Details of the Target

General Information of Target

Target ID LDTP13080
Target Name GMP reductase 2 (GMPR2)
Gene Name GMPR2
Gene ID 51292
Synonyms
GMP reductase 2; GMPR 2; EC 1.7.1.7; Guanosine 5'-monophosphate oxidoreductase 2; Guanosine monophosphate reductase 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNFSEVFKLSSLLCKFSPDGKYLASCVQYRLVVRDVNTLQILQLYTCLDQIQHIEWSADS
LFILCAMYKRGLVQVWSLEQPEWHCKIDEGSAGLVASCWSPDGRHILNTTEFHLRITVWS
LCTKSVSYIKYPKACLQGITFTRDGRYMALAERRDCKDYVSIFVCSDWQLLRHFDTDTQD
LTGIEWAPNGCVLAVWDTCLEYKILLYSLDGRLLSTYSAYEWSLGIKSVAWSPSSQFLAV
GSYDGKVRILNHVTWKMITEFGHPAAINDPKIVVYKEAEKSPQLGLGCLSFPPPRAGAGP
LPSSESKYEIASVPVSLQTLKPVTDRANPKIGIGMLAFSPDSYFLATRNDNIPNAVWVWD
IQKLRLFAVLEQLSPVRAFQWDPQQPRLAICTGGSRLYLWSPAGCMSVQVPGEGDFAVLS
LCWHLSGDSMALLSKDHFCLCFLETEAVVGTACRQLGGHT
Target Bioclass
Enzyme
Family
IMPDH/GMPR family, GuaC type 1 subfamily
Function
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation. {|HAMAP-Rule:MF_03195}.
Uniprot ID
Q9P2T1
Ensemble ID
ENST00000355299.8
HGNC ID
HGNC:4377
ChEMBL ID
CHEMBL4296017

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MDAMB436 SNV: p.L32F DBIA    Probe Info 
PEO1 Deletion: p.R18SfsTer2 DBIA    Probe Info 
SKMEL28 SNV: p.D259N DBIA    Probe Info 
TE1 SNV: p.D7H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.89  LDD0402  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K13(10.00); K25(0.61); K277(10.00); K298(1.92)  LDD0277  [3]
ONAyne
 Probe Info  		K291(7.69)  LDD0275  [3]
Probe 1
 Probe Info  		Y278(37.55); Y285(34.48)  LDD3495  [4]
DBIA
 Probe Info  		C334(1.88)  LDD3312  [5]
BTD
 Probe Info  		C316(2.28); C222(1.23); C186(0.97)  LDD1700  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C186(0.00); C224(0.00); C222(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C224(0.00); C222(0.00); C316(0.00); C186(0.00)  LDD0036  [7]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		C224(0.00); C222(0.00); C316(0.00); C186(0.00)  LDD0037  [7]
IPM
 Probe Info  		C348(0.00); C186(0.00)  LDD0025  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
WYneN
 Probe Info  		C186(0.00); C224(0.00)  LDD0021  [11]
WYneO
 Probe Info  		N.A.  LDD0022  [11]
1d-yne
 Probe Info  		N.A.  LDD0356  [12]
ENE
 Probe Info  		N.A.  LDD0006  [11]
PF-06672131
 Probe Info  		N.A.  LDD0017  [13]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
VSF
 Probe Info  		N.A.  LDD0007  [11]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
AOyne
 Probe Info  		10.10  LDD0443  [16]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C222(0.75)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C222(1.00)  LDD2112  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C222(1.33)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C186(0.78); C222(0.90)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C186(1.14); C316(1.22)  LDD2152  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C222(0.59)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C222(1.12)  LDD2131  [6]
 LDCM0214  AC1 HEK-293T C186(0.96); C348(1.05)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C186(1.03); C348(1.05); C222(1.02)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C186(1.08); C348(1.00); C316(1.14)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C186(1.05); C348(1.18); C222(0.92)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C186(1.01); C224(1.02)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C186(1.03); C348(0.99); C205(1.06); C222(1.20)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C186(0.93); C348(1.00)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C186(1.00); C348(0.94); C222(0.95)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C186(0.96); C348(1.29); C316(1.12)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C186(0.94); C348(1.03); C222(1.11)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C186(1.02); C348(1.00); C222(0.95)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C186(0.98); C348(0.93); C316(1.12); C205(1.04)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C186(0.99); C224(0.96)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C186(0.97); C348(1.13); C205(0.97); C222(1.08)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C186(1.01); C348(1.02)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C186(0.99); C348(0.97)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C186(1.05); C348(1.12); C222(0.93)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C186(1.01); C348(0.99); C316(1.10)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C186(1.04); C348(1.05); C222(0.84)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C186(1.02); C348(1.06); C316(1.06); C205(1.00)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C186(0.98); C348(0.95); C316(1.10)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C186(1.01); C224(0.98)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C186(1.04); C348(0.96); C205(1.05); C222(1.10)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C186(1.02); C348(0.98)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C186(0.95); C348(1.07)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C186(0.98); C348(1.05); C222(1.02)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C186(0.99); C348(1.03); C316(0.97)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C186(0.98); C348(1.11); C222(0.84)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C186(1.05); C348(0.96); C316(1.09); C205(1.05)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C186(1.00); C224(0.92)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C186(0.98); C348(1.01); C205(0.99); C222(1.25)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C186(0.96); C348(1.03); C222(0.99)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C186(0.98); C348(0.97)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C186(1.02); C348(1.00)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C186(1.01); C348(1.02); C222(0.99)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C186(1.01); C348(1.16); C316(1.05)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C186(1.03); C348(1.24); C222(0.98)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C186(1.05); C348(1.02); C316(1.16); C205(1.12)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C186(1.01); C224(0.96)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C186(1.03); C348(1.03); C205(0.95); C222(1.12)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C186(1.00); C348(0.93)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C186(0.92); C348(1.11)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C186(1.02); C348(1.01); C316(1.10); C205(0.90)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C186(0.96); C348(0.91); C222(1.00)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C186(0.95); C348(1.08); C316(1.12)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C186(1.01); C348(1.05); C222(0.84)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C186(0.96); C348(1.04); C316(1.08); C205(0.98)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C186(1.00); C224(0.92)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C186(0.95); C348(0.96); C205(1.04); C222(1.08)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C186(0.94); C348(1.08)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C186(0.96); C348(0.98)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C186(1.02); C348(1.16); C222(1.05)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C186(1.01); C348(1.10); C316(1.11)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C186(0.99); C224(0.91)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C186(1.00); C348(1.04); C222(0.92)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C186(0.95); C348(0.93); C316(1.07); C205(0.96)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C186(0.99); C224(0.87)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C186(0.96); C348(1.05); C205(1.00); C222(1.07)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C186(0.99); C348(1.08)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C186(0.95); C348(1.04); C205(0.93); C222(1.20)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C186(0.98); C348(1.15)  LDD1569  [17]
 LDCM0545  Acetamide MDA-MB-231 C186(0.33)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C186(3.14); C222(0.67); C316(0.74)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C186(1.03); C348(1.02); C316(1.07); C205(1.05)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C186(0.97); C348(1.07)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C186(0.98); C348(0.81)  LDD1514  [17]
 LDCM0156  Aniline NCI-H1299 12.68  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C222(1.30); C224(0.94)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C348(1.29)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C186(0.91); C348(0.96); C222(1.17)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C186(0.97); C224(1.01)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C186(1.01); C348(0.93); C316(0.99); C222(1.08)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C186(0.98); C348(0.97); C222(1.08)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C186(0.98); C348(0.86); C316(0.98); C224(0.76)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C186(0.97); C348(0.72); C222(1.14)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C186(1.01); C348(0.92); C316(1.10); C222(1.00)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C186(0.94); C348(0.99); C222(1.07)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C186(0.98); C348(0.84); C316(1.11); C224(0.90)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C186(0.98); C348(1.00); C222(1.09)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C186(1.02); C348(0.79); C316(0.99); C222(1.03)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C186(0.98); C348(1.03); C222(0.90)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C186(1.17); C348(1.07); C205(1.05); C222(1.29)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C186(0.94); C348(0.79); C316(1.09); C224(0.82)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C186(1.01); C348(0.78); C222(1.12)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C186(0.99); C348(0.98); C316(0.90); C222(1.02)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C186(1.01); C348(1.03); C222(1.12)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C186(0.92); C348(0.81); C316(1.06); C224(0.86)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C186(1.00); C348(0.78); C222(1.25)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C186(1.03); C348(0.78); C316(1.08); C222(1.01)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C186(1.03); C348(1.12); C222(1.04)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C186(1.00); C348(0.89); C316(1.03); C224(0.82)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C186(1.00); C348(0.74); C222(1.04)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C186(1.13); C348(1.20)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C186(1.07); C348(0.88); C316(0.99); C222(0.86)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C186(0.94); C348(1.05); C222(0.92)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C186(0.98); C348(0.90); C316(1.05); C224(0.85)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C186(0.90); C348(0.74); C222(0.97)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C186(0.99); C348(0.86); C316(0.96); C222(0.86)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C186(0.93); C348(1.04); C222(0.93)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C186(0.99); C348(0.90); C316(1.02); C224(0.71)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C186(1.01); C348(0.87); C222(0.97)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C186(0.99); C348(0.94); C316(0.94); C222(0.89)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C186(0.93); C348(0.96); C222(0.80)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C186(1.03); C348(0.83); C316(1.06); C224(0.83)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C186(0.87); C348(0.97); C222(0.97)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C186(1.03); C348(0.86); C316(1.21); C222(0.99)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C186(0.85); C348(0.90)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C186(1.04); C348(1.08); C222(1.14)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C186(1.07); C348(1.14); C316(1.12)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C186(1.05); C348(0.84); C316(1.02); C224(0.91)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C186(1.21); C348(1.30); C222(0.97)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C186(1.18); C348(0.99); C316(1.15); C205(1.15)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C186(1.20); C224(1.10)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C186(1.19); C348(1.03); C205(1.14); C222(1.13)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C186(1.15); C348(1.42)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C186(0.97); C348(1.00); C222(1.09)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C186(1.04); C348(0.75); C316(1.15); C224(1.00)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C186(1.02); C348(0.89); C222(1.14)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C186(1.05); C348(0.80); C316(1.07); C222(0.97)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C186(1.08); C348(0.96)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C186(0.95); C348(0.86); C222(0.95)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C186(1.12); C348(1.16); C222(1.02)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C186(1.20); C348(1.15); C316(1.11)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C186(1.25); C348(1.08); C222(1.03)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C186(1.14); C348(0.92); C316(1.08); C205(1.10)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C186(1.35); C224(1.23)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C186(1.35); C348(1.07); C205(1.19); C222(1.06)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C186(1.35); C348(1.07)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C186(1.06); C348(1.13); C222(1.03)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C186(1.00); C348(1.19); C222(1.25)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C186(0.96); C348(0.86); C316(0.94); C222(0.88)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C186(1.03); C348(0.97); C316(0.97); C222(1.09)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C186(1.03); C348(1.04)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C186(1.15); C348(1.03); C222(1.17)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C186(1.34); C348(1.14); C316(1.19)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C186(1.24); C348(1.15); C222(0.94)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C186(1.24); C348(1.10); C316(1.25); C205(1.21)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C186(1.39); C224(1.19)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C186(1.32); C348(1.03); C205(1.09); C222(1.16)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C186(1.39); C348(1.17)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C186(1.06); C348(1.09); C222(1.07)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C186(0.91); C348(1.10)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C186(1.09); C348(0.81); C316(1.09); C224(0.83)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C186(1.07); C348(0.96); C316(1.05); C222(1.08)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C186(0.95); C348(0.97)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C186(1.00); C348(1.05); C222(1.19)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C186(1.20); C348(0.97); C316(1.19)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C186(1.32); C348(1.29); C222(1.16)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C186(1.27); C348(1.12); C316(1.25); C205(1.32)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C186(1.34); C224(1.25)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C186(1.36); C348(1.14); C205(1.19); C222(1.17)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C186(0.94); C348(0.96); C222(1.09)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C186(1.33); C348(1.10)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C186(1.02); C348(1.09); C222(0.95)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C186(1.04); C348(0.94); C316(1.06); C224(0.95)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C186(1.00); C348(0.66); C222(1.11)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C186(0.97); C348(0.94); C316(1.08); C222(0.95)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C186(1.02); C348(1.05)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C186(1.12); C348(1.02); C222(1.21)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C186(1.24); C348(1.28); C316(1.03)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C186(1.29); C348(1.19); C222(1.33)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C186(1.36); C348(1.08); C316(1.26); C205(1.12)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C186(1.03); C348(1.06); C316(0.99)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C186(1.37); C224(1.17)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C186(1.30); C348(1.08); C205(1.14); C222(1.37)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C186(1.25); C348(1.33)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C186(0.99); C348(1.04); C222(0.86)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C186(1.01); C348(0.85); C316(0.95); C224(0.82)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C186(1.01); C348(0.90); C316(0.96); C222(1.15)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C186(0.93); C348(0.87)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C186(1.08); C348(1.02); C222(1.11)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C186(1.03); C348(1.22); C316(0.98)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C186(0.75); C348(0.90); C222(0.80)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C186(1.12); C348(1.26); C222(0.99)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C186(1.16); C348(1.23); C316(1.12); C205(0.95)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C186(1.23); C224(1.13)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C186(1.14); C348(1.02); C205(1.23); C222(1.30)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C186(1.11); C348(1.09)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C186(0.99); C348(1.13); C222(0.94)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C186(1.09); C348(0.88); C316(1.03); C224(0.77)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C186(1.01); C348(0.68); C222(0.95)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C186(1.01); C348(0.90); C316(1.21); C222(1.05)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C186(1.03); C348(1.11)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C186(1.13); C348(1.05); C316(1.19); C205(1.08)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C186(0.84); C348(0.95); C222(1.34)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C186(1.18); C348(1.12); C316(1.35)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C186(1.10); C348(1.10); C222(0.85)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C186(1.19); C348(1.03); C316(1.24); C205(0.97)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C186(1.25); C224(0.97)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C186(1.10); C348(0.85); C205(0.94); C222(1.09)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C186(1.53); C348(0.81)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C186(0.91); C348(0.90); C222(0.92)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C186(1.03); C348(0.89); C316(1.03); C224(0.95)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C186(0.99); C348(0.76); C222(0.97)  LDD1697  [17]
 LDCM0634  CY-0357 Hep-G2 C348(0.62)  LDD2228  [10]
 LDCM0495  E2913 HEK-293T C186(1.09); C348(0.98); C222(1.32)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C186(1.51); C222(1.29); C224(0.88)  LDD1702  [6]
 LDCM0625  F8 Ramos C348(1.17); C316(0.49); C186(0.77)  LDD2187  [18]
 LDCM0572  Fragment10 MDA-MB-231 C186(5.03)  LDD1389  [19]
 LDCM0573  Fragment11 MDA-MB-231 C186(1.79)  LDD1391  [19]
 LDCM0574  Fragment12 Ramos C348(0.67); C316(0.71); C186(0.62)  LDD2191  [18]
 LDCM0575  Fragment13 MDA-MB-231 C186(1.23)  LDD1395  [19]
 LDCM0576  Fragment14 Ramos C348(0.82); C316(0.97); C186(0.96)  LDD2193  [18]
 LDCM0579  Fragment20 MDA-MB-231 C186(1.81)  LDD1402  [19]
 LDCM0580  Fragment21 MDA-MB-231 C186(0.75)  LDD1404  [19]
 LDCM0581  Fragment22 MDA-MB-231 C186(1.20)  LDD1406  [19]
 LDCM0582  Fragment23 MDA-MB-231 C186(0.83)  LDD1408  [19]
 LDCM0578  Fragment27 MDA-MB-231 C186(0.56)  LDD1401  [19]
 LDCM0586  Fragment28 MDA-MB-231 C186(0.94)  LDD1415  [19]
 LDCM0587  Fragment29 MDA-MB-231 C186(1.08)  LDD1417  [19]
 LDCM0588  Fragment30 MDA-MB-231 C186(0.86)  LDD1419  [19]
 LDCM0589  Fragment31 MDA-MB-231 C186(1.26)  LDD1421  [19]
 LDCM0590  Fragment32 MDA-MB-231 C186(20.00)  LDD1423  [19]
 LDCM0468  Fragment33 HEK-293T C186(0.99); C348(0.54); C222(1.04)  LDD1671  [17]
 LDCM0596  Fragment38 MDA-MB-231 C186(1.18)  LDD1433  [19]
 LDCM0597  Fragment39 MDA-MB-231 C186(3.61)  LDD1435  [19]
 LDCM0566  Fragment4 MDA-MB-231 C186(0.95)  LDD1378  [19]
 LDCM0599  Fragment41 MDA-MB-231 C186(0.95)  LDD1438  [19]
 LDCM0601  Fragment43 MDA-MB-231 C186(2.03)  LDD1441  [19]
 LDCM0604  Fragment46 MDA-MB-231 C186(0.87)  LDD1445  [19]
 LDCM0607  Fragment49 MDA-MB-231 C186(3.02)  LDD1448  [19]
 LDCM0608  Fragment50 MDA-MB-231 C186(1.24)  LDD1449  [19]
 LDCM0427  Fragment51 MDA-MB-231 C186(1.67)  LDD1450  [19]
 LDCM0610  Fragment52 MDA-MB-231 C186(1.06)  LDD1452  [19]
 LDCM0611  Fragment53 MDA-MB-231 C186(0.86)  LDD1454  [19]
 LDCM0612  Fragment54 MDA-MB-231 C186(1.15)  LDD1456  [19]
 LDCM0614  Fragment56 MDA-MB-231 C186(0.90)  LDD1458  [19]
 LDCM0569  Fragment7 Ramos C348(1.01); C316(0.52); C186(0.64)  LDD2186  [18]
 LDCM0570  Fragment8 MDA-MB-231 C186(1.47)  LDD1385  [19]
 LDCM0571  Fragment9 MDA-MB-231 C186(0.88)  LDD1387  [19]
 LDCM0022  KB02 MDA-MB-231 C186(1.30)  LDD1374  [19]
 LDCM0023  KB03 MDA-MB-231 C186(1.27)  LDD1376  [19]
 LDCM0024  KB05 HMCB C334(1.88)  LDD3312  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C222(1.82); C316(0.90)  LDD2121  [6]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C222(1.08); C316(0.58)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C186(1.67)  LDD2090  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C186(0.73); C316(1.11)  LDD2093  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C222(1.00)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C222(0.97); C224(0.91)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C186(0.78); C316(1.06)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C222(0.94)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C186(4.41); C222(0.71); C316(0.91)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C222(0.94); C316(0.76)  LDD2104  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C222(0.83); C316(1.02); C224(1.28)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C222(0.84)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C186(0.69); C222(0.74); C316(0.87)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C186(0.74); C316(0.98)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C222(0.72); C316(1.30)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C186(4.85); C222(0.41)  LDD2115  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C186(2.12)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C186(1.10); C316(0.54)  LDD2120  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C186(0.84); C222(0.92); C316(0.75); C224(0.55)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C186(0.57); C222(0.80); C316(0.76); C224(0.64)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C186(0.82); C222(0.95); C316(1.15); C224(0.88)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C186(0.87)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C186(5.97); C222(0.52); C316(0.53)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C186(2.85); C222(0.67); C316(0.47)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C222(1.19); C224(0.82)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C222(1.22); C224(0.85)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C186(1.08); C222(0.70); C316(0.85); C224(0.83)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C316(2.28); C222(1.23); C186(0.97)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C186(0.96); C222(1.02); C316(0.67)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C222(0.78); C316(0.48)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C316(0.98)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C222(2.36)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C186(0.85); C316(0.93)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C186(2.71); C222(0.47); C316(0.40)  LDD2148  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C316(0.41)  LDD2150  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C348(0.59)  LDD2206  [20]
 LDCM0628  OTUB2-COV-1 HEK-293T C348(0.55)  LDD2207  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-2 (MEOX2) . P50222

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.