Details of the Target

General Information of Target

Target ID LDTP12883
Target Name Constitutive coactivator of PPAR-gamma-like protein 1 (FAM120A)
Gene Name FAM120A
Gene ID 23196
Synonyms
C9orf10; KIAA0183; OSSA; Constitutive coactivator of PPAR-gamma-like protein 1; Oxidative stress-associated SRC activator; Protein FAM120A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNDEDYSTIYDTIQNERTYEVPDQPEENESPHYDDVHEYLRPENDLYATQLNTHEYDFVS
VYTIKGEETSLASVQSEDRGYLLPDEIYSELQEAHPGEPQEDRGISMEGLYSSTQDQQLC
AAELQENGSVMKEDLPSPSSFTIQHSKAFSTTKYSCYSDAEGLEEKEGAHMNPEIYLFVK
AGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDV
KTDVNKIEEFLEETLTPEKYPKLAAKHRESNTAGIDIFSKFSAYIKNTKQQNNAALERGL
TKALKKLDDYLNTPLPEEIDANTCGEDKGSRRKFLDGDELTLADCNLLPKLHVVKIVAKK
YRNYDIPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVAKRLSRS
Target Bioclass
Other
Family
Constitutive coactivator of PPAR-gamma family
Subcellular location
Cytoplasm
Function
Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases. May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase. Binds IGF2 RNA and promotes the production of IGF2 protein.
Uniprot ID
Q9NZB2
Ensemble ID
ENST00000277165.11
HGNC ID
HGNC:13247
ChEMBL ID
CHEMBL4295966

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.M702T DBIA    Probe Info 
CCK81 SNV: p.R1104C DBIA    Probe Info 
COLO678 Deletion: p.E483GfsTer31 DBIA    Probe Info 
DOTC24510 SNV: p.P635R DBIA    Probe Info 
DU145 SNV: p.A1096T DBIA    Probe Info 
HCT15 SNV: p.V290A DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.S332T; p.K333R DBIA    Probe Info 
MFE319 SNV: p.R232L DBIA    Probe Info 
MOLT4 SNV: p.S927R IA-alkyne    Probe Info 
NCIH23 SNV: p.S652C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.68  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
W1
 Probe Info  		11.72  LDD0235  [4]
STPyne
 Probe Info  		K110(10.00); K673(0.67); K679(1.28)  LDD0277  [5]
OPA-S-S-alkyne
 Probe Info  		K673(1.15)  LDD3494  [6]
Probe 1
 Probe Info  		Y1020(12.01)  LDD3495  [7]
BTD
 Probe Info  		C279(0.93); C919(0.99)  LDD2089  [8]
Sulforaphane-probe2
 Probe Info  		1.82  LDD0160  [9]
DA-P3
 Probe Info  		5.76  LDD0183  [10]
AHL-Pu-1
 Probe Info  		C1103(2.62)  LDD0168  [11]
DBIA
 Probe Info  		C1088(14.21); C1103(14.21)  LDD0204  [12]
5E-2FA
 Probe Info  		H1076(0.00); H1093(0.00)  LDD2235  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C694(0.00); C279(0.00); C192(0.00); C669(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C53(0.00); C919(0.00); C694(0.00)  LDD0032  [15]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C694(0.00); C279(0.00); C825(0.00); C669(0.00)  LDD0037  [14]
JW-RF-010
 Probe Info  		C279(0.00); C919(0.00)  LDD0026  [17]
NAIA_4
 Probe Info  		C14(0.00); C174(0.00); C192(0.00); C279(0.00)  LDD2226  [18]
TFBX
 Probe Info  		C279(0.00); C919(0.00)  LDD0027  [17]
WYneN
 Probe Info  		C279(0.00); C1103(0.00); C531(0.00); C53(0.00)  LDD0021  [19]
aHNE
 Probe Info  		C919(0.00); C531(0.00); C1088(0.00); C1103(0.00)  LDD0001  [19]
Compound 10
 Probe Info  		C279(0.00); C531(0.00); C892(0.00); C919(0.00)  LDD2216  [20]
Compound 11
 Probe Info  		C1088(0.00); C279(0.00); C531(0.00); C892(0.00)  LDD2213  [20]
ENE
 Probe Info  		C919(0.00); C531(0.00)  LDD0006  [19]
IPM
 Probe Info  		C919(0.00); C279(0.00); C531(0.00)  LDD0005  [19]
VSF
 Probe Info  		C1103(0.00); C1088(0.00); C531(0.00)  LDD0007  [19]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [21]
Acrolein
 Probe Info  		C919(0.00); C53(0.00); C14(0.00); C1103(0.00)  LDD0217  [22]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [22]
Methacrolein
 Probe Info  		C919(0.00); C53(0.00); C14(0.00); C694(0.00)  LDD0218  [22]
AOyne
 Probe Info  		12.60  LDD0443  [23]
NAIA_5
 Probe Info  		C825(0.00); C192(0.00); C669(0.00); C531(0.00)  LDD2223  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C279(0.66)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C279(0.55); C919(0.96)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C279(0.93); C53(1.15); C919(1.02)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C694(1.48); C53(1.28); C919(1.29); C174(2.01)  LDD2152  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C279(1.03)  LDD2132  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C14(1.03)  LDD2131  [8]
 LDCM0025  4SU-RNA HEK-293T C1103(2.62)  LDD0168  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C279(2.06); C1103(3.18)  LDD0169  [11]
 LDCM0214  AC1 HEK-293T C14(1.06); C694(1.05); C279(1.17); C531(1.10)  LDD1507  [24]
 LDCM0215  AC10 HEK-293T C694(0.76); C279(0.91); C531(1.04); C919(1.01)  LDD1508  [24]
 LDCM0226  AC11 HEK-293T C14(1.06); C694(1.03); C279(0.99); C531(1.10)  LDD1509  [24]
 LDCM0237  AC12 HEK-293T C14(1.17); C694(1.13); C279(1.05); C531(1.07)  LDD1510  [24]
 LDCM0259  AC14 HEK-293T C14(1.07); C694(1.03); C279(1.00); C531(0.98)  LDD1512  [24]
 LDCM0270  AC15 HEK-293T C14(1.09); C694(0.96); C279(1.04); C531(1.00)  LDD1513  [24]
 LDCM0276  AC17 HEK-293T C14(1.03); C694(1.11); C279(1.08); C531(1.13)  LDD1515  [24]
 LDCM0277  AC18 HEK-293T C694(0.83); C279(0.97); C531(1.01); C919(1.00)  LDD1516  [24]
 LDCM0278  AC19 HEK-293T C14(1.02); C694(0.95); C279(0.87); C531(0.99)  LDD1517  [24]
 LDCM0279  AC2 HEK-293T C694(0.93); C279(0.97); C531(1.05); C919(1.03)  LDD1518  [24]
 LDCM0280  AC20 HEK-293T C14(0.96); C694(1.13); C279(1.01); C531(0.90)  LDD1519  [24]
 LDCM0281  AC21 HEK-293T C14(0.92); C694(1.13); C279(0.89); C531(0.99)  LDD1520  [24]
 LDCM0282  AC22 HEK-293T C14(0.99); C694(0.97); C279(1.00); C531(1.03)  LDD1521  [24]
 LDCM0283  AC23 HEK-293T C14(1.02); C694(0.90); C279(0.98); C531(1.06)  LDD1522  [24]
 LDCM0284  AC24 HEK-293T C14(1.02); C694(0.99); C279(1.01); C531(1.12)  LDD1523  [24]
 LDCM0285  AC25 HEK-293T C14(1.08); C694(0.93); C279(1.07); C531(1.05)  LDD1524  [24]
 LDCM0286  AC26 HEK-293T C694(1.21); C279(1.03); C531(0.97); C919(1.00)  LDD1525  [24]
 LDCM0287  AC27 HEK-293T C14(0.98); C694(1.08); C279(1.03); C531(1.03)  LDD1526  [24]
 LDCM0288  AC28 HEK-293T C14(1.06); C694(1.09); C279(1.02); C531(0.96)  LDD1527  [24]
 LDCM0289  AC29 HEK-293T C14(1.03); C694(1.03); C279(1.05); C531(0.98)  LDD1528  [24]
 LDCM0290  AC3 HEK-293T C14(1.02); C694(1.04); C279(1.02); C531(1.08)  LDD1529  [24]
 LDCM0291  AC30 HEK-293T C14(1.16); C694(1.08); C279(0.94); C531(0.95)  LDD1530  [24]
 LDCM0292  AC31 HEK-293T C14(1.01); C694(0.97); C279(1.07); C531(0.94)  LDD1531  [24]
 LDCM0293  AC32 HEK-293T C14(0.95); C694(0.99); C279(0.98); C531(0.98)  LDD1532  [24]
 LDCM0294  AC33 HEK-293T C14(1.01); C694(1.04); C279(1.10); C531(1.06)  LDD1533  [24]
 LDCM0295  AC34 HEK-293T C694(0.80); C279(0.93); C531(1.03); C919(1.03)  LDD1534  [24]
 LDCM0296  AC35 HEK-293T C14(1.11); C694(0.98); C279(1.02); C531(1.10)  LDD1535  [24]
 LDCM0297  AC36 HEK-293T C14(1.11); C694(0.98); C279(1.11); C531(0.99)  LDD1536  [24]
 LDCM0298  AC37 HEK-293T C14(1.08); C694(1.08); C279(1.02); C531(0.89)  LDD1537  [24]
 LDCM0299  AC38 HEK-293T C14(1.18); C694(1.12); C279(1.01); C531(0.99)  LDD1538  [24]
 LDCM0300  AC39 HEK-293T C14(1.12); C694(0.88); C279(0.92); C531(0.97)  LDD1539  [24]
 LDCM0301  AC4 HEK-293T C14(1.17); C694(1.06); C279(0.99); C531(0.99)  LDD1540  [24]
 LDCM0302  AC40 HEK-293T C14(1.03); C694(1.18); C279(1.00); C531(1.06)  LDD1541  [24]
 LDCM0303  AC41 HEK-293T C14(1.05); C694(0.91); C279(1.09); C531(1.10)  LDD1542  [24]
 LDCM0304  AC42 HEK-293T C694(1.04); C279(1.02); C531(1.10); C919(1.12)  LDD1543  [24]
 LDCM0305  AC43 HEK-293T C14(1.04); C694(1.06); C279(0.97); C531(1.17)  LDD1544  [24]
 LDCM0306  AC44 HEK-293T C14(1.18); C694(1.08); C279(1.00); C531(1.04)  LDD1545  [24]
 LDCM0307  AC45 HEK-293T C14(1.04); C694(1.08); C279(0.91); C531(1.03)  LDD1546  [24]
 LDCM0308  AC46 HEK-293T C14(1.12); C694(0.99); C279(1.07); C531(0.99)  LDD1547  [24]
 LDCM0309  AC47 HEK-293T C14(1.08); C694(0.89); C279(0.98); C531(0.92)  LDD1548  [24]
 LDCM0310  AC48 HEK-293T C14(1.07); C694(1.07); C279(0.99); C531(0.97)  LDD1549  [24]
 LDCM0311  AC49 HEK-293T C14(1.06); C694(1.15); C279(1.12); C531(1.06)  LDD1550  [24]
 LDCM0312  AC5 HEK-293T C14(1.06); C694(0.96); C279(0.99); C531(1.07)  LDD1551  [24]
 LDCM0313  AC50 HEK-293T C694(1.06); C279(0.94); C531(1.11); C919(0.96)  LDD1552  [24]
 LDCM0314  AC51 HEK-293T C14(1.05); C694(1.05); C279(1.00); C531(1.13)  LDD1553  [24]
 LDCM0315  AC52 HEK-293T C14(1.17); C694(1.05); C279(1.09); C531(1.03)  LDD1554  [24]
 LDCM0316  AC53 HEK-293T C14(1.02); C694(1.07); C279(0.95); C531(1.01)  LDD1555  [24]
 LDCM0317  AC54 HEK-293T C14(1.13); C694(0.91); C279(1.05); C531(1.01)  LDD1556  [24]
 LDCM0318  AC55 HEK-293T C14(1.05); C694(0.86); C279(0.99); C531(1.05)  LDD1557  [24]
 LDCM0319  AC56 HEK-293T C14(1.05); C694(0.99); C279(0.97); C531(1.04)  LDD1558  [24]
 LDCM0320  AC57 HEK-293T C14(1.11); C694(0.78); C279(1.13); C531(1.06)  LDD1559  [24]
 LDCM0321  AC58 HEK-293T C694(0.87); C279(0.99); C531(1.09); C919(1.00)  LDD1560  [24]
 LDCM0322  AC59 HEK-293T C14(1.00); C694(1.06); C279(1.06); C531(1.14)  LDD1561  [24]
 LDCM0323  AC6 HEK-293T C14(1.13); C694(0.99); C279(1.03); C531(0.95)  LDD1562  [24]
 LDCM0324  AC60 HEK-293T C14(1.14); C694(1.08); C279(1.03); C531(1.00)  LDD1563  [24]
 LDCM0325  AC61 HEK-293T C14(1.07); C694(1.02); C279(0.94); C531(1.00)  LDD1564  [24]
 LDCM0326  AC62 HEK-293T C14(0.99); C694(1.02); C279(1.01); C531(1.03)  LDD1565  [24]
 LDCM0327  AC63 HEK-293T C14(1.01); C694(0.98); C279(1.00); C531(1.02)  LDD1566  [24]
 LDCM0328  AC64 HEK-293T C14(1.06); C694(1.16); C279(0.93); C531(1.14)  LDD1567  [24]
 LDCM0334  AC7 HEK-293T C14(1.06); C694(0.90); C279(0.99); C531(1.00)  LDD1568  [24]
 LDCM0345  AC8 HEK-293T C14(1.04); C694(1.31); C279(0.93); C531(1.02)  LDD1569  [24]
 LDCM0545  Acetamide MDA-MB-231 C53(0.62)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C53(0.88); C919(0.94)  LDD2113  [8]
 LDCM0248  AKOS034007472 HEK-293T C14(1.03); C694(1.02); C279(0.95); C531(1.02)  LDD1511  [24]
 LDCM0356  AKOS034007680 HEK-293T C14(1.04); C694(1.05); C279(1.15); C531(1.08)  LDD1570  [24]
 LDCM0275  AKOS034007705 HEK-293T C14(1.05); C694(1.39); C279(1.00); C531(1.01)  LDD1514  [24]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0405  [1]
 LDCM0102  BDHI 8 Jurkat C1088(14.21); C1103(14.21)  LDD0204  [12]
 LDCM0498  BS-3668 MDA-MB-231 C279(1.09); C919(0.75); C14(0.61); C531(1.28)  LDD2091  [8]
 LDCM0630  CCW28-3 231MFP C279(1.84); C919(1.37); C531(1.20)  LDD2214  [25]
 LDCM0108  Chloroacetamide HeLa C919(0.00); C53(0.00); C694(0.00); H918(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C279(1.76); C531(1.18); C919(1.04); C174(0.31)  LDD2227  [18]
 LDCM0367  CL1 HEK-293T C14(0.99); C694(1.01); C279(0.98); C531(1.19)  LDD1571  [24]
 LDCM0368  CL10 HEK-293T C14(1.10); C694(0.98); C279(1.08); C531(1.76)  LDD1572  [24]
 LDCM0369  CL100 HEK-293T C14(1.06); C279(0.96); C531(1.14); C919(0.98)  LDD1573  [24]
 LDCM0370  CL101 HEK-293T C14(0.97); C694(1.01); C279(1.03); C531(1.15)  LDD1574  [24]
 LDCM0371  CL102 HEK-293T C14(1.03); C694(1.09); C279(0.97); C531(1.12)  LDD1575  [24]
 LDCM0372  CL103 HEK-293T C694(0.83); C279(1.07); C531(1.01); C919(0.90)  LDD1576  [24]
 LDCM0373  CL104 HEK-293T C14(1.05); C279(0.93); C531(1.05); C919(0.97)  LDD1577  [24]
 LDCM0374  CL105 HEK-293T C14(0.92); C694(0.99); C279(1.05); C531(1.07)  LDD1578  [24]
 LDCM0375  CL106 HEK-293T C14(1.00); C694(1.36); C279(1.02); C531(1.11)  LDD1579  [24]
 LDCM0376  CL107 HEK-293T C694(1.14); C279(1.05); C531(0.93); C919(0.99)  LDD1580  [24]
 LDCM0377  CL108 HEK-293T C14(1.02); C279(0.97); C531(1.13); C919(0.89)  LDD1581  [24]
 LDCM0378  CL109 HEK-293T C14(0.98); C694(1.03); C279(1.06); C531(1.23)  LDD1582  [24]
 LDCM0379  CL11 HEK-293T C14(1.07); C694(0.92); C279(1.03); C531(1.17)  LDD1583  [24]
 LDCM0380  CL110 HEK-293T C14(1.03); C694(1.13); C279(0.98); C531(1.15)  LDD1584  [24]
 LDCM0381  CL111 HEK-293T C694(0.90); C279(0.96); C531(0.91); C919(1.03)  LDD1585  [24]
 LDCM0382  CL112 HEK-293T C14(1.00); C279(1.04); C531(1.12); C919(0.93)  LDD1586  [24]
 LDCM0383  CL113 HEK-293T C14(1.01); C694(1.08); C279(0.97); C531(1.02)  LDD1587  [24]
 LDCM0384  CL114 HEK-293T C14(1.04); C694(1.16); C279(1.01); C531(1.05)  LDD1588  [24]
 LDCM0385  CL115 HEK-293T C694(0.89); C279(1.03); C531(1.10); C919(1.02)  LDD1589  [24]
 LDCM0386  CL116 HEK-293T C14(1.15); C279(0.95); C531(1.02); C919(0.93)  LDD1590  [24]
 LDCM0387  CL117 HEK-293T C14(0.99); C694(0.98); C279(1.04); C531(1.04)  LDD1591  [24]
 LDCM0388  CL118 HEK-293T C14(1.06); C694(1.17); C279(1.03); C531(1.02)  LDD1592  [24]
 LDCM0389  CL119 HEK-293T C694(0.84); C279(1.01); C531(1.06); C919(1.02)  LDD1593  [24]
 LDCM0390  CL12 HEK-293T C14(1.00); C694(1.15); C279(1.01); C531(1.16)  LDD1594  [24]
 LDCM0391  CL120 HEK-293T C14(1.20); C279(0.93); C531(1.13); C919(0.98)  LDD1595  [24]
 LDCM0392  CL121 HEK-293T C14(0.97); C694(1.05); C279(1.00); C531(1.10)  LDD1596  [24]
 LDCM0393  CL122 HEK-293T C14(1.08); C694(1.62); C279(0.93); C531(1.07)  LDD1597  [24]
 LDCM0394  CL123 HEK-293T C694(1.08); C279(0.93); C531(1.06); C919(0.90)  LDD1598  [24]
 LDCM0395  CL124 HEK-293T C14(1.06); C279(1.03); C531(1.11); C919(0.84)  LDD1599  [24]
 LDCM0396  CL125 HEK-293T C14(0.98); C694(1.06); C279(0.97); C531(1.09)  LDD1600  [24]
 LDCM0397  CL126 HEK-293T C14(0.99); C694(1.03); C279(1.06); C531(1.04)  LDD1601  [24]
 LDCM0398  CL127 HEK-293T C694(0.86); C279(1.11); C531(0.92); C919(0.87)  LDD1602  [24]
 LDCM0399  CL128 HEK-293T C14(1.11); C279(1.00); C531(1.13); C919(0.83)  LDD1603  [24]
 LDCM0400  CL13 HEK-293T C14(0.94); C694(0.92); C279(0.96); C531(1.40)  LDD1604  [24]
 LDCM0401  CL14 HEK-293T C14(0.91); C694(1.25); C279(1.04); C531(1.23)  LDD1605  [24]
 LDCM0402  CL15 HEK-293T C694(0.91); C279(0.95); C531(1.16); C919(0.89)  LDD1606  [24]
 LDCM0403  CL16 HEK-293T C14(1.12); C279(0.95); C531(1.21); C919(0.91)  LDD1607  [24]
 LDCM0404  CL17 HEK-293T C14(1.01); C694(1.30); C279(1.05); C531(1.25)  LDD1608  [24]
 LDCM0405  CL18 HEK-293T C694(1.04); C279(0.95); C531(1.19); C919(0.98)  LDD1609  [24]
 LDCM0406  CL19 HEK-293T C14(1.04); C694(1.04); C279(1.03); C531(1.19)  LDD1610  [24]
 LDCM0407  CL2 HEK-293T C14(1.08); C694(0.94); C279(1.04); C531(1.07)  LDD1611  [24]
 LDCM0408  CL20 HEK-293T C14(1.14); C694(1.02); C279(1.04); C531(1.15)  LDD1612  [24]
 LDCM0409  CL21 HEK-293T C14(1.22); C694(0.96); C279(0.95); C531(1.51)  LDD1613  [24]
 LDCM0410  CL22 HEK-293T C14(1.14); C694(1.02); C279(1.02); C531(1.10)  LDD1614  [24]
 LDCM0411  CL23 HEK-293T C14(1.08); C694(0.90); C279(1.03); C531(1.17)  LDD1615  [24]
 LDCM0412  CL24 HEK-293T C14(1.05); C694(0.78); C279(1.08); C531(1.17)  LDD1616  [24]
 LDCM0413  CL25 HEK-293T C14(0.96); C694(1.03); C279(0.95); C531(1.06)  LDD1617  [24]
 LDCM0414  CL26 HEK-293T C14(1.07); C694(1.17); C279(1.01); C531(1.02)  LDD1618  [24]
 LDCM0415  CL27 HEK-293T C694(0.71); C279(0.99); C531(1.03); C919(0.84)  LDD1619  [24]
 LDCM0416  CL28 HEK-293T C14(0.91); C279(0.91); C531(1.10); C919(0.94)  LDD1620  [24]
 LDCM0417  CL29 HEK-293T C14(1.15); C694(1.00); C279(1.01); C531(0.97)  LDD1621  [24]
 LDCM0418  CL3 HEK-293T C694(0.78); C279(1.00); C531(0.91); C919(0.93)  LDD1622  [24]
 LDCM0419  CL30 HEK-293T C694(0.97); C279(0.95); C531(1.02); C919(0.99)  LDD1623  [24]
 LDCM0420  CL31 HEK-293T C14(1.01); C694(0.99); C279(1.01); C531(1.11)  LDD1624  [24]
 LDCM0421  CL32 HEK-293T C14(1.11); C694(0.98); C279(1.06); C531(0.95)  LDD1625  [24]
 LDCM0422  CL33 HEK-293T C14(1.11); C694(1.10); C279(0.99); C531(1.76)  LDD1626  [24]
 LDCM0423  CL34 HEK-293T C14(1.11); C694(0.97); C279(0.96); C531(1.01)  LDD1627  [24]
 LDCM0424  CL35 HEK-293T C14(1.07); C694(0.92); C279(1.04); C531(1.08)  LDD1628  [24]
 LDCM0425  CL36 HEK-293T C14(0.96); C694(0.92); C279(1.00); C531(1.17)  LDD1629  [24]
 LDCM0426  CL37 HEK-293T C14(0.96); C694(1.00); C279(1.04); C531(1.05)  LDD1630  [24]
 LDCM0428  CL39 HEK-293T C694(0.72); C279(0.94); C531(1.46); C919(1.09)  LDD1632  [24]
 LDCM0429  CL4 HEK-293T C14(1.01); C279(0.98); C531(1.16); C919(0.85)  LDD1633  [24]
 LDCM0430  CL40 HEK-293T C14(1.15); C279(1.03); C531(1.04); C919(1.02)  LDD1634  [24]
 LDCM0431  CL41 HEK-293T C14(1.07); C694(0.76); C279(1.06); C531(1.19)  LDD1635  [24]
 LDCM0432  CL42 HEK-293T C694(0.93); C279(0.93); C531(1.15); C919(1.01)  LDD1636  [24]
 LDCM0433  CL43 HEK-293T C14(1.04); C694(0.96); C279(0.99); C531(1.13)  LDD1637  [24]
 LDCM0434  CL44 HEK-293T C14(1.12); C694(0.99); C279(1.11); C531(0.99)  LDD1638  [24]
 LDCM0435  CL45 HEK-293T C14(1.00); C694(1.04); C279(1.28); C531(1.48)  LDD1639  [24]
 LDCM0436  CL46 HEK-293T C14(1.14); C694(0.98); C279(1.01); C531(1.03)  LDD1640  [24]
 LDCM0437  CL47 HEK-293T C14(1.06); C694(1.00); C279(0.96); C531(1.25)  LDD1641  [24]
 LDCM0438  CL48 HEK-293T C14(1.02); C694(1.33); C279(0.99); C531(1.13)  LDD1642  [24]
 LDCM0439  CL49 HEK-293T C14(0.96); C694(1.11); C279(1.01); C531(0.98)  LDD1643  [24]
 LDCM0440  CL5 HEK-293T C14(0.95); C694(1.04); C279(1.12); C531(1.09)  LDD1644  [24]
 LDCM0441  CL50 HEK-293T C14(1.07); C694(1.11); C279(1.06); C531(1.13)  LDD1645  [24]
 LDCM0443  CL52 HEK-293T C14(1.09); C279(0.99); C531(1.07); C919(1.00)  LDD1646  [24]
 LDCM0444  CL53 HEK-293T C14(1.04); C694(1.13); C279(1.03); C531(1.13)  LDD1647  [24]
 LDCM0445  CL54 HEK-293T C694(0.79); C279(0.90); C531(1.39); C919(1.19)  LDD1648  [24]
 LDCM0446  CL55 HEK-293T C14(1.12); C694(1.09); C279(1.04); C531(1.12)  LDD1649  [24]
 LDCM0447  CL56 HEK-293T C14(1.22); C694(1.03); C279(1.05); C531(1.28)  LDD1650  [24]
 LDCM0448  CL57 HEK-293T C14(1.09); C694(0.91); C279(0.96); C531(1.45)  LDD1651  [24]
 LDCM0449  CL58 HEK-293T C14(1.16); C694(0.99); C279(0.97); C531(1.06)  LDD1652  [24]
 LDCM0450  CL59 HEK-293T C14(1.14); C694(0.93); C279(0.97); C531(1.21)  LDD1653  [24]
 LDCM0451  CL6 HEK-293T C694(0.81); C279(0.94); C531(1.18); C919(1.15)  LDD1654  [24]
 LDCM0452  CL60 HEK-293T C14(1.15); C694(1.07); C279(1.09); C531(1.12)  LDD1655  [24]
 LDCM0453  CL61 HEK-293T C14(1.01); C694(0.96); C279(1.00); C531(1.07)  LDD1656  [24]
 LDCM0454  CL62 HEK-293T C14(0.97); C694(1.06); C279(1.12); C531(1.06)  LDD1657  [24]
 LDCM0455  CL63 HEK-293T C694(0.79); C279(1.01); C531(0.92); C919(1.03)  LDD1658  [24]
 LDCM0456  CL64 HEK-293T C14(0.99); C279(0.87); C531(1.11); C919(0.99)  LDD1659  [24]
 LDCM0457  CL65 HEK-293T C14(1.03); C694(0.97); C279(1.10); C531(1.07)  LDD1660  [24]
 LDCM0458  CL66 HEK-293T C694(0.92); C279(0.99); C531(1.15); C919(1.11)  LDD1661  [24]
 LDCM0459  CL67 HEK-293T C14(1.09); C694(1.12); C279(1.03); C531(1.07)  LDD1662  [24]
 LDCM0460  CL68 HEK-293T C14(1.17); C694(1.12); C279(0.98); C531(1.05)  LDD1663  [24]
 LDCM0461  CL69 HEK-293T C14(0.97); C694(0.99); C279(1.01); C531(1.20)  LDD1664  [24]
 LDCM0462  CL7 HEK-293T C14(1.07); C694(1.09); C279(1.05); C531(1.14)  LDD1665  [24]
 LDCM0463  CL70 HEK-293T C14(1.05); C694(1.04); C279(0.99); C531(1.03)  LDD1666  [24]
 LDCM0464  CL71 HEK-293T C14(1.07); C694(0.94); C279(1.01); C531(1.21)  LDD1667  [24]
 LDCM0465  CL72 HEK-293T C14(1.06); C694(1.03); C279(0.99); C531(1.15)  LDD1668  [24]
 LDCM0466  CL73 HEK-293T C14(1.03); C694(0.99); C279(0.96); C531(1.17)  LDD1669  [24]
 LDCM0467  CL74 HEK-293T C14(0.93); C694(1.41); C279(1.04); C531(1.10)  LDD1670  [24]
 LDCM0469  CL76 HEK-293T C14(1.05); C279(0.98); C531(1.08); C919(0.88)  LDD1672  [24]
 LDCM0470  CL77 HEK-293T C14(1.04); C694(1.01); C279(1.12); C531(1.27)  LDD1673  [24]
 LDCM0471  CL78 HEK-293T C694(0.79); C279(0.90); C531(1.00); C919(1.02)  LDD1674  [24]
 LDCM0472  CL79 HEK-293T C14(1.06); C694(1.05); C279(1.00); C531(1.04)  LDD1675  [24]
 LDCM0473  CL8 HEK-293T C14(1.28); C694(1.09); C279(0.88); C531(2.04)  LDD1676  [24]
 LDCM0474  CL80 HEK-293T C14(1.06); C694(1.07); C279(1.04); C531(1.01)  LDD1677  [24]
 LDCM0475  CL81 HEK-293T C14(1.08); C694(1.09); C279(1.04); C531(1.01)  LDD1678  [24]
 LDCM0476  CL82 HEK-293T C14(1.17); C694(0.99); C279(1.03); C531(1.05)  LDD1679  [24]
 LDCM0477  CL83 HEK-293T C14(1.08); C694(0.99); C279(1.06); C531(1.00)  LDD1680  [24]
 LDCM0478  CL84 HEK-293T C14(0.98); C694(1.08); C279(0.93); C531(1.27)  LDD1681  [24]
 LDCM0479  CL85 HEK-293T C14(1.00); C694(0.99); C279(0.95); C531(1.07)  LDD1682  [24]
 LDCM0480  CL86 HEK-293T C14(1.02); C694(0.82); C279(1.02); C531(1.08)  LDD1683  [24]
 LDCM0481  CL87 HEK-293T C694(0.75); C279(1.02); C531(1.05); C919(0.84)  LDD1684  [24]
 LDCM0482  CL88 HEK-293T C14(1.07); C279(0.94); C531(1.21); C919(0.81)  LDD1685  [24]
 LDCM0483  CL89 HEK-293T C14(0.92); C694(0.99); C279(1.15); C531(1.01)  LDD1686  [24]
 LDCM0484  CL9 HEK-293T C14(0.98); C694(1.04); C279(1.04); C531(1.14)  LDD1687  [24]
 LDCM0485  CL90 HEK-293T C694(1.05); C279(0.91); C531(2.08); C919(1.17)  LDD1688  [24]
 LDCM0486  CL91 HEK-293T C14(1.01); C694(1.03); C279(0.94); C531(1.22)  LDD1689  [24]
 LDCM0487  CL92 HEK-293T C14(1.05); C694(1.17); C279(1.10); C531(1.07)  LDD1690  [24]
 LDCM0488  CL93 HEK-293T C14(1.09); C694(1.11); C279(0.83); C531(1.02)  LDD1691  [24]
 LDCM0489  CL94 HEK-293T C14(1.07); C694(1.02); C279(1.18); C531(0.97)  LDD1692  [24]
 LDCM0490  CL95 HEK-293T C14(1.10); C694(1.10); C279(0.95); C531(1.38)  LDD1693  [24]
 LDCM0491  CL96 HEK-293T C14(1.01); C694(1.07); C279(1.03); C531(1.24)  LDD1694  [24]
 LDCM0492  CL97 HEK-293T C14(1.02); C694(1.04); C279(1.03); C531(1.17)  LDD1695  [24]
 LDCM0493  CL98 HEK-293T C14(1.15); C694(1.03); C279(1.07); C531(0.98)  LDD1696  [24]
 LDCM0494  CL99 HEK-293T C694(0.83); C279(1.17); C531(1.31); C919(1.00)  LDD1697  [24]
 LDCM0634  CY-0357 Hep-G2 C919(0.73); C279(0.59); C531(0.53)  LDD2228  [18]
 LDCM0495  E2913 HEK-293T C694(0.58); C279(0.94); C531(1.09); C919(1.04)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C531(1.34); C919(1.30); C1088(1.30); C14(1.28)  LDD1702  [8]
 LDCM0031  Epigallocatechin gallate HEK-293T 5.76  LDD0183  [10]
 LDCM0625  F8 Ramos C279(0.72); C919(1.13); C531(0.83); 1.81  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C279(0.52); C919(6.09); 1.18  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C279(12.10); C919(0.66)  LDD2190  [26]
 LDCM0574  Fragment12 MDA-MB-231 C531(20.00)  LDD1468  [27]
 LDCM0575  Fragment13 Ramos C279(0.47); C919(1.25); C531(1.42); 1.06  LDD2192  [26]
 LDCM0576  Fragment14 Ramos C279(0.76); C919(0.75); C531(0.65); 1.18  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C279(0.34); C919(2.13); 0.98  LDD2194  [26]
 LDCM0580  Fragment21 MDA-MB-231 C531(1.59)  LDD1473  [27]
 LDCM0582  Fragment23 Ramos C279(0.97); C919(1.09); C531(0.64); 1.13  LDD2196  [26]
 LDCM0578  Fragment27 Ramos C279(0.45); C919(1.06); C531(0.79); 1.41  LDD2197  [26]
 LDCM0586  Fragment28 Ramos C279(0.79); C919(1.03); C531(1.01); 1.07  LDD2198  [26]
 LDCM0588  Fragment30 Ramos C279(0.48); C919(1.71); C531(1.37); 0.95  LDD2199  [26]
 LDCM0589  Fragment31 Ramos C279(0.40); C919(1.10); C531(0.89); 1.53  LDD2200  [26]
 LDCM0590  Fragment32 Ramos C279(1.62); C919(3.21)  LDD2201  [26]
 LDCM0468  Fragment33 MDA-MB-231 C531(2.40)  LDD1479  [27]
 LDCM0596  Fragment38 Ramos C279(0.37); C919(1.23); C531(0.42); 1.57  LDD2203  [26]
 LDCM0566  Fragment4 Ramos C279(0.77); C919(1.86); C531(0.86)  LDD2184  [26]
 LDCM0427  Fragment51 HEK-293T C14(1.05); C694(1.27); C279(0.94); C531(0.97)  LDD1631  [24]
 LDCM0610  Fragment52 Ramos C279(0.55); C919(1.49); C531(1.23); 1.30  LDD2204  [26]
 LDCM0614  Fragment56 MDA-MB-231 C531(0.55)  LDD1484  [27]
 LDCM0569  Fragment7 Ramos C279(0.94); C919(1.83); C531(6.75); 1.12  LDD2186  [26]
 LDCM0571  Fragment9 Ramos C279(0.38); C919(3.33); 0.81  LDD2188  [26]
 LDCM0015  HNE MDA-MB-231 C919(0.89)  LDD0346  [26]
 LDCM0107  IAA HeLa C53(0.00); C694(0.00)  LDD0221  [22]
 LDCM0022  KB02 HEK-293T C919(0.97); C14(1.00); C694(0.92); C279(1.07)  LDD1492  [24]
 LDCM0023  KB03 Jurkat C531(8.84)  LDD0209  [12]
 LDCM0024  KB05 G361 C559(1.99); C947(2.68)  LDD3311  [28]
 LDCM0109  NEM HeLa H309(0.00); H956(0.00); H540(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C279(0.93); C919(0.99)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C919(1.04)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C279(0.98)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C694(1.38); C53(1.32); C919(1.14)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C279(1.02); C1103(0.85)  LDD2094  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C53(2.07); C825(0.55)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C53(0.93); C919(1.15)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C279(1.05); C14(0.54)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C694(1.19); C919(0.90); C14(1.03); C531(1.00)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C14(0.64)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C919(1.13)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C919(0.64)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C279(1.58)  LDD2105  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C279(1.17); C694(1.00); C53(0.90); C919(0.88)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C53(0.77); C919(0.93)  LDD2109  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C14(0.66)  LDD2110  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C694(1.48); C53(1.21); C919(1.03)  LDD2111  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C919(0.58)  LDD2115  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C53(1.47)  LDD2118  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C279(1.08); C694(1.72); C53(1.47)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C919(0.72); C1088(0.86)  LDD2120  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C279(1.19); C694(1.30); C53(1.00); C919(0.80)  LDD2123  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C279(1.11); C694(0.95); C53(1.04); C919(0.87)  LDD2125  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C694(1.19); C53(0.98); C919(1.12); C14(0.78)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C919(0.73)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C694(1.49); C53(1.17); C919(1.03); C14(0.95)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C919(0.81)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C919(0.66)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C694(1.93); C53(2.59); C919(1.04); C14(0.62)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C694(1.05); C919(1.40)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C279(1.07); C694(0.76); C53(1.04); C919(0.95)  LDD2137  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C694(1.26); C53(1.03); C919(0.84)  LDD2140  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C919(0.74); C1088(1.06)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C279(1.25); C694(1.34); C53(2.10)  LDD2144  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C279(1.03); C694(1.29); C53(1.02); C919(0.98)  LDD2146  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C919(0.53)  LDD2148  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C279(0.85); C53(0.94); C919(0.80); C531(0.58)  LDD2150  [8]
 LDCM0628  OTUB2-COV-1 HEK-293T C919(1.70); C531(0.84)  LDD2207  [29]
 LDCM0131  RA190 MM1.R C919(4.67)  LDD0304  [30]
 LDCM0003  Sulforaphane MDA-MB-231 1.82  LDD0160  [9]
 LDCM0112  W16 Hep-G2 C531(1.98)  LDD0239  [4]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
10 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
28 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
29 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
30 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.