Details of the Target

General Information of Target

Target ID LDTP03620
Target Name Protein S100-A11 (S100A11)
Gene Name S100A11
Gene ID 6282
Synonyms
MLN70; S100C; Protein S100-A11; Calgizzarin; Metastatic lymph node gene 70 protein; MLN 70; Protein S100-C; S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKISSPTETERCIESLIAVFQKYAGKDGYNYTLSKTEFLSFMNTELAAFTKNQKDPGVL
DRMMKKLDTNSDGQLDFSEFLNLIGGLAMACHDSFLKAVPSQKRT
Target Bioclass
Other
Family
S-100 family
Subcellular location
Cytoplasm
Function Facilitates the differentiation and the cornification of keratinocytes.
Uniprot ID
P31949
Ensemble ID
ENST00000271638.3
HGNC ID
HGNC:10488

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P2
 Probe Info  		1.87  LDD0449  [2]
P3
 Probe Info  		4.06  LDD0450  [2]
P8
 Probe Info  		3.68  LDD0451  [2]
AZ-9
 Probe Info  		2.36  LDD0393  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
ONAyne
 Probe Info  		K103(0.46); K27(0.79); K55(0.36)  LDD0274  [5]
OPA-S-S-alkyne
 Probe Info  		K55(1.54)  LDD3494  [6]
Probe 1
 Probe Info  		Y30(25.11); Y32(101.28)  LDD3495  [7]
JZ128-DTB
 Probe Info  		C13(0.00); C91(0.00)  LDD0462  [8]
THZ1-DTB
 Probe Info  		C13(1.09); C91(1.07)  LDD0460  [8]
HHS-482
 Probe Info  		Y30(1.13); Y32(1.13)  LDD0285  [9]
HHS-475
 Probe Info  		Y32(0.83); Y30(0.89)  LDD0264  [10]
HHS-465
 Probe Info  		Y30(9.50); Y32(6.38)  LDD2237  [11]
DBIA
 Probe Info  		C13(0.98)  LDD0532  [12]
ATP probe
 Probe Info  		K3(0.00); K27(0.00)  LDD0199  [13]
ATP probe
 Probe Info  		K52(0.00); K55(0.00); K66(0.00)  LDD0035  [14]
NAIA_4
 Probe Info  		C13(0.00); C91(0.00)  LDD2226  [15]
WYneN
 Probe Info  		N.A.  LDD0021  [16]
IA-alkyne
 Probe Info  		C13(0.00); C91(0.00)  LDD0149  [17]
IPM
 Probe Info  		N.A.  LDD0147  [18]
NHS
 Probe Info  		K27(0.00); K55(0.00)  LDD0010  [16]
SF
 Probe Info  		N.A.  LDD0028  [19]
STPyne
 Probe Info  		N.A.  LDD0009  [16]
TFBX
 Probe Info  		N.A.  LDD0148  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [20]
Acrolein
 Probe Info  		N.A.  LDD0217  [21]
AOyne
 Probe Info  		14.00  LDD0443  [22]
MPP-AC
 Probe Info  		N.A.  LDD0428  [23]
NAIA_5
 Probe Info  		C13(0.00); C91(0.00)  LDD2223  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C13(1.06)  LDD1093  [12]
 LDCM0215  AC10 HCT 116 C13(0.98)  LDD0532  [12]
 LDCM0216  AC100 PaTu 8988t C13(0.96)  LDD1095  [12]
 LDCM0217  AC101 PaTu 8988t C13(0.97)  LDD1096  [12]
 LDCM0218  AC102 PaTu 8988t C13(1.02)  LDD1097  [12]
 LDCM0219  AC103 PaTu 8988t C13(1.04)  LDD1098  [12]
 LDCM0220  AC104 PaTu 8988t C13(0.97)  LDD1099  [12]
 LDCM0221  AC105 PaTu 8988t C13(1.05)  LDD1100  [12]
 LDCM0222  AC106 PaTu 8988t C13(1.12)  LDD1101  [12]
 LDCM0223  AC107 PaTu 8988t C13(1.19)  LDD1102  [12]
 LDCM0224  AC108 PaTu 8988t C13(1.19)  LDD1103  [12]
 LDCM0225  AC109 PaTu 8988t C13(1.03)  LDD1104  [12]
 LDCM0226  AC11 HCT 116 C13(0.96)  LDD0543  [12]
 LDCM0227  AC110 PaTu 8988t C13(0.97)  LDD1106  [12]
 LDCM0228  AC111 PaTu 8988t C13(1.39)  LDD1107  [12]
 LDCM0229  AC112 PaTu 8988t C13(1.03)  LDD1108  [12]
 LDCM0230  AC113 PaTu 8988t C13(1.20)  LDD1109  [12]
 LDCM0231  AC114 PaTu 8988t C13(0.98)  LDD1110  [12]
 LDCM0232  AC115 PaTu 8988t C13(1.00)  LDD1111  [12]
 LDCM0233  AC116 PaTu 8988t C13(0.93)  LDD1112  [12]
 LDCM0234  AC117 PaTu 8988t C13(0.99)  LDD1113  [12]
 LDCM0235  AC118 PaTu 8988t C13(0.98)  LDD1114  [12]
 LDCM0236  AC119 PaTu 8988t C13(0.89)  LDD1115  [12]
 LDCM0237  AC12 HCT 116 C13(0.85)  LDD0554  [12]
 LDCM0238  AC120 PaTu 8988t C13(1.16)  LDD1117  [12]
 LDCM0239  AC121 PaTu 8988t C13(1.03)  LDD1118  [12]
 LDCM0240  AC122 PaTu 8988t C13(1.09)  LDD1119  [12]
 LDCM0241  AC123 PaTu 8988t C13(1.11)  LDD1120  [12]
 LDCM0242  AC124 PaTu 8988t C13(0.90)  LDD1121  [12]
 LDCM0243  AC125 PaTu 8988t C13(1.03)  LDD1122  [12]
 LDCM0244  AC126 PaTu 8988t C13(1.03)  LDD1123  [12]
 LDCM0245  AC127 PaTu 8988t C13(1.02)  LDD1124  [12]
 LDCM0246  AC128 HCT 116 C13(1.28)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C13(0.80)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C13(1.06)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C13(0.99)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C13(0.85)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C13(1.06)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C13(1.11)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C13(1.25)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C13(1.05)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C13(0.91)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C13(1.04)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C13(1.05)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C13(0.94)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C13(1.33)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C13(1.23)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C13(0.73)  LDD0579  [12]
 LDCM0263  AC143 PaTu 8988t C13(1.11)  LDD1142  [12]
 LDCM0264  AC144 PaTu 8988t C13(1.01)  LDD1143  [12]
 LDCM0265  AC145 PaTu 8988t C13(1.01)  LDD1144  [12]
 LDCM0266  AC146 PaTu 8988t C13(1.04)  LDD1145  [12]
 LDCM0267  AC147 PaTu 8988t C13(1.10)  LDD1146  [12]
 LDCM0268  AC148 PaTu 8988t C13(1.25)  LDD1147  [12]
 LDCM0269  AC149 PaTu 8988t C13(1.48)  LDD1148  [12]
 LDCM0270  AC15 HCT 116 C13(1.03)  LDD0587  [12]
 LDCM0271  AC150 PaTu 8988t C13(1.29)  LDD1150  [12]
 LDCM0272  AC151 PaTu 8988t C13(1.83)  LDD1151  [12]
 LDCM0273  AC152 PaTu 8988t C13(1.59)  LDD1152  [12]
 LDCM0274  AC153 PaTu 8988t C13(2.10)  LDD1153  [12]
 LDCM0621  AC154 PaTu 8988t C13(2.10)  LDD2166  [12]
 LDCM0622  AC155 PaTu 8988t C13(1.47)  LDD2167  [12]
 LDCM0623  AC156 PaTu 8988t C13(1.53)  LDD2168  [12]
 LDCM0624  AC157 PaTu 8988t C13(1.38)  LDD2169  [12]
 LDCM0276  AC17 PaTu 8988t C13(0.97)  LDD1155  [12]
 LDCM0277  AC18 PaTu 8988t C13(0.91)  LDD1156  [12]
 LDCM0278  AC19 PaTu 8988t C13(0.80)  LDD1157  [12]
 LDCM0279  AC2 PaTu 8988t C13(0.87)  LDD1158  [12]
 LDCM0280  AC20 PaTu 8988t C13(1.13)  LDD1159  [12]
 LDCM0281  AC21 PaTu 8988t C13(0.90)  LDD1160  [12]
 LDCM0282  AC22 PaTu 8988t C13(0.87)  LDD1161  [12]
 LDCM0283  AC23 PaTu 8988t C13(1.18)  LDD1162  [12]
 LDCM0284  AC24 PaTu 8988t C13(1.16)  LDD1163  [12]
 LDCM0285  AC25 PaTu 8988t C13(1.13)  LDD1164  [12]
 LDCM0286  AC26 PaTu 8988t C13(0.98)  LDD1165  [12]
 LDCM0287  AC27 PaTu 8988t C13(1.08)  LDD1166  [12]
 LDCM0288  AC28 PaTu 8988t C13(1.29)  LDD1167  [12]
 LDCM0289  AC29 PaTu 8988t C13(1.07)  LDD1168  [12]
 LDCM0290  AC3 PaTu 8988t C13(0.87)  LDD1169  [12]
 LDCM0291  AC30 PaTu 8988t C13(1.13)  LDD1170  [12]
 LDCM0292  AC31 PaTu 8988t C13(1.00)  LDD1171  [12]
 LDCM0293  AC32 PaTu 8988t C13(0.96)  LDD1172  [12]
 LDCM0294  AC33 PaTu 8988t C13(1.21)  LDD1173  [12]
 LDCM0295  AC34 PaTu 8988t C13(1.56)  LDD1174  [12]
 LDCM0296  AC35 HCT 116 C13(0.79)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C13(0.70)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C13(0.76)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C13(0.79)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C13(0.85)  LDD0617  [12]
 LDCM0301  AC4 PaTu 8988t C13(0.84)  LDD1180  [12]
 LDCM0302  AC40 HCT 116 C13(0.97)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C13(0.74)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C13(0.90)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C13(0.82)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C13(0.89)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C13(1.00)  LDD0624  [12]
 LDCM0308  AC46 PaTu 8988t C13(0.95)  LDD1187  [12]
 LDCM0309  AC47 PaTu 8988t C13(1.02)  LDD1188  [12]
 LDCM0310  AC48 PaTu 8988t C13(1.24)  LDD1189  [12]
 LDCM0311  AC49 PaTu 8988t C13(1.42)  LDD1190  [12]
 LDCM0312  AC5 PaTu 8988t C13(1.06)  LDD1191  [12]
 LDCM0313  AC50 PaTu 8988t C13(1.35)  LDD1192  [12]
 LDCM0314  AC51 PaTu 8988t C13(0.79)  LDD1193  [12]
 LDCM0315  AC52 PaTu 8988t C13(1.30)  LDD1194  [12]
 LDCM0316  AC53 PaTu 8988t C13(1.49)  LDD1195  [12]
 LDCM0317  AC54 PaTu 8988t C13(1.74)  LDD1196  [12]
 LDCM0318  AC55 PaTu 8988t C13(0.94)  LDD1197  [12]
 LDCM0319  AC56 PaTu 8988t C13(1.11)  LDD1198  [12]
 LDCM0320  AC57 PaTu 8988t C13(1.22)  LDD1199  [12]
 LDCM0321  AC58 PaTu 8988t C13(1.29)  LDD1200  [12]
 LDCM0322  AC59 PaTu 8988t C13(1.17)  LDD1201  [12]
 LDCM0323  AC6 HCT 116 C13(1.13)  LDD0640  [12]
 LDCM0324  AC60 PaTu 8988t C13(1.15)  LDD1203  [12]
 LDCM0325  AC61 PaTu 8988t C13(1.07)  LDD1204  [12]
 LDCM0326  AC62 PaTu 8988t C13(1.09)  LDD1205  [12]
 LDCM0327  AC63 PaTu 8988t C13(1.10)  LDD1206  [12]
 LDCM0328  AC64 PaTu 8988t C13(1.02)  LDD1207  [12]
 LDCM0329  AC65 PaTu 8988t C13(1.01)  LDD1208  [12]
 LDCM0330  AC66 PaTu 8988t C13(0.98)  LDD1209  [12]
 LDCM0331  AC67 PaTu 8988t C13(0.93)  LDD1210  [12]
 LDCM0332  AC68 PaTu 8988t C13(0.90)  LDD1211  [12]
 LDCM0333  AC69 PaTu 8988t C13(0.93)  LDD1212  [12]
 LDCM0334  AC7 HCT 116 C13(1.00)  LDD0651  [12]
 LDCM0335  AC70 PaTu 8988t C13(0.91)  LDD1214  [12]
 LDCM0336  AC71 PaTu 8988t C13(0.76)  LDD1215  [12]
 LDCM0337  AC72 PaTu 8988t C13(0.86)  LDD1216  [12]
 LDCM0338  AC73 PaTu 8988t C13(0.93)  LDD1217  [12]
 LDCM0339  AC74 PaTu 8988t C13(0.87)  LDD1218  [12]
 LDCM0340  AC75 PaTu 8988t C13(0.86)  LDD1219  [12]
 LDCM0341  AC76 PaTu 8988t C13(0.88)  LDD1220  [12]
 LDCM0342  AC77 PaTu 8988t C13(0.81)  LDD1221  [12]
 LDCM0343  AC78 PaTu 8988t C13(0.94)  LDD1222  [12]
 LDCM0344  AC79 PaTu 8988t C13(0.83)  LDD1223  [12]
 LDCM0345  AC8 HCT 116 C13(1.11)  LDD0662  [12]
 LDCM0346  AC80 PaTu 8988t C13(0.88)  LDD1225  [12]
 LDCM0347  AC81 PaTu 8988t C13(0.93)  LDD1226  [12]
 LDCM0348  AC82 PaTu 8988t C13(1.01)  LDD1227  [12]
 LDCM0349  AC83 PaTu 8988t C13(0.82)  LDD1228  [12]
 LDCM0350  AC84 PaTu 8988t C13(1.19)  LDD1229  [12]
 LDCM0351  AC85 PaTu 8988t C13(0.91)  LDD1230  [12]
 LDCM0352  AC86 PaTu 8988t C13(0.89)  LDD1231  [12]
 LDCM0353  AC87 PaTu 8988t C13(1.12)  LDD1232  [12]
 LDCM0354  AC88 PaTu 8988t C13(0.88)  LDD1233  [12]
 LDCM0355  AC89 PaTu 8988t C13(0.99)  LDD1234  [12]
 LDCM0357  AC90 PaTu 8988t C13(1.07)  LDD1236  [12]
 LDCM0358  AC91 PaTu 8988t C13(1.01)  LDD1237  [12]
 LDCM0359  AC92 PaTu 8988t C13(0.90)  LDD1238  [12]
 LDCM0360  AC93 PaTu 8988t C13(1.00)  LDD1239  [12]
 LDCM0361  AC94 PaTu 8988t C13(0.99)  LDD1240  [12]
 LDCM0362  AC95 PaTu 8988t C13(0.92)  LDD1241  [12]
 LDCM0363  AC96 PaTu 8988t C13(0.86)  LDD1242  [12]
 LDCM0364  AC97 PaTu 8988t C13(0.98)  LDD1243  [12]
 LDCM0365  AC98 PaTu 8988t C13(0.94)  LDD1244  [12]
 LDCM0366  AC99 PaTu 8988t C13(1.19)  LDD1245  [12]
 LDCM0248  AKOS034007472 HCT 116 C13(0.86)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C13(0.97)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C13(1.62)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 11.34  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C91(1.37)  LDD2214  [24]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C91(20.00); C13(0.64)  LDD2227  [15]
 LDCM0367  CL1 HEK-293T C13(1.01)  LDD1571  [25]
 LDCM0368  CL10 HEK-293T C13(1.04)  LDD1572  [25]
 LDCM0369  CL100 PaTu 8988t C13(0.76)  LDD1248  [12]
 LDCM0370  CL101 HCT 116 C13(1.18)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C13(0.97)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C13(1.04)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C13(1.03)  LDD0690  [12]
 LDCM0374  CL105 PaTu 8988t C13(0.85)  LDD1253  [12]
 LDCM0375  CL106 PaTu 8988t C13(0.79)  LDD1254  [12]
 LDCM0376  CL107 PaTu 8988t C13(0.63)  LDD1255  [12]
 LDCM0377  CL108 PaTu 8988t C13(0.86)  LDD1256  [12]
 LDCM0378  CL109 PaTu 8988t C13(0.97)  LDD1257  [12]
 LDCM0379  CL11 HEK-293T C13(0.99)  LDD1583  [25]
 LDCM0380  CL110 PaTu 8988t C13(0.86)  LDD1259  [12]
 LDCM0381  CL111 PaTu 8988t C13(1.14)  LDD1260  [12]
 LDCM0382  CL112 PaTu 8988t C13(0.98)  LDD1261  [12]
 LDCM0383  CL113 PaTu 8988t C13(1.11)  LDD1262  [12]
 LDCM0384  CL114 PaTu 8988t C13(1.11)  LDD1263  [12]
 LDCM0385  CL115 PaTu 8988t C13(1.10)  LDD1264  [12]
 LDCM0386  CL116 PaTu 8988t C13(0.76)  LDD1265  [12]
 LDCM0387  CL117 HCT 116 C13(1.37)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C13(0.94)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C13(0.94)  LDD0706  [12]
 LDCM0390  CL12 HEK-293T C13(0.84)  LDD1594  [25]
 LDCM0391  CL120 HCT 116 C13(0.73)  LDD0708  [12]
 LDCM0392  CL121 PaTu 8988t C13(1.02)  LDD1271  [12]
 LDCM0393  CL122 PaTu 8988t C13(1.36)  LDD1272  [12]
 LDCM0394  CL123 PaTu 8988t C13(1.27)  LDD1273  [12]
 LDCM0395  CL124 PaTu 8988t C13(1.25)  LDD1274  [12]
 LDCM0396  CL125 PaTu 8988t C13(1.12)  LDD1275  [12]
 LDCM0397  CL126 PaTu 8988t C13(1.17)  LDD1276  [12]
 LDCM0398  CL127 PaTu 8988t C13(1.06)  LDD1277  [12]
 LDCM0399  CL128 PaTu 8988t C13(1.06)  LDD1278  [12]
 LDCM0400  CL13 HEK-293T C13(0.94)  LDD1604  [25]
 LDCM0401  CL14 HEK-293T C13(1.02)  LDD1605  [25]
 LDCM0402  CL15 HEK-293T C13(1.63)  LDD1606  [25]
 LDCM0403  CL16 HCT 116 C13(1.23)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C13(0.91)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C13(0.79)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C13(1.04)  LDD0723  [12]
 LDCM0407  CL2 HEK-293T C13(0.95)  LDD1611  [25]
 LDCM0408  CL20 HCT 116 C13(1.71)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C13(1.33)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C13(2.03)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C13(1.43)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C13(1.79)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C13(1.53)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C13(1.29)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C13(1.20)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C13(1.28)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C13(1.36)  LDD0734  [12]
 LDCM0418  CL3 HEK-293T C13(0.49)  LDD1622  [25]
 LDCM0419  CL30 HCT 116 C13(1.10)  LDD0736  [12]
 LDCM0420  CL31 PaTu 8988t C13(0.82)  LDD1299  [12]
 LDCM0421  CL32 PaTu 8988t C13(0.73)  LDD1300  [12]
 LDCM0422  CL33 PaTu 8988t C13(0.57)  LDD1301  [12]
 LDCM0423  CL34 PaTu 8988t C13(0.79)  LDD1302  [12]
 LDCM0424  CL35 PaTu 8988t C13(0.87)  LDD1303  [12]
 LDCM0425  CL36 PaTu 8988t C13(0.19)  LDD1304  [12]
 LDCM0426  CL37 PaTu 8988t C13(0.72)  LDD1305  [12]
 LDCM0428  CL39 PaTu 8988t C13(0.69)  LDD1307  [12]
 LDCM0429  CL4 HEK-293T C13(1.03)  LDD1633  [25]
 LDCM0430  CL40 PaTu 8988t C13(0.73)  LDD1309  [12]
 LDCM0431  CL41 PaTu 8988t C13(0.65)  LDD1310  [12]
 LDCM0432  CL42 PaTu 8988t C13(0.79)  LDD1311  [12]
 LDCM0433  CL43 PaTu 8988t C13(0.71)  LDD1312  [12]
 LDCM0434  CL44 PaTu 8988t C13(0.64)  LDD1313  [12]
 LDCM0435  CL45 PaTu 8988t C13(0.72)  LDD1314  [12]
 LDCM0436  CL46 HCT 116 C13(0.96)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C13(0.96)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C13(0.95)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C13(1.16)  LDD0756  [12]
 LDCM0440  CL5 HEK-293T C13(1.24)  LDD1644  [25]
 LDCM0441  CL50 HCT 116 C13(0.95)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C13(0.90)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C13(0.86)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C13(1.01)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C13(0.85)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C13(0.88)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C13(0.96)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C13(0.77)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C13(0.88)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C13(1.00)  LDD0767  [12]
 LDCM0451  CL6 HEK-293T C13(1.21)  LDD1654  [25]
 LDCM0452  CL60 HCT 116 C13(0.97)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C13(0.98)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C13(1.11)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C13(1.00)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C13(1.27)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C13(1.00)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C13(1.55)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C13(1.27)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C13(0.95)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C13(0.74)  LDD0778  [12]
 LDCM0462  CL7 HEK-293T C13(1.03)  LDD1665  [25]
 LDCM0463  CL70 HCT 116 C13(0.90)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C13(1.10)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C13(0.95)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C13(1.07)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C13(1.11)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C13(0.90)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C13(1.17)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C13(1.14)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C13(1.36)  LDD0789  [12]
 LDCM0473  CL8 HEK-293T C13(1.49)  LDD1676  [25]
 LDCM0474  CL80 HCT 116 C13(0.77)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C13(1.19)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C13(1.72)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C13(1.52)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C13(2.05)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C13(1.19)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C13(1.06)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C13(1.11)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C13(1.50)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C13(2.11)  LDD0800  [12]
 LDCM0484  CL9 HEK-293T C13(0.78)  LDD1687  [25]
 LDCM0485  CL90 HCT 116 C13(1.02)  LDD0802  [12]
 LDCM0486  CL91 PaTu 8988t C13(0.91)  LDD1365  [12]
 LDCM0487  CL92 PaTu 8988t C13(0.96)  LDD1366  [12]
 LDCM0488  CL93 PaTu 8988t C13(0.87)  LDD1367  [12]
 LDCM0489  CL94 PaTu 8988t C13(0.90)  LDD1368  [12]
 LDCM0490  CL95 PaTu 8988t C13(0.94)  LDD1369  [12]
 LDCM0491  CL96 PaTu 8988t C13(0.73)  LDD1370  [12]
 LDCM0492  CL97 PaTu 8988t C13(0.83)  LDD1371  [12]
 LDCM0493  CL98 PaTu 8988t C13(0.90)  LDD1372  [12]
 LDCM0494  CL99 PaTu 8988t C13(0.83)  LDD1373  [12]
 LDCM0634  CY-0357 Hep-G2 C91(7.50); C91(1.13)  LDD2228  [15]
 LDCM0495  E2913 HEK-293T C13(1.13)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C13(1.17)  LDD1702  [26]
 LDCM0086  EN4 231MFP C13(4.60)  LDD0194  [27]
 LDCM0572  Fragment10 MDA-MB-231 C91(4.87)  LDD1389  [28]
 LDCM0573  Fragment11 MDA-MB-231 C91(1.15)  LDD1391  [28]
 LDCM0574  Fragment12 MDA-MB-231 C91(1.49)  LDD1393  [28]
 LDCM0575  Fragment13 MDA-MB-231 C91(0.96)  LDD1395  [28]
 LDCM0576  Fragment14 MDA-MB-231 C91(0.94)  LDD1397  [28]
 LDCM0577  Fragment15 MDA-MB-231 C91(1.35)  LDD1399  [28]
 LDCM0579  Fragment20 MDA-MB-231 C91(1.66)  LDD1402  [28]
 LDCM0580  Fragment21 MDA-MB-231 C91(2.37)  LDD1404  [28]
 LDCM0581  Fragment22 MDA-MB-231 C91(1.10)  LDD1406  [28]
 LDCM0584  Fragment25 MDA-MB-231 C91(0.94)  LDD1411  [28]
 LDCM0578  Fragment27 MDA-MB-231 C91(0.79)  LDD1401  [28]
 LDCM0586  Fragment28 MDA-MB-231 C91(1.06)  LDD1415  [28]
 LDCM0587  Fragment29 MDA-MB-231 C91(1.04)  LDD1417  [28]
 LDCM0588  Fragment30 MDA-MB-231 C91(1.07)  LDD1419  [28]
 LDCM0589  Fragment31 MDA-MB-231 C91(1.78)  LDD1421  [28]
 LDCM0590  Fragment32 MDA-MB-231 C91(3.12)  LDD1423  [28]
 LDCM0468  Fragment33 HCT 116 C13(1.13)  LDD0785  [12]
 LDCM0594  Fragment36 MDA-MB-231 C91(1.09)  LDD1431  [28]
 LDCM0596  Fragment38 MDA-MB-231 C91(1.17)  LDD1433  [28]
 LDCM0597  Fragment39 MDA-MB-231 C91(1.98)  LDD1435  [28]
 LDCM0566  Fragment4 MDA-MB-231 C91(1.02)  LDD1378  [28]
 LDCM0598  Fragment40 MDA-MB-231 C91(0.72)  LDD1436  [28]
 LDCM0599  Fragment41 MDA-MB-231 C91(20.00)  LDD1438  [28]
 LDCM0601  Fragment43 MDA-MB-231 C91(1.48)  LDD1441  [28]
 LDCM0602  Fragment44 MDA-MB-231 C91(0.80)  LDD1443  [28]
 LDCM0603  Fragment45 MDA-MB-231 C91(20.00)  LDD1444  [28]
 LDCM0604  Fragment46 MDA-MB-231 C91(1.12)  LDD1445  [28]
 LDCM0605  Fragment47 MDA-MB-231 C91(0.84)  LDD1446  [28]
 LDCM0606  Fragment48 MDA-MB-231 C91(1.25)  LDD1447  [28]
 LDCM0607  Fragment49 MDA-MB-231 C91(3.42)  LDD1448  [28]
 LDCM0608  Fragment50 MDA-MB-231 C91(2.42)  LDD1449  [28]
 LDCM0427  Fragment51 PaTu 8988t C13(0.69)  LDD1306  [12]
 LDCM0610  Fragment52 MDA-MB-231 C91(0.68)  LDD1452  [28]
 LDCM0611  Fragment53 MDA-MB-231 C91(0.94)  LDD1454  [28]
 LDCM0612  Fragment54 MDA-MB-231 C91(1.14)  LDD1456  [28]
 LDCM0613  Fragment55 MDA-MB-231 C91(0.77)  LDD1457  [28]
 LDCM0614  Fragment56 MDA-MB-231 C91(1.02)  LDD1458  [28]
 LDCM0568  Fragment6 MDA-MB-231 C91(1.15)  LDD1382  [28]
 LDCM0569  Fragment7 MDA-MB-231 C91(0.93)  LDD1383  [28]
 LDCM0570  Fragment8 MDA-MB-231 C91(1.03)  LDD1385  [28]
 LDCM0571  Fragment9 MDA-MB-231 C91(0.98)  LDD1387  [28]
 LDCM0116  HHS-0101 DM93 Y32(0.83); Y30(0.89)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y32(0.76); Y30(0.77)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y30(0.78); Y32(0.81)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y32(0.81); Y30(0.82)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y30(0.84); Y32(0.86)  LDD0268  [10]
 LDCM0015  HNE MDA-MB-231 C13(0.98)  LDD0346  [29]
 LDCM0123  JWB131 DM93 Y30(1.13); Y32(1.13)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y30(0.94); Y32(1.19)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y30(1.16); Y32(1.12)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y30(3.80); Y32(3.56)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y30(2.47); Y32(2.27)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y30(0.89); Y32(1.62)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y30(1.11); Y32(1.16)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y30(1.16); Y32(1.32)  LDD0292  [9]
 LDCM0179  JZ128 PC-3 C13(0.00); C91(0.00)  LDD0462  [8]
 LDCM0022  KB02 MDA-MB-231 C91(2.11)  LDD1374  [28]
 LDCM0023  KB03 MDA-MB-231 C91(1.04)  LDD1376  [28]
 LDCM0024  KB05 G361 C13(2.05)  LDD3311  [30]
 LDCM0109  NEM HeLa N.A.  LDD0223  [21]
 LDCM0131  RA190 MM1.R C13(1.39); C91(1.10)  LDD0304  [31]
 LDCM0021  THZ1 HeLa S3 C13(1.09); C91(1.07)  LDD0460  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Protein S100-B (S100B) S-100 family P04271
Transient receptor potential cation channel subfamily M member 4 (TRPM4) Transient receptor (TC 1.A.4) family Q8TD43

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phosphonothreonine Small molecular drug DB02482

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
24 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
27 Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC. Cell Chem Biol. 2021 Jan 21;28(1):4-13.e17. doi: 10.1016/j.chembiol.2020.09.001. Epub 2020 Sep 22.
28 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
29 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
30 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
31 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.