Details of the Target

General Information of Target

Target ID LDTP08214
Target Name N6-adenosine-methyltransferase catalytic subunit (METTL3)
Gene Name METTL3
Gene ID 56339
Synonyms
MTA70; N6-adenosine-methyltransferase catalytic subunit; EC 2.1.1.348; Methyltransferase-like protein 3; hMETTL3; N6-adenosine-methyltransferase 70 kDa subunit; MT-A70
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHLDLRNPEAALSPTFRSDSPVPTAPTSGG
PKPSTASAVPELATDPELEKKLLHHLSDLALTLPTDAVSICLAISTPDAPATQDGVESLL
QKFAAQELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAVAEKKGPGEVAGTVTGQKRRA
EQDSTTVAAFASSLVSGLNSSASEPAKEPAKKSRKHAASDVDLEIESLLNQQSTKEQQSK
KVSQEILELLNTTTAKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKASDADRPCRKLHFR
RIINKHTDESLGDCSFLNTCFHMDTCKYVHYEIDACMDSEAPGSKDHTPSQELALTQSVG
GDSSADRLFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIP
VLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGK
EHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNV
QPNWITLGNQLDGIHLLDPDVVARFKQRYPDGIISKPKNL
Target Bioclass
Enzyme
Family
MT-A70-like family
Subcellular location
Nucleus
Function
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing . In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing. M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs. M6A regulates the length of the circadian clock: acts as an early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop. M6A also regulates circadian regulation of hepatic lipid metabolism. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. Also required for oogenesis. Involved in the response to DNA damage: in response to ultraviolet irradiation, METTL3 rapidly catalyzes the formation of m6A on poly(A) transcripts at DNA damage sites, leading to the recruitment of POLK to DNA damage sites. M6A is also required for T-cell homeostasis and differentiation: m6A methylation of transcripts of SOCS family members (SOCS1, SOCS3 and CISH) in naive T-cells promotes mRNA destabilization and degradation, promoting T-cell differentiation. Inhibits the type I interferon response by mediating m6A methylation of IFNB. M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs). Mediates m6A methylation of Xist RNA, thereby participating in random X inactivation: m6A methylation of Xist leads to target YTHDC1 reader on Xist and promote transcription repression activity of Xist. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells. METTL3 mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8. Acts as a positive regulator of mRNA translation independently of the methyltransferase activity: promotes translation by interacting with the translation initiation machinery in the cytoplasm. Its overexpression in a number of cancer cells suggests that it may participate in cancer cell proliferation by promoting mRNA translation. During human coronorivus SARS-CoV-2 infection, adds m6A modifications in SARS-CoV-2 RNA leading to decreased RIGI binding and subsequently dampening the sensing and activation of innate immune responses.
Uniprot ID
Q86U44
Ensemble ID
ENST00000298717.9
HGNC ID
HGNC:17563
ChEMBL ID
CHEMBL4739695

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BT549 SNV: p.W5C DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.A341T DBIA    Probe Info 
TFK1 SNV: p.L404R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K132(2.57); K215(7.69)  LDD0277  [2]
BTD
 Probe Info  		C483(2.02)  LDD1700  [3]
AHL-Pu-1
 Probe Info  		C336(3.05)  LDD0168  [4]
DBIA
 Probe Info  		C314(1.13); C320(1.13); C326(1.13)  LDD0078  [5]
ATP probe
 Probe Info  		K513(0.00); K480(0.00); K488(0.00)  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C276(0.00); C483(0.00); C500(0.00); C336(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C276(0.00); C443(0.00); C483(0.00); C500(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C276(0.00); C443(0.00); C483(0.00); C500(0.00)  LDD0037  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
IPM
 Probe Info  		N.A.  LDD0147  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
W1
 Probe Info  		C276(0.00); C294(0.00)  LDD0236  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		C294(0.00); C483(0.00)  LDD2223  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C483(0.44)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C483(0.90)  LDD2112  [3]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C483(0.79)  LDD2095  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C483(0.83); C294(1.06)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C294(1.39)  LDD2152  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C483(0.66)  LDD2132  [3]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C483(0.93)  LDD2131  [3]
 LDCM0025  4SU-RNA HEK-293T C336(3.05)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C336(3.12)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C276(1.03); C314(1.06); C320(0.94); C326(1.06)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C276(0.86); C314(1.10); C320(1.04); C326(1.09)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C276(0.62); C314(0.83); C320(0.69); C326(0.73)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C276(0.70); C314(0.86); C320(0.72); C326(0.73)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C276(0.76); C314(0.90); C320(0.70); C326(0.77)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C276(0.75); C314(0.88); C320(0.63); C326(0.75)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C276(0.76); C314(0.90); C320(0.68); C326(0.80)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C276(0.83); C314(0.95); C320(0.68); C326(0.78)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C276(0.76); C314(0.87); C320(0.70); C326(0.78)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C276(0.74); C314(0.81); C320(0.68); C326(0.76)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C276(0.70); C314(0.75); C320(0.66); C326(0.69)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C276(0.67); C314(0.85); C320(0.75); C326(0.80)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C276(0.97); C314(1.16); C320(1.03); C326(1.14)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C276(0.68); C314(0.80); C320(0.69); C326(0.72)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C276(0.72); C314(0.77); C320(0.64); C326(0.67)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C276(0.66); C314(0.87); C320(0.77); C326(0.74)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C276(0.94); C314(1.10); C320(1.04); C326(1.07)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C276(1.07); C314(1.20); C320(1.11); C326(1.10)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C276(1.21); C314(1.55); C320(1.42); C326(1.37)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C276(1.13); C314(1.62); C320(1.45); C326(1.38)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C276(0.99); C314(1.15); C320(1.18); C326(1.10)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C276(1.23); C314(1.15); C320(1.19); C326(1.08)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C276(1.20); C314(1.23); C320(1.17); C326(1.18)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C276(0.79); C314(1.05); C320(1.07); C326(1.04)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C276(0.98); C314(1.28); C320(1.22); C326(1.18)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C276(1.02); C314(1.20); C320(1.15); C326(1.09)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C276(1.22); C314(1.13); C320(1.16); C326(1.08)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C276(0.88); C314(1.02); C320(1.01); C326(0.98)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C276(1.03); C314(1.07); C320(0.98); C326(0.98)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C276(1.18); C314(1.10); C320(1.02); C326(1.01)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C276(1.36); C314(1.36); C320(1.20); C326(1.18)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C276(1.03); C314(1.18); C320(1.16); C326(1.09)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C276(0.55); C314(1.24); C320(1.54); C326(1.46)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C276(0.47); C314(0.78); C320(1.26); C326(1.13)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C276(0.51); C314(1.02); C320(1.56); C326(1.43)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C276(0.52); C314(0.93); C320(1.06); C326(1.10)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C276(0.52); C314(0.79); C320(1.21); C326(1.12)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C276(0.56); C314(0.91); C320(1.30); C326(1.22)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C276(0.45); C314(0.99); C320(1.37); C326(1.29)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C276(0.46); C314(1.05); C320(1.36); C326(1.26)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C276(0.55); C314(0.94); C320(1.12); C326(1.08)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C276(0.49); C314(1.05); C320(1.10); C326(1.09)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C276(0.38); C314(0.95); C320(1.31); C326(1.25)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C276(0.54); C314(1.08); C320(1.40); C326(1.32)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C276(0.82); C314(1.20); C320(1.13); C326(1.19)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C276(0.42); C314(0.93); C320(1.55); C326(1.44)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C276(0.45); C314(0.98); C320(1.28); C326(1.22)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C276(0.54); C314(0.96); C320(1.05); C326(1.08)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C443(0.92); C376(0.92); C375(0.93); C276(0.94)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C376(0.85); C375(0.91); C276(1.02); C443(1.11)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C276(0.84); C376(0.84); C375(0.88); C443(1.01)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C376(0.79); C375(0.86); C276(0.90); C443(1.06)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C376(0.80); C375(0.86); C443(0.93); C276(1.07)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C376(0.85); C375(0.89); C443(0.98); C276(1.01)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C376(0.91); C375(0.93); C276(1.06); C443(1.20)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C276(0.74); C320(1.11); C375(1.11); C326(1.14)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C376(0.84); C375(0.91); C276(1.04); C326(1.09)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C376(0.82); C375(0.85); C443(0.92); C276(0.97)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C376(0.84); C375(0.86); C276(1.11); C443(1.11)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C376(0.73); C375(0.74); C276(1.05); C443(1.30)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C276(1.14); C314(1.24); C320(1.16); C326(1.26)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C276(1.09); C314(1.36); C320(1.63); C326(1.38)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C276(0.92); C314(1.20); C320(1.10); C326(1.13)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C276(0.92); C314(1.16); C320(1.13); C326(1.18)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C326(0.91); C314(0.93); C320(0.97); C375(1.00)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C376(0.70); C375(0.76); C314(1.12); C320(1.28)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C376(0.89); C375(0.93); C314(1.10); C320(1.16)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C276(1.05); C320(1.06); C376(1.08); C314(1.16)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C376(1.00); C314(1.02); C326(1.02); C375(1.04)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C375(0.84); C376(0.86); C314(1.03); C320(1.12)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C376(0.93); C375(0.94); C314(0.98); C326(1.01)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C326(0.86); C320(0.90); C314(0.90); C375(0.93)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C376(0.94); C375(0.95); C326(0.96); C314(1.00)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C314(0.84); C326(0.86); C320(0.93)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C314(0.98); C320(1.01); C326(1.02)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C314(1.06); C326(1.10); C320(1.15)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C314(0.93); C326(0.95); C320(0.96)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C314(1.02); C326(1.05); C320(1.13)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C276(0.99); C320(1.01); C314(1.08); C326(1.08)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C314(1.09); C326(1.14); C320(1.20)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C314(1.00); C326(1.03); C320(1.07)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C314(1.21); C326(1.23); C320(1.30)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C314(1.03); C326(1.06); C320(1.13)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C314(1.12); C326(1.14); C320(1.20)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C375(0.73); C376(0.80); C314(0.84); C326(0.87)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C326(0.84); C314(0.85); C320(0.89); C443(0.89)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C483(0.88); C326(0.92); C314(0.92); C320(1.01)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C326(0.83); C376(0.83); C320(0.86); C314(0.87)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C483(0.86); C314(0.96); C376(0.97); C326(0.99)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C276(0.89); C320(0.99); C314(1.11); C326(1.11)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C483(0.84); C443(0.97); C376(0.99); C314(1.05)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C314(0.87); C483(0.92); C326(0.93); C376(0.96)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C375(0.78); C483(0.87); C376(0.89); C320(0.96)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C314(0.87); C483(0.88); C326(0.91); C320(0.91)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C483(0.86); C375(0.95); C376(0.99); C314(0.99)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C483(0.87); C375(0.95); C376(0.98); C314(1.02)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C443(0.58); C376(1.00); C326(1.01); C483(1.03)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C443(0.88); C483(0.94); C314(0.95); C320(0.97)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C443(0.58); C326(1.02); C320(1.03); C314(1.04)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C443(0.44); C483(0.87); C376(1.03); C375(1.13)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C276(0.92); C320(1.14); C314(1.21); C326(1.21)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C443(0.54); C483(0.86); C376(1.03); C314(1.18)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C443(0.51); C320(0.99); C314(0.99); C326(1.01)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C443(0.56); C483(1.00); C376(1.05); C320(1.07)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C443(0.62); C376(0.98); C375(1.00); C483(1.01)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C443(0.61); C483(0.91); C376(1.01); C314(1.10)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C443(0.86); C483(0.89); C375(1.05); C376(1.08)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C443(0.62); C483(0.76); C376(0.99); C375(1.05)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C375(0.87); C376(1.05); C314(1.05); C320(1.07)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C443(0.81); C375(0.86); C376(0.90); C320(1.01)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C443(0.59); C375(0.80); C376(0.97); C320(1.20)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C276(0.78); C375(1.01); C376(1.02); C326(1.22)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C443(0.80); C375(0.91); C376(1.03); C320(1.23)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C443(0.82); C375(0.91); C376(1.07); C320(1.10)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C375(0.80); C443(0.88); C376(0.93); C320(1.12)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C443(0.83); C375(0.93); C320(1.07); C326(1.14)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C443(0.78); C375(0.79); C376(0.90); C320(1.19)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C443(0.74); C375(0.99); C376(1.09); C314(1.19)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C375(1.00); C376(1.05); C320(1.11); C314(1.16)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C443(0.57); C376(0.75); C375(0.76); C320(1.13)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C276(0.84); C314(0.97); C326(1.01); C375(1.01)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C276(0.79); C376(0.89); C375(0.92); C320(0.93)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C276(0.95); C376(1.06); C375(1.07); C326(1.10)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C276(0.55); C376(0.75); C314(0.91); C320(0.93)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C276(0.61); C314(0.76); C320(0.81); C326(0.86)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C314(0.81); C320(0.86); C326(0.89); C276(0.90)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C276(0.73); C376(0.81); C375(0.89); C314(0.93)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C276(0.76); C375(0.89); C314(0.92); C376(0.92)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C276(0.75); C376(0.97); C314(1.02); C375(1.10)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C276(0.81); C375(0.92); C314(0.95); C376(0.95)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C276(0.90); C376(0.91); C375(0.97); C314(0.99)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C276(0.74); C314(0.75); C320(0.79); C326(0.83)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C276(0.63); C320(0.84); C314(0.90); C376(0.94)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C276(0.90); C375(1.00); C376(1.08); C320(1.09)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C314(0.78); C276(0.85); C326(0.86); C320(0.91)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C276(0.87); C320(0.88); C314(0.91); C376(0.96)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C276(0.56); C376(0.98); C314(1.02); C375(1.03)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C320(1.29); C314(1.39); C326(1.45)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C314(1.31); C320(1.37); C326(1.45)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C320(1.08); C314(1.14); C326(1.22)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C320(1.09); C326(1.25); C314(1.33)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C320(0.95); C314(1.07); C326(1.08)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C314(1.09); C320(1.12); C326(1.20)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C320(1.00); C326(1.15); C314(1.16)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C320(0.92); C326(0.95); C314(1.06)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C314(1.35); C320(1.45); C326(1.50)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C320(1.27); C326(1.40); C314(1.47)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C320(1.04); C314(1.04); C326(1.08)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C320(0.93); C314(1.13); C326(1.14)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C320(0.94); C326(1.09); C314(1.12)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C314(1.16); C320(1.19); C326(1.26)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C320(1.14); C326(1.32); C314(1.44)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C483(0.42); C376(0.57); C276(0.58); C375(0.70)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C376(0.62); C483(0.65); C276(0.67); C375(0.71)  LDD0683  [5]
 LDCM0545  Acetamide MDA-MB-231 C483(0.96)  LDD2138  [3]
 LDCM0248  AKOS034007472 HCT 116 C276(0.89); C314(0.91); C320(0.89); C326(0.90)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C276(0.92); C375(1.00); C326(1.07); C320(1.07)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C276(0.75); C376(1.18); C375(1.19); C320(1.31)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C314(1.13); C320(1.13); C326(1.13)  LDD0078  [5]
 LDCM0367  CL1 HCT 116 C320(0.79); C326(0.80); C375(0.81); C314(0.84)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C375(0.90); C376(0.95); C326(1.17); C314(1.19)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C320(0.93); C276(1.04); C314(1.08); C326(1.08)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C276(0.83); C375(1.16); C376(1.23); C326(1.33)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C276(0.67); C326(1.08); C320(1.09); C314(1.10)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C276(0.78); C320(1.08); C326(1.09); C314(1.10)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C276(0.71); C320(0.95); C326(1.00); C314(1.01)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C376(0.93); C375(0.97); C314(1.03); C320(1.08)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C376(0.88); C375(0.96); C314(1.22); C320(1.27)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C376(0.96); C375(1.00); C314(1.13); C320(1.15)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C376(0.89); C375(1.02); C314(1.26); C326(1.28)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C375(0.92); C376(0.94); C314(1.07); C326(1.08)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C320(1.00); C326(1.01); C375(1.03); C314(1.04)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C375(0.97); C376(0.98); C326(1.03); C320(1.07)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C376(0.91); C375(0.94); C326(1.03); C314(1.03)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C314(0.86); C326(0.90); C320(0.92)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C314(1.08); C326(1.13); C320(1.20)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C314(0.96); C326(1.00); C320(1.01)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C314(0.98); C326(1.04); C320(1.10)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C314(0.91); C326(0.93); C320(0.97)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C483(0.78); C376(0.92); C375(1.00); C314(1.20)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C483(0.88); C326(0.92); C375(0.94); C376(0.95)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C483(0.88); C376(0.97); C326(0.99); C375(1.00)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C376(0.97); C375(0.99); C320(1.38); C326(1.44)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C314(0.85); C320(0.92); C326(0.94); C443(0.95)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C443(0.57); C483(0.84); C375(1.57); C376(1.76)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C443(0.75); C483(0.90); C376(0.98); C320(1.08)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C443(0.65); C483(0.94); C376(1.02); C314(1.05)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C443(0.65); C483(0.93); C376(1.04); C320(1.11)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C443(0.68); C375(0.85); C376(0.93); C314(0.95)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C443(0.44); C375(0.91); C376(0.98); C314(1.13)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C443(0.70); C375(0.81); C376(0.81); C320(1.02)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C375(0.83); C376(0.89); C320(1.14); C443(1.17)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C375(0.94); C376(1.08); C320(1.26); C326(1.34)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C375(0.77); C326(0.91); C376(0.91); C320(0.91)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C375(0.83); C376(0.91); C326(1.34); C314(1.35)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C443(0.70); C483(0.81); C276(0.98); C375(1.11)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C276(0.74); C443(0.86); C483(1.00); C326(1.07)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C276(0.91); C443(1.14); C375(1.16); C483(1.17)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C483(0.74); C443(0.81); C276(0.93); C376(1.11)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C375(0.76); C320(0.79); C326(0.81); C314(0.87)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C483(0.71); C443(0.76); C276(0.85); C375(0.98)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C483(0.73); C276(0.74); C443(0.88); C375(0.96)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C483(0.61); C443(0.73); C276(0.95); C376(1.02)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C483(0.76); C276(0.91); C443(0.91); C375(1.04)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C483(0.76); C443(0.83); C276(0.98); C375(1.11)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C276(0.87); C314(1.41); C320(1.44); C326(1.40)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C276(0.78); C314(1.22); C320(1.29); C326(1.23)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C276(0.90); C314(1.32); C320(1.42); C326(1.32)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C276(0.94); C314(1.44); C320(1.56); C326(1.44)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C276(0.87); C314(1.34); C320(1.44); C326(1.32)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C314(0.98); C320(0.96); C326(0.96); C375(0.94)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C276(0.92); C314(1.20); C320(1.34); C326(1.22)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C314(0.86); C320(0.81); C326(0.87); C375(1.14)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C314(0.96); C320(0.85); C326(0.97); C375(1.60)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C314(1.04); C320(0.91); C326(1.02); C375(1.25)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C314(1.01); C320(0.98); C326(1.02); C375(1.13)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C314(1.14); C320(1.06); C326(1.15); C375(1.67)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C314(1.27); C320(1.10); C326(1.14); C375(1.18)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C314(1.24); C320(1.05); C326(1.17); C375(1.20)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C314(1.18); C320(1.07); C326(1.08); C375(1.00)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C314(1.14); C320(1.12); C326(1.11); C375(1.04)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C314(1.24); C320(1.15); C326(1.13); C375(1.35)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C314(1.00); C320(0.92); C326(0.98); C375(1.24)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C314(1.29); C320(0.98); C326(1.12); C375(1.48)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C314(1.29); C320(1.22); C326(1.20); C375(1.30)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C314(1.13); C320(1.04); C326(1.15); C375(1.10)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C314(1.24); C320(1.08); C326(1.17); C375(1.06)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C314(0.95); C320(0.94); C326(0.90); C375(0.82)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C314(0.86); C320(1.00); C326(0.91); C375(1.04)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C314(0.98); C320(0.91); C326(0.91); C375(0.82)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C314(0.98); C320(1.05); C326(1.00); C375(0.91)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C314(1.04); C320(0.94); C326(0.99); C375(0.92)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C314(1.02); C320(1.08); C326(1.03); C375(0.88)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C314(0.89); C320(0.97); C326(0.91); C375(0.78)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C314(1.04); C320(1.27); C326(1.07); C375(0.81)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C314(0.99); C320(0.96); C326(0.95); C375(0.83)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C314(0.87); C320(0.88); C326(0.89); C375(0.77)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C314(0.94); C320(0.97); C326(0.94); C375(0.85)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C314(0.99); C320(1.02); C326(0.99); C375(0.91)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C314(1.03); C320(1.00); C326(1.05); C375(0.88)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C314(0.90); C320(1.21); C326(1.00); C375(1.12)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C314(0.96); C320(0.99); C326(0.99); C375(0.88)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C314(1.05); C320(1.02); C326(1.03); C375(0.83)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C314(0.97); C320(1.06); C326(1.03); C375(1.00)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C276(0.93); C314(0.88); C320(0.94); C326(0.90)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C276(1.23); C314(0.89); C320(1.00); C326(0.89)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C276(0.97); C314(0.98); C320(1.14); C326(0.97)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C276(0.72); C314(1.04); C320(1.07); C326(1.00)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C276(0.78); C314(0.88); C320(0.88); C326(0.86)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C276(1.27); C314(1.14); C320(1.41); C326(1.15)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C276(0.97); C314(0.91); C320(1.03); C326(0.93)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C276(0.91); C314(0.97); C320(1.08); C326(0.93)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C276(1.00); C314(0.93); C320(0.94); C326(0.94)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C314(1.19); C320(1.13); C326(1.15); C375(0.84)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C276(1.17); C314(0.95); C320(1.03); C326(0.95)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C276(0.96); C314(0.94); C320(1.02); C326(0.91)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C276(0.98); C314(0.88); C320(0.97); C326(0.90)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C276(1.04); C314(0.99); C320(1.21); C326(1.01)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C276(1.05); C314(0.96); C320(1.11); C326(0.99)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C276(0.77); C314(1.05); C320(1.09); C326(1.03)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C276(0.78); C314(1.04); C320(1.05); C326(1.06)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C276(0.80); C314(1.02); C320(1.10); C326(1.07)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C276(0.88); C314(1.15); C320(1.19); C326(1.17)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C314(1.14); C320(1.04); C326(1.10); C375(0.86)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C276(0.84); C314(0.91); C320(0.97); C326(0.93)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C276(0.75); C314(0.88); C320(1.00); C326(0.94)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C276(0.70); C314(1.25); C320(1.32); C326(1.24)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C276(0.77); C314(1.18); C320(1.24); C326(1.17)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C276(0.90); C314(1.32); C320(1.43); C326(1.30)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C276(0.89); C314(1.06); C320(1.08); C326(1.10)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C276(0.74); C314(0.95); C320(0.93); C326(0.96)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C276(0.78); C314(0.97); C320(1.08); C326(1.00)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C276(0.67); C314(1.13); C320(1.25); C326(1.18)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C276(0.79); C314(1.43); C320(1.61); C326(1.48)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C314(0.93); C320(0.87); C326(0.89); C375(0.77)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C276(0.66); C314(0.75); C320(0.77); C326(0.80)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C276(0.90); C314(1.35); C320(1.34); C326(1.35)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C276(0.86); C314(1.11); C320(1.02); C326(1.11)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C276(0.82); C314(1.06); C320(1.08); C326(1.06)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C276(1.11); C314(1.06); C320(1.04); C326(1.06)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C276(0.85); C314(1.18); C320(1.04); C326(1.18)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C276(1.00); C314(1.11); C320(1.08); C326(1.11)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C276(0.89); C314(1.19); C320(1.14); C326(1.19)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C276(1.15); C314(1.20); C320(1.04); C326(1.20)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C276(1.04); C314(1.17); C320(1.14); C326(1.17)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C294(1.00); C483(0.97); C336(0.98); C276(0.92)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C336(1.02)  LDD1702  [3]
 LDCM0625  F8 Ramos C294(1.26)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C294(0.58)  LDD2189  [14]
 LDCM0574  Fragment12 Ramos C294(0.50)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C294(0.63)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C294(1.20)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C294(0.57)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C294(0.72)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C294(0.70)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C294(0.79)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C294(0.37)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C294(0.77)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C294(0.67)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C294(0.49)  LDD2201  [14]
 LDCM0468  Fragment33 HCT 116 C276(0.85); C314(0.99); C320(1.12); C326(1.01)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C294(0.54)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C294(1.10)  LDD2184  [14]
 LDCM0427  Fragment51 HCT 116 C314(1.23); C320(1.09); C326(1.13); C375(1.15)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C294(0.59)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C294(0.96)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C294(0.85)  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C294(0.62)  LDD2188  [14]
 LDCM0022  KB02 HCT 116 C314(2.02); C326(2.02); C320(2.02); C294(0.98)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C314(1.69); C326(1.69); C320(1.69); C294(1.02)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C314(1.44); C326(1.44); C320(1.44); C294(0.84)  LDD0082  [5]
 LDCM0169  KB63 Ramos 4.14  LDD0432  [15]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C483(0.94)  LDD2089  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C483(1.01)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C294(0.64)  LDD2093  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C483(1.20)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C483(0.62)  LDD2100  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C483(1.06)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C483(0.81); C294(0.50)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C483(1.02)  LDD2111  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C483(0.83)  LDD2114  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C483(0.93)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C483(1.92)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C483(0.69)  LDD2120  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C483(0.67)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C483(0.83)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C483(0.56)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C294(0.74)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C483(0.56)  LDD2126  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C483(0.73)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C483(0.65)  LDD2128  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C483(1.51)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C294(1.13)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C294(0.79)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C483(2.02)  LDD1700  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C483(0.46)  LDD2141  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C483(2.42)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C483(1.09)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C483(0.53)  LDD2148  [3]
 LDCM0021  THZ1 HCT 116 C375(1.18); C314(1.18); C320(1.18); C326(1.18)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N6-adenosine-methyltransferase non-catalytic subunit (METTL14) MT-A70-like family Q9HCE5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.