Details of the Target

General Information of Target

Target ID LDTP03458
Target Name ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)
Gene Name CD38
Gene ID 952
Synonyms
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; EC 3.2.2.-; EC 3.2.2.6; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; EC 2.4.99.20; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPR hydrolase 1; T10; CD antigen CD38
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFP
ETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCN
KILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDC
SNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEA
WVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
Target Type
Successful
Target Bioclass
Enzyme
Family
ADP-ribosyl cyclase family
Subcellular location
Cell surface
Function
Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion. Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+). Has cADPR hydrolase activity.
TTD ID
T10877
Uniprot ID
P28907
DrugMap ID
TTPURFN
Ensemble ID
ENST00000226279.8
HGNC ID
HGNC:1667
ChEMBL ID
CHEMBL4660

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LS180 SNV: p.V68I .
RL952 SNV: p.R58H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C275(1.72)  LDD3397  [1]
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [2]
Alkyne-RA190
 Probe Info  		4.08  LDD0299  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C180(0.00); C254(0.00); C82(0.00); C173(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C180(0.00); C254(0.00); C82(0.00); C173(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C180(0.00); C254(0.00); C82(0.00); C173(0.00)  LDD0037  [4]
Compound 10
 Probe Info  		N.A.  LDD2216  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0201  EV-3 T cell C287(4.61)  LDD0515  [6]
 LDCM0202  EV-93 T cell C287(6.49)  LDD0514  [6]
 LDCM0203  EV-96 T cell C275(4.06)  LDD0523  [6]
 LDCM0206  EV-99 T cell C296(6.50)  LDD0521  [6]
 LDCM0625  F8 Ramos 1.43  LDD2187  [7]
 LDCM0578  Fragment27 Ramos 1.07  LDD2197  [7]
 LDCM0586  Fragment28 Ramos 1.85  LDD2198  [7]
 LDCM0616  Fragment61 Jurkat _(20.00)  LDD1489  [2]
 LDCM0615  Fragment63-R Jurkat _(8.16)  LDD1487  [2]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [2]
 LDCM0022  KB02 Ramos 20.00  LDD0431  [8]
 LDCM0023  KB03 697 C180(2.90); C119(3.07)  LDD2662  [1]
 LDCM0024  KB05 PF-382 C275(1.72)  LDD3397  [1]
 LDCM0169  KB63 Ramos 7.90  LDD0432  [8]
 LDCM0131  RA190 MM1.R 4.08  LDD0299  [3]
 LDCM0170  Structure8 Ramos 20.00; 5.86  LDD0433  [8]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Daratumumab Antibody D0RV4P
Isatuximab . DB14811
Phase 2
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Isb 1342 Antibody DE0L6O
Mor-202 Antibody D0O4IN
Sar-650984 Antibody D0NS1X
Cd38 Car T Cells CAR T Cell Therapy D09UFZ
Cd38 Car-t Cell CAR T Cell Therapy D0M8EF
Cd38-specific Gene-engineered T Cells CAR T Cell Therapy D0UJ3C
4scar19 And 4scar38 CAR T Cell Therapy (Dual specific) D0I4HG
Cd38 And Bcma Car-t Cells CAR T Cell Therapy (Dual specific) D0G0PI
Phase 1
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amg 424 Antibody DLY65X
Sar442085 Antibody D5VE7C
Sar442257 Antibody DBP9Q5
Anti-cd38 Car-t Cells CAR T Cell Therapy D05WET
Cart-38 Cells CAR T Cell Therapy D06OES
Cd38 Car-t CAR T Cell Therapy DSWZ60
225ac-labelled Acd38 Radiopharmaceutical therapy DK1PA2
Tak-169 Recombinant protein D2HE9I
Tak-573 Recombinant protein D0ZDP2
Clinical trial
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Car-t Cells Targeting Cd38 CAR T Cell Therapy D0V6WU
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Humax-cd38b . D0N1QH
Mezagitamab . DB16370

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
8 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.