Details of the Target

General Information of Target

Target ID LDTP06276
Target Name MAD2L1-binding protein (MAD2L1BP)
Gene Name MAD2L1BP
Gene ID 9587
Synonyms
CMT2; KIAA0110; MAD2L1-binding protein; Caught by MAD2 protein; p31(comet)
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPEAEVLSSAAVPDLEWYEKSEETHASQIELLETSSTQEPLNASEAFCPRDCMVPVVF
PGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKHFYRKPSPQAEEMLKKKPRATTEVS
SRKCQQALAELESVLSHLEDFFARTLVPRVLILLGGNALSPKEFYELDLSLLAPYSVDQS
LSTAACLRRLFRAIFMADAFSELQAPPLMGTVVMAQGHRNCGEDWFRPKLNYRVPSRGHK
LTVTLSCGRPSIRTTAWEDYIWFQAPVTFKGFRE
Target Bioclass
Other
Family
MAD2L1BP family
Subcellular location
Nucleus
Function May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.
Uniprot ID
Q15013
Ensemble ID
ENST00000372171.5
HGNC ID
HGNC:21059

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.E166G .
IGROV1 SNV: p.A256D .
MCC13 SNV: p.H239Y DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
m-APA
 Probe Info  		15.00  LDD0403  [2]
AHL-Pu-1
 Probe Info  		C50(3.94)  LDD0168  [3]
DBIA
 Probe Info  		C124(17.44)  LDD0204  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C221(0.00); C124(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C124(0.00); C221(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C124(0.00); C247(0.00); C221(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
NAIA_5
 Probe Info  		C247(0.00); C221(0.00)  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C50(3.94)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C50(3.04)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C221(0.89); C247(1.03); C186(1.07); C54(1.03)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C221(1.11); C247(0.98); C186(1.12); C124(0.98)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C221(1.10); C247(1.01); C186(0.71); C50(0.99)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C221(1.03); C247(1.03); C186(1.22); C124(0.95)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C221(1.06); C247(1.01); C186(0.99); C124(0.95)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C221(1.10); C247(0.99); C186(0.90); C124(1.04)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C221(0.94); C247(0.96); C186(1.06); C54(1.02)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C221(0.98); C247(0.96); C186(1.04); C124(0.95)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C221(0.70); C247(0.91); C186(0.85); C50(0.83)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C221(1.07); C247(0.98); C186(0.98); C124(0.89)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C221(1.06); C247(0.98); C186(1.17); C124(0.86)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C221(0.96); C247(1.01); C186(1.00); C124(1.06)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C221(0.99); C247(1.05); C186(0.88); C124(1.03)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C221(1.15); C247(0.96); C186(0.99); C124(0.91)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C221(1.17); C247(1.02); C186(0.99); C54(1.01)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C221(0.95); C247(1.00); C186(1.11); C54(1.01)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C221(0.98); C247(0.97); C186(1.02); C124(1.04)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C221(0.99); C247(0.99); C186(0.74); C50(0.88)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C221(0.94); C247(0.94); C186(1.12); C124(1.08)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C221(1.01); C247(1.01); C186(0.99); C124(1.09)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C221(1.03); C247(1.03); C186(0.72); C50(1.11)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C221(0.97); C247(0.98); C186(0.91); C124(1.11)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C221(1.03); C247(1.00); C186(0.98); C124(1.12)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C221(1.09); C247(1.04); C186(1.00); C54(0.99)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C221(0.95); C247(0.98); C186(1.20); C54(1.09)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C221(1.03); C247(1.00); C186(1.04); C124(1.00)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C221(1.02); C247(1.00); C186(0.71); C50(1.06)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C221(0.99); C247(1.03); C186(1.10); C124(1.14)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C221(1.20); C247(1.07); C186(1.18); C124(0.90)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C221(1.06); C247(0.93); C186(0.83); C124(1.10)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C221(1.07); C247(0.94); C186(0.93); C124(0.99)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C221(1.00); C247(1.01); C186(1.19); C124(0.87)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C221(0.97); C247(0.87); C186(0.98); C54(0.82)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C221(0.93); C247(0.99); C186(1.13); C54(1.04)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C221(0.99); C247(0.93); C186(1.07); C124(0.99)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C221(1.06); C247(0.99); C186(0.71); C50(1.15)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C221(1.06); C247(0.98); C186(1.16); C124(0.84)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C221(1.05); C247(1.04); C186(1.12); C124(1.01)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C221(1.04); C247(1.00); C186(0.91); C124(1.07)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C221(1.05); C247(0.95); C186(0.94); C124(0.98)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C221(1.18); C247(0.99); C186(0.99); C54(0.82)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C221(1.09); C247(0.99); C186(1.04); C54(0.96)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C221(1.05); C247(1.05); C186(0.96); C124(0.97)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C221(1.06); C247(1.01); C186(1.05); C124(1.01)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C221(1.21); C247(1.10); C186(0.78); C50(1.08)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C221(1.06); C247(1.04); C186(1.21); C124(0.90)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C221(1.14); C247(1.07); C186(0.96); C124(1.05)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C221(1.10); C247(0.99); C186(0.96); C124(1.06)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C221(1.11); C247(0.96); C186(0.97); C124(1.00)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C221(0.99); C247(0.96); C186(1.09); C54(0.86)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C221(0.95); C247(1.01); C186(1.06); C54(1.00)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C221(1.05); C247(0.95); C186(1.12); C124(0.88)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C221(1.13); C247(1.08); C186(0.84); C50(1.01)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C221(0.92); C247(0.90); C186(0.89); C124(0.91)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C221(0.97); C247(0.95); C186(1.27); C124(1.04)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C221(1.02); C247(1.01); C186(1.08); C124(0.97)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C221(1.05); C247(1.00); C186(0.94); C124(1.02)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C221(0.97); C247(1.00); C186(0.96); C124(1.00)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C221(1.07); C247(0.98); C186(1.05); C54(1.03)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C221(1.19); C247(0.96); C186(1.19); C124(1.03)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C221(0.94); C247(0.93); C186(1.07); C54(0.96)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C221(1.16); C247(1.03); C186(1.00); C124(1.15)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C221(1.01); C247(0.95); C186(1.01); C54(1.13)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C221(1.08); C247(0.85); C186(1.05); C54(0.97)  LDD1514  [9]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [2]
 LDCM0102  BDHI 8 Jurkat C124(17.44)  LDD0204  [4]
 LDCM0367  CL1 HEK-293T C221(1.04); C247(1.03); C186(0.93); C50(1.31)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C221(0.61); C247(0.89); C186(0.90); C124(1.17)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C221(1.02); C247(0.92); C186(0.97); C54(1.01)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C221(1.00); C247(1.10); C186(0.85); C50(1.06)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C221(0.89); C247(0.90); C186(0.81); C54(0.94)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C221(1.03); C247(0.93); C186(0.94); C124(0.79)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C221(1.10); C247(0.97); C186(0.91); C54(1.06)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C221(0.98); C247(0.96); C186(1.08); C50(0.91)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C221(1.00); C247(0.92); C186(0.90); C54(1.05)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C221(1.06); C247(0.99); C186(0.83); C124(1.25)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C221(1.12); C247(0.92); C186(0.92); C54(1.39)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C221(0.92); C247(1.02); C186(0.82); C50(1.11)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C221(0.77); C247(0.86); C186(1.08); C124(0.98)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C221(0.81); C247(0.84); C186(0.99); C54(0.84)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C221(0.82); C247(0.86); C186(0.88); C124(0.59)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C221(0.95); C247(0.94); C186(1.11); C54(1.08)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C221(1.07); C247(1.07); C186(0.90); C50(1.03)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C221(0.84); C247(0.92); C186(0.76); C54(0.85)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C221(1.08); C247(0.92); C186(1.18); C124(0.75)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C221(1.00); C247(0.98); C186(1.05); C54(1.24)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C221(1.04); C247(1.11); C186(0.83); C50(0.90)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C221(1.06); C247(0.93); C186(1.06); C54(1.02)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C221(1.12); C247(0.93); C186(0.98); C124(0.85)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C221(0.77); C247(1.02); C186(0.99); C54(1.16)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C221(1.04); C247(0.94); C186(0.99); C54(1.19)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C221(1.04); C247(1.00); C186(0.79); C50(0.98)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C221(1.09); C247(1.04); C186(0.93); C54(0.90)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C221(0.92); C247(0.81); C186(0.71); C124(0.79)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C221(1.06); C247(0.83); C186(1.03); C54(0.93)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C221(1.09); C247(1.05); C186(1.10); C50(1.03)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C221(0.95); C247(0.96); C186(1.14); C54(1.02)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C221(1.09); C247(0.92); C186(1.13); C124(0.84)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C221(1.03); C247(0.93); C186(0.83); C54(1.01)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C221(1.02); C247(1.03); C186(0.98); C50(0.90)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C221(1.26); C247(0.97); C186(0.97); C54(0.93)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C221(0.84); C247(0.76); C186(0.90); C124(0.63)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C221(1.21); C247(0.86); C186(1.27); C54(0.96)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C221(0.73); C247(0.95); C186(1.11); C54(1.08)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C221(1.04); C247(0.99); C186(0.96); C124(0.91)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C221(1.16); C247(0.93); C186(0.87); C50(0.91)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C221(1.10); C247(1.09); C186(0.86); C54(0.96)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C221(1.00); C247(1.09); C186(1.26); C124(1.23)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C221(0.74); C247(0.87); C186(0.94); C124(1.01)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C221(0.94); C247(1.03); C186(0.97); C124(1.14)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C221(0.92); C247(0.93); C186(1.11); C124(1.01)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C221(0.85); C247(0.88); C186(1.07); C54(1.21)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C221(0.96); C247(1.01); C186(0.82); C50(1.08)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C221(1.14); C247(0.93); C186(0.86); C54(0.94)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C221(1.12); C247(0.90); C186(0.92); C124(0.59)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C221(1.07); C247(0.94); C186(1.13); C54(1.09)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C221(0.98); C247(0.92); C186(1.11); C54(1.01)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C221(0.93); C247(0.91); C186(1.20); C124(0.71)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C221(1.10); C247(1.03); C186(1.08); C124(1.02)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C221(1.02); C247(1.03); C186(0.82); C50(1.03)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C221(0.96); C247(0.96); C186(1.03); C124(0.97)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C221(0.77); C247(0.93); C186(0.80); C124(0.98)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C221(0.95); C247(0.97); C186(0.81); C124(1.28)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C221(0.98); C247(1.00); C186(1.05); C124(1.11)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C221(0.91); C247(0.88); C186(1.05); C54(1.01)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C221(1.04); C247(1.19); C186(0.92); C50(0.95)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C221(1.00); C247(0.88); C186(0.91); C124(0.68)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C221(0.98); C247(0.85); C186(0.91); C54(0.97)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C221(1.14); C247(1.01); C186(0.95); C54(0.99)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C221(0.93); C247(0.94); C186(1.09); C54(0.91)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C221(1.00); C247(1.07); C186(1.01); C124(0.90)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C221(1.09); C247(1.05); C186(0.70); C50(0.97)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C221(0.92); C247(0.94); C186(1.06); C124(1.00)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C221(0.84); C247(0.98); C186(1.06); C124(1.22)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C221(0.95); C247(1.08); C186(0.93); C124(1.05)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C221(0.99); C247(0.97); C186(1.00); C124(1.10)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C221(0.97); C247(0.99); C186(0.99); C54(0.89)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C221(1.16); C247(1.15); C186(0.95); C50(0.93)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C221(0.93); C247(0.99); C186(1.10); C54(1.05)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C221(0.95); C247(0.86); C186(1.04); C54(0.92)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C221(1.04); C247(0.93); C186(0.92); C54(1.15)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C221(0.77); C247(0.95); C186(0.96); C54(1.10)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C221(0.80); C247(0.89); C186(1.01); C124(0.91)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C221(1.01); C247(0.94); C186(0.85); C50(1.06)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C221(0.92); C247(0.97); C186(1.11); C124(2.00)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C221(0.74); C247(0.91); C186(1.04); C124(0.93)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C221(0.85); C247(0.97); C186(0.99); C124(1.08)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C221(0.89); C247(0.95); C186(1.09); C124(0.94)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C221(0.77); C247(0.84); C186(0.98); C124(0.91)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C221(0.78); C247(0.91); C186(1.06); C54(1.14)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C221(1.14); C247(1.13); C186(0.89); C50(0.81)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C221(1.19); C247(0.99); C186(1.01); C54(0.84)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C221(1.18); C247(0.90); C186(1.09); C124(0.68)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C221(0.97); C247(0.87); C186(0.85); C54(0.93)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C221(0.97); C247(1.04); C186(1.16); C54(1.12)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C221(0.96); C247(0.92); C186(0.98); C124(0.97)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C221(1.07); C247(1.00); C186(0.87); C50(0.86)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C221(0.97); C247(0.97); C186(1.19); C124(1.66)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C221(0.95); C247(1.07); C186(1.02); C124(1.23)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C221(0.98); C247(0.94); C186(0.88); C50(1.13)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C221(0.93); C247(1.00); C186(0.95); C124(1.00)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C221(1.00); C247(1.03); C186(1.30); C124(1.11)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C221(0.87); C247(0.93); C186(1.01); C54(1.30)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C221(0.99); C247(1.05); C186(0.83); C50(0.91)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C221(1.27); C247(0.97); C186(1.00); C54(0.93)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C221(1.09); C247(0.94); C186(1.02); C54(1.20)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C221(0.78); C247(0.93); C186(0.96); C54(1.03)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C221(1.06); C247(0.99); C186(1.04); C124(0.98)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C221(1.10); C247(0.99); C186(0.84); C50(0.96)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C221(0.52); C247(0.76); C186(1.09); C124(3.38)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C221(0.96); C247(0.94); C186(1.01); C124(1.46)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C221(1.09); C247(0.94); C186(0.90); C124(1.18)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C221(0.99); C247(1.06); C186(0.90); C124(1.09)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C221(0.90); C247(0.91); C186(1.00); C124(0.91)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C221(0.84); C247(0.83); C186(0.87); C54(0.69)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C221(1.11); C247(1.15); C186(1.02); C50(0.92)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C221(1.09); C247(0.96); C186(0.78); C54(1.00)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C221(0.99); C247(0.88); C186(0.99); C124(0.77)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C221(1.08); C247(0.97); C186(1.12); C54(1.07)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C221(1.03); C247(1.08); C186(1.17); C54(0.98)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C221(0.92); C247(0.98); C186(1.14); C124(1.03)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C221(0.72); C247(0.81); C186(1.06); C124(0.81)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C221(1.03); C247(1.02); C186(0.83); C50(1.08)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C221(0.85); C247(0.93); C186(1.03); C124(1.01)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C221(0.97); C247(0.94); C186(0.97); C124(0.91)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C221(0.92); C247(0.95); C186(1.00); C124(1.13)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C221(0.66); C247(0.84); C186(0.88); C124(0.85)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C221(0.83); C247(0.96); C186(0.94); C54(0.95)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C221(0.83); C247(1.00); C186(0.92); C50(0.82)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C221(0.96); C247(0.88); C186(0.80); C54(0.95)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C221(0.99); C247(0.88); C186(1.03); C124(0.90)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C221(1.09); C247(0.93); C186(0.76); C124(0.76)  LDD1698  [9]
 LDCM0204  EV-97 T cell C247(4.53)  LDD0525  [10]
 LDCM0573  Fragment11 MDA-MB-231 C124(0.95)  LDD1467  [11]
 LDCM0576  Fragment14 MDA-MB-231 C124(1.42)  LDD1471  [11]
 LDCM0578  Fragment27 MDA-MB-231 C124(0.96)  LDD1474  [11]
 LDCM0586  Fragment28 MDA-MB-231 C124(0.98)  LDD1475  [11]
 LDCM0468  Fragment33 HEK-293T C221(1.10); C247(0.86); C186(1.18); C124(0.69)  LDD1671  [9]
 LDCM0566  Fragment4 MDA-MB-231 C124(13.04)  LDD1461  [11]
 LDCM0603  Fragment45 MDA-MB-231 C124(20.00)  LDD1482  [11]
 LDCM0427  Fragment51 MDA-MB-231 C124(1.18)  LDD1483  [11]
 LDCM0570  Fragment8 MDA-MB-231 C124(5.36)  LDD1462  [11]
 LDCM0022  KB02 HEK-293T C221(0.96); C247(1.02); C186(0.87); C124(0.87)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C221(0.94); C247(0.91); C186(0.78); C124(0.97)  LDD1497  [9]
 LDCM0024  KB05 COLO792 C253(3.41)  LDD3310  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Inositol polyphosphate 5-phosphatase K (INPP5K) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q9BT40
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Zinc finger protein 202 (ZNF202) . O95125
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) MAD2 family Q13257
N-myc-interactor (NMI) NMI family Q13287
Shugoshin 2 (SGO2) Shugoshin family Q562F6
Fibronectin type III domain-containing protein 8 (FNDC8) . Q8TC99

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
11 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840