Details of the Target

General Information of Target

Target ID LDTP01173
Target Name RNA/RNP complex-1-interacting phosphatase (DUSP11)
Gene Name DUSP11
Gene ID 8446
Synonyms
PIR1; RNA/RNP complex-1-interacting phosphatase; EC 3.1.3.-; Dual specificity protein phosphatase 11; Phosphatase that interacts with RNA/RNP complex 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQWHHPRSGWGRRRDFSGRSSAKKKGGNHIPERWKDYLPVGQRMPGTRFIAFKVPLQKS
FEKKLAPEECFSPLDLFNKIREQNEELGLIIDLTYTQRYYKPEDLPETVPYLKIFTVGHQ
VPDDETIFKFKHAVNGFLKENKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIE
LFNRCRGHCLERQNYIEDLQNGPIRKNWNSSVPRSSDFEDSAHLMQPVHNKPVKQGPRYN
LHQIQGHSAPRHFHTQTQSLQQSVRKFSENPHVYQRHHLPPPGPPGEDYSHRRYSWNVKP
NASRAAQDRRRWYPYNYSRLSYPACWEWTQ
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Subcellular location
Nucleus
Function
Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism.
Uniprot ID
O75319
Ensemble ID
ENST00000272444.8
HGNC ID
HGNC:3066

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C236(1.76)  LDD1702  [1]
DBIA
 Probe Info  		C325(1.13)  LDD0078  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
TFBX
 Probe Info  		C211(0.00); C117(0.00)  LDD0148  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
W1
 Probe Info  		N.A.  LDD0236  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C372(1.07)  LDD1507  [10]
 LDCM0215  AC10 HCT 116 C325(0.89)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C325(1.15)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C325(1.15)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C325(1.12)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C325(1.36)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C325(1.42)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C325(1.34)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C325(1.26)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C325(0.88)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C325(0.94)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C325(0.76)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C325(1.30)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C325(1.03)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C325(0.91)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C325(1.01)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C325(1.26)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C325(0.99)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C325(0.83)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C325(0.96)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C325(1.37)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C325(1.13)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C325(1.61)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C325(0.88)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C325(0.99)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C325(1.39)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C325(0.97)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C325(2.37)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C325(1.44)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C325(0.93)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C325(0.81)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C325(1.05)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C325(0.74)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C325(0.71)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C325(0.86)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C325(0.60)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C325(0.72)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C325(1.06)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C325(1.04)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C325(0.65)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C325(0.73)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C325(0.66)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C325(0.65)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C325(0.62)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C325(1.12)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C325(0.67)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C325(0.66)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C325(0.56)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C325(0.98)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C325(1.33)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C325(0.90)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C325(1.02)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C325(1.02)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C325(1.00)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C325(1.18)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C325(1.23)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C325(0.89)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C325(1.07)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C325(0.85)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C325(1.34)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C325(1.03)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C325(1.01)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C325(1.08)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C325(1.40)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C325(0.34)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C325(0.44)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C325(0.37)  LDD0595  [2]
 LDCM0279  AC2 HEK-293T C372(1.14)  LDD1518  [10]
 LDCM0280  AC20 HCT 116 C325(0.36)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C325(0.36)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C325(0.31)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C325(0.30)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C325(0.38)  LDD0601  [2]
 LDCM0285  AC25 PaTu 8988t C325(1.05)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C325(1.00)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C325(0.96)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C325(1.13)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C325(0.97)  LDD1168  [2]
 LDCM0290  AC3 HEK-293T C372(1.11); C117(1.14)  LDD1529  [10]
 LDCM0291  AC30 PaTu 8988t C325(0.98)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C325(1.09)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C325(1.34)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C325(1.19)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C325(1.12)  LDD1174  [2]
 LDCM0296  AC35 HEK-293T C325(1.23)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C325(1.16)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C325(1.43)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C325(1.48)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C325(1.43)  LDD0898  [2]
 LDCM0301  AC4 HEK-293T C372(1.02)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C325(1.36)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C325(1.15)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C325(1.00)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C325(1.41)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C325(1.23)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C325(1.33)  LDD0905  [2]
 LDCM0308  AC46 HEK-293T C325(0.93); C70(0.81)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C325(1.27); C70(0.67)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C325(1.03); C70(0.69)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C325(1.21); C70(0.77)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C372(1.04); C117(1.02)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C325(1.59); C70(0.72)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C325(1.35); C70(0.64)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C325(1.29); C70(0.64)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C325(1.66); C70(0.65)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C325(1.00); C70(0.78)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C325(1.37); C70(0.70)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C325(1.25); C70(0.70)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C70(1.18)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C70(1.10)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C70(1.14)  LDD0920  [2]
 LDCM0323  AC6 HCT 116 C325(0.94)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C70(1.12)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C70(0.94)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C70(0.92)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C70(0.94)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C70(1.03)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C70(0.94)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C70(1.14)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C70(0.93)  LDD0929  [2]
 LDCM0332  AC68 HCT 116 C325(0.82)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C325(1.11)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C325(0.97)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C325(2.28)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C325(0.90)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C325(0.94)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C325(0.93)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C325(1.08)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C325(0.73)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C325(1.00)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C325(1.13)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C325(1.47)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C325(1.21)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C325(1.03)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C325(1.30)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C325(0.64)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C325(0.62)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C325(1.94)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C325(2.26)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C325(1.40)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C325(1.45)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C325(1.57)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C325(1.87)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C325(1.67)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C325(1.33)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C325(1.33)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C325(1.76)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C325(1.50)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C325(1.24)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C325(1.40)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C325(1.30)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C325(1.42)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C325(0.93)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C325(0.98)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C325(0.95)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C325(1.14)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C325(0.96)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C325(1.13)  LDD0078  [2]
 LDCM0367  CL1 HCT 116 C325(0.99)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C325(0.77)  LDD0685  [2]
 LDCM0369  CL100 HEK-293T C372(1.01)  LDD1573  [10]
 LDCM0370  CL101 HCT 116 C325(1.02)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C325(1.05)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C325(1.11)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C325(1.35)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C325(0.33)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C325(0.30)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C325(0.31)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C325(0.29)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C325(0.33)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C325(1.20)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C325(0.22)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C325(0.34)  LDD0698  [2]
 LDCM0382  CL112 PaTu 8988t C325(1.21)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C325(1.25)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C325(1.09)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C325(0.99)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C325(1.13)  LDD1265  [2]
 LDCM0387  CL117 HEK-293T C325(1.29)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C325(0.94)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C325(1.15)  LDD0987  [2]
 LDCM0390  CL12 HCT 116 C325(0.68)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C325(1.13)  LDD0989  [2]
 LDCM0392  CL121 HEK-293T C325(1.06); C70(0.68)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C325(1.25); C70(0.71)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C325(1.17); C70(0.57)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C325(1.29); C70(0.71)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C70(1.20)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C70(1.09)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C70(1.12)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C70(1.17)  LDD0997  [2]
 LDCM0400  CL13 HCT 116 C325(1.16)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C325(0.96)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C325(1.19)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C325(0.92)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C325(1.12)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C325(1.00)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C325(2.44)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C325(1.05)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C325(1.15)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C325(1.51)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C325(0.88)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C325(1.23)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C325(0.80)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C325(1.17)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C325(1.02)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C325(0.80)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C325(1.05)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C325(0.76)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C325(0.95)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C325(0.84)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C325(0.94)  LDD1018  [2]
 LDCM0421  CL32 HCT 116 C325(0.93)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C325(1.20)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C325(1.02)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C325(1.20)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C325(1.01)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C325(1.10)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C325(0.77)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C325(0.75)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C325(1.26)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C325(1.59)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C325(1.77)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C325(1.18)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C325(0.82)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C325(0.83)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C325(1.59)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C325(0.88)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C325(0.83)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C325(0.96)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C325(1.02)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C325(1.13)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C325(0.91)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C325(1.13)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C325(1.44)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C325(1.33)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C325(1.10)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C325(0.95)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C325(0.85)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C325(1.56)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C325(1.01)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C325(1.17)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C325(0.90)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C325(1.22); C70(0.92)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C325(0.80); C70(0.87)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C325(0.72); C70(0.98)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C325(1.46); C70(0.83)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C325(1.20); C70(0.88)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C325(0.91); C70(0.88)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C325(1.36); C70(0.89)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C325(0.97); C70(0.74)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C325(1.18); C70(0.82)  LDD1059  [2]
 LDCM0462  CL7 HCT 116 C325(0.75)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C325(0.90); C70(0.83)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C325(1.09); C70(0.76)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C325(1.13); C70(0.82)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C325(1.50); C70(0.73)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C325(0.99); C70(0.87)  LDD1065  [2]
 LDCM0469  CL76 HCT 116 C325(1.25)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C325(0.98)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C325(1.13)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C325(0.76)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C325(1.62)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C325(0.75)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C325(0.86)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C325(0.72)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C325(0.62)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C325(1.76)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C325(0.96)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C325(1.22)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C325(0.79)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C325(0.84)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C325(0.69)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C325(0.77)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C325(1.32)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C372(1.06); C117(1.40)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C372(0.98)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C372(0.89); C117(0.95)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C372(0.88)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C372(0.98); C117(0.97)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C372(1.19); C117(1.31)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C372(0.93); C117(0.76)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C372(1.01); C117(0.93)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C372(0.98)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C372(1.08)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C236(1.76)  LDD1702  [1]
 LDCM0468  Fragment33 HEK-293T C325(1.29); C70(0.78)  LDD1066  [2]
 LDCM0427  Fragment51 HCT 116 C325(0.81)  LDD0744  [2]
 LDCM0022  KB02 HCT 116 C325(4.09)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C325(2.52)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C325(4.12)  LDD0082  [2]
 LDCM0169  KB63 Ramos 4.10  LDD0432  [11]
 LDCM0131  RA190 MM1.R C325(4.10)  LDD0304  [12]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.
12 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.