Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IMP-1710  Probe Info 
Probe concentration 20 nM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Panyain_cp1  Competitor Info 
Competitor Concentration 4 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03133  Fibroblast growth factor receptor 2 (FGFR2) 8.5
 LDTP02383  Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) 6.6
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 3.3
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 2.8
 LDTP07407  Desumoylating isopeptidase 1 (DESI1) 2.2
 LDTP02783  Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCHL3) 2.2
Transporter and channel
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP06994  ER membrane protein complex subunit 4 (EMC4) 2.4
Other
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07136  Keratinocyte proline-rich protein (KPRP) 8.1
 LDTP06431  Thyroid receptor-interacting protein 11 (TRIP11) 5.9

References

1 Correction to "Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity". J Am Chem Soc. 2020 Sep 2;142(35):15199. doi: 10.1021/jacs.0c08385. Epub 2020 Aug 19.
Mass spectrometry data entry: PXD015825