Details of the Target

General Information of Target

Target ID LDTP19787
Target Name RING finger protein 214 (RNF214)
Gene Name RNF214
Gene ID 257160
Synonyms
RING finger protein 214
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLAPQGRSFSKKRMGLNRWKRFTRKPSPKPTFGPDSVEHWIKRVEKASEFAVSNAFFTR
NSDLPRSPWGQITDLKTSEQIEDHDEIYAEAQELVNDWLDTKLKQELASEEEGDAKNTVS
SVTIMPEANGHLKYDKFDDLCGYLEEEEESTTVQKFIDHLLHKNVVDSAMMEDLGRKENQ
DKKQQKDPRLTMEMRHKQVKENRLRREKELEYQRIEKTLKKSAFLEAQCLVQEEKKRKAL
EAKKEEEEIQREMVKLRREIIERRRTVKAAWKIEKKRQEENSQNSSEKVMFQSTHILPDE
EKMVKERKRKLKEVLIQTFKENQQCQKRYFAAWHKLILDHRIKLGKAGTLSDWKIQLKVL
RAWRDYTRFQKLERETQALENDLREENRKQQLATEYNRKQVLRHCFTEWQHWHGAELLKR
ELALTKEETRKKMDALLQAASLGKLSANGLSGISLPEEATAMVGPPVKNGQETAVPPLWE
KPPLGSSGCMLSPPLGRTTTGNLQGSLQNVSLSAPGNKQHKTLGAEPSQQPGSNETLRTT
SQKAEPLCLGHFHNRHVFQQQLIEKQKKKLQEQQKTILELKKNLQLAEAQWAAEHALAVT
EAQSHLLSKPREEEPRTCQMLVNSPVASPGTEGRSDSRNSLSGLRRKPKQLMTPHPILKA
MEERAIQRAECRRILAEKKKKQEEEKLAQLKAQEEERQKREAEEKEAQLERKREEKRLKK
MKELEKQKRIKRNQQLEAIAKEHYERVLLRKKGLEPWKRLRMQSKQNIQVAEEHYSLFLQ
RKYMLTWFQRSQESLARKMAQADQFYSQILLKRVIQSWLQYVIDLQEEVRKFCVHFLQKK
IFRAWFNMVREVKIDSQGKHEIAAEHSDRRILWITLRTWKKFVKFMKEERVKEERRQQLR
RKVVEILPDFQVPGRYHELYQQSDTWSLSKTSLVNE
Target Bioclass
Other
Uniprot ID
Q8ND24
Ensemble ID
ENST00000300650.9
HGNC ID
HGNC:25335

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DOTC24510 SNV: p.Q192Ter .
MFE319 SNV: p.D219Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C655(1.69)  LDD1700  [2]
DA-P3
 Probe Info  		32.52  LDD0179  [3]
DBIA
 Probe Info  		C696(0.98); C699(0.98); C658(0.93); C661(0.93)  LDD0078  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
NAIA_4
 Probe Info  		C149(0.00); C655(0.00)  LDD2226  [6]
NAIA_5
 Probe Info  		N.A.  LDD2225  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
WYneO
 Probe Info  		N.A.  LDD0022  [7]
Compound 11
 Probe Info  		N.A.  LDD2213  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0150  [9]
IPM
 Probe Info  		N.A.  LDD0005  [7]
NHS
 Probe Info  		N.A.  LDD0010  [7]
STPyne
 Probe Info  		K554(0.00); K582(0.00)  LDD0009  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
VSF
 Probe Info  		N.A.  LDD0007  [7]
Phosphinate-6
 Probe Info  		C655(0.00); C149(0.00)  LDD0018  [11]
W1
 Probe Info  		N.A.  LDD0236  [12]
AOyne
 Probe Info  		12.70  LDD0443  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C655(0.41)  LDD2132  [2]
 LDCM0214  AC1 HCT 116 C655(2.01)  LDD0531  [4]
 LDCM0215  AC10 HEK-293T C699(0.80)  LDD0813  [4]
 LDCM0216  AC100 HEK-293T C699(1.06)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C699(1.10)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C699(1.06)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C699(1.31)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C699(1.28)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C699(0.89)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C699(0.85)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C699(1.41)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C699(1.10)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C699(0.99)  LDD0823  [4]
 LDCM0226  AC11 HEK-293T C699(0.78)  LDD0824  [4]
 LDCM0227  AC110 HEK-293T C699(1.46)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C699(2.03)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C699(1.49)  LDD0827  [4]
 LDCM0237  AC12 HEK-293T C699(0.93)  LDD0835  [4]
 LDCM0246  AC128 HEK-293T C658(1.03); C661(1.03); C699(0.99)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C658(1.20); C661(1.20); C699(1.25)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C658(1.18); C661(1.18); C699(1.08)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C658(1.04); C661(1.04); C699(1.06)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C658(1.13); C661(1.13); C699(1.22)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C658(1.20); C661(1.20); C699(1.40)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C658(1.53); C661(1.53); C699(1.17)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C658(1.72); C661(1.72); C699(1.89)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C658(1.19); C661(1.19); C699(1.23)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C658(1.71); C661(1.71); C699(1.92)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C658(2.09); C661(2.09); C699(1.90)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C658(1.82); C661(1.82); C699(1.73)  LDD0856  [4]
 LDCM0259  AC14 HEK-293T C699(0.84)  LDD0857  [4]
 LDCM0260  AC140 HEK-293T C658(1.48); C661(1.48); C699(1.42)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C658(1.61); C661(1.61); C699(1.43)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C658(1.91); C661(1.91); C699(1.53)  LDD0860  [4]
 LDCM0270  AC15 HEK-293T C699(0.92)  LDD0868  [4]
 LDCM0276  AC17 HEK-293T C699(1.14)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C699(1.56)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C699(1.36)  LDD0876  [4]
 LDCM0279  AC2 HCT 116 C655(1.53)  LDD0596  [4]
 LDCM0280  AC20 HEK-293T C699(1.28)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C699(1.09)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C699(1.48)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C699(1.91)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C699(1.00)  LDD0882  [4]
 LDCM0285  AC25 HEK-293T C658(1.40); C661(1.40); C699(1.13)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C658(1.51); C661(1.51); C699(1.48)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C658(1.73); C661(1.73); C699(1.44)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C658(1.86); C661(1.86); C699(1.25)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C658(1.84); C661(1.84); C699(1.42)  LDD0887  [4]
 LDCM0290  AC3 HCT 116 C655(1.70)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C658(1.65); C661(1.65); C699(1.48)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C658(1.32); C661(1.32); C699(1.18)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C658(1.40); C661(1.40); C699(1.22)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C658(2.13); C661(2.13); C699(1.25)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C658(1.30); C661(1.30); C699(1.10)  LDD0893  [4]
 LDCM0296  AC35 HCT 116 C655(1.27)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C655(0.98)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C655(0.54)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C655(0.55)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C655(1.02)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C655(1.73)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C655(0.50)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C655(0.36)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C655(0.36)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C655(0.33)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C655(0.26)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C655(0.31)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C655(0.97)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C655(1.08)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C655(0.71)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C655(0.48)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C655(1.95)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C655(0.63)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C655(0.54)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C655(0.61)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C655(0.89)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C655(0.61)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C655(1.08)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C655(0.64)  LDD0636  [4]
 LDCM0320  AC57 HEK-293T C658(0.98); C661(0.98); C699(1.06)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C658(0.82); C661(0.82); C699(1.21)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C658(1.15); C661(1.15); C699(1.21)  LDD0920  [4]
 LDCM0323  AC6 HEK-293T C699(0.62)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C658(1.43); C661(1.43); C699(1.39)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C658(2.14); C661(2.14); C699(1.38)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C658(1.45); C661(1.45); C699(1.56)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C658(1.54); C661(1.54); C699(1.50)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C658(1.27); C661(1.27); C699(1.38)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C658(1.86); C661(1.86); C699(1.55)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C658(1.09); C661(1.09); C699(1.30)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C658(1.32); C661(1.32); C699(1.29)  LDD0929  [4]
 LDCM0332  AC68 HEK-293T C658(0.91); C661(0.91)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C658(1.01); C661(1.01)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C699(0.90)  LDD0932  [4]
 LDCM0335  AC70 HEK-293T C658(1.04); C661(1.04)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C658(0.97); C661(0.97)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C658(0.93); C661(0.93)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C658(1.06); C661(1.06)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C658(1.81); C661(1.81)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C658(1.02); C661(1.02)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C658(1.08); C661(1.08)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C658(0.88); C661(0.88)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C658(1.34); C661(1.34)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C658(0.64); C661(0.64)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C699(0.85)  LDD0943  [4]
 LDCM0346  AC80 HEK-293T C658(1.07); C661(1.07)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C658(0.98); C661(0.98)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C658(1.03); C661(1.03)  LDD0946  [4]
 LDCM0349  AC83 HEK-293T C699(1.03)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C699(1.17)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C699(1.19)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C699(1.13)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C699(1.12)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C699(1.28)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C699(1.17)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C699(1.37)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C699(1.32)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C699(1.27)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C699(1.61)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C699(1.37)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C699(1.14)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C699(1.21)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C699(1.91)  LDD0962  [4]
 LDCM0365  AC98 HEK-293T C699(0.99)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C699(1.39)  LDD0964  [4]
 LDCM0545  Acetamide MDA-MB-231 C139(1.47)  LDD2138  [2]
 LDCM0248  AKOS034007472 HEK-293T C699(0.89)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C699(0.97)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C699(0.87)  LDD0873  [4]
 LDCM0020  ARS-1620 HCC44 C696(0.98); C699(0.98); C658(0.93); C661(0.93)  LDD0078  [4]
 LDCM0498  BS-3668 MDA-MB-231 C655(0.72); C315(0.65)  LDD2091  [2]
 LDCM0087  Capsaicin HEK-293T 29.00  LDD0185  [3]
 LDCM0632  CL-Sc Hep-G2 C655(0.93)  LDD2227  [6]
 LDCM0367  CL1 HCT 116 C655(1.09)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C655(0.73)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C655(1.54)  LDD0686  [4]
 LDCM0370  CL101 HEK-293T C699(1.06)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C699(1.19)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C699(0.98)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C699(0.92)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C699(1.33)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C699(1.57)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C699(0.97)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C699(1.09)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C699(1.39)  LDD0976  [4]
 LDCM0379  CL11 HCT 116 C655(0.87)  LDD0696  [4]
 LDCM0380  CL110 HEK-293T C699(1.25)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C699(1.49)  LDD0979  [4]
 LDCM0382  CL112 HEK-293T C658(2.19); C661(2.19); C699(1.51)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C658(1.63); C661(1.63); C699(1.41)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C658(3.35); C661(3.35); C699(2.33)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C658(1.82); C661(1.82); C699(1.22)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C658(2.10); C661(2.10); C699(1.29)  LDD0984  [4]
 LDCM0387  CL117 HCT 116 C655(0.40)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C655(0.76)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C655(0.79)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C655(0.77)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C655(0.64)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C655(0.94)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C655(0.73)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C655(0.82)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C655(0.79)  LDD0712  [4]
 LDCM0396  CL125 HEK-293T C658(1.11); C661(1.11); C699(1.02)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C658(1.69); C661(1.69); C699(1.13)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C658(1.17); C661(1.17); C699(1.06)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C658(1.14); C661(1.14); C699(1.14)  LDD0997  [4]
 LDCM0400  CL13 HCT 116 C655(0.78)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C655(0.73)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C655(0.68)  LDD0719  [4]
 LDCM0403  CL16 HEK-293T C699(1.03)  LDD1001  [4]
 LDCM0404  CL17 HCT 116 C655(1.69)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C655(1.74)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C655(1.59)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C655(0.94)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C655(0.87)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C655(1.14)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C655(0.75)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C655(1.00)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C655(1.17)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C655(2.04)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C655(1.12)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C655(1.22)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C655(1.97)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C655(0.73)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C655(0.89)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C655(0.53)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C655(2.15)  LDD0737  [4]
 LDCM0421  CL32 PaTu 8988t C696(1.13); C699(1.13)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C696(0.91); C699(0.91)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C696(1.24); C699(1.24)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C696(1.21); C699(1.21)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C696(0.79); C699(0.79)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C696(1.13); C699(1.13)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C696(0.94); C699(0.94)  LDD1307  [4]
 LDCM0429  CL4 HCT 116 C655(0.89)  LDD0746  [4]
 LDCM0430  CL40 PaTu 8988t C696(1.06); C699(1.06)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C696(1.14); C699(1.14)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C696(1.10); C699(1.10)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C696(1.17); C699(1.17)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C696(1.05); C699(1.05)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C696(1.22); C699(1.22)  LDD1314  [4]
 LDCM0436  CL46 HEK-293T C699(0.98)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C699(1.05)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C699(0.96)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C699(1.05)  LDD1037  [4]
 LDCM0440  CL5 HCT 116 C655(0.93)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C699(1.41)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C699(1.43)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C699(0.77)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C699(1.18)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C699(1.59)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C699(1.13)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C699(1.18)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C699(1.15)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C699(1.03)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C699(1.14)  LDD1048  [4]
 LDCM0451  CL6 HCT 116 C655(0.70)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C699(1.36)  LDD1050  [4]
 LDCM0453  CL61 HEK-293T C658(1.14); C661(1.14)  LDD1051  [4]
 LDCM0454  CL62 HEK-293T C658(1.39); C661(1.39)  LDD1052  [4]
 LDCM0455  CL63 HEK-293T C658(1.60); C661(1.60)  LDD1053  [4]
 LDCM0456  CL64 HEK-293T C658(2.14); C661(2.14)  LDD1054  [4]
 LDCM0457  CL65 HEK-293T C658(1.04); C661(1.04)  LDD1055  [4]
 LDCM0458  CL66 HEK-293T C658(1.76); C661(1.76)  LDD1056  [4]
 LDCM0459  CL67 HEK-293T C658(1.08); C661(1.08)  LDD1057  [4]
 LDCM0460  CL68 HEK-293T C658(1.51); C661(1.51)  LDD1058  [4]
 LDCM0461  CL69 HEK-293T C658(1.67); C661(1.67)  LDD1059  [4]
 LDCM0462  CL7 HCT 116 C655(0.67)  LDD0779  [4]
 LDCM0463  CL70 HEK-293T C658(1.36); C661(1.36)  LDD1061  [4]
 LDCM0464  CL71 HEK-293T C658(2.40); C661(2.40)  LDD1062  [4]
 LDCM0465  CL72 HEK-293T C658(0.96); C661(0.96)  LDD1063  [4]
 LDCM0466  CL73 HEK-293T C658(2.23); C661(2.23)  LDD1064  [4]
 LDCM0467  CL74 HEK-293T C658(2.58); C661(2.58)  LDD1065  [4]
 LDCM0469  CL76 HEK-293T C658(1.01); C661(1.01)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C658(2.00); C661(2.00)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C658(1.72); C661(1.72)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C658(1.39); C661(1.39)  LDD1070  [4]
 LDCM0473  CL8 HCT 116 C655(0.81)  LDD0790  [4]
 LDCM0474  CL80 HEK-293T C658(1.23); C661(1.23)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C658(1.25); C661(1.25)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C658(0.96); C661(0.96)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C658(1.21); C661(1.21)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C658(1.58); C661(1.58)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C658(1.06); C661(1.06)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C658(1.87); C661(1.87)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C658(1.37); C661(1.37)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C658(1.36); C661(1.36)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C658(1.25); C661(1.25)  LDD1081  [4]
 LDCM0484  CL9 HCT 116 C655(0.98)  LDD0801  [4]
 LDCM0485  CL90 HEK-293T C658(2.47); C661(2.47)  LDD1083  [4]
 LDCM0486  CL91 HCT 116 C655(1.16)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C655(1.02)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C655(1.00)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C655(1.20)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C655(1.04)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C655(1.53)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C655(1.21)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C655(1.88)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C655(2.27)  LDD0811  [4]
 LDCM0028  Dobutamine HEK-293T 14.22  LDD0180  [3]
 LDCM0027  Dopamine HEK-293T 32.52  LDD0179  [3]
 LDCM0495  E2913 HEK-293T C655(2.47); C675(1.19); C696(0.89)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C655(2.59)  LDD1702  [2]
 LDCM0625  F8 Ramos C655(1.14); C149(1.52)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C655(3.80)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C655(1.77)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C655(1.39); C149(0.81)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C655(1.12)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C655(0.62)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C655(1.18); C149(0.85)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C655(0.97)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C655(0.85)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C655(0.90)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C655(0.47)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C655(1.24); C149(1.82)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C655(0.65)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C149(1.08)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C658(2.41); C661(2.41)  LDD1066  [4]
 LDCM0596  Fragment38 Ramos C655(0.97); C149(1.27)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C655(0.76); C149(0.65)  LDD2184  [15]
 LDCM0427  Fragment51 PaTu 8988t C696(1.05); C699(1.05)  LDD1306  [4]
 LDCM0610  Fragment52 Ramos C655(1.68)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C655(1.33)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C655(4.99); C149(0.88)  LDD2186  [15]
 LDCM0571  Fragment9 MDA-MB-231 C655(4.02)  LDD1463  [16]
 LDCM0022  KB02 HCT 116 C655(2.96); C658(2.40); C661(2.40); C696(2.36)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C655(1.60); C658(3.25); C661(3.25); C696(2.53)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C655(2.62); C658(2.62); C661(2.62); C696(1.68)  LDD0082  [4]
 LDCM0030  Luteolin HEK-293T 39.20  LDD0182  [3]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C655(0.59)  LDD2089  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C655(0.37)  LDD2096  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C315(0.72)  LDD2099  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C655(0.88)  LDD2107  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C655(1.07)  LDD2111  [2]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C315(1.11)  LDD2115  [2]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C315(0.36)  LDD2116  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C315(0.53)  LDD2122  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C655(0.93)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C315(1.64)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C655(1.00); C315(0.83)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C655(1.06)  LDD2129  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C315(0.64)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C315(1.01)  LDD2136  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C655(1.69)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C655(0.90); C315(0.49)  LDD2140  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C655(0.32)  LDD2150  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C315(0.95)  LDD2153  [2]
 LDCM0032  Oleacein HEK-293T 15.49  LDD0184  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C655(2.13)  LDD2207  [17]
 LDCM0029  Quercetin HEK-293T 46.46  LDD0181  [3]
 LDCM0021  THZ1 HCT 116 C658(1.56); C661(1.56); C696(1.26); C699(1.26)  LDD2173  [4]

References

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2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.