1) 7.2
 LDTP07419  Centromere protein P (CENPP) 5.2
 LDTP14251  Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 (CHCHD2) 4.2
 LDTP07718  MICOS complex subunit MIC27 (APOOL) 4.2
 LDTP04092  Crk-like protein (CRKL) 4.0

References

1 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.