Details of the Target

General Information of Target

Target ID LDTP01689
Target Name Chloride intracellular channel protein 3 (CLIC3)
Gene Name CLIC3
Gene ID 9022
Synonyms
Chloride intracellular channel protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAPGS
QLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKNPV
PAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRESRRRFLDGDRLTLADCSLLPKL
HIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAVHPR
Target Bioclass
Transporter and channel
Family
Chloride channel CLIC family
Subcellular location
Nucleus
Function Can insert into membranes and form chloride ion channels. May participate in cellular growth control.
Uniprot ID
O95833
Ensemble ID
ENST00000494426.2
HGNC ID
HGNC:2064

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K111(7.46); K117(5.53); K213(10.00); K54(5.56)  LDD0277  [1]
Probe 1
 Probe Info  		Y98(14.81); Y205(9.58)  LDD3495  [2]
DBIA
 Probe Info  		C22(1.12); C25(1.12)  LDD0078  [3]
m-APA
 Probe Info  		N.A.  LDD2232  [4]
IPM
 Probe Info  		N.A.  LDD0025  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0149  [6]
NAIA_5
 Probe Info  		C25(0.00); C219(0.00); C174(0.00); C187(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C22(1.39); C25(1.39)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C22(0.86); C25(0.86)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C22(0.93); C25(0.93)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C22(0.85); C25(0.85)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C22(1.14); C25(1.14)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C22(1.07); C25(1.07)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C22(1.16); C25(1.16)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C22(0.89); C25(0.89)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C22(0.97); C25(0.97)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C22(0.87); C25(0.87)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C22(0.81); C25(0.81)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C22(1.44); C25(1.44)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C22(1.57); C25(1.57)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C22(1.19); C25(1.19)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C22(1.17); C25(1.17)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C22(1.04); C25(1.04)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C22(0.82); C25(0.83)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C22(0.93); C25(0.93)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C22(1.11); C25(1.17)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C22(0.90); C25(0.90)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C22(0.87); C25(0.89)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C22(0.95); C25(0.93)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C22(0.99); C25(1.02)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C22(1.48); C25(1.48)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C22(1.23); C25(1.23)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C22(0.83); C25(0.76)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C22(0.90); C25(0.94)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C22(0.82); C25(0.83)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C22(0.82); C25(0.82)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C22(1.01); C25(0.92)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C22(0.82); C25(0.76)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C22(0.92); C25(0.78)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C22(0.87); C25(0.87)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C22(0.49); C25(0.49)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C22(0.70); C25(0.70)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C22(0.59); C25(0.59)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C22(0.69); C25(0.69)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C22(0.67); C25(0.67)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C22(0.72); C25(0.72)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C22(0.70); C25(0.70)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C22(0.89); C25(0.89)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C22(0.85); C25(0.85)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C22(0.86); C25(0.86)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C22(0.64); C25(0.64)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C22(1.43); C25(1.43)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C22(0.64); C25(0.64)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C22(0.63); C25(0.63)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C22(0.71); C25(0.71)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C22(0.93); C25(1.00)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C22(1.01); C25(1.10)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C22(0.96); C25(1.02)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C22(1.13); C25(1.30)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C22(1.11); C25(1.15)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C22(1.22); C25(2.10)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C22(1.22); C25(1.46)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C22(1.39); C25(1.39)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C22(0.96); C25(0.98)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C22(1.28); C25(1.35)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C22(1.38); C25(1.56)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C22(1.25); C25(1.61)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C22(1.20); C25(1.29)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C22(1.17); C25(1.20)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C22(1.09); C25(1.09)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C22(0.93); C25(0.97)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C22(0.97); C25(0.97)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C22(1.36); C25(1.36)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C22(0.87); C25(0.87)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C22(1.41); C25(1.41)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C22(1.23); C25(1.23)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C22(1.26); C25(1.26)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C22(0.90); C25(0.90)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C22(0.83); C25(0.83)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C22(1.00); C25(1.00)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C22(0.79); C25(0.79)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C22(0.93); C25(0.93)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C22(0.88); C25(0.88)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C22(1.01); C25(1.01)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C22(0.99); C25(0.99)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C22(1.17); C25(1.17)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C22(1.20); C25(1.20)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C22(0.87); C25(0.87)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C22(1.11); C25(1.11)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C22(1.00); C25(1.00)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C22(1.42); C25(1.42)  LDD0612  [3]
 LDCM0301  AC4 HCT 116 C22(1.52); C25(1.52)  LDD0618  [3]
 LDCM0308  AC46 HCT 116 C22(0.70); C25(0.70)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C22(0.82); C25(0.82)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C22(0.84); C25(0.84)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C22(0.71); C25(0.71)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C22(1.42); C25(1.42)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C22(0.76); C25(0.76)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C22(0.99); C25(0.99)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C22(0.68); C25(0.68)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C22(0.79); C25(0.79)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C22(0.56); C25(0.56)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C22(0.91); C25(0.91)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C22(0.77); C25(0.77)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C22(1.05); C25(1.05)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C22(1.35); C25(1.35)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C22(1.74); C25(1.74)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C22(0.82); C25(0.82)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C22(1.43); C25(1.43)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C22(1.09); C25(1.09)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C22(1.04); C25(1.04)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C22(1.02); C25(1.02)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C22(1.46); C25(1.46)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C22(1.22); C25(1.22)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C22(1.49); C25(1.49)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C22(1.38); C25(1.38)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C22(0.79); C25(0.79)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C22(0.87); C25(0.87)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C22(1.05); C25(1.05)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C22(0.99); C25(0.99)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C22(0.89); C25(0.89)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C22(1.24); C25(1.24)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C22(0.98); C25(0.98)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C22(0.97); C25(0.97)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C22(1.09); C25(1.09)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C22(1.04); C25(1.04)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C22(1.02); C25(1.02)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C22(0.82); C25(0.82)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C22(1.07); C25(1.07)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C22(1.71); C25(1.71)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C22(1.27); C25(1.27)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C22(1.22); C25(1.22)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C22(1.34); C25(1.34)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C22(1.42); C25(1.42)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C22(1.62); C25(1.62)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C22(1.17); C25(1.17)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C22(1.27); C25(1.27)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C22(1.35); C25(1.35)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C22(1.16); C25(1.16)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C22(1.18); C25(1.18)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C22(0.93); C25(0.93)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C22(1.20); C25(1.20)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C22(1.17); C25(1.17)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C22(1.21); C25(1.21)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C22(1.28); C25(1.28)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C22(0.90); C25(0.90)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C22(0.97); C25(0.97)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C22(1.25); C25(1.25)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C22(1.03); C25(1.03)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C22(0.93); C25(0.93)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C22(1.19); C25(1.19)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C22(0.99); C25(0.99)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C22(1.41); C25(1.41)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C22(1.12); C25(1.12)  LDD0078  [3]
 LDCM0632  CL-Sc Hep-G2 C174(1.53); C219(1.14); C187(1.12); C174(1.12)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C22(1.64); C25(1.64)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C22(2.61); C25(2.61)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C22(1.62); C25(1.62)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C22(1.42); C25(1.42)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C22(1.18); C25(1.18)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C22(1.71); C25(1.71)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C22(0.82); C25(0.82)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C22(1.28); C25(1.28)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C22(1.44); C25(1.44)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C22(1.25); C25(1.25)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C22(1.88); C25(1.88)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C22(1.30); C25(1.30)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C22(1.33); C25(1.33)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C22(3.43); C25(3.43)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C25(14.22); C22(29.22)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C22(1.41); C25(1.41)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C22(1.20); C25(1.20)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C22(2.02); C25(2.02)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C22(1.48); C25(1.48)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C22(1.15); C25(1.15)  LDD0703  [3]
 LDCM0390  CL12 HCT 116 C22(1.32); C25(1.32)  LDD0707  [3]
 LDCM0392  CL121 HCT 116 C22(0.84); C25(0.84)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C22(0.77); C25(0.77)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C22(1.30); C25(1.30)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C22(0.67); C25(0.67)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C22(0.93); C25(0.93)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C22(1.86); C25(1.86)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C22(1.76); C25(1.76)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C22(1.37); C25(1.37)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C22(1.11); C25(1.11)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C22(1.48); C25(1.48)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C22(1.74); C25(1.74)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C22(1.77); C25(1.77)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C22(1.59); C25(1.59)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C22(0.83); C25(0.83)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C22(1.01); C25(1.01)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C22(1.10); C25(1.10)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C22(0.90); C25(0.90)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C22(1.37); C25(1.37)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C22(1.41); C25(1.41)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C22(1.01); C25(1.01)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C22(0.91); C25(0.91)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C22(1.04); C25(1.04)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C22(0.92); C25(0.92)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C22(0.88); C25(0.88)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C22(1.02); C25(1.02)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C22(1.00); C25(1.00)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C22(1.16); C25(1.16)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C22(0.91); C25(0.91)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C22(1.40); C25(1.40)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C22(1.15); C25(1.15)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C22(2.41); C25(2.41)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C22(1.72); C25(1.72)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C22(3.20); C25(3.20)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C22(1.72); C25(1.72)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C22(1.42); C25(1.42)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C22(2.28); C25(2.28)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C22(3.44); C25(3.44)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C22(1.30); C25(1.30)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C22(1.60); C25(1.60)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C22(1.52); C25(1.52)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C22(1.51); C25(1.51)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C22(1.98); C25(1.98)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C22(2.61); C25(2.61)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C22(2.15); C25(2.15)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C22(1.75); C25(1.75)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C22(1.44); C25(1.44)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C22(4.19); C25(4.19)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C22(1.06); C25(1.06)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C22(2.12); C25(2.12)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C22(1.01); C25(1.01)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C22(1.69); C25(1.69)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C22(1.23); C25(1.23)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C22(1.48); C25(1.48)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C22(2.02); C25(2.02)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C22(1.40); C25(1.40)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C22(1.20); C25(1.20)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C22(1.07); C25(1.07)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C22(1.09); C25(1.09)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C22(1.20); C25(1.20)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C22(1.38); C25(1.38)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C22(1.08); C25(1.08)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C22(1.26); C25(1.26)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C22(1.69); C25(1.69)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C22(1.68); C25(1.68)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C22(1.34); C25(1.34)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C22(1.49); C25(1.49)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C22(1.31); C25(1.31)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C22(1.21); C25(1.21)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C22(1.37); C25(1.37)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C22(1.26); C25(1.26)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C22(1.22); C25(1.22)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C22(1.58); C25(1.58)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C22(1.10); C25(1.10)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C22(1.38); C25(1.38)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C22(1.45); C25(1.45)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C22(0.95); C25(0.95)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C22(1.29); C25(1.29)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C22(1.12); C25(1.12)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C22(1.29); C25(1.29)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C22(4.44); C25(4.44)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C22(0.97); C25(0.97)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C22(0.95); C25(0.95)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C22(1.29); C25(1.29)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C22(1.30); C25(1.30)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C22(1.77); C25(1.77)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C22(1.90); C25(1.90)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C22(1.27); C25(1.27)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C22(1.52); C25(1.52)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C22(1.43); C25(1.43)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C22(1.57); C25(1.57)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C22(1.24); C25(1.24)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C22(11.36); C25(11.36)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C22(0.95); C25(0.95)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C22(1.81); C25(1.81)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C22(1.02); C25(1.02)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C22(1.28); C25(1.28)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C22(1.64); C25(1.64)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C22(1.28); C25(1.28)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C22(1.72); C25(1.72)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C22(1.51); C25(1.51)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C22(2.01); C25(2.01)  LDD0811  [3]
 LDCM0576  Fragment14 MDA-MB-231 C22(0.77)  LDD1471  [8]
 LDCM0580  Fragment21 MDA-MB-231 C22(1.03)  LDD1473  [8]
 LDCM0589  Fragment31 MDA-MB-231 C22(0.51)  LDD1477  [8]
 LDCM0468  Fragment33 HCT 116 C22(1.70); C25(1.70)  LDD0785  [3]
 LDCM0603  Fragment45 MDA-MB-231 C22(13.76)  LDD1482  [8]
 LDCM0427  Fragment51 HCT 116 C22(1.62); C25(1.62)  LDD0744  [3]
 LDCM0571  Fragment9 MDA-MB-231 C22(20.00)  LDD1463  [8]
 LDCM0022  KB02 T cell C22(20.00); C25(0.00)  LDD1703  [9]
 LDCM0023  KB03 22RV1 C184(2.27)  LDD2660  [10]
 LDCM0024  KB05 MEL167 C184(3.63)  LDD3316  [10]
 LDCM0021  THZ1 HCT 116 C22(1.13); C25(1.13)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vacuolar protein sorting-associated protein 4A (VPS4A) AAA ATPase family Q9UN37
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transport and Golgi organization protein 1 homolog (MIA3) MIA/OTOR family Q5JRA6
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Zinc finger and BTB domain-containing protein 42 (ZBTB42) Krueppel C2H2-type zinc-finger protein family B2RXF5
Homeobox protein MSX-2 (MSX2) Msh homeobox family P35548
ALX homeobox protein 1 (ALX1) Paired homeobox family Q15699
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Late cornified envelope-like proline-rich protein 1 (LELP1) Cornifin (SPRR) family Q5T871
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type II cuticular Hb5 (KRT85) Intermediate filament family P78386
Methyl-CpG-binding domain protein 3-like 1 (MBD3L1) MBD3L family Q8WWY6
Keratin-associated protein 13-3 (KRTAP13-3) PMG family Q3SY46
Sperm microtubule inner protein 6 (SPMIP6) SMRP1 family Q8NCR6
Stathmin-3 (STMN3) Stathmin family Q9NZ72
Protection of telomeres protein 1 (POT1) Telombin family Q9NUX5
Ankyrin repeat domain-containing protein 23 (ANKRD23) . Q86SG2
Ankyrin repeat domain-containing protein 55 (ANKRD55) . Q3KP44
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
KATNB1-like protein 1 (KATNBL1) . Q9H079
Sperm-associated microtubule inner protein 4 (SPMIP4) . Q8N865
TBC1 domain family member 3F (TBC1D3F) . A6NER0

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
9 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840