Details of the Target

General Information of Target

Target ID LDTP03497
Target Name Non-receptor tyrosine-protein kinase TYK2 (TYK2)
Gene Name TYK2
Gene ID 7297
Synonyms
Non-receptor tyrosine-protein kinase TYK2; EC 2.7.10.2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP
AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK
NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR
FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP
TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK
AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV
DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP
YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA
GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR
TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS
LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS
ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA
PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ
LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI
RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII
KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI
HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY
ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC
PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
Target Type
Successful
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Tyr protein kinase family, JAK subfamily
Function
Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity. Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling. Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6. The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2. In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members. In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes. Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling.
TTD ID
T78932
Uniprot ID
P29597
DrugMap ID
TTBYWP2
Ensemble ID
ENST00000525621.6
HGNC ID
HGNC:12440
ChEMBL ID
CHEMBL3553

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C838(2.17)  LDD0169  [1]
HPAP
 Probe Info  		3.23  LDD0063  [2]
DBIA
 Probe Info  		C838(1.02); C848(1.02); C736(0.98); C1140(0.92)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
NAIA_4
 Probe Info  		C536(0.00); C1151(0.00)  LDD2226  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
TFBX
 Probe Info  		C536(0.00); C736(0.00); C1187(0.00); C544(0.00)  LDD0148  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
AOyne
 Probe Info  		13.70  LDD0443  [9]
NAIA_5
 Probe Info  		C736(0.00); C1151(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C838(2.17)  LDD0169  [1]
 LDCM0214  AC1 HCT 116 C278(1.24); C736(0.93)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C965(1.11); C966(1.11)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C1140(0.87); C1142(0.87); C736(0.93)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C1140(1.02); C1142(1.02); C736(0.95)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C1140(0.68); C1142(0.68); C736(0.98)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C1140(1.08); C1142(1.08); C736(1.01)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C1140(1.04); C1142(1.04); C736(1.11)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C1140(0.86); C1142(0.86); C736(0.88)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C1140(0.91); C1142(0.91); C736(1.04)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C1140(0.96); C1142(0.96); C736(0.85)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C1140(0.68); C1142(0.68); C736(0.91)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C1140(0.95); C1142(0.95); C736(0.73)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C965(1.18); C966(1.18)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C1140(0.76); C1142(0.76); C736(1.11)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C1140(0.84); C1142(0.84); C736(0.86)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C1140(0.79); C1142(0.79); C736(0.89)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C278(0.99)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C278(1.24)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C278(1.39)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C278(1.12)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C278(1.18)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C278(1.23)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C278(1.17)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C965(1.01); C966(1.01)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C278(1.24)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C278(1.18)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C278(1.17)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C278(1.07)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C278(1.17)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C278(1.04)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C278(1.18)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C278(1.10)  LDD0562  [3]
 LDCM0246  AC128 HEK-293T C736(0.93); C848(0.86)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C736(1.45); C848(1.23)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C736(0.72); C848(1.01)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C736(0.71); C848(1.00)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C736(0.98); C848(1.08)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C736(0.72); C848(1.39)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C736(0.84); C848(1.53)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C736(0.70); C848(1.33)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C736(0.82); C848(1.00)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C736(1.21); C848(1.48)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C736(0.97); C848(1.49)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C736(1.00); C848(1.85)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C965(1.03); C966(1.03)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C736(1.11); C848(1.63)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C736(1.19); C848(1.94)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C736(0.95); C848(1.64)  LDD0860  [3]
 LDCM0263  AC143 HCT 116 C965(0.94); C966(0.94); C278(1.24)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C278(1.02); C965(1.05); C966(1.05)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C278(1.01); C965(1.04); C966(1.04)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C278(1.12); C965(1.14); C966(1.14)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C965(1.14); C966(1.14); C278(1.18)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C278(1.12); C965(1.55); C966(1.55)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C278(1.15); C965(1.22); C966(1.22)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C965(1.09); C966(1.09)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C965(0.89); C966(0.89); C278(1.17)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C965(0.91); C966(0.91); C278(1.03)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C965(1.02); C966(1.02); C278(1.07)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C278(1.17); C965(1.66); C966(1.66)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C278(1.20); C965(0.97); C966(0.97)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C278(1.04); C965(0.94); C966(0.94)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C278(1.06); C965(0.94); C966(0.94)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C278(0.97); C965(0.92); C966(0.92)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C736(0.81); C1140(1.07); C1142(1.07)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C736(0.71); C1140(1.41); C1142(1.41)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C736(0.86); C1140(0.93); C1142(0.93)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C736(1.02); C278(1.23)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C736(0.95); C1140(1.10); C1142(1.10)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C736(0.82); C1140(1.12); C1142(1.12)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C736(0.99); C1140(1.11); C1142(1.11)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C736(0.91); C1140(1.18); C1142(1.18)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C736(0.97); C1140(1.14); C1142(1.14)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C736(0.91); C965(0.94); C966(0.94); C278(1.00)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C736(0.92); C965(1.06); C966(1.06); C278(1.17)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C736(0.95); C965(1.10); C966(1.10); C278(1.16)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C736(0.82); C278(1.06); C965(1.49); C966(1.49)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C736(0.93); C278(1.04); C965(1.37); C966(1.37)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C736(1.16); C278(1.30)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C736(0.85); C278(1.04); C965(1.33); C966(1.33)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C736(0.97); C278(1.07); C965(1.35); C966(1.35)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C736(0.93); C278(1.12); C965(1.43); C966(1.43)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C736(0.84); C965(1.04); C966(1.04); C278(1.09)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C736(0.91); C965(0.98); C966(0.98); C278(1.01)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C1140(0.64); C1142(0.64); C736(0.85); C965(0.86)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C1140(0.85); C1142(0.85); C965(0.86); C966(0.86)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C1140(0.84); C1142(0.84); C965(0.87); C966(0.87)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C1140(0.86); C1142(0.86); C736(1.06); C965(1.10)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C965(0.97); C966(0.97); C1140(0.98); C1142(0.98)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C736(1.04); C278(1.33)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C1140(0.88); C1142(0.88); C965(1.16); C966(1.16)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C1140(0.81); C1142(0.81); C736(0.97); C965(1.05)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C1140(0.83); C1142(0.83); C736(1.02); C965(1.13)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C1140(0.87); C1142(0.87); C965(1.07); C966(1.07)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C1140(0.89); C1142(0.89); C965(0.99); C966(0.99)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C1140(0.91); C1142(0.91); C965(1.01); C966(1.01)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C965(0.96); C966(0.96); C736(1.08)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C965(0.96); C966(0.96); C736(1.10)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C965(1.02); C966(1.02); C736(1.58)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C736(1.14); C965(1.19); C966(1.19)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C736(1.01); C278(1.41)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C965(1.12); C966(1.12); C736(1.19)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C965(0.89); C966(0.89); C736(1.16)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C736(0.98); C965(1.07); C966(1.07)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C736(1.11); C965(1.26); C966(1.26)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C736(0.92); C965(1.10); C966(1.10)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C736(1.23); C965(1.40); C966(1.40)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C965(1.27); C966(1.27); C736(1.57)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C1140(1.10); C1142(1.10); C965(1.19); C966(1.19)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C965(1.25); C966(1.25); C1140(1.29); C1142(1.29)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C1140(1.25); C1142(1.25); C965(1.44); C966(1.44)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C965(1.18); C966(1.18)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C1140(1.13); C1142(1.13); C965(1.18); C966(1.18)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C1140(1.34); C1142(1.34); C965(1.36); C966(1.36)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C1140(0.99); C1142(0.99); C965(1.40); C966(1.40)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C1140(0.99); C1142(0.99); C965(1.25); C966(1.25)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C1140(1.03); C1142(1.03); C965(1.50); C966(1.50)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C1140(1.04); C1142(1.04); C965(1.51); C966(1.51)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C1140(1.02); C1142(1.02); C965(1.36); C966(1.36)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C1140(1.12); C1142(1.12); C965(1.60); C966(1.60)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C278(1.02)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C278(1.07)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C965(1.08); C966(1.08)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C278(0.84)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C278(1.20)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C278(1.07)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C278(1.16)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C278(1.13)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C278(1.31)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C278(1.13)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C278(1.02)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C278(1.23)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C278(1.08)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C965(1.02); C966(1.02)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C278(1.04)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C278(1.44)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C278(1.15)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C278(0.94); C1140(1.55); C1142(1.55)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C278(1.03); C1140(1.20); C1142(1.20)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C278(0.97); C1140(1.14); C1142(1.14)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C278(0.96); C1140(1.08); C1142(1.08)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C278(1.08); C1140(1.18); C1142(1.18)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C278(1.01); C1140(1.05); C1142(1.05)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C278(0.99); C1140(1.16); C1142(1.16)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C278(1.01); C1140(1.15); C1142(1.15)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C278(0.70); C1140(1.40); C1142(1.40)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C278(0.92); C1140(1.40); C1142(1.40)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C278(0.86); C1140(0.93); C1142(0.93)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C278(0.83); C1140(1.13); C1142(1.13)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C278(0.92); C1140(1.25); C1142(1.25)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C278(0.84); C1140(1.44); C1142(1.44)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C278(0.85); C1140(1.31); C1142(1.31)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C1140(0.97); C1142(0.97); C736(1.09)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C1140(0.71); C1142(0.71); C736(1.11)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C965(1.11); C966(1.11)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C965(0.98); C966(0.98)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C965(1.18); C966(1.18)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C838(1.02); C848(1.02); C736(0.98); C1140(0.92)  LDD0078  [3]
 LDCM0106  BDHI 18 Jurkat C402(13.34)  LDD0208  [10]
 LDCM0102  BDHI 8 Jurkat C402(13.34)  LDD0204  [10]
 LDCM0632  CL-Sc Hep-G2 C1187(20.00)  LDD2227  [6]
 LDCM0367  CL1 HCT 116 C278(0.95); C965(0.99); C966(0.99); C736(1.01)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C736(1.07); C278(1.30); C965(1.72); C966(1.72)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C736(1.08); C278(1.27)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C965(1.02); C966(1.02)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C965(0.98); C966(0.98)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C965(0.95); C966(0.95)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C965(1.12); C966(1.12)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C736(0.82); C1140(1.26); C1142(1.26)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C736(0.84); C1140(1.27); C1142(1.27)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C736(0.83); C1140(1.21); C1142(1.21)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C736(0.73); C1140(1.20); C1142(1.20)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C736(0.80); C1140(1.39); C1142(1.39)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C278(1.10); C736(1.24); C965(1.51); C966(1.51)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C736(0.77); C1140(1.51); C1142(1.51)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C736(0.68); C1140(1.15); C1142(1.15)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C736(0.96); C278(0.98); C965(1.04); C966(1.04)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C736(0.74); C278(0.94); C965(1.25); C966(1.25)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C736(0.82); C278(0.96); C965(1.05); C966(1.05)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C736(0.88); C965(0.98); C966(0.98); C278(1.03)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C736(1.00); C278(1.05); C965(1.16); C966(1.16)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C1140(1.12); C1142(1.12); C965(1.24); C966(1.24)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C1140(0.78); C1142(0.78); C736(0.99); C965(1.08)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C1140(0.87); C1142(0.87); C736(0.95); C965(1.01)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C278(1.08); C965(1.34); C966(1.34); C736(1.54)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C1140(0.68); C1142(0.68); C965(1.04); C966(1.04)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C736(0.76); C965(1.36); C966(1.36)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C965(1.11); C966(1.11); C736(1.15)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C736(1.26); C965(1.30); C966(1.30)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C736(1.17); C965(1.19); C966(1.19)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C965(0.98); C966(0.98); C1140(1.00); C1142(1.00)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C965(0.84); C966(0.84); C1140(0.97); C1142(0.97)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C1140(1.01); C1142(1.01); C965(1.02); C966(1.02)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C965(1.18); C966(1.18); C1140(1.25); C1142(1.25)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C965(1.10); C966(1.10); C278(1.19); C736(1.26)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C736(1.01); C965(1.07); C966(1.07); C278(1.22)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C278(1.12); C736(1.31); C965(1.32); C966(1.32)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C736(0.76); C278(1.06)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C736(0.96); C278(1.04)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C736(1.04); C278(1.06)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C736(0.93); C278(1.05)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C965(0.84); C966(0.84); C736(0.99); C278(1.01)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C278(0.95); C736(1.08)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C278(0.97); C736(1.22)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C278(0.80); C736(1.46)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C736(0.89); C278(0.97)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C278(0.87); C736(1.01)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C278(0.90); C736(0.93)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C278(0.89); C736(0.76)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C278(1.04); C736(1.02)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C278(0.88); C736(0.83)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C278(1.02); C736(1.01)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C278(1.12); C736(0.98); C965(0.92); C966(0.92)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C278(0.95); C736(0.84)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C736(0.80)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C736(0.92)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C736(0.93)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C736(0.93)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C736(0.97)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C736(0.90)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C736(0.99)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C736(1.08)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C278(1.20); C736(1.00); C965(0.90); C966(0.90)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C736(0.79)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C736(1.03)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C736(1.06)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C736(0.98)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C736(0.85)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C736(0.96)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C278(0.93)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C278(0.92)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C278(0.88)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C278(0.93)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C278(1.18); C736(1.03); C965(1.01); C966(1.01)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C278(0.94)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C278(0.96)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C278(0.85)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C278(0.81)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C278(0.83)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C278(0.86)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C278(0.98)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C278(0.89)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C278(0.87)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C278(0.95)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C278(1.13); C736(1.13); C965(1.17); C966(1.17)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C278(0.93)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C736(1.13); C965(0.96); C966(0.96)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C736(1.01); C965(0.97); C966(0.97)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C736(1.02); C965(0.85); C966(0.85)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C736(1.07); C965(1.02); C966(1.02)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C736(1.07); C965(0.90); C966(0.90)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C736(1.21); C965(1.07); C966(1.07)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C736(0.95); C965(0.98); C966(0.98)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C736(0.85); C965(1.02); C966(1.02)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C736(1.06); C965(1.05); C966(1.05)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C278(1.05); C736(1.34); C965(1.24); C966(1.24)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C736(1.19); C965(1.04); C966(1.04)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C736(0.86); C965(0.96); C966(0.96)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C736(0.94); C965(1.04); C966(1.04)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C736(1.05); C965(0.88); C966(0.88)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C736(0.96); C965(0.94); C966(0.94)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C278(0.97); C736(0.84); C965(0.90); C966(0.90)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C278(0.87); C736(0.90); C965(0.90); C966(0.90)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C278(1.02); C736(0.91); C965(0.86); C966(0.86)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C278(0.99); C736(0.83); C965(0.94); C966(0.94)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C278(1.15); C736(1.38); C965(1.53); C966(1.53)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C278(0.95); C736(0.99); C965(0.94); C966(0.94)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C278(0.95); C736(0.88); C965(0.85); C966(0.85)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C278(0.87); C736(0.96); C965(1.06); C966(1.06)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C278(1.05); C736(0.80); C965(0.86); C966(0.86)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C278(0.85); C736(0.86); C965(0.91); C966(0.91)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C278(1.00); C736(0.69); C965(0.93); C966(0.93)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C278(1.00); C736(0.75); C965(0.93); C966(0.93)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C278(1.01); C736(0.84); C965(0.82); C966(0.82)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C278(0.95); C736(0.82); C965(0.90); C966(0.90)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C278(1.03); C736(0.63); C965(0.88); C966(0.88)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C278(1.12); C736(1.21); C965(1.08); C966(1.08)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C278(0.95); C736(0.62); C965(0.90); C966(0.90)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C278(1.00); C736(0.95)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C278(0.97); C736(1.01)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C278(1.11); C736(1.09)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C278(1.08); C736(0.99)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C278(1.17); C736(0.88)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C278(1.14); C736(0.97)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C278(1.19); C736(0.98)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C278(1.19); C736(0.95)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C278(1.27); C736(1.00)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C736(0.99); C402(1.03); C1151(0.79); C278(0.97)  LDD1698  [11]
 LDCM0201  EV-3 T cell C838(5.02)  LDD0515  [12]
 LDCM0468  Fragment33 HCT 116 C736(0.98); C965(0.98); C966(0.98)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C736(0.93)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C965(5.10); C966(5.10); C278(1.18)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C965(4.81); C966(4.81); C278(1.58)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C965(20.00); C966(20.00); C278(1.16)  LDD0082  [3]
 LDCM0014  Panhematin K562 3.23  LDD0063  [2]
 LDCM0021  THZ1 HCT 116 C965(2.97); C966(2.97)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
Tyrosine-protein kinase JAK2 (JAK2) Tyr protein kinase family O60674
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Signal transducer and activator of transcription 2 (STAT2) Transcription factor STAT family P52630
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) KHDRBS family Q5VWX1
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) KHDRBS family O75525
Four and a half LIM domains protein 3 (FHL3) . Q13643
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978

The Drug(s) Related To This Target

Approved
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Baricitinib Small molecular drug DB11817
Fostamatinib Small molecular drug DB12010
Ruxolitinib Small molecular drug DB08877
Tofacitinib Small molecular drug DB08895
Abrocitinib . DB14973
Deucravacitinib . DB16650
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bms-986165 . D0S1XX
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pf-06826647 Small molecular drug D7TA4P
Pf-06700841 . D0V4DX
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-tert-butyl-9-fluoro-16-dihydrobenzo[H]Imidazo[45-f]Isoquinolin-7-one Small molecular drug DB04716
Cmp-6 Small molecular drug D0IR6U
Patented
Click To Hide/Show 35 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aminooxazole Carboxamide Derivative 1 Small molecular drug D05AXE
Aminopyridine Derivative 1 Small molecular drug D0M2JK
Aminopyrimidine Derivative 5 Small molecular drug D0M8YW
Aminotriazolopyridine Derivative 1 Small molecular drug D09ALF
Benzimidazole Derivative 7 Small molecular drug D01CRX
Bis-aminopyrimidine Derivative 2 Small molecular drug D0LR6J
Bis-aminopyrimidine Derivative 3 Small molecular drug D0S6XT
Bis-aminopyrimidine Derivative 4 Small molecular drug D0SJ1Q
Bis-aminopyrimidine Derivative 5 Small molecular drug D0M2OK
Imidazopyridine Derivative 3 Small molecular drug D0IB3R
Imidazo[4,5-c]Pyridine Derivative 1 Small molecular drug D07PTU
Imidazo[4,5-c]Pyridine Derivative 2 Small molecular drug D0VJ1R
N-methylmethanesulfonamide Derivative 1 Small molecular drug D0XH7H
Pmid27774822-compound-figure11example5 Small molecular drug D0RJ3W
Pmid27774822-compound-figure3compoundi-165 Small molecular drug D0NY6M
Pmid27774822-compound-figure9example15 Small molecular drug D0C3HN
Pmid27774824-compound-figure11example1up Small molecular drug D0YR8S
Pmid27774824-compound-figure3example18 Small molecular drug D0U1HA
Pmid27774824-compound-figure6example12 Small molecular drug D0GB7G
Pmid27774824-compound-figure9example2down Small molecular drug D01DBB
Pmid27774824-compound-figure9example2up Small molecular drug D0WZ8N
Pyrazolopyridine Derivative 3 Small molecular drug D03QAY
Pyrazolopyridine Derivative 5 Small molecular drug D01GNL
Pyrrole Derivative 7 Small molecular drug D0YJ4D
Pyrrolo-pyridone Derivative 3 Small molecular drug D0T6CY
Pyrrolo[2,3-d]Pyrimidine Derivative 6 Small molecular drug D0FQ4Z
Pyrrolo[2,3-d]Pyrimidine Derivative 7 Small molecular drug D0U5FZ
Pyrrolo[2,3-d]Pyrimidine Derivative 8 Small molecular drug D0KL3B
Thiazolopyridine Derivative 1 Small molecular drug D0UG8S
Tricyclic Compound 11 Small molecular drug D0LS1O
Tricyclic Heterocycle Derivative 1 Small molecular drug D0X1FD
Tricyclic Heterocycle Derivative 5 Small molecular drug D0M2WA
Tricyclic Pyrrolopyridine Compound 1 Small molecular drug D04BOW
Bis-aminopyrimidine Derivative 1 . D01FVC
Pyrazolo[4,3-c]Pyridine Derivative 2 . D09PIS

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.