Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	Fragment56					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP02022	Thymidine kinase, cytosolic (TK1)				C230	4.5
LDTP02502	Thioredoxin (TXN)				C32	4.0
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	3.4
LDTP03400	Deoxycytidine kinase (DCK)				C9	3.4
LDTP02022	Thymidine kinase, cytosolic (TK1)				C66	3.0
LDTP10386	ERO1-like protein alpha (ERO1A)				C166	2.5
LDTP02188	Protein disulfide-isomerase (P4HB)				C397	2.2
LDTP10386	ERO1-like protein alpha (ERO1A)				C241	2.2
LDTP09598	Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8)				C207	1.9
LDTP04601	Arginine--tRNA ligase, cytoplasmic (RARS1)				C34	1.8
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	1.8
LDTP16025	Ketosamine-3-kinase (FN3KRP)				C24	1.8
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	1.8
LDTP10954	3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)				C214	1.7
LDTP12190	NmrA-like family domain-containing protein 1 (NMRAL1)				C154	1.6
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C129	1.6
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	1.5
LDTP10878	Parkinson disease protein 7 (PARK7)				C106	1.5
LDTP02672	Elongation factor 2 (EEF2)				C41	1.5
LDTP03400	Deoxycytidine kinase (DCK)				C45	1.4
LDTP05859	Integrin-linked protein kinase (ILK)				C346	1.4
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	1.4
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)				C119	1.3
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	1.3
LDTP05070	Ubiquitin-conjugating enzyme E2 L3 (UBE2L3)				C86	1.3
LDTP00273	Dynamin-1-like protein (DNM1L)				C367	1.3
LDTP17082	Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)				C137	1.3
LDTP02333	Glutathione S-transferase P (GSTP1)				C48	1.2
LDTP15306	Transmembrane protease serine 12 (TMPRSS12)				C64	1.2
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	1.2
LDTP10418	Mannose-1-phosphate guanyltransferase alpha (GMPPA)				C389	1.2
LDTP04689	Adenosine kinase (ADK)				C353	1.2
LDTP02765	Aldo-keto reductase family 1 member B1 (AKR1B1)				C299	1.2
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	1.2
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C406	1.2
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	1.2
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	1.2
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C350	1.2
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	1.2
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	1.2
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	1.1
LDTP09338	NEDD8-activating enzyme E1 catalytic subunit (UBA3)				C237	1.1
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C217	1.1
LDTP03786	Glutaredoxin-1 (GLRX)				C23	1.1
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C721	1.1
LDTP13147	Cathepsin Z (CTSZ)				C92	1.1
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	1.1
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)				C55	1.1
LDTP04424	Galactokinase (GALK1)				C182	1.1
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	1.1
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	1.1
LDTP02672	Elongation factor 2 (EEF2)				C136	1.1
LDTP01495	E3 ubiquitin-protein ligase UBR5 (UBR5)				C2267	1.1
LDTP06199	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D)				C17	1.1
LDTP00246	Eukaryotic translation initiation factor 3 subunit F (EIF3F)				C256	1.1
LDTP00089	Glycerol-3-phosphate phosphatase (PGP)				C297	1.1
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	1.1
LDTP06621	Ubiquitin-conjugating enzyme E2 S (UBE2S)				C118	1.1
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C331	1.0
LDTP10929	Cell cycle checkpoint control protein RAD9A (RAD9A)				C114	1.0
LDTP12166	Ras-related GTP-binding protein C (RRAGC)				C358	1.0
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	1.0
LDTP07098	Probable ATP-dependent RNA helicase DDX59 (DDX59)				C414	1.0
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C322	1.0
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	1.0
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C196	1.0
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C918	1.0
LDTP02733	Pyruvate kinase PKM (PKM)				C423	1.0
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	1.0
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	1.0
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	1.0
LDTP03159	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)				C374	0.9
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	0.9
LDTP12960	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1)				C149	0.9
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C863	0.9
LDTP14159	Ubiquitin carboxyl-terminal hydrolase 16 (USP16)				C205	0.9
LDTP04061	26S proteasome regulatory subunit 6B (PSMC4)				C210	0.9
LDTP06603	Cyclin-dependent kinase inhibitor 3 (CDKN3)				C39	0.9
LDTP06150	DNA replication licensing factor MCM6 (MCM6)				C301	0.9
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C413	0.9
LDTP13663	Dual specificity protein phosphatase 12 (DUSP12)				C265	0.9

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	2.5
LDTP04662	Exportin-2 (CSE1L)				C842	1.9
LDTP08315	THO complex subunit 6 homolog (THOC6)				C35	1.1
LDTP08769	Nuclear pore complex protein Nup93 (NUP93)				C522	1.1
LDTP00244	Chloride intracellular channel protein 1 (CLIC1)				C24	1.0
LDTP04801	Gasdermin-D (GSDMD)				C268	1.0
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	0.9
LDTP04259	Signal recognition particle 9 kDa protein (SRP9)				C48	0.9
LDTP00501	Exportin-1 (XPO1)				C34	0.9
LDTP04707	Protein SEC13 homolog (SEC13)				C187	0.8

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP03969	Signal transducer and activator of transcription 1-alpha/beta (STAT1)				C492	1.5
LDTP05485	Recombining binding protein suppressor of hairless (RBPJ)				C313	1.4
LDTP06341	Non-POU domain-containing octamer-binding protein (NONO)				C145	1.2
LDTP09311	SWI/SNF complex subunit SMARCC2 (SMARCC2)				C145	1.2
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	1.0

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)				C267	3.1
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C6	3.0
LDTP10864	Calponin-2 (CNN2)				C215	2.7
LDTP05008	Large ribosomal subunit protein uL14 (RPL23)				C28	2.4
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	2.1
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C116	2.1
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)				C77	2.1
LDTP04971	Small ribosomal subunit protein uS12 (RPS23)				C90	2.1
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C60	1.9
LDTP11718	Cleavage stimulation factor subunit 2 tau variant (CSTF2T)				C150	1.8
LDTP13580	Coronin-1C (CORO1C)				C420	1.7
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	1.6
LDTP15677	Ribosomal protein eL42-like (RPL36AL)				C88	1.6
LDTP11191	WW domain-containing adapter protein with coiled-coil (WAC)				C553	1.6
LDTP11197	Mini-chromosome maintenance complex-binding protein (MCMBP)				C325	1.6
LDTP12412	Reticulon-4 (RTN4)				C1101	1.5
LDTP02205	Tubulin beta chain (TUBB)				C354	1.5
LDTP03865	Large ribosomal subunit protein uL3 (RPL3)				C253	1.5
LDTP01532	ZW10 interactor (ZWINT)				C54	1.4
LDTP04092	Crk-like protein (CRKL)				C249	1.4
LDTP12754	H/ACA ribonucleoprotein complex subunit 2 (NHP2)				C18	1.4
LDTP06250	Proteasome activator complex subunit 4 (PSME4)				C1840	1.4
LDTP04110	Small ribosomal subunit protein uS7 (RPS5)				C66	1.4
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	1.3
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C23	1.3
LDTP12914	Hsp70-binding protein 1 (HSPBP1)				C204	1.3
LDTP15730	Ataxin-7-like protein 3B (ATXN7L3B)				C75	1.3
LDTP03815	Large ribosomal subunit protein uL4 (RPL4)				C96	1.2
LDTP04028	DNA mismatch repair protein Msh2 (MSH2)				C843	1.2
LDTP10990	T-complex protein 1 subunit eta (CCT7)				C29	1.2
LDTP13964	MOB-like protein phocein (MOB4)				C134	1.2
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C291	1.2
LDTP13979	Cytosolic iron-sulfur assembly component 2B (CIAO2B)				C93	1.2
LDTP10843	MMS19 nucleotide excision repair protein homolog (MMS19)				C848	1.2
LDTP00552	Actin-related protein 2/3 complex subunit 3 (ARPC3)				C162	1.1
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	1.1
LDTP12685	Integrator complex subunit 13 (INTS13)				C349	1.1
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)				C31	1.1
LDTP02205	Tubulin beta chain (TUBB)				C239	1.0
LDTP06378	Disks large-associated protein 5 (DLGAP5)				C129	1.0
LDTP12144	GrpE protein homolog 1, mitochondrial (GRPEL1)				C124	1.0
LDTP09580	Programmed cell death 6-interacting protein (PDCD6IP)				C250	1.0
LDTP03665	Cleavage stimulation factor subunit 2 (CSTF2)				C150	0.9
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C109	0.9
LDTP04201	T-complex protein 1 subunit epsilon (CCT5)				C253	0.9
LDTP03244	Cofilin-1 (CFL1)				C80	0.9
LDTP00202	AH receptor-interacting protein (AIP)				C122	0.9
LDTP11239	Protein misato homolog 1 (MSTO1)				C403	0.9
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	0.9

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.