Details of the Target

General Information of Target

Target ID LDTP01460
Target Name Protein furry homolog-like (FRYL)
Gene Name FRYL
Gene ID 285527
Synonyms
AF4P12; KIAA0826; Protein furry homolog-like; ALL1-fused gene from chromosome 4p12 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSNITIDPDVKPGEYVIKSLFAEFAVQAEKKIEVVMAEPLEKLLSRSLQRGEDLQFDQLI
SSMSSVAEHCLPSLLRTLFDWYRRQNGTEDESYEYRPRSSTKSKGDEQQRERDYLLERRD
LAVDFIFCLVLVEVLKQIPVHPVPDPLVHEVLNLAFKHFKHKEGYSGTNTGNVHIIADLY
AEVIGVLAQSKFQAVRKKFVTELKELRQKEQSPHVVQSVISLIMGMKFFRVKMYPVEDFE
ASFQFMQECAQYFLEVKDKDIKHALAGLFVEILIPVAAAVKNEVNVPCLKNFVEMLYQTT
FELSSRKKHSLALYPLITCLLCVSQKQFFLNNWHIFLQNCLSHLKNKDPKMSRVALESLY
RLLWVYVIRIKCESNTVTQSRLMSIVSALFPKGSRSVVPRDTPLNIFVKIIQFIAQERLD
FAMKEIIFDLLSVGKSTKTFTINPERMNIGLRVFLVIADSLQQKDGEPPMPTTGVILPSG
NTLRVKKIFLNKTLTDEEAKVIGMSVYYPQVRKALDSILRHLDKEVGRPMCMTSVQMSNK
EPEDMITGERKPKIDLFRTCIAAIPRLIPDGMSRTDLIELLARLTIHMDEELRALAFNTL
QALMLDFPDWREDVLSGFVYFIVREVTDVHPTLLDNAVKMLVQLINQWKQAAQMHNKNQD
TQHGVANGASHPPPLERSPYSNVFHVVEGFALVILCSSRPATRRLAVSVLREIRALFALL
EIPKGDDELAIDVMDRLSPSILESFIHLTGADQTTLLYCPSSIDLQTLAEWNSSPISHQF
DVISPSHIWIFAHVTQGQDPWIISLSSFLKQENLPKHCSTAVSYAWMFAYTRLQLLSPQV
DINSPINAKKVNTTTSSDSYIGLWRNYLILCCSAATSSSSTSAGSVRCSPPETLASTPDS
GYSIDSKIIGIPSPSSLFKHIVPMMRSESMEITESLVLGLGRTNPGAFRELIEELHPIIK
EALERRPENMKRRRRRDILRVQLVRIFELLADAGVISHSASGGLDNETHFLNNTLLEYVD
LTRQLLEAENEKDSDTLKDIRCHFSALVANIIQNVPVHQRRSIFPQQSLRHSLFMLFSHW
AGPFSIMFTPLDRYSDRNMQINRHQYCALKAMSAVLCCGPVADNVGLSSDGYLYKWLDNI
LDSLDKKVHQLGCEAVTLLLELNPDQSNLMYWAVDRCYTGSGRVAAGCFKAIANVFQNRD
YQCDTVMLLNLILFKAADSSRSIYEVAMQLLQILEPKMFRYAHKLEVQRTDGVLSQLSPL
PHLYSVSYYQLSEELARAYPELTLAIFSEISQRIQTAHPAGRQVMLHYLLPWMNNIELVD
LKPLPTARRHDEDEDDSLKDRELMVTSRRWLRGEGWGSPQATAMVLNNLMYMTAKYGDEL
AWSEVENVWTTLADGWPKNLKIILHFLISICGVNSEPSLLPYVKKVIVYLGRDKTMQLLE
ELVSELQLTDPVSSGVTHMDNPPYYRITSSYKIPSVTSGTTSSSNTMVAPTDGNPDNKPI
KENIEESYVHLDIYSGLNSHLNRQHHRLESRYSSSSGGSYEEEKSDSMPLYSNWRLKVME
HNQGEPLPFPPAGGCWSPLVDYVPETSSPGLPLHRCNIAVILLTDLIIDHSVKVEWGSYL
HLLLHAIFIGFDHCHPEVYEHCKRLLLHLLIVMGPNSNIRTVASVLLRNKEFNEPRVLTV
KQVAHLDYNFTAGINDFIPDYQPSPMTDSGLSSSSTSSSISLGNNSAAISHLHTTILNEV
DISVEQDGKVKTLMEFITSRKRGPLWNHEDVSAKNPSIKSAEQLTTFLKHVVSVFKQSSS
EGIHLEHHLSEVALQTALSCSSRHYAGRSFQIFRALKQPLTATTLSDVLSRLVETVGDPG
EDAQGFVIELLLTLESAIDTLAETMKHYDLLSALSQTSYHDPIMGNKYAANRKSTGQLNL
STSPINSSSYLGYNSNARSNSLRLSLIGDRRGDRRRSNTLDIMDGRINHSSSLARTRSLS
SLREKGMYDVQSTTEPTNLMATIFWIAASLLESDYEYEYLLALRLLNKLLIHLPLDKSES
REKIENVQSKLKWTNFPGLQQLFLKGFTSASTQEMTVHLLSKLISVSKHTLVDPSQLSGF
PLNILCLLPHLIQHFDSPTQFCKETASRIAKVCAEEKCPTLVNLAHMMSLYSTHTYSRDC
SNWINVVCRYLHDSFSDTTFNLVTYLAELLEKGLSSMQQSLLQIIYSLLSHIDLSAAPAK
QFNLEIIKIIGKYVQSPYWKEALNILKLVVSRSASLVVPSDIPKTYGGDTGSPEISFTKI
FNNVSKELPGKTLDFHFDISETPIIGNKYGDQHSAAGRNGKPKVIAVTRSTSSTSSGSNS
NALVPVSWKRPQLSQRRTREKLMNVLSLCGPESGLPKNPSVVFSSNEDLEVGDQQTSLIS
TTEDINQEEEVAVEDNSSEQQFGVFKDFDFLDVELEDAEGESMDNFNWGVRRRSLDSIDK
GDTPSLQEYQCSSSTPSLNLTNQEDTDESSEEEAALTASQILSRTQMLNSDSATDETIPD
HPDLLLQSEDSTGSITTEEVLQIRDETPTLEASLDNANSRLPEDTTSVLKEEHVTTFEDE
GSYIIQEQQESLVCQGILDLEETEMPEPLAPESYPESVCEEDVTLALKELDERCEEEEAD
FSGLSSQDEEEQDGFPEVQTSPLPSPFLSAIIAAFQPVAYDDEEEAWRCHVNQMLSDTDG
SSAVFTFHVFSRLFQTIQRKFGEITNEAVSFLGDSLQRIGTKFKSSLEVMMLCSECPTVF
VDAETLMSCGLLETLKFGVLELQEHLDTYNVKREAAEQWLDDCKRTFGAKEDMYRINTDA
QQMEILAELELCRRLYKLHFQLLLLFQAYCKLINQVNTIKNEAEVINMSEELAQLESILK
EAESASENEEIDISKAAQTTIETAIHSLIETLKNKEFISAVAQVKAFRSLWPSDIFGSCE
DDPVQTLLHIYFHHQTLGQTGSFAVIGSNLDMSEANYKLMELNLEIRESLRMVQSYQLLA
QAKPMGNMVSTGF
Target Bioclass
Other
Family
Furry protein family
Function
Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching. May function as a transcriptional activator.
Uniprot ID
O94915
Ensemble ID
ENST00000358350.9
HGNC ID
HGNC:29127

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAOV3 SNV: p.G2596R DBIA    Probe Info 
CCK81 SNV: p.Y1888C DBIA    Probe Info 
COLO792 SNV: p.Q1702Ter DBIA    Probe Info 
HCT15 SNV: p.P2476L .
HSC3 SNV: p.S2300C; p.Q2945H DBIA    Probe Info 
HT Deletion: p.N1399TfsTer2 DBIA    Probe Info 
HT115 SNV: p.E202Ter; p.R2453H .
Ishikawa (Heraklio) 02 ER SNV: p.T2956M DBIA    Probe Info 
LNCaP clone FGC Deletion: p.P2237LfsTer10 DBIA    Probe Info 
MCC13 SNV: p.S2335F DBIA    Probe Info 
MDAMB453 SNV: p.D899N .
MDST8 SNV: p.S2174F DBIA    Probe Info 
MFE296 SNV: p.G1353Ter DBIA    Probe Info 
MFE319 SNV: p.D609A .
NB1 SNV: p.I1868V .
NCIH2172 SNV: p.V851L; p.S1552C DBIA    Probe Info 
PF382 SNV: p.V981A DBIA    Probe Info 
RCC10RGB SNV: p.E202Ter DBIA    Probe Info 
RKO SNV: p.R1595M .
RL952 SNV: p.R1093G DBIA    Probe Info 
RT112 SNV: p.E1281Q .
SNGM SNV: p.T1205I DBIA    Probe Info 
SNU423 SNV: p.D2173V DBIA    Probe Info 
SUPT1 SNV: p.A1193V DBIA    Probe Info 
SW480 SNV: p.Q2470Ter .
SW837 SNV: p.S2040N DBIA    Probe Info 
TYKNU SNV: p.M1207I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.99  LDD0402  [1]
STPyne
 Probe Info  		K1244(0.33); K204(3.45); K513(2.17); K960(9.41)  LDD0277  [2]
Probe 1
 Probe Info  		Y114(19.12); Y1471(46.84)  LDD3495  [3]
BTD
 Probe Info  		C1188(2.03); C372(1.26)  LDD1700  [4]
HHS-475
 Probe Info  		Y2309(0.30)  LDD0265  [5]
DBIA
 Probe Info  		C2369(1.01)  LDD0080  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C372(0.00); C1177(0.00); C70(0.00); C1188(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C1177(0.00); C2803(0.00); C70(0.00); C560(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C2689(0.00); C2803(0.00); C70(0.00); C560(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
IPM
 Probe Info  		N.A.  LDD0005  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
AOyne
 Probe Info  		8.70  LDD0443  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C403
 Probe Info  		28.25  LDD2061  [13]
Photonaproxen
 Probe Info  		N.A.  LDD0157  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1188(1.22)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C372(1.35); C1188(2.75)  LDD2152  [4]
 LDCM0214  AC1 HCT 116 C2160(1.05); C1177(0.95); C2369(1.15); C2803(1.02)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C2160(1.15); C1177(1.25); C2168(1.44); C372(1.06)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C2160(0.90); C1177(0.81); C372(0.89); C888(0.98)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C2160(0.83); C1177(1.03); C372(1.09); C888(1.07)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C2160(0.84); C1177(0.84); C372(0.92); C888(0.96)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C2160(0.80); C1177(0.89); C372(0.96); C888(1.32)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C2160(0.72); C1177(0.90); C372(0.67); C888(1.27)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C2160(0.79); C1177(1.05); C372(1.04); C888(1.31)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C2160(0.89); C1177(0.98); C372(0.47); C888(1.24)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C2160(0.74); C1177(0.89); C372(0.51); C888(1.52)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C2160(0.74); C1177(0.88); C372(0.39); C888(0.94)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C2160(0.72); C1177(0.91); C372(0.30); C888(0.96)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C2160(1.06); C1177(1.27); C2168(1.18); C372(1.26)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C2160(0.67); C1177(0.94); C372(0.54); C888(0.79)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C2160(0.85); C1177(1.05); C372(0.51); C888(0.83)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C2160(0.86); C1177(0.97); C372(0.55); C888(1.25)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C2160(0.95); C1177(0.84); C2168(0.92); C2803(1.02)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C2160(0.91); C1177(0.91); C2168(0.91); C2803(1.10)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C2160(1.07); C1177(1.16); C2168(1.05); C2803(1.04)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C2160(0.98); C1177(1.11); C2168(1.01); C2803(0.90)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C2160(0.96); C1177(1.08); C2168(0.94); C2803(0.93)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C2160(1.02); C1177(1.13); C2168(1.01); C2803(1.02)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C2160(0.91); C1177(0.96); C2168(0.88); C2803(0.91)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C2160(1.16); C1177(1.44); C2168(1.21); C372(1.68)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C2160(1.01); C1177(0.98); C2168(0.92); C2803(1.04)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C2160(0.89); C1177(0.96); C2168(0.87); C2803(1.10)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C2160(0.89); C1177(1.02); C2168(0.89); C2803(0.85)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C2160(0.81); C1177(0.91); C2168(0.79); C2803(0.95)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C2160(0.89); C1177(1.10); C2168(0.87); C2803(1.20)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C2160(0.90); C1177(1.18); C2168(0.87); C2803(1.08)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C2160(1.10); C1177(0.97); C2168(1.02); C2803(1.22)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C2160(0.98); C1177(1.12); C2168(0.98); C2803(0.99)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C2160(0.95); C1177(1.50); C888(1.21)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C2160(0.98); C1177(1.37); C888(1.05)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C2160(0.76); C1177(1.87); C888(1.18)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C2160(1.02); C1177(1.45); C888(0.91)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C2160(0.81); C1177(1.71); C888(0.83)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C2160(0.88); C1177(1.49); C888(1.10)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C2160(0.82); C1177(1.85); C888(1.24)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C2160(1.15); C1177(1.78); C888(1.19)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C2160(0.82); C1177(1.62); C888(1.03)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C2160(0.87); C1177(1.53); C888(0.89)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C2160(0.91); C1177(1.66); C888(1.05)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C2160(0.91); C1177(2.40); C888(1.07)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C2160(1.18); C1177(1.15); C2168(1.28); C372(1.18)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C2160(0.90); C1177(1.99); C888(1.23)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C2160(0.89); C1177(1.79); C888(1.03)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C2160(0.98); C1177(1.53); C888(0.94)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C2160(0.99); C1177(1.11); C2168(0.99); C372(1.09)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C372(0.81); C2160(1.07); C2168(1.09); C1177(1.09)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C372(0.82); C2160(0.98); C2168(1.03); C888(1.12)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C1177(0.98); C2168(1.01); C2160(1.01); C372(1.07)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C1177(0.89); C372(1.00); C2160(1.16); C2168(1.21)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C372(0.60); C1177(1.01); C2160(1.30); C2168(1.50)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C372(0.75); C2160(1.07); C1177(1.10); C2168(1.14)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C560(1.06); C1177(1.12); C2168(1.13); C888(1.13)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C372(0.83); C2168(0.96); C2160(1.00); C888(1.06)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C372(0.78); C888(1.04); C2160(1.04); C2168(1.05)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C372(0.86); C1177(0.92); C2160(1.13); C888(1.21)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C372(0.97); C1177(1.01); C2160(1.41); C2168(1.60)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C2160(1.11); C1177(1.33); C2168(1.16); C372(1.14)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C2160(1.19); C1177(0.99); C2168(1.22); C372(0.87)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C2160(1.04); C1177(1.03); C2168(1.01); C372(1.09)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C2160(1.07); C1177(1.05); C2168(1.06); C372(0.94)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C871(0.69); C872(0.69); C372(0.89); C560(0.97)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C871(0.61); C872(0.61); C372(0.75); C560(0.94)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C372(0.91); C871(0.95); C872(0.95); C1177(1.02)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C1177(0.83); C372(1.00); C2803(1.08); C2369(1.13)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C1177(0.93); C372(0.93); C871(1.02); C872(1.02)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C871(0.68); C872(0.68); C372(0.82); C560(1.04)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C871(0.74); C872(0.74); C372(0.79); C888(1.02)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C372(0.66); C871(0.70); C872(0.70); C560(1.04)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C372(0.76); C888(1.03); C1177(1.04); C871(1.09)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C888(0.78); C2168(1.00); C1177(1.00); C2160(1.04)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C2803(0.72); C888(0.88); C1177(1.01); C2168(1.04)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C2168(0.89); C2160(0.92); C2803(0.92); C560(0.98)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C2803(0.89); C1177(1.06); C372(1.13); C560(1.14)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C2803(0.81); C2168(0.98); C2160(1.01); C1177(1.02)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C1177(1.00); C2160(1.04); C2803(1.06); C2369(1.11)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C2803(0.76); C1177(0.82); C560(1.03); C2168(1.05)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C2803(0.76); C888(0.82); C2168(1.01); C2160(1.03)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C2803(0.84); C2168(0.96); C1177(1.02); C2160(1.06)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C888(0.84); C1177(0.89); C2803(0.90); C2168(1.01)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C888(0.87); C2803(0.88); C2168(0.96); C560(0.99)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C560(0.36); C2168(0.78); C2160(0.87); C372(0.87)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C2160(0.80); C2168(0.83); C888(0.91); C560(1.04)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C2160(0.87); C2168(0.95); C1177(1.08); C888(1.10)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C2168(0.86); C560(0.87); C2160(0.88); C1177(1.05)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C2168(0.86); C560(0.88); C2160(0.91); C888(1.03)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C1177(0.96); C2160(1.06); C2369(1.20); C888(1.21)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C2160(0.89); C2168(0.90); C1177(1.05); C560(1.09)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C2168(0.76); C560(0.77); C1177(0.90); C2160(0.90)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C2168(0.95); C2160(0.96); C1177(1.00); C888(1.20)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C2168(0.75); C2160(0.78); C560(0.84); C1177(1.05)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C2168(0.96); C2160(0.97); C1177(1.00); C560(1.05)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C2160(0.98); C2168(1.00); C1177(1.07); C560(1.10)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C2168(0.97); C2160(0.99); C871(1.09); C872(1.09)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C871(0.96); C872(0.96); C2160(0.97); C888(0.97)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C2160(0.89); C888(0.98); C2168(0.99); C871(1.17)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C1177(0.84); C560(1.01); C871(1.04); C872(1.04)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C1177(0.88); C2160(0.97); C2803(1.13); C888(1.22)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C888(0.92); C1177(1.16); C560(1.24); C871(1.25)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C2160(0.86); C2168(0.90); C888(0.92); C1177(1.03)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C888(0.96); C2160(0.97); C2168(1.03); C560(1.12)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C560(1.08); C1177(1.11); C2160(1.15); C888(1.16)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C888(0.86); C871(0.87); C872(0.87); C2160(1.11)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C871(1.21); C872(1.21); C2160(1.30); C372(1.36)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C1177(1.09); C888(1.13); C871(1.34); C872(1.34)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C1177(0.72); C2160(1.00); C2168(1.12); C888(1.24)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C1177(0.82); C2168(1.07); C2160(1.08); C888(1.32)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C1177(0.90); C2160(1.09); C2168(1.17); C871(1.31)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C1177(0.98); C560(1.01); C888(1.03); C2160(1.07)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C1177(0.67); C2160(1.08); C2168(1.10); C871(1.35)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C1177(0.90); C2160(1.18); C888(1.19); C871(1.22)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C1177(0.70); C888(1.26); C2160(1.36); C871(1.69)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C1177(0.69); C2168(1.06); C888(1.27); C871(1.29)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C1177(0.93); C871(1.33); C872(1.33); C2160(1.37)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C1177(1.08); C2160(1.21); C2168(1.34); C871(1.53)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C1177(0.84); C2160(1.04); C2168(1.19); C888(1.41)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C1177(0.81); C2168(1.27); C2160(1.30); C888(1.49)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C871(0.60); C872(0.60); C1177(0.83); C2168(0.96)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C560(0.78); C871(0.82); C872(0.82); C372(0.94)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C560(0.96); C888(1.01); C372(1.05); C1177(1.08)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C871(0.98); C872(0.98); C2160(1.02); C2168(1.04)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C871(0.62); C872(0.62); C2168(0.93); C2160(0.97)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C871(0.73); C872(0.73); C2168(0.95); C2160(1.00)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C871(1.03); C872(1.03); C2168(1.14); C2160(1.21)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C871(0.82); C872(0.82); C2160(1.24); C2168(1.25)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C560(0.95); C1177(1.21); C871(1.22); C872(1.22)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C871(1.00); C872(1.00); C1177(1.06); C2168(1.07)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C560(0.82); C1177(0.99); C2168(1.01); C2160(1.07)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C2160(0.89); C871(0.89); C872(0.89); C560(0.95)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C871(0.51); C872(0.51); C2168(0.97); C2160(0.99)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C372(0.84); C888(0.96); C560(1.02); C871(1.04)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C2168(1.15); C560(1.17); C871(1.20); C872(1.20)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C2160(0.98); C888(1.00); C2168(1.02); C871(1.20)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C2168(1.29); C2160(1.30); C1177(1.31); C372(1.38)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C2803(0.75); C1177(0.90); C888(1.04); C871(1.13)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C2803(0.76); C871(0.84); C872(0.84); C1177(1.08)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C2803(0.63); C871(0.82); C872(0.82); C1177(0.89)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C871(0.93); C872(0.93); C2803(0.93); C1177(0.96)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C1177(0.89); C871(0.93); C872(0.93); C2803(1.03)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C2803(0.73); C871(0.99); C872(0.99); C1177(1.11)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C1177(0.82); C2803(0.83); C888(1.07); C871(1.40)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C2803(0.83); C871(0.99); C872(0.99); C1177(1.08)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C2803(0.72); C1177(0.95); C888(1.10); C871(1.28)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C2803(0.72); C1177(0.88); C871(1.25); C872(1.25)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C2803(0.74); C871(0.83); C872(0.83); C1177(0.84)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C2803(0.56); C871(0.73); C872(0.73); C1177(1.00)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C2803(0.87); C1177(1.06); C871(1.36); C872(1.36)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C2803(0.71); C888(1.09); C1177(1.15); C871(1.15)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C2803(0.66); C1177(0.82); C871(0.91); C872(0.91)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C372(0.96); C2160(1.00); C1177(1.10); C888(1.28)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C2160(0.78); C1177(0.89); C888(0.93); C372(1.23)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C2160(1.02); C1177(1.34); C2168(1.08); C372(1.31)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C871(0.98); C872(0.98); C2160(1.07); C372(1.07)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C1177(1.08); C560(1.26); C2160(1.30); C372(1.38)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 12.00  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C1177(0.98); C2160(1.19); C2168(1.19)  LDD2171  [6]
 LDCM0106  BDHI 18 Jurkat C1203(6.20)  LDD0208  [15]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C2369(1.70); C2369(0.76)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C560(0.51); C372(0.57); C2160(0.74); C2369(0.77)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C560(0.69); C2160(0.85); C372(1.01); C2369(1.04)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C2803(0.83); C1177(0.90); C888(0.94); C2160(1.09)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C1177(0.87); C372(1.09); C2160(1.13); C560(1.16)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C888(0.94); C2160(1.12); C871(1.13); C872(1.13)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C888(0.95); C372(0.99); C2168(1.04); C2160(1.09)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C888(0.99); C372(1.03); C560(1.05); C1177(1.08)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C871(0.80); C872(0.80); C372(0.90); C560(1.04)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C871(0.80); C872(0.80); C372(0.88); C888(1.14)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C372(0.76); C871(0.77); C872(0.77); C560(1.04)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C871(0.75); C872(0.75); C560(0.93); C372(0.97)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C871(0.77); C872(0.77); C372(0.92); C1177(1.05)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C560(0.75); C2160(0.88); C372(1.00); C1177(1.12)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C871(0.86); C872(0.86); C560(0.90); C372(0.96)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C871(0.74); C872(0.74); C372(0.84); C2160(1.13)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C560(0.72); C888(0.75); C2803(0.82); C372(0.85)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C1177(0.87); C2803(0.92); C2160(0.94); C2168(0.96)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C2168(0.84); C560(0.87); C2160(0.87); C1177(0.90)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C2803(0.78); C1177(0.80); C2168(0.88); C2160(0.94)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C888(0.94); C1177(1.00); C2803(1.00); C2168(1.04)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C2160(1.10); C1177(1.10); C2168(1.25); C560(1.31)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C2168(0.89); C2160(0.93); C560(0.98); C1177(1.06)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C2168(0.86); C2160(0.98); C372(1.00); C888(1.09)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C2160(0.77); C372(1.05); C2369(1.29); C888(1.47)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C2168(0.81); C2160(0.92); C1177(0.93); C560(0.94)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C1177(0.87); C372(1.01); C888(1.19); C871(1.30)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C1177(0.88); C888(1.01); C2160(1.06); C2168(1.11)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C871(0.94); C872(0.94); C2160(0.99); C888(1.01)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C2160(1.06); C1177(1.11); C2168(1.11); C372(1.17)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C1177(0.69); C2168(0.91); C2160(0.97); C888(1.03)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C871(0.97); C872(0.97); C888(1.01); C1177(1.05)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C1177(0.76); C2160(0.88); C2168(0.96); C871(1.05)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C1177(0.65); C2160(1.02); C871(1.19); C872(1.19)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C372(0.83); C560(0.90); C2369(1.10); C2160(1.13)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C2160(0.80); C2369(0.88); C372(0.92); C888(1.11)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C560(0.64); C2160(0.86); C372(1.05); C2369(1.14)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C560(0.55); C1177(0.83); C372(0.89); C2160(0.99)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C2160(0.96); C888(1.00); C372(1.06); C2369(1.07)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C560(0.90); C888(0.90); C2168(0.99); C1177(1.00)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C888(0.95); C1177(0.97); C560(1.03); C2160(1.18)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C560(0.46); C372(0.74); C2160(0.79); C2369(0.84)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C1177(0.97); C560(0.97); C2160(1.05); C2168(1.12)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C888(1.00); C1177(1.04); C2160(1.17); C372(1.29)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C888(0.90); C2160(1.34); C560(1.38); C1177(1.42)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C1177(0.90); C2160(0.94); C888(0.99); C2168(1.12)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C888(1.02); C1177(1.06); C2160(1.12); C2168(1.24)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C2160(0.97); C1177(0.95); C2168(1.14); C2369(1.21)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C2160(0.99); C1177(0.87); C2168(1.14); C2369(1.22)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C2160(0.96); C1177(1.07); C2168(1.15); C2369(1.26)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C2160(1.09); C1177(0.98); C2168(1.17); C2369(1.29)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C2160(1.08); C1177(1.10); C2168(1.30); C2369(1.34)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C2160(0.83); C1177(1.06); C2369(0.86); C372(0.80)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C2160(1.02); C1177(0.97); C2168(1.05); C2369(1.16)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C2160(0.97); C1177(0.95); C372(0.89); C560(1.21)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C2160(0.90); C1177(1.13); C372(1.04); C560(0.39)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C2160(0.92); C1177(0.85); C372(0.80); C560(1.95)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C2160(1.03); C1177(0.92); C372(0.92); C560(1.27)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C2160(1.03); C1177(1.03); C372(0.88); C560(1.20)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C2160(1.16); C1177(0.85); C372(1.07); C560(1.12)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C2160(1.02); C1177(0.99); C372(0.77); C560(0.76)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C2160(0.92); C1177(1.04); C372(1.01); C560(1.25)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C2160(0.88); C1177(1.05); C2369(0.92); C372(0.85)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C2160(0.89); C1177(1.00); C372(0.90); C560(0.82)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C2160(1.06); C1177(0.84); C372(0.84); C560(2.33)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C2160(1.17); C1177(0.97); C372(0.76); C560(1.01)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C2160(1.02); C1177(0.97); C372(1.02); C560(1.01)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C2160(0.99); C1177(1.11); C372(0.89); C560(1.83)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C2160(1.00); C1177(1.04); C372(1.08); C560(1.01)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C2160(0.79); C1177(1.04); C2803(0.74); C871(1.26)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C2160(1.00); C1177(0.90); C2803(0.64); C871(1.02)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C2160(1.10); C1177(0.95); C2803(0.66); C871(1.20)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C2160(1.02); C1177(0.93); C2803(0.96); C871(1.17)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C2160(1.03); C1177(1.06); C2369(0.91); C372(0.90)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C2160(1.10); C1177(1.01); C2803(0.88); C871(1.19)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C2160(1.05); C1177(1.52); C2803(0.66); C871(1.24)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C2160(0.96); C1177(2.10); C2803(0.61); C871(1.64)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C2160(1.14); C1177(1.04); C2803(0.83); C871(1.17)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C2160(0.96); C1177(1.12); C2803(0.59); C871(1.23)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C2160(0.98); C1177(1.02); C2803(0.93); C871(1.26)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C2160(1.00); C1177(0.92); C2803(0.77); C871(1.19)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C2160(1.12); C1177(1.19); C2803(0.80); C871(1.20)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C2160(1.06); C1177(0.82); C2803(0.69); C871(1.13)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C2160(1.04); C1177(1.03); C2803(0.77); C871(1.21)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C2160(0.79); C1177(0.94); C2369(1.05); C372(0.77)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C2160(1.03); C1177(0.90); C2803(0.68); C871(1.07)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C2160(0.99); C1177(0.75); C2803(1.29); C372(1.09)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C2160(0.82); C1177(0.77); C2803(1.83); C372(1.08)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C2160(0.87); C1177(1.06); C2803(1.57); C372(1.07)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C2160(0.93); C1177(1.03); C2803(0.91); C372(1.19)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C2160(1.11); C1177(0.89); C2803(0.85); C372(1.05)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C2160(0.92); C1177(0.84); C2803(1.49); C372(1.18)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C2160(1.51); C1177(1.02); C2803(1.36); C372(1.06)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C2160(0.79); C1177(0.90); C2803(1.21); C372(0.95)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C2160(0.96); C1177(0.86); C2803(0.96); C372(0.95)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C2160(0.71); C1177(1.46); C2369(1.12); C372(1.04)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C2160(0.82); C1177(0.95); C2803(1.15); C372(1.31)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C2160(1.13); C1177(0.76); C2803(0.88); C372(1.03)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C2160(1.00); C1177(1.10); C2803(1.17); C372(0.98)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C2160(0.83); C1177(0.96); C2803(2.22); C372(0.92)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C2160(0.83); C1177(0.78); C2803(1.16); C372(1.01)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C2160(1.14); C1177(1.00); C2168(0.88); C2369(1.22)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C2160(1.15); C1177(1.43); C2168(0.82); C2369(1.05)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C2160(1.18); C1177(0.96); C2168(0.79); C2369(1.17)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C2160(1.21); C1177(1.03); C2168(0.73); C2369(1.49)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C2160(0.97); C1177(1.13); C2369(1.31); C372(0.94)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C2160(1.27); C1177(1.07); C2168(1.02); C2369(1.42)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C2160(1.12); C1177(1.13); C2168(0.88); C2369(1.17)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C2160(1.03); C1177(1.74); C2168(0.86); C2369(1.52)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C2160(1.04); C1177(1.10); C2168(1.09); C2369(1.51)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C2160(0.94); C1177(1.27); C2168(0.80); C2369(1.82)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C2160(1.02); C1177(1.35); C2168(0.92); C2369(1.15)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C2160(0.96); C1177(1.06); C2168(0.86); C2369(1.25)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C2160(1.15); C1177(1.07); C2168(1.01); C2369(1.35)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C2160(1.03); C1177(1.07); C2168(0.98); C2369(1.51)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C2160(0.96); C1177(1.22); C2168(0.86); C2369(2.18)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C2160(0.72); C1177(1.06); C2369(0.98); C372(0.87)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C2160(1.25); C1177(1.20); C2168(0.95); C2369(1.24)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C2160(1.06); C1177(1.00); C2369(1.28); C2803(1.22)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C2160(1.10); C1177(0.97); C2369(1.24); C2803(1.08)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C2160(1.10); C1177(0.91); C2369(1.02); C2803(0.93)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C2160(1.20); C1177(0.95); C2369(1.08); C2803(0.85)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C2160(1.00); C1177(0.84); C2369(1.19); C2803(0.87)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C2160(1.07); C1177(0.84); C2369(1.18); C2803(0.97)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C2160(1.12); C1177(0.97); C2369(1.19); C2803(0.77)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C2160(1.07); C1177(1.13); C2369(1.23); C2803(0.89)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C2160(1.01); C1177(0.94); C2369(1.18); C2803(0.97)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C1188(0.89); C70(1.12); C372(1.06); C1177(1.04)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1188(3.44); C560(1.99)  LDD1702  [4]
 LDCM0625  F8 Ramos C372(1.44)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C372(1.24); C2803(0.70)  LDD2189  [17]
 LDCM0573  Fragment11 Ramos C1042(20.00)  LDD2190  [17]
 LDCM0574  Fragment12 Ramos C372(1.62); C2803(0.57)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C372(0.80)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C372(1.46); C1042(0.63)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C372(2.93); C2803(0.77)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C372(0.77); 1.75; C2803(1.10)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C372(1.38)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C372(0.89); C2803(0.87)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C372(0.83); C2803(0.62)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C372(1.07); C2803(0.69)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C372(1.01)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C372(1.87); C2803(0.80)  LDD2201  [17]
 LDCM0468  Fragment33 HCT 116 C2160(1.68); C1177(0.91); C2803(1.04); C372(0.99)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C372(1.01); 2.63; C2803(0.71)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C372(1.69); C1042(0.95)  LDD2184  [17]
 LDCM0427  Fragment51 HCT 116 C2160(1.09); C1177(1.08); C372(1.19); C560(0.76)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C372(1.40); C2803(0.52)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C372(1.16)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C372(1.49); C2803(0.99); C1042(0.77)  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C372(3.81); C2803(1.70)  LDD2188  [17]
 LDCM0117  HHS-0201 DM93 Y2309(0.30)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y2309(1.30)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y2309(1.64)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y2309(1.11)  LDD0268  [5]
 LDCM0022  KB02 HCT 116 C2369(1.01)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C2369(1.20)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C2369(1.65)  LDD0082  [6]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C288(1.51)  LDD2102  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C288(1.56)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C288(0.97)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C372(0.58)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C288(1.04)  LDD2094  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C288(0.89)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C372(0.64)  LDD2099  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C288(1.46)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1188(4.10)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C372(0.42); C1188(1.45)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C372(0.72)  LDD2111  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1188(3.50)  LDD2119  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C372(0.50)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1188(1.25); C288(0.81)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C372(0.61)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C372(0.99); C1188(2.32); C288(0.97)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C372(0.75); C1188(1.46); C288(0.95)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C372(0.76); C1188(3.78)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1188(2.03); C372(1.26)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C372(0.46)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C288(0.70)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1188(2.31)  LDD2144  [4]
 LDCM0021  THZ1 HCT 116 C1177(0.98); C2160(1.19); C2168(1.19)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Programmed cell death protein 10 (PDCD10) PDCD10 family Q9BUL8
Proline-rich protein 35 (PRR35) . P0CG20

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
15 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578