Details of the Target

General Information of Target

Target ID LDTP05795
Target Name Nucleoside diphosphate kinase 3 (NME3)
Gene Name NME3
Gene ID 4832
Synonyms
Nucleoside diphosphate kinase 3; NDK 3; NDP kinase 3; EC 2.7.4.6; DR-nm23; Nucleoside diphosphate kinase C; NDPKC; nm23-H3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MICLVLTIFANLFPAACTGAHERTFLAVKPDGVQRRLVGEIVRRFERKGFKLVALKLVQA
SEELLREHYAELRERPFYGRLVKYMASGPVVAMVWQGLDVVRTSRALIGATNPADAPPGT
IRGDFCIEVGKNLIHGSDSVESARREIALWFRADELLCWEDSAGHWLYE
Target Bioclass
Enzyme
Family
NDK family
Function
Catalyzes the phosphorylation of ribonucleosides and deoxyribonucleoside diphosphates, other than ATP, into the corresponding triphosphates with ATP as the major phosphate donor. The ATP gamma phosphate is transferred to the nucleoside diphosphate beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis. Inhibits granulocyte differentiation. May be required for ciliary function during renal development.; Independently of its kinase activity, facilitates mitochondrial tethering prior to membrane fusion through its direct membrane-binding and hexamerization. Implicated in repair of both single- and double-stranded breaks in DNA through its association with the ribonucleotide reductase complex (RNR complex) via its interaction with the histone acetyltransferase KAT5, this interaction enables recruitment of NME3 at DNA damage sites where it plays a role in the repair of DNA, independently of its kinase activity.
Uniprot ID
Q13232
Ensemble ID
ENST00000219302.8
HGNC ID
HGNC:7851

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C126(2.38)  LDD3313  [2]
P12
 Probe Info  		20.00  LDD0202  [3]
Alkyne-RA190
 Probe Info  		3.39  LDD0300  [4]
EA-probe
 Probe Info  		N.A.  LDD0440  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0149  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
Acrolein
 Probe Info  		C126(0.00); C158(0.00)  LDD0217  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C269
 Probe Info  		5.98  LDD1939  [12]
Alk-rapa
 Probe Info  		7.02  LDD0213  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C126(0.92); C158(1.14)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C126(0.96); C158(0.90)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C126(1.00); C158(1.04)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C126(1.02); C158(1.00)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C126(0.96); C158(0.92)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C126(1.04); C158(0.96)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C126(0.91); C158(1.09)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C126(0.95); C158(0.91)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C126(0.88); C158(1.36)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C126(0.97); C158(0.94)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C126(0.97); C158(0.95)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C126(1.01); C158(0.96)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C126(0.95); C158(0.94)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C126(1.01); C158(0.91)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C126(0.98); C158(1.00)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C126(0.92); C158(0.92)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C126(1.00); C158(0.95)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C126(0.98); C158(1.06)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C126(0.97); C158(0.87)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C126(1.04); C158(0.95)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C126(1.00); C158(0.92)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C126(0.99); C158(0.93)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C126(1.00); C158(0.98)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C126(0.98); C158(0.94)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C126(0.94); C158(1.18)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C126(0.94); C158(1.03)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C126(1.04); C158(1.02)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C126(0.99); C158(1.00)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C126(1.06); C158(0.94)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C126(1.01); C158(0.99)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C126(1.00); C158(1.04)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C126(1.00); C158(0.97)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C126(1.04); C158(1.16)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C126(0.92); C158(1.29)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C126(1.00); C158(0.87)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C126(0.99); C158(1.00)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C126(0.99); C158(0.98)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C126(1.01); C158(0.95)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C126(1.01); C158(0.95)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C126(1.05); C158(1.05)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C126(0.99); C158(1.00)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C126(0.90); C158(1.13)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C126(1.08); C158(1.04)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C126(0.95); C158(0.97)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C126(1.01); C158(1.04)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C126(0.97); C158(1.05)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C126(0.99); C158(1.00)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C126(0.90); C158(0.96)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C126(1.01); C158(0.95)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C126(1.02); C158(1.02)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C126(0.92); C158(1.00)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C126(1.00); C158(0.93)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C126(0.99); C158(1.01)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C126(0.98); C158(0.85)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C126(0.98); C158(0.99)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C126(0.97); C158(0.96)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C126(0.94); C158(0.94)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C126(0.94); C158(1.01)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C126(1.00); C158(0.95)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C126(1.04); C158(0.98)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C126(1.00); C158(1.05)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C126(1.08); C158(0.93)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C126(0.93); C158(1.31)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C126(0.98); C158(1.00)  LDD1514  [14]
 LDCM0156  Aniline NCI-H1299 12.27  LDD0403  [1]
 LDCM0088  C45 HEK-293T 20.00  LDD0202  [3]
 LDCM0630  CCW28-3 231MFP C158(1.26)  LDD2214  [15]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C158(20.00)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C126(0.92); C158(0.98)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C126(1.07); C158(0.55)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C126(0.91); C158(1.08)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C126(0.95); C158(1.05)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C126(1.02); C158(1.26)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C126(0.94); C158(0.95)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C126(0.90); C158(1.13)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C126(0.99); C158(1.00)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C126(0.91); C158(1.05)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C126(0.92); C158(0.94)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C126(0.99); C158(1.08)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C126(0.99); C158(1.03)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C126(1.14); C158(1.02)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C126(0.90); C158(1.13)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C126(0.91); C158(1.12)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C126(0.91); C158(1.49)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C126(0.99); C158(1.00)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C126(1.10); C158(1.31)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C126(0.98); C158(0.95)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C126(0.87); C158(0.96)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C126(0.97); C158(1.04)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C126(1.01); C158(0.99)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C126(1.02); C158(0.90)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C126(1.04); C158(1.08)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C126(0.92); C158(1.09)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C126(0.94); C158(0.89)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C126(0.93); C158(0.95)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C126(0.93); C158(0.87)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C126(0.85); C158(1.12)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C126(0.95); C158(0.96)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C126(0.93); C158(0.90)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C126(0.96); C158(1.01)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C126(0.95); C158(1.17)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C126(0.94); C158(1.17)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C126(0.92); C158(1.09)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C126(0.85); C158(1.15)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C126(0.96); C158(1.13)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C126(0.89); C158(1.27)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C126(1.00); C158(0.98)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C126(1.10); C158(0.97)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C126(1.01); C158(0.95)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C126(1.06); C158(0.99)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C126(1.02); C158(1.08)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C126(1.08); C158(0.99)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C126(1.09); C158(1.02)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C126(1.10); C158(1.07)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C126(0.93); C158(0.97)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C126(0.96); C158(1.04)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C126(0.94); C158(1.00)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C126(0.97); C158(1.12)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C126(0.93); C158(1.12)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C126(0.97); C158(1.01)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C126(0.98); C158(0.93)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C126(1.06); C158(1.00)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C126(1.00); C158(1.05)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C126(1.13); C158(1.10)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C126(1.06); C158(0.95)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C126(1.03); C158(1.03)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C126(1.08); C158(1.12)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C126(0.99); C158(1.06)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C126(0.95); C158(0.99)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C126(0.84); C158(0.88)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C126(0.89); C158(0.99)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C126(0.91); C158(1.10)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C126(1.01); C158(0.95)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C126(1.05); C158(0.91)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C126(1.01); C158(0.94)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C126(1.05); C158(0.76)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C126(1.08); C158(0.94)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C126(1.10); C158(0.99)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C126(1.00); C158(1.07)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C126(0.97); C158(0.92)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C126(0.96); C158(1.16)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C126(1.02); C158(1.07)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C126(0.74); C158(0.95)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C126(0.92); C158(1.04)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C126(1.01); C158(0.78)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C126(1.09); C158(0.89)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C126(1.09); C158(1.14)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C126(1.04); C158(0.95)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C126(1.07); C158(0.85)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C126(1.18); C158(0.95)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C126(1.07); C158(0.99)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C126(0.90); C158(1.15)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C126(0.94); C158(0.99)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C126(0.97); C158(1.04)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C126(0.96); C158(0.97)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C126(0.85); C158(0.96)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C126(0.94); C158(1.03)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C126(0.96); C158(0.88)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C126(1.04); C158(1.02)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C126(1.06); C158(0.97)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C126(1.18); C158(0.96)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C126(1.09); C158(1.02)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C126(1.02); C158(0.86)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C126(1.11); C158(0.96)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C126(1.03); C158(1.15)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C126(0.96); C158(0.99)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C126(0.96); C158(1.04)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C126(0.93); C158(1.07)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C126(0.88); C158(1.23)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C126(0.99); C158(0.96)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C126(1.11); C158(0.95)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C126(1.00); C158(1.01)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C126(1.07); C158(0.82)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C126(1.16); C158(0.98)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C126(1.02); C158(1.00)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C126(1.10); C158(1.04)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C126(1.01); C158(1.22)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C126(0.91); C158(0.96)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C126(1.01); C158(0.87)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C126(0.99); C158(0.98)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C126(0.88); C158(0.78)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C126(0.92); C158(1.28)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C126(1.11); C158(1.00)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C126(0.96); C158(0.84)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C126(1.13); C158(0.89)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C126(1.05); C158(0.77)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C126(1.07); C158(1.09)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C126(1.04); C158(0.98)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C126(1.01); C158(1.14)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C126(0.98); C158(1.12)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C126(1.00); C158(1.03)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C126(1.03); C158(0.97)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C126(0.95); C158(0.88)  LDD1697  [14]
 LDCM0634  CY-0357 Hep-G2 C158(3.18)  LDD2228  [7]
 LDCM0495  E2913 HEK-293T C126(0.91); C158(0.95)  LDD1698  [14]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [5]
 LDCM0587  Fragment29 Ramos C158(1.50)  LDD1476  [16]
 LDCM0468  Fragment33 HEK-293T C126(0.94); C158(0.89)  LDD1671  [14]
 LDCM0603  Fragment45 MDA-MB-231 C158(8.77)  LDD1482  [16]
 LDCM0427  Fragment51 HEK-293T C126(0.96); C158(0.93)  LDD1631  [14]
 LDCM0571  Fragment9 MDA-MB-231 C158(2.72)  LDD1463  [16]
 LDCM0022  KB02 HEK-293T C158(1.09)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C158(1.06)  LDD1497  [14]
 LDCM0024  KB05 Hs 936.T C126(2.38)  LDD3313  [2]
 LDCM0109  NEM HeLa H135(0.00); H68(0.00)  LDD0223  [10]
 LDCM0628  OTUB2-COV-1 HEK-293T C158(1.04)  LDD2207  [17]
 LDCM0131  RA190 MM1.R 3.39  LDD0300  [4]
 LDCM0090  Rapamycin JHH-7 7.02  LDD0213  [13]
 LDCM0170  Structure8 Ramos 9.30  LDD0433  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Desumoylating isopeptidase 1 (DESI1) DeSI family Q6ICB0
Nucleoside diphosphate kinase A (NME1) NDK family P15531
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0
Ubiquilin-1 (UBQLN1) . Q9UMX0
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
4 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
16 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
18 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.