Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name DBIA  Probe Info 
Probe concentration 50 mM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
TMT
Competitor Name BDHI 18  Competitor Info 
Competitor Concentration 50 mM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Bone marrow
Disease Model T acute lymphoblastic leukemia [ICD-11:2A90]
Model Name Human T acute lymphoblastic leukemia cell lysate (Jurkat)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C27 18.8
 LDTP05258  Sorbitol dehydrogenase (SORD) C45 14.0
 LDTP01787  Phosphoglycerate kinase 1 (PGK1) C50 13.8
 LDTP03497  Non-receptor tyrosine-protein kinase TYK2 (TYK2) C402 13.3
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 6.5
Transporter and channel
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10073  Protein RFT1 homolog (RFT1) C70 11.2
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP17518  Zinc finger protein 627 (ZNF627) C234 13.0
 LDTP04281  Transcriptional repressor CTCF (CTCF) C577 9.7
Other
Click to Show/Hide to Show 9 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP07333  Integrator complex subunit 3 (INTS3) C843 16.2
 LDTP06055  Eukaryotic translation initiation factor 3 subunit A (EIF3A) C160 15.0
 LDTP11138  Protein pelota homolog (PELO) C204 11.7
 LDTP18918  MORF4 family associated protein 1 like 2 (MRFAP1L2) C89 10.4
 LDTP12678  Integrator complex subunit 7 (INTS7) C618 7.0
 LDTP17802  Glutathione S-transferase C-terminal domain-containing protein (GSTCD) C140 6.6
 LDTP16111  Integrator complex subunit 10 (INTS10) C176 6.4
 LDTP03520  Phosphatidylethanolamine-binding protein 1 (PEBP1) C133 6.4
 LDTP01460  Protein furry homolog-like (FRYL) C1203 6.2

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.