Details of the Target

General Information of Target

Target ID LDTP07407
Target Name Desumoylating isopeptidase 1 (DESI1)
Gene Name DESI1
Gene ID 27351
Synonyms
FAM152B; PPPDE2; Desumoylating isopeptidase 1; DeSI-1; EC 3.4.-.-; PPPDE peptidase domain-containing protein 2; Palmitoyl protein thioesterase DESI1; EC 3.1.2.22; Polyubiquitinated substrate transporter; POST; S-depalmitoylase DESI1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPPNLYPVKLYVYDLSKGLARRLSPIMLGKQLEGIWHTSIVVHKDEFFFGSGGISSCPP
GGTLLGPPDSVVDVGSTEVTEEIFLEYLSSLGESLFRGEAYNLFEHNCNTFSNEVAQFLT
GRKIPSYITDLPSEVLSTPFGQALRPLLDSIQIQPPGGSSVGRPNGQS
Target Bioclass
Enzyme
Family
DeSI family
Subcellular location
Cytoplasm
Function
Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46. Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm. Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5).
Uniprot ID
Q6ICB0
Ensemble ID
ENST00000263256.7
HGNC ID
HGNC:24577

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y12(11.65)  LDD0257  [1]
TH216
 Probe Info  		Y12(17.36)  LDD0259  [1]
DBIA
 Probe Info  		C108(1.16)  LDD3331  [2]
IMP-1710
 Probe Info  		2.17  LDD0212  [3]
EA-probe
 Probe Info  		C108(0.82)  LDD2210  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0174  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [8]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
IPM
 Probe Info  		N.A.  LDD0147  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C108(2.72)  LDD0372  [11]
 LDCM0215  AC10 HEK-293T C108(1.04)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C108(1.21)  LDD1509  [12]
 LDCM0259  AC14 HEK-293T C108(1.07)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C108(1.01)  LDD1513  [12]
 LDCM0277  AC18 HEK-293T C108(0.98)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C108(1.06)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C108(1.12)  LDD1518  [12]
 LDCM0281  AC21 HEK-293T C108(1.00)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C108(1.11)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C108(1.08)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C108(1.14)  LDD1523  [12]
 LDCM0286  AC26 HEK-293T C108(0.91)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C108(1.22)  LDD1526  [12]
 LDCM0289  AC29 HEK-293T C108(1.01)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C108(1.12)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C108(0.96)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C108(1.10)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C108(1.03)  LDD1532  [12]
 LDCM0295  AC34 HEK-293T C108(1.06)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C108(1.06)  LDD1535  [12]
 LDCM0298  AC37 HEK-293T C108(1.00)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C108(1.15)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C108(1.06)  LDD1539  [12]
 LDCM0302  AC40 HEK-293T C108(0.94)  LDD1541  [12]
 LDCM0304  AC42 HEK-293T C108(0.88)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C108(1.12)  LDD1544  [12]
 LDCM0307  AC45 HEK-293T C108(1.03)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C108(1.18)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C108(1.11)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C108(0.89)  LDD1549  [12]
 LDCM0312  AC5 HEK-293T C108(1.20)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C108(0.95)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C108(1.16)  LDD1553  [12]
 LDCM0316  AC53 HEK-293T C108(0.93)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C108(1.06)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C108(1.01)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C108(1.20)  LDD1558  [12]
 LDCM0321  AC58 HEK-293T C108(1.01)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C108(1.17)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C108(1.07)  LDD1562  [12]
 LDCM0325  AC61 HEK-293T C108(1.05)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C108(1.00)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C108(0.96)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C108(1.02)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C108(1.05)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C108(0.94)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C108(0.99)  LDD1511  [12]
 LDCM0275  AKOS034007705 HEK-293T C108(0.91)  LDD1514  [12]
 LDCM0630  CCW28-3 231MFP C108(1.54)  LDD2214  [13]
 LDCM0367  CL1 HEK-293T C108(1.17)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C108(1.39)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C108(1.07)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C108(0.97)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C108(0.99)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C108(0.96)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C108(0.96)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C108(1.05)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C108(0.89)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C108(1.00)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C108(0.98)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C108(0.99)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C108(1.20)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C108(1.10)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C108(1.28)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C108(0.94)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C108(1.15)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C108(1.00)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C108(1.00)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C108(1.17)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C108(1.07)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C108(1.04)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C108(0.97)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C108(0.95)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C108(1.14)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C108(1.17)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C108(0.90)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C108(0.94)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C108(1.09)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C108(0.96)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C108(0.95)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C108(0.93)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C108(0.85)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C108(1.20)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C108(0.87)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C108(1.02)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C108(1.03)  LDD1607  [12]
 LDCM0405  CL18 HEK-293T C108(1.14)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C108(1.43)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C108(1.07)  LDD1611  [12]
 LDCM0409  CL21 HEK-293T C108(1.01)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C108(1.36)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C108(1.27)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C108(1.05)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C108(1.01)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C108(0.93)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C108(1.12)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C108(1.10)  LDD1620  [12]
 LDCM0418  CL3 HEK-293T C108(1.30)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C108(1.11)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C108(1.35)  LDD1624  [12]
 LDCM0422  CL33 HEK-293T C108(1.01)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C108(1.19)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C108(1.20)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C108(0.98)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C108(1.17)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C108(0.97)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C108(0.99)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C108(0.95)  LDD1634  [12]
 LDCM0432  CL42 HEK-293T C108(0.99)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C108(1.38)  LDD1637  [12]
 LDCM0435  CL45 HEK-293T C108(1.14)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C108(1.24)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C108(1.23)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C108(0.90)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C108(1.02)  LDD1643  [12]
 LDCM0441  CL50 HEK-293T C108(0.93)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C108(1.02)  LDD1646  [12]
 LDCM0445  CL54 HEK-293T C108(1.10)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C108(1.40)  LDD1649  [12]
 LDCM0448  CL57 HEK-293T C108(1.17)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C108(1.44)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C108(0.82)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C108(1.06)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C108(0.89)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C108(1.16)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C108(0.97)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C108(1.05)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C108(0.90)  LDD1659  [12]
 LDCM0458  CL66 HEK-293T C108(1.04)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C108(1.35)  LDD1662  [12]
 LDCM0461  CL69 HEK-293T C108(0.97)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C108(1.71)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C108(1.43)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C108(1.00)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C108(1.14)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C108(1.17)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C108(1.03)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C108(0.95)  LDD1672  [12]
 LDCM0471  CL78 HEK-293T C108(0.99)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C108(1.15)  LDD1675  [12]
 LDCM0475  CL81 HEK-293T C108(1.03)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C108(1.19)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C108(0.94)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C108(1.01)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C108(1.06)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C108(0.97)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C108(0.97)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C108(0.96)  LDD1685  [12]
 LDCM0484  CL9 HEK-293T C108(1.09)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C108(0.84)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C108(1.32)  LDD1689  [12]
 LDCM0488  CL93 HEK-293T C108(1.17)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C108(1.15)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C108(0.94)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C108(1.25)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C108(1.06)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C108(0.99)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C108(0.95)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C108(1.16)  LDD1698  [12]
 LDCM0175  Ethacrynic acid HeLa C108(0.82)  LDD2210  [4]
 LDCM0201  EV-3 T cell C108(13.81)  LDD0528  [14]
 LDCM0625  F8 Ramos C108(1.50)  LDD2187  [15]
 LDCM0573  Fragment11 MDA-MB-231 C108(0.66)  LDD1467  [16]
 LDCM0575  Fragment13 Ramos C108(3.99)  LDD1470  [16]
 LDCM0576  Fragment14 Ramos C108(0.92)  LDD2193  [15]
 LDCM0580  Fragment21 MDA-MB-231 C108(0.58)  LDD1473  [16]
 LDCM0578  Fragment27 MDA-MB-231 C108(1.94)  LDD1474  [16]
 LDCM0586  Fragment28 Ramos C108(0.43)  LDD2198  [15]
 LDCM0587  Fragment29 Ramos C108(1.04)  LDD1476  [16]
 LDCM0589  Fragment31 MDA-MB-231 C108(1.24)  LDD1477  [16]
 LDCM0468  Fragment33 HEK-293T C108(0.95)  LDD1671  [12]
 LDCM0596  Fragment38 MDA-MB-231 C108(1.06)  LDD1480  [16]
 LDCM0566  Fragment4 Ramos C108(1.11)  LDD2184  [15]
 LDCM0603  Fragment45 MDA-MB-231 C108(3.10)  LDD1482  [16]
 LDCM0427  Fragment51 MDA-MB-231 C108(1.11)  LDD1483  [16]
 LDCM0569  Fragment7 Ramos C108(0.72)  LDD2186  [15]
 LDCM0570  Fragment8 MDA-MB-231 C108(20.00)  LDD1462  [16]
 LDCM0022  KB02 MDA-MB-231 C108(20.00)  LDD1460  [16]
 LDCM0023  KB03 HEK-293T C108(0.90)  LDD1497  [12]
 LDCM0024  KB05 MKN-1 C108(1.16)  LDD3331  [2]
 LDCM0001  Panyain_cp1 HEK-293T 2.17  LDD0212  [3]
 LDCM0131  RA190 MM1.R C108(1.37)  LDD0304  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 3 (AGR3) AGR family Q8TD06
Nucleoside diphosphate kinase 3 (NME3) NDK family Q13232
Cytosolic 5'-nucleotidase 3A (NT5C3A) Pyrimidine 5'-nucleotidase family Q9H0P0
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Taste receptor type 2 member 41 (TAS2R41) G-protein coupled receptor T2R family P59536
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ABI gene family member 3 (ABI3) ABI family Q9P2A4
Cell death-inducing p53-target protein 1 (CDIP1) CDIP1/LITAF family Q9H305
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Golgi membrane protein 1 (GOLM1) GOLM family Q8NBJ4
Protein shisa-4 (SHISA4) Shisa family Q96DD7
Polyubiquitin-B (UBB) Ubiquitin family P0CG47
Polyubiquitin-C (UBC) Ubiquitin family P0CG48
Ubiquitin-ribosomal protein eL40 fusion protein (UBA52) Ubiquitin family; Eukaryotic ribosomal protein eL40 family P62987
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) Ubiquitin family; Eukaryotic ribosomal protein eS31 family P62979
DAZ-associated protein 2 (DAZAP2) . Q15038
Endoplasmic reticulum resident protein 29 (ERP29) . P30040
Small integral membrane protein 21 (SMIM21) . Q3B7S5
Ubiquilin-1 (UBQLN1) . Q9UMX0
Ubiquilin-2 (UBQLN2) . Q9UHD9
Ubiquilin-like protein (UBQLNL) . Q8IYU4

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Correction to "Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity". J Am Chem Soc. 2020 Sep 2;142(35):15199. doi: 10.1021/jacs.0c08385. Epub 2020 Aug 19.
Mass spectrometry data entry: PXD015825
4 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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