Details of the Target

General Information of Target

Target ID LDTP12678
Target Name Integrator complex subunit 7 (INTS7)
Gene Name INTS7
Gene ID 25896
Synonyms
C1orf73; Integrator complex subunit 7; Int7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATALSEEELDNEDYYSLLNVRREASSEELKAAYRRLCMLYHPDKHRDPELKSQAERLFN
LVHQAYEVLSDPQTRAIYDIYGKRGLEMEGWEVVERRRTPAEIREEFERLQREREERRLQ
QRTNPKGTISVGVDATDLFDRYDEEYEDVSGSSFPQIEINKMHISQSIEAPLTATDTAIL
SGSLSTQNGNGGGSINFALRRVTSAKGWGELEFGAGDLQGPLFGLKLFRNLTPRCFVTTN
CALQFSSRGIRPGLTTVLARNLDKNTVGYLQWRWGIQSAMNTSIVRDTKTSHFTVALQLG
IPHSFALISYQHKFQDDDQTRVKGSLKAGFFGTVVEYGAERKISRHSVLGAAVSVGVPQG
VSLKVKLNRASQTYFFPIHLTDQLLPSAMFYATVGPLVVYFAMHRLIIKPYLRAQKEKEL
EKQRESAATDVLQKKQEAESAVRLMQESVRRIIEAEESRMGLIIVNAWYGKFVNDKSRKS
EKVKVIDVTVPLQCLVKDSKLILTEASKAGLPGFYDPCVGEEKNLKVLYQFRGVLHQVMV
LDSEALRIPKQSHRIDTDG
Target Bioclass
Other
Family
Integrator subunit 7 family
Subcellular location
Nucleus
Function
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Plays a role in DNA damage response (DDR) signaling during the S phase. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex.
Uniprot ID
Q9NVH2
Ensemble ID
ENST00000366992.7
HGNC ID
HGNC:24484

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R480Ter DBIA    Probe Info 
HEL SNV: p.L123V DBIA    Probe Info 
HEL9217 SNV: p.L123V DBIA    Probe Info 
HT Deletion: p.S109LfsTer2 DBIA    Probe Info 
HT115 SNV: p.S337Y; p.A783D .
HUH28 SNV: p.Q617Ter DBIA    Probe Info 
K562 SNV: p.T735N .
MFE319 SNV: p.S398G DBIA    Probe Info 
NCIH2286 SNV: p.A542S .
ONS76 SNV: p.E725K DBIA    Probe Info 
SKMEL2 SNV: p.H425R DBIA    Probe Info 
SNGM SNV: p.K31N DBIA    Probe Info 
SNU1 SNV: p.V45I DBIA    Probe Info 
SW620 SNV: p.S392F DBIA    Probe Info 
SW756 SNV: p.E19K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.97  LDD0402  [1]
TH211
 Probe Info  		Y353(16.76)  LDD0257  [2]
STPyne
 Probe Info  		K137(1.24)  LDD0277  [3]
Probe 1
 Probe Info  		Y935(20.21)  LDD3495  [4]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [5]
BTD
 Probe Info  		C42(1.05)  LDD2099  [6]
DBIA
 Probe Info  		C618(7.01)  LDD0208  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C177(0.00); C374(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C177(0.00); C42(0.00); C374(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C177(0.00); C374(0.00); C618(0.00); C42(0.00)  LDD0037  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IPM
 Probe Info  		N.A.  LDD0005  [9]
PPMS
 Probe Info  		N.A.  LDD0008  [9]
TFBX
 Probe Info  		C177(0.00); C42(0.00)  LDD0148  [10]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		C42(0.00); C351(0.00)  LDD0018  [11]
W1
 Probe Info  		N.A.  LDD0236  [12]
AOyne
 Probe Info  		14.90  LDD0443  [13]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [14]
Alk-rapa
 Probe Info  		2.43  LDD0213  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C42(0.27)  LDD2112  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C42(0.88)  LDD2152  [6]
 LDCM0025  4SU-RNA HEK-293T C42(2.07)  LDD0371  [16]
 LDCM0026  4SU-RNA+native RNA HEK-293T C42(2.32)  LDD0372  [16]
 LDCM0214  AC1 HCT 116 C351(0.89); C352(0.89); C374(1.24); C42(1.37)  LDD0531  [17]
 LDCM0215  AC10 HCT 116 C351(0.59); C352(0.59); C374(1.16); C42(1.12)  LDD0532  [17]
 LDCM0216  AC100 HCT 116 C351(0.71); C352(0.71); C374(0.71); C42(0.54)  LDD0533  [17]
 LDCM0217  AC101 HCT 116 C351(0.75); C352(0.75); C374(0.82); C42(0.57)  LDD0534  [17]
 LDCM0218  AC102 HCT 116 C351(0.64); C352(0.64); C374(0.80); C42(0.63)  LDD0535  [17]
 LDCM0219  AC103 HCT 116 C351(0.63); C352(0.63); C374(0.88); C42(0.54)  LDD0536  [17]
 LDCM0220  AC104 HCT 116 C351(0.66); C352(0.66); C374(0.86); C42(0.48)  LDD0537  [17]
 LDCM0221  AC105 HCT 116 C351(0.69); C352(0.69); C374(0.86); C42(0.57)  LDD0538  [17]
 LDCM0222  AC106 HCT 116 C351(0.68); C352(0.68); C374(0.96); C42(0.57)  LDD0539  [17]
 LDCM0223  AC107 HCT 116 C351(0.69); C352(0.72); C374(0.75); C42(0.30)  LDD0540  [17]
 LDCM0224  AC108 HCT 116 C351(0.67); C352(0.62); C374(1.16); C42(0.77)  LDD0541  [17]
 LDCM0225  AC109 HCT 116 C351(0.70); C352(0.74); C374(0.93); C42(1.23)  LDD0542  [17]
 LDCM0226  AC11 HCT 116 C351(0.49); C352(0.49); C374(1.02); C42(0.99)  LDD0543  [17]
 LDCM0227  AC110 HCT 116 C351(0.63); C352(0.67); C374(0.83); C42(0.45)  LDD0544  [17]
 LDCM0228  AC111 HCT 116 C351(0.61); C352(0.65); C374(0.95); C42(1.20)  LDD0545  [17]
 LDCM0229  AC112 HCT 116 C351(0.71); C352(0.71); C374(0.80); C42(0.54)  LDD0546  [17]
 LDCM0230  AC113 HCT 116 C351(1.14); C352(1.14); C374(0.94); C42(1.28)  LDD0547  [17]
 LDCM0231  AC114 HCT 116 C351(1.04); C352(1.28); C374(1.11); C42(1.09)  LDD0548  [17]
 LDCM0232  AC115 HCT 116 C351(1.40); C352(1.21); C374(1.03); C42(1.06)  LDD0549  [17]
 LDCM0233  AC116 HCT 116 C351(1.41); C352(1.21); C374(1.11); C42(1.12)  LDD0550  [17]
 LDCM0234  AC117 HCT 116 C351(1.14); C352(1.31); C374(0.96); C42(1.46)  LDD0551  [17]
 LDCM0235  AC118 HCT 116 C351(1.11); C352(1.37); C374(1.02); C42(0.94)  LDD0552  [17]
 LDCM0236  AC119 HCT 116 C351(1.14); C352(1.28); C374(0.95); C42(1.17)  LDD0553  [17]
 LDCM0237  AC12 HCT 116 C351(0.65); C352(0.65); C374(0.92); C42(1.05)  LDD0554  [17]
 LDCM0238  AC120 HCT 116 C351(1.06); C352(1.16); C374(1.10); C42(1.23)  LDD0555  [17]
 LDCM0239  AC121 HCT 116 C351(1.18); C352(1.48); C374(1.05); C42(1.33)  LDD0556  [17]
 LDCM0240  AC122 HCT 116 C351(1.07); C352(1.20); C374(1.13); C42(1.25)  LDD0557  [17]
 LDCM0241  AC123 HCT 116 C351(1.13); C352(1.01); C374(0.94); C42(1.04)  LDD0558  [17]
 LDCM0242  AC124 HCT 116 C351(1.37); C352(1.37); C374(1.01); C42(1.01)  LDD0559  [17]
 LDCM0243  AC125 HCT 116 C351(1.15); C352(1.17); C374(1.10); C42(1.31)  LDD0560  [17]
 LDCM0244  AC126 HCT 116 C351(1.25); C352(1.17); C374(1.04); C42(1.40)  LDD0561  [17]
 LDCM0245  AC127 HCT 116 C351(1.05); C352(1.68); C374(1.11); C42(1.19)  LDD0562  [17]
 LDCM0246  AC128 HCT 116 C296(0.93); C298(0.93)  LDD0563  [17]
 LDCM0247  AC129 HCT 116 C296(1.15); C298(1.15)  LDD0564  [17]
 LDCM0249  AC130 HCT 116 C296(0.90); C298(0.90)  LDD0566  [17]
 LDCM0250  AC131 HCT 116 C296(1.38); C298(1.38)  LDD0567  [17]
 LDCM0251  AC132 HCT 116 C296(1.45); C298(1.45)  LDD0568  [17]
 LDCM0252  AC133 HCT 116 C296(1.07); C298(1.07)  LDD0569  [17]
 LDCM0253  AC134 HCT 116 C296(0.95); C298(0.95)  LDD0570  [17]
 LDCM0254  AC135 HCT 116 C296(0.98); C298(0.98)  LDD0571  [17]
 LDCM0255  AC136 HCT 116 C296(0.98); C298(0.98)  LDD0572  [17]
 LDCM0256  AC137 HCT 116 C296(1.02); C298(1.02)  LDD0573  [17]
 LDCM0257  AC138 HCT 116 C296(1.04); C298(1.04)  LDD0574  [17]
 LDCM0258  AC139 HCT 116 C296(1.16); C298(1.16)  LDD0575  [17]
 LDCM0259  AC14 HCT 116 C351(0.55); C352(0.55); C374(1.04); C42(1.06)  LDD0576  [17]
 LDCM0260  AC140 HCT 116 C296(1.01); C298(1.01)  LDD0577  [17]
 LDCM0261  AC141 HCT 116 C296(1.04); C298(1.04)  LDD0578  [17]
 LDCM0262  AC142 HCT 116 C296(1.23); C298(1.23)  LDD0579  [17]
 LDCM0263  AC143 HCT 116 C351(0.82); C352(0.82); C374(1.51)  LDD0580  [17]
 LDCM0264  AC144 HCT 116 C374(2.01)  LDD0581  [17]
 LDCM0265  AC145 HCT 116 C374(0.85)  LDD0582  [17]
 LDCM0266  AC146 HCT 116 C374(1.06)  LDD0583  [17]
 LDCM0267  AC147 HCT 116 C374(0.92)  LDD0584  [17]
 LDCM0268  AC148 HCT 116 C374(1.59)  LDD0585  [17]
 LDCM0269  AC149 HCT 116 C374(1.27)  LDD0586  [17]
 LDCM0270  AC15 HCT 116 C351(0.59); C352(0.59); C374(1.04); C42(1.28)  LDD0587  [17]
 LDCM0271  AC150 HCT 116 C374(0.92)  LDD0588  [17]
 LDCM0272  AC151 HCT 116 C374(0.99)  LDD0589  [17]
 LDCM0273  AC152 HCT 116 C374(1.13)  LDD0590  [17]
 LDCM0274  AC153 HCT 116 C374(1.02)  LDD0591  [17]
 LDCM0621  AC154 HCT 116 C374(1.03)  LDD2158  [17]
 LDCM0622  AC155 HCT 116 C374(1.21)  LDD2159  [17]
 LDCM0623  AC156 HCT 116 C374(1.22)  LDD2160  [17]
 LDCM0624  AC157 HCT 116 C374(0.75)  LDD2161  [17]
 LDCM0276  AC17 HCT 116 C42(0.88); C351(0.99); C352(0.99); C374(1.08)  LDD0593  [17]
 LDCM0277  AC18 HCT 116 C351(0.90); C352(0.90); C42(0.95); C374(1.26)  LDD0594  [17]
 LDCM0278  AC19 HCT 116 C351(0.85); C352(0.85); C42(0.86); C374(1.09)  LDD0595  [17]
 LDCM0279  AC2 HCT 116 C574(0.76); C589(0.76); C351(0.83); C352(0.83)  LDD0596  [17]
 LDCM0280  AC20 HCT 116 C42(0.78); C351(0.92); C352(0.92); C374(1.03)  LDD0597  [17]
 LDCM0281  AC21 HCT 116 C42(0.83); C351(0.90); C352(0.90); C374(1.03)  LDD0598  [17]
 LDCM0282  AC22 HCT 116 C42(0.68); C374(0.99); C351(1.12); C352(1.12)  LDD0599  [17]
 LDCM0283  AC23 HCT 116 C42(0.68); C351(0.95); C352(0.95); C374(0.99)  LDD0600  [17]
 LDCM0284  AC24 HCT 116 C42(0.91); C374(1.00); C351(1.02); C352(1.02)  LDD0601  [17]
 LDCM0285  AC25 HCT 116 C296(0.59); C298(0.59); C351(0.85); C352(0.96)  LDD0602  [17]
 LDCM0286  AC26 HCT 116 C296(0.49); C298(0.49); C351(0.75); C352(0.78)  LDD0603  [17]
 LDCM0287  AC27 HCT 116 C296(0.47); C298(0.47); C352(0.75); C351(0.78)  LDD0604  [17]
 LDCM0288  AC28 HCT 116 C296(0.46); C298(0.46); C351(0.78); C352(0.80)  LDD0605  [17]
 LDCM0289  AC29 HCT 116 C296(0.51); C298(0.51); C352(0.66); C351(0.70)  LDD0606  [17]
 LDCM0290  AC3 HCT 116 C574(0.86); C589(0.86); C351(0.92); C352(0.92)  LDD0607  [17]
 LDCM0291  AC30 HCT 116 C296(0.57); C298(0.57); C352(0.62); C351(0.65)  LDD0608  [17]
 LDCM0292  AC31 HCT 116 C296(0.42); C298(0.42); C352(0.68); C351(0.72)  LDD0609  [17]
 LDCM0293  AC32 HCT 116 C296(0.43); C298(0.43); C352(0.64); C351(0.72)  LDD0610  [17]
 LDCM0294  AC33 HCT 116 C296(0.44); C298(0.44); C351(0.66); C352(0.69)  LDD0611  [17]
 LDCM0295  AC34 HCT 116 C296(0.42); C298(0.42); C42(0.62); C351(0.67)  LDD0612  [17]
 LDCM0296  AC35 HCT 116 C42(0.91); C374(0.91); C351(1.14); C352(1.14)  LDD0613  [17]
 LDCM0297  AC36 HCT 116 C374(0.83); C42(1.04); C351(1.18); C352(1.18)  LDD0614  [17]
 LDCM0298  AC37 HCT 116 C374(0.86); C42(0.92); C351(1.01); C352(1.01)  LDD0615  [17]
 LDCM0299  AC38 HCT 116 C374(0.97); C351(1.06); C352(1.06); C42(1.06)  LDD0616  [17]
 LDCM0300  AC39 HCT 116 C42(0.91); C374(1.03); C351(1.09); C352(1.09)  LDD0617  [17]
 LDCM0301  AC4 HCT 116 C574(0.63); C589(0.63); C351(0.85); C352(0.85)  LDD0618  [17]
 LDCM0302  AC40 HCT 116 C42(0.89); C351(1.04); C352(1.04); C374(1.08)  LDD0619  [17]
 LDCM0303  AC41 HCT 116 C374(0.97); C42(0.99); C351(1.04); C352(1.04)  LDD0620  [17]
 LDCM0304  AC42 HCT 116 C42(1.00); C374(1.01); C351(1.06); C352(1.06)  LDD0621  [17]
 LDCM0305  AC43 HCT 116 C351(0.96); C352(0.96); C42(1.07); C374(1.11)  LDD0622  [17]
 LDCM0306  AC44 HCT 116 C374(1.05); C42(1.05); C351(1.08); C352(1.08)  LDD0623  [17]
 LDCM0307  AC45 HCT 116 C351(0.95); C352(0.95); C374(1.10); C42(1.13)  LDD0624  [17]
 LDCM0308  AC46 HCT 116 C351(0.99); C352(0.99); C374(1.00); C296(1.01)  LDD0625  [17]
 LDCM0309  AC47 HCT 116 C42(0.91); C374(1.06); C296(1.07); C298(1.07)  LDD0626  [17]
 LDCM0310  AC48 HCT 116 C574(0.89); C589(0.89); C351(0.92); C352(0.92)  LDD0627  [17]
 LDCM0311  AC49 HCT 116 C42(0.83); C351(0.90); C352(0.90); C296(0.97)  LDD0628  [17]
 LDCM0312  AC5 HCT 116 C574(0.59); C589(0.59); C351(0.95); C352(0.95)  LDD0629  [17]
 LDCM0313  AC50 HCT 116 C296(0.76); C298(0.76); C574(0.88); C589(0.88)  LDD0630  [17]
 LDCM0314  AC51 HCT 116 C42(0.88); C351(0.96); C352(0.96); C374(1.03)  LDD0631  [17]
 LDCM0315  AC52 HCT 116 C351(0.94); C352(0.94); C296(1.03); C298(1.03)  LDD0632  [17]
 LDCM0316  AC53 HCT 116 C351(0.83); C352(0.83); C296(0.94); C298(0.94)  LDD0633  [17]
 LDCM0317  AC54 HCT 116 C574(0.89); C589(0.89); C42(1.00); C351(1.01)  LDD0634  [17]
 LDCM0318  AC55 HCT 116 C351(0.84); C352(0.84); C296(0.86); C298(0.86)  LDD0635  [17]
 LDCM0319  AC56 HCT 116 C574(0.87); C589(0.87); C296(0.90); C298(0.90)  LDD0636  [17]
 LDCM0320  AC57 HCT 116 C296(0.43); C298(0.43); C351(0.79); C352(0.79)  LDD0637  [17]
 LDCM0321  AC58 HCT 116 C296(0.34); C298(0.34); C351(0.78); C352(0.78)  LDD0638  [17]
 LDCM0322  AC59 HCT 116 C296(0.44); C298(0.44); C351(0.72); C352(0.72)  LDD0639  [17]
 LDCM0323  AC6 HCT 116 C351(0.53); C352(0.53); C42(1.00); C374(1.01)  LDD0640  [17]
 LDCM0324  AC60 HCT 116 C296(0.36); C298(0.36); C351(0.66); C352(0.66)  LDD0641  [17]
 LDCM0325  AC61 HCT 116 C296(0.36); C298(0.36); C351(0.68); C352(0.68)  LDD0642  [17]
 LDCM0326  AC62 HCT 116 C296(0.38); C298(0.38); C351(0.67); C352(0.67)  LDD0643  [17]
 LDCM0327  AC63 HCT 116 C296(0.37); C298(0.37); C351(0.50); C352(0.50)  LDD0644  [17]
 LDCM0328  AC64 HCT 116 C296(0.37); C298(0.37); C42(0.78); C351(0.84)  LDD0645  [17]
 LDCM0329  AC65 HCT 116 C296(0.45); C298(0.45); C42(0.63); C351(0.72)  LDD0646  [17]
 LDCM0330  AC66 HCT 116 C296(0.45); C298(0.45); C351(0.80); C352(0.80)  LDD0647  [17]
 LDCM0331  AC67 HCT 116 C296(0.34); C298(0.34); C42(0.50); C351(0.64)  LDD0648  [17]
 LDCM0332  AC68 HCT 116 C351(0.58); C352(0.58); C296(0.63); C298(0.63)  LDD0649  [17]
 LDCM0333  AC69 HCT 116 C351(0.64); C352(0.64); C296(0.72); C298(0.72)  LDD0650  [17]
 LDCM0334  AC7 HCT 116 C351(0.70); C352(0.70); C374(0.96); C42(1.01)  LDD0651  [17]
 LDCM0335  AC70 HCT 116 C296(0.67); C298(0.67); C351(0.68); C352(0.68)  LDD0652  [17]
 LDCM0336  AC71 HCT 116 C351(0.68); C352(0.68); C296(1.02); C298(1.02)  LDD0653  [17]
 LDCM0337  AC72 HCT 116 C351(0.73); C352(0.73); C296(0.82); C298(0.82)  LDD0654  [17]
 LDCM0338  AC73 HCT 116 C296(0.56); C298(0.56); C351(0.67); C352(0.67)  LDD0655  [17]
 LDCM0339  AC74 HCT 116 C296(0.53); C298(0.53); C351(0.87); C352(0.87)  LDD0656  [17]
 LDCM0340  AC75 HCT 116 C351(0.71); C352(0.71); C296(0.73); C298(0.73)  LDD0657  [17]
 LDCM0341  AC76 HCT 116 C351(0.70); C352(0.70); C296(0.78); C298(0.78)  LDD0658  [17]
 LDCM0342  AC77 HCT 116 C351(0.49); C352(0.49); C296(0.60); C298(0.60)  LDD0659  [17]
 LDCM0343  AC78 HCT 116 C351(0.62); C352(0.62); C296(0.72); C298(0.72)  LDD0660  [17]
 LDCM0344  AC79 HCT 116 C351(0.74); C352(0.74); C296(0.80); C298(0.80)  LDD0661  [17]
 LDCM0345  AC8 HCT 116 C351(0.65); C352(0.65); C42(0.86); C374(0.94)  LDD0662  [17]
 LDCM0346  AC80 HCT 116 C296(0.63); C298(0.63); C351(0.71); C352(0.71)  LDD0663  [17]
 LDCM0347  AC81 HCT 116 C351(0.56); C352(0.56); C296(0.95); C298(0.95)  LDD0664  [17]
 LDCM0348  AC82 HCT 116 C296(0.68); C298(0.68); C351(0.78); C352(0.78)  LDD0665  [17]
 LDCM0349  AC83 HCT 116 C296(0.63); C298(0.63); C351(0.69); C352(0.69)  LDD0666  [17]
 LDCM0350  AC84 HCT 116 C351(0.64); C352(0.64); C296(0.65); C298(0.65)  LDD0667  [17]
 LDCM0351  AC85 HCT 116 C351(0.65); C352(0.65); C296(0.65); C298(0.65)  LDD0668  [17]
 LDCM0352  AC86 HCT 116 C42(0.70); C351(0.79); C352(0.79); C296(0.82)  LDD0669  [17]
 LDCM0353  AC87 HCT 116 C296(0.74); C298(0.74); C351(0.79); C352(0.79)  LDD0670  [17]
 LDCM0354  AC88 HCT 116 C42(0.73); C296(0.83); C298(0.83); C351(0.89)  LDD0671  [17]
 LDCM0355  AC89 HCT 116 C351(0.69); C352(0.69); C296(0.69); C298(0.69)  LDD0672  [17]
 LDCM0357  AC90 HCT 116 C42(1.13); C351(1.28); C352(1.28); C296(1.30)  LDD0674  [17]
 LDCM0358  AC91 HCT 116 C351(0.61); C352(0.61); C296(0.66); C298(0.66)  LDD0675  [17]
 LDCM0359  AC92 HCT 116 C296(0.62); C298(0.62); C351(0.66); C352(0.66)  LDD0676  [17]
 LDCM0360  AC93 HCT 116 C351(0.72); C352(0.72); C42(0.78); C296(0.80)  LDD0677  [17]
 LDCM0361  AC94 HCT 116 C351(0.77); C352(0.77); C296(0.82); C298(0.82)  LDD0678  [17]
 LDCM0362  AC95 HCT 116 C351(0.65); C352(0.65); C296(0.71); C298(0.71)  LDD0679  [17]
 LDCM0363  AC96 HCT 116 C296(0.63); C298(0.63); C351(0.76); C352(0.76)  LDD0680  [17]
 LDCM0364  AC97 HCT 116 C351(0.66); C352(0.66); C296(0.69); C298(0.69)  LDD0681  [17]
 LDCM0365  AC98 HCT 116 C42(0.62); C351(0.64); C352(0.64); C374(0.92)  LDD0682  [17]
 LDCM0366  AC99 HCT 116 C42(0.49); C351(0.74); C352(0.74); C374(0.89)  LDD0683  [17]
 LDCM0248  AKOS034007472 HCT 116 C351(0.92); C352(0.92); C374(0.98); C42(1.33)  LDD0565  [17]
 LDCM0356  AKOS034007680 HCT 116 C351(0.63); C352(0.63); C374(1.04); C42(1.11)  LDD0673  [17]
 LDCM0275  AKOS034007705 HCT 116 C351(0.46); C352(0.46); C42(0.94); C374(1.28)  LDD0592  [17]
 LDCM0156  Aniline NCI-H1299 13.42  LDD0403  [1]
 LDCM0106  BDHI 18 Jurkat C618(7.01)  LDD0208  [7]
 LDCM0367  CL1 HCT 116 C374(0.79); C351(0.91); C352(0.91); C177(0.92)  LDD0684  [17]
 LDCM0368  CL10 HCT 116 C374(0.88); C351(0.97); C352(0.97); C177(1.04)  LDD0685  [17]
 LDCM0369  CL100 HCT 116 C574(0.62); C589(0.62); C351(0.95); C352(0.95)  LDD0686  [17]
 LDCM0370  CL101 HCT 116 C351(0.57); C352(0.57); C374(1.05); C42(1.34)  LDD0687  [17]
 LDCM0371  CL102 HCT 116 C351(0.67); C352(0.67); C42(1.08); C374(1.16)  LDD0688  [17]
 LDCM0372  CL103 HCT 116 C351(0.75); C352(0.75); C374(0.89); C42(1.10)  LDD0689  [17]
 LDCM0373  CL104 HCT 116 C351(0.75); C352(0.75); C374(0.98); C42(1.13)  LDD0690  [17]
 LDCM0374  CL105 HCT 116 C42(0.66); C351(0.97); C352(0.97); C374(1.15)  LDD0691  [17]
 LDCM0375  CL106 HCT 116 C42(0.56); C351(0.84); C352(0.84); C374(1.38)  LDD0692  [17]
 LDCM0376  CL107 HCT 116 C42(0.74); C351(0.95); C352(0.95); C374(1.32)  LDD0693  [17]
 LDCM0377  CL108 HCT 116 C42(0.69); C351(0.90); C352(0.90); C374(1.41)  LDD0694  [17]
 LDCM0378  CL109 HCT 116 C42(0.70); C351(0.95); C352(0.95); C374(1.14)  LDD0695  [17]
 LDCM0379  CL11 HCT 116 C296(0.82); C298(0.82); C374(0.86); C351(0.90)  LDD0696  [17]
 LDCM0380  CL110 HCT 116 C42(0.55); C351(0.93); C352(0.93); C374(1.15)  LDD0697  [17]
 LDCM0381  CL111 HCT 116 C42(0.64); C351(0.91); C352(0.91); C374(1.13)  LDD0698  [17]
 LDCM0382  CL112 HCT 116 C296(0.71); C298(0.71); C42(0.83); C352(0.88)  LDD0699  [17]
 LDCM0383  CL113 HCT 116 C296(0.45); C298(0.45); C352(0.67); C351(0.71)  LDD0700  [17]
 LDCM0384  CL114 HCT 116 C296(0.60); C298(0.60); C352(0.70); C351(0.72)  LDD0701  [17]
 LDCM0385  CL115 HCT 116 C296(0.53); C298(0.53); C352(0.69); C351(0.73)  LDD0702  [17]
 LDCM0386  CL116 HCT 116 C296(0.53); C298(0.53); C352(0.69); C351(0.73)  LDD0703  [17]
 LDCM0387  CL117 HCT 116 C351(1.02); C352(1.02); C42(1.06); C374(1.33)  LDD0704  [17]
 LDCM0388  CL118 HCT 116 C42(0.97); C374(1.02); C351(1.03); C352(1.03)  LDD0705  [17]
 LDCM0389  CL119 HCT 116 C374(1.03); C42(1.05); C351(1.06); C352(1.06)  LDD0706  [17]
 LDCM0390  CL12 HCT 116 C374(0.80); C296(1.02); C298(1.02); C177(1.07)  LDD0707  [17]
 LDCM0391  CL120 HCT 116 C42(0.98); C351(0.98); C352(0.98); C374(1.01)  LDD0708  [17]
 LDCM0392  CL121 HCT 116 C374(0.98); C42(1.03); C351(1.28); C352(1.28)  LDD0709  [17]
 LDCM0393  CL122 HCT 116 C296(0.78); C298(0.78); C351(0.90); C352(0.90)  LDD0710  [17]
 LDCM0394  CL123 HCT 116 C351(0.77); C352(0.77); C296(0.79); C298(0.79)  LDD0711  [17]
 LDCM0395  CL124 HCT 116 C296(0.79); C298(0.79); C351(0.93); C352(0.93)  LDD0712  [17]
 LDCM0396  CL125 HCT 116 C296(0.52); C298(0.52); C351(0.72); C352(0.72)  LDD0713  [17]
 LDCM0397  CL126 HCT 116 C296(0.58); C298(0.58); C351(0.61); C352(0.61)  LDD0714  [17]
 LDCM0398  CL127 HCT 116 C296(0.64); C298(0.64); C351(0.89); C352(0.89)  LDD0715  [17]
 LDCM0399  CL128 HCT 116 C296(0.50); C298(0.50); C42(0.81); C351(0.85)  LDD0716  [17]
 LDCM0400  CL13 HCT 116 C351(0.82); C352(0.82); C374(0.89); C177(0.95)  LDD0717  [17]
 LDCM0401  CL14 HCT 116 C177(0.86); C374(0.96); C351(0.96); C352(0.96)  LDD0718  [17]
 LDCM0402  CL15 HCT 116 C351(0.77); C352(0.77); C374(0.91); C296(0.94)  LDD0719  [17]
 LDCM0403  CL16 HCT 116 C351(0.79); C352(0.79); C574(0.87); C589(0.87)  LDD0720  [17]
 LDCM0404  CL17 HCT 116 C351(0.68); C352(0.68); C296(0.79); C298(0.79)  LDD0721  [17]
 LDCM0405  CL18 HCT 116 C574(0.48); C589(0.48); C296(0.56); C298(0.56)  LDD0722  [17]
 LDCM0406  CL19 HCT 116 C574(0.69); C589(0.69); C296(0.75); C298(0.75)  LDD0723  [17]
 LDCM0407  CL2 HCT 116 C177(0.89); C374(0.90); C351(0.96); C352(0.96)  LDD0724  [17]
 LDCM0408  CL20 HCT 116 C351(0.69); C352(0.69); C574(0.73); C589(0.73)  LDD0725  [17]
 LDCM0409  CL21 HCT 116 C574(0.58); C589(0.58); C351(0.71); C352(0.71)  LDD0726  [17]
 LDCM0410  CL22 HCT 116 C574(0.51); C589(0.51); C374(0.75); C351(0.78)  LDD0727  [17]
 LDCM0411  CL23 HCT 116 C574(0.57); C589(0.57); C351(0.77); C352(0.77)  LDD0728  [17]
 LDCM0412  CL24 HCT 116 C574(0.65); C589(0.65); C351(0.85); C352(0.85)  LDD0729  [17]
 LDCM0413  CL25 HCT 116 C296(0.66); C298(0.66); C351(0.76); C352(0.76)  LDD0730  [17]
 LDCM0414  CL26 HCT 116 C296(0.79); C298(0.79); C351(0.80); C352(0.80)  LDD0731  [17]
 LDCM0415  CL27 HCT 116 C296(0.87); C298(0.87); C351(0.79); C352(0.79)  LDD0732  [17]
 LDCM0416  CL28 HCT 116 C296(0.79); C298(0.79); C351(0.71); C352(0.71)  LDD0733  [17]
 LDCM0417  CL29 HCT 116 C296(0.78); C298(0.78); C351(0.77); C352(0.77)  LDD0734  [17]
 LDCM0418  CL3 HCT 116 C177(0.89); C296(0.88); C298(0.88); C351(1.00)  LDD0735  [17]
 LDCM0419  CL30 HCT 116 C296(0.91); C298(0.91); C351(0.75); C352(0.75)  LDD0736  [17]
 LDCM0420  CL31 HCT 116 C177(0.67); C296(0.70); C298(0.70); C351(1.01)  LDD0737  [17]
 LDCM0421  CL32 HCT 116 C177(0.67); C296(0.62); C298(0.62); C351(0.90)  LDD0738  [17]
 LDCM0422  CL33 HCT 116 C177(0.64); C296(0.47); C298(0.47); C351(0.75)  LDD0739  [17]
 LDCM0423  CL34 HCT 116 C177(0.91); C296(0.56); C298(0.56); C351(0.85)  LDD0740  [17]
 LDCM0424  CL35 HCT 116 C177(0.68); C296(0.61); C298(0.61); C351(0.83)  LDD0741  [17]
 LDCM0425  CL36 HCT 116 C177(0.70); C296(0.58); C298(0.58); C351(0.80)  LDD0742  [17]
 LDCM0426  CL37 HCT 116 C177(0.79); C296(0.59); C298(0.59); C351(0.79)  LDD0743  [17]
 LDCM0428  CL39 HCT 116 C177(0.63); C296(0.53); C298(0.53); C351(0.95)  LDD0745  [17]
 LDCM0429  CL4 HCT 116 C177(0.91); C296(0.84); C298(0.84); C351(0.97)  LDD0746  [17]
 LDCM0430  CL40 HCT 116 C177(0.89); C296(0.61); C298(0.61); C351(0.69)  LDD0747  [17]
 LDCM0431  CL41 HCT 116 C177(0.79); C296(0.63); C298(0.63); C351(0.81)  LDD0748  [17]
 LDCM0432  CL42 HCT 116 C177(0.94); C296(0.50); C298(0.50); C351(0.80)  LDD0749  [17]
 LDCM0433  CL43 HCT 116 C177(0.80); C296(0.49); C298(0.49); C351(0.81)  LDD0750  [17]
 LDCM0434  CL44 HCT 116 C177(0.66); C296(0.50); C298(0.50); C351(0.69)  LDD0751  [17]
 LDCM0435  CL45 HCT 116 C177(0.87); C296(0.54); C298(0.54); C351(0.70)  LDD0752  [17]
 LDCM0436  CL46 HCT 116 C296(1.41); C298(1.41); C351(1.25); C352(1.25)  LDD0753  [17]
 LDCM0437  CL47 HCT 116 C296(1.29); C298(1.29); C351(1.20); C352(1.20)  LDD0754  [17]
 LDCM0438  CL48 HCT 116 C296(1.32); C298(1.32); C351(1.10); C352(1.10)  LDD0755  [17]
 LDCM0439  CL49 HCT 116 C296(1.09); C298(1.09); C351(1.35); C352(1.35)  LDD0756  [17]
 LDCM0440  CL5 HCT 116 C177(1.01); C296(1.18); C298(1.18); C351(1.07)  LDD0757  [17]
 LDCM0441  CL50 HCT 116 C296(1.25); C298(1.25); C351(1.16); C352(1.16)  LDD0758  [17]
 LDCM0442  CL51 HCT 116 C296(1.24); C298(1.24); C351(1.33); C352(1.33)  LDD0759  [17]
 LDCM0443  CL52 HCT 116 C296(1.29); C298(1.29); C351(1.20); C352(1.20)  LDD0760  [17]
 LDCM0444  CL53 HCT 116 C296(1.20); C298(1.20); C351(1.28); C352(1.28)  LDD0761  [17]
 LDCM0445  CL54 HCT 116 C296(1.24); C298(1.24); C351(0.98); C352(0.98)  LDD0762  [17]
 LDCM0446  CL55 HCT 116 C296(1.22); C298(1.22); C351(1.27); C352(1.27)  LDD0763  [17]
 LDCM0447  CL56 HCT 116 C296(1.12); C298(1.12); C351(1.25); C352(1.25)  LDD0764  [17]
 LDCM0448  CL57 HCT 116 C296(1.31); C298(1.31); C351(1.27); C352(1.27)  LDD0765  [17]
 LDCM0449  CL58 HCT 116 C296(1.35); C298(1.35); C351(1.52); C352(1.52)  LDD0766  [17]
 LDCM0450  CL59 HCT 116 C296(1.11); C298(1.11); C351(1.10); C352(1.10)  LDD0767  [17]
 LDCM0451  CL6 HCT 116 C177(0.82); C296(0.78); C298(0.78); C351(0.84)  LDD0768  [17]
 LDCM0452  CL60 HCT 116 C296(1.15); C298(1.15); C351(1.15); C352(1.15)  LDD0769  [17]
 LDCM0453  CL61 HCT 116 C177(0.95); C296(0.83); C298(0.83); C351(0.91)  LDD0770  [17]
 LDCM0454  CL62 HCT 116 C177(0.97); C296(0.81); C298(0.81); C351(0.80)  LDD0771  [17]
 LDCM0455  CL63 HCT 116 C177(0.81); C296(0.67); C298(0.67); C351(0.72)  LDD0772  [17]
 LDCM0456  CL64 HCT 116 C177(0.79); C296(0.61); C298(0.61); C351(0.93)  LDD0773  [17]
 LDCM0457  CL65 HCT 116 C177(0.86); C296(0.80); C298(0.80); C351(0.77)  LDD0774  [17]
 LDCM0458  CL66 HCT 116 C177(0.88); C296(0.55); C298(0.55); C351(0.88)  LDD0775  [17]
 LDCM0459  CL67 HCT 116 C177(0.89); C296(0.60); C298(0.60); C351(0.89)  LDD0776  [17]
 LDCM0460  CL68 HCT 116 C177(0.83); C296(0.58); C298(0.58); C351(2.29)  LDD0777  [17]
 LDCM0461  CL69 HCT 116 C177(0.75); C296(0.63); C298(0.63); C351(0.77)  LDD0778  [17]
 LDCM0462  CL7 HCT 116 C177(1.19); C296(1.11); C298(1.11); C351(1.07)  LDD0779  [17]
 LDCM0463  CL70 HCT 116 C177(0.75); C296(0.61); C298(0.61); C351(0.83)  LDD0780  [17]
 LDCM0464  CL71 HCT 116 C177(0.76); C296(0.60); C298(0.60); C351(0.91)  LDD0781  [17]
 LDCM0465  CL72 HCT 116 C177(1.00); C296(0.86); C298(0.86); C351(0.77)  LDD0782  [17]
 LDCM0466  CL73 HCT 116 C177(0.83); C296(0.66); C298(0.66); C351(0.81)  LDD0783  [17]
 LDCM0467  CL74 HCT 116 C177(0.82); C296(0.61); C298(0.61); C351(0.98)  LDD0784  [17]
 LDCM0469  CL76 HCT 116 C296(0.88); C298(0.88); C351(0.89); C352(0.89)  LDD0786  [17]
 LDCM0470  CL77 HCT 116 C296(1.00); C298(1.00); C351(0.85); C352(0.85)  LDD0787  [17]
 LDCM0471  CL78 HCT 116 C296(1.06); C298(1.06); C351(1.11); C352(1.11)  LDD0788  [17]
 LDCM0472  CL79 HCT 116 C296(0.83); C298(0.83); C351(1.02); C352(1.02)  LDD0789  [17]
 LDCM0473  CL8 HCT 116 C177(0.93); C296(0.67); C298(0.67); C351(0.78)  LDD0790  [17]
 LDCM0474  CL80 HCT 116 C296(0.75); C298(0.75); C351(1.09); C352(1.09)  LDD0791  [17]
 LDCM0475  CL81 HCT 116 C296(0.83); C298(0.83); C351(1.06); C352(1.06)  LDD0792  [17]
 LDCM0476  CL82 HCT 116 C296(0.70); C298(0.70); C351(1.27); C352(1.27)  LDD0793  [17]
 LDCM0477  CL83 HCT 116 C296(0.67); C298(0.67); C351(0.90); C352(0.90)  LDD0794  [17]
 LDCM0478  CL84 HCT 116 C296(0.73); C298(0.73); C351(1.06); C352(1.06)  LDD0795  [17]
 LDCM0479  CL85 HCT 116 C296(0.67); C298(0.67); C351(0.85); C352(0.85)  LDD0796  [17]
 LDCM0480  CL86 HCT 116 C296(0.97); C298(0.97); C351(0.80); C352(0.80)  LDD0797  [17]
 LDCM0481  CL87 HCT 116 C296(0.82); C298(0.82); C351(0.87); C352(0.87)  LDD0798  [17]
 LDCM0482  CL88 HCT 116 C296(0.84); C298(0.84); C351(0.84); C352(0.84)  LDD0799  [17]
 LDCM0483  CL89 HCT 116 C296(0.76); C298(0.76); C351(1.37); C352(1.37)  LDD0800  [17]
 LDCM0484  CL9 HCT 116 C177(0.89); C296(0.90); C298(0.90); C351(0.93)  LDD0801  [17]
 LDCM0485  CL90 HCT 116 C296(0.97); C298(0.97); C351(0.80); C352(0.80)  LDD0802  [17]
 LDCM0486  CL91 HCT 116 C351(0.84); C352(0.84); C374(1.12); C42(1.26)  LDD0803  [17]
 LDCM0487  CL92 HCT 116 C351(0.90); C352(0.90); C374(1.12); C42(1.26)  LDD0804  [17]
 LDCM0488  CL93 HCT 116 C351(0.96); C352(0.96); C374(1.07); C42(2.05)  LDD0805  [17]
 LDCM0489  CL94 HCT 116 C351(0.84); C352(0.84); C374(1.25); C42(1.42)  LDD0806  [17]
 LDCM0490  CL95 HCT 116 C351(0.74); C352(0.74); C374(1.25); C42(1.48)  LDD0807  [17]
 LDCM0491  CL96 HCT 116 C351(0.88); C352(0.88); C374(1.18); C42(1.49)  LDD0808  [17]
 LDCM0492  CL97 HCT 116 C351(0.88); C352(0.88); C374(1.22); C42(1.54)  LDD0809  [17]
 LDCM0493  CL98 HCT 116 C351(0.83); C352(0.83); C374(1.30); C42(1.34)  LDD0810  [17]
 LDCM0494  CL99 HCT 116 C351(0.90); C352(0.90); C374(1.30); C42(0.95)  LDD0811  [17]
 LDCM0495  E2913 HEK-293T C42(0.93); C374(0.98); C415(1.04); C618(1.48)  LDD1698  [18]
 LDCM0625  F8 Ramos C177(0.86); C42(1.02)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C177(1.73); C42(5.01)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C177(0.62)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C177(1.92); C42(6.13)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C177(0.94); C42(1.22)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C177(2.92); C42(5.74)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C177(3.95); C42(5.45)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C177(1.27); C42(1.28)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C177(1.25); C42(1.30)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C177(1.00); C42(0.81)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C177(0.78); C42(0.91)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C177(0.96); C42(1.89)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C177(1.25); C42(1.49)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C177(1.16); C42(4.61)  LDD2201  [19]
 LDCM0468  Fragment33 HCT 116 C177(0.79); C296(0.69); C298(0.69); C351(1.09)  LDD0785  [17]
 LDCM0596  Fragment38 Ramos C177(1.21); C42(1.30)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C177(1.63); C42(6.62)  LDD2184  [19]
 LDCM0427  Fragment51 HCT 116 C177(1.08); C296(0.55); C298(0.55); C351(0.76)  LDD0744  [17]
 LDCM0610  Fragment52 Ramos C177(0.99); C42(2.42)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C177(0.90); C42(1.09)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C177(1.65); C42(6.51)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C42(8.16)  LDD2188  [19]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [5]
 LDCM0022  KB02 HEK-293T C42(0.83); C177(0.91); C374(0.96); C851(1.02)  LDD1492  [18]
 LDCM0023  KB03 Jurkat C374(23.35); C42(252.60)  LDD0209  [7]
 LDCM0024  KB05 IGR37 C374(8.01)  LDD3314  [20]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C42(1.05)  LDD2099  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C42(1.10)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C42(0.67)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C42(0.74)  LDD2109  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C42(1.08)  LDD2125  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C42(1.14); C415(0.70)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C42(0.95)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C42(1.01)  LDD2140  [6]
 LDCM0090  Rapamycin JHH-7 2.43  LDD0213  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carbonic anhydrase-related protein (CA8) Alpha-carbonic anhydrase family P35219

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
15 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
16 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
17 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840