Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	Fragment31					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	20.0
LDTP16025	Ketosamine-3-kinase (FN3KRP)				C24	20.0
LDTP04374	Dynamin-2 (DNM2)				C27	17.7
LDTP02765	Aldo-keto reductase family 1 member B1 (AKR1B1)				C299	5.5
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	3.2
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)				C119	3.1
LDTP04076	Mitogen-activated protein kinase 9 (MAPK9)				C177	2.2
LDTP00273	Dynamin-1-like protein (DNM1L)				C367	2.1
LDTP13449	Cleavage and polyadenylation specificity factor subunit 3 (CPSF3)				C498	1.8
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	1.5
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	1.5
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	1.4
LDTP00601	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)				C620	1.4
LDTP10954	3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)				C214	1.4
LDTP00089	Glycerol-3-phosphate phosphatase (PGP)				C297	1.4
LDTP02333	Glutathione S-transferase P (GSTP1)				C48	1.3
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	1.3
LDTP05070	Ubiquitin-conjugating enzyme E2 L3 (UBE2L3)				C86	1.3
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C204	1.3
LDTP10386	ERO1-like protein alpha (ERO1A)				C241	1.3
LDTP04424	Galactokinase (GALK1)				C182	1.2
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C100	1.2
LDTP09412	Serine/threonine-protein kinase Nek9 (NEK9)				C623	1.2
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C331	1.2
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C863	1.2
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	1.1
LDTP02502	Thioredoxin (TXN)				C32	1.1
LDTP11107	Serine/threonine-protein phosphatase CPPED1 (CPPED1)				C54	1.1
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C217	1.1
LDTP03159	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)				C374	1.1
LDTP04211	Isocitrate dehydrogenase [NADP], mitochondrial (IDH2)				C308	1.1
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)				C55	1.1
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C350	1.1
LDTP03299	Cyclin-dependent kinase 2 (CDK2)				C177	1.1
LDTP03786	Glutaredoxin-1 (GLRX)				C23	1.1
LDTP06150	DNA replication licensing factor MCM6 (MCM6)				C301	1.1
LDTP06199	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D)				C17	1.1
LDTP02188	Protein disulfide-isomerase (P4HB)				C397	1.0
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C406	1.0
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	1.0
LDTP10418	Mannose-1-phosphate guanyltransferase alpha (GMPPA)				C389	1.0
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	1.0
LDTP09338	NEDD8-activating enzyme E1 catalytic subunit (UBA3)				C237	1.0
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	1.0
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	1.0
LDTP10929	Cell cycle checkpoint control protein RAD9A (RAD9A)				C114	1.0
LDTP17082	Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)				C137	1.0
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C413	1.0
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	1.0
LDTP14888	Pre-rRNA-processing protein TSR1 homolog (TSR1)				C126	0.9
LDTP02693	Acylamino-acid-releasing enzyme (APEH)				C641	0.9
LDTP10878	Parkinson disease protein 7 (PARK7)				C106	0.9
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	0.9
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C129	0.9
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C196	0.9
LDTP03400	Deoxycytidine kinase (DCK)				C45	0.8
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C721	0.8
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C918	0.8
LDTP13147	Cathepsin Z (CTSZ)				C92	0.8
LDTP04103	Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)				C207	0.8
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	0.8
LDTP06603	Cyclin-dependent kinase inhibitor 3 (CDKN3)				C39	0.8
LDTP04306	Adenosine 5'-monophosphoramidase HINT1 (HINT1)				C84	0.8
LDTP03400	Deoxycytidine kinase (DCK)				C9	0.8
LDTP02672	Elongation factor 2 (EEF2)				C41	0.8
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	0.8
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	0.8
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	0.8
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	0.8
LDTP06621	Ubiquitin-conjugating enzyme E2 S (UBE2S)				C118	0.8
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	0.7
LDTP04689	Adenosine kinase (ADK)				C353	0.7
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	0.7
LDTP02733	Pyruvate kinase PKM (PKM)				C423	0.7
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	0.7
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	0.7
LDTP02672	Elongation factor 2 (EEF2)				C136	0.7
LDTP01333	Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)				C269	0.7
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	0.7
LDTP02329	3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)				C381	0.6
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C322	0.6
LDTP10386	ERO1-like protein alpha (ERO1A)				C166	0.6
LDTP04061	26S proteasome regulatory subunit 6B (PSMC4)				C210	0.1

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP00501	Exportin-1 (XPO1)				C528	3.2
LDTP03327	ATP synthase subunit alpha, mitochondrial (ATP5F1A)				C294	1.4
LDTP13490	Apoptotic chromatin condensation inducer in the nucleus (ACIN1)				C1223	1.1
LDTP08315	THO complex subunit 6 homolog (THOC6)				C35	1.1
LDTP04707	Protein SEC13 homolog (SEC13)				C187	1.0
LDTP00244	Chloride intracellular channel protein 1 (CLIC1)				C24	1.0
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	0.9
LDTP00501	Exportin-1 (XPO1)				C34	0.8
LDTP04662	Exportin-2 (CSE1L)				C842	0.8
LDTP13661	Sorting nexin-6 (SNX6)				C264	0.7
LDTP04259	Signal recognition particle 9 kDa protein (SRP9)				C48	0.7

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP12507	Chromatin accessibility complex protein 1 (CHRAC1)				C55	2.0
LDTP06341	Non-POU domain-containing octamer-binding protein (NONO)				C145	1.1
LDTP09311	SWI/SNF complex subunit SMARCC2 (SMARCC2)				C145	0.9
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	0.8

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP10843	MMS19 nucleotide excision repair protein homolog (MMS19)				C848	20.0
LDTP11191	WW domain-containing adapter protein with coiled-coil (WAC)				C553	3.7
LDTP05867	Treacle protein (TCOF1)				C38	2.3
LDTP13964	MOB-like protein phocein (MOB4)				C134	2.0
LDTP11197	Mini-chromosome maintenance complex-binding protein (MCMBP)				C325	1.8
LDTP09821	Stalled ribosome sensor GCN1 (GCN1)				C1692	1.7
LDTP04092	Crk-like protein (CRKL)				C249	1.6
LDTP10990	T-complex protein 1 subunit eta (CCT7)				C29	1.6
LDTP06378	Disks large-associated protein 5 (DLGAP5)				C129	1.6
LDTP12651	TBC1 domain family member 23 (TBC1D23)				C283	1.4
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C561	1.3
LDTP13979	Cytosolic iron-sulfur assembly component 2B (CIAO2B)				C93	1.3
LDTP04110	Small ribosomal subunit protein uS7 (RPS5)				C66	1.3
LDTP05867	Treacle protein (TCOF1)				C1298	1.2
LDTP05930	SNW domain-containing protein 1 (SNW1)				C250	1.2
LDTP01320	Eukaryotic translation initiation factor 3 subunit J (EIF3J)				C207	1.1
LDTP06268	Condensin complex subunit 2 (NCAPH)				C418	1.1
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C60	1.1
LDTP03815	Large ribosomal subunit protein uL4 (RPL4)				C96	1.1
LDTP02205	Tubulin beta chain (TUBB)				C239	1.0
LDTP09580	Programmed cell death 6-interacting protein (PDCD6IP)				C250	1.0
LDTP01011	Protein diaphanous homolog 1 (DIAPH1)				C1227	1.0
LDTP11890	Protein unc-45 homolog A (UNC45A)				C426	1.0
LDTP15701	EF-hand domain-containing protein D2 (EFHD2)				C172	1.0
LDTP06250	Proteasome activator complex subunit 4 (PSME4)				C1840	1.0
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C341	1.0
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C291	0.9
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)				C31	0.9
LDTP00552	Actin-related protein 2/3 complex subunit 3 (ARPC3)				C162	0.9
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	0.9
LDTP03244	Cofilin-1 (CFL1)				C80	0.9
LDTP13580	Coronin-1C (CORO1C)				C420	0.9
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)				C267	0.9
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	0.9
LDTP10864	Calponin-2 (CNN2)				C164	0.9
LDTP04902	Actin-related protein 3 (ACTR3)				C235	0.8
LDTP00756	Heterogeneous nuclear ribonucleoprotein R (HNRNPR)				C99	0.8
LDTP01299	WD repeat and HMG-box DNA-binding protein 1 (WDHD1)				C773	0.8
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C109	0.8
LDTP06684	Sister chromatid cohesion protein PDS5 homolog A (PDS5A)				C242	0.8
LDTP02934	T-complex protein 1 subunit alpha (TCP1)				C76	0.8
LDTP00431	Kinetochore protein NDC80 homolog (NDC80)				C449	0.8
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	0.8
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)				C122	0.8
LDTP04997	Small ribosomal subunit protein eS4, X isoform (RPS4X)				C41	0.8
LDTP04201	T-complex protein 1 subunit epsilon (CCT5)				C253	0.8
LDTP03695	Heat shock 70 kDa protein 4 (HSPA4)				C34	0.8
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	0.8
LDTP02205	Tubulin beta chain (TUBB)				C354	0.7
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	0.7
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C36	0.7
LDTP13580	Coronin-1C (CORO1C)				C456	0.7
LDTP06082	Dynactin subunit 1 (DCTN1)				C1252	0.7
LDTP00202	AH receptor-interacting protein (AIP)				C122	0.6
LDTP06083	Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)				C1999	0.6

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.