Details of the Target

General Information of Target

Target ID LDTP11389
Target Name Bcl-2-like protein 13 (BCL2L13)
Gene Name BCL2L13
Gene ID 23786
Synonyms
MIL1; Bcl-2-like protein 13; Bcl2-L-13; Bcl-rambo; Protein Mil1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPAVSLPPKENALFKRILRCYEHKQYRNGLKFCKQILSNPKFAEHGETLAMKGLTLNCLG
KKEEAYELVRRGLRNDLKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWDKDNLQILRDL
SLLQIQMRDLEGYRETRYQLLQLRPAQRASWIGYAIAYHLLEDYEMAAKILEEFRKTQQT
SPDKVDYEYSELLLYQNQVLREAGLYREALEHLCTYEKQICDKLAVEETKGELLLQLCRL
EDAADVYRGLQERNPENWAYYKGLEKALKPANMLERLKIYEEAWTKYPRGLVPRRLPLNF
LSGEKFKECLDKFLRMNFSKGCPPVFNTLRSLYKDKEKVAIIEELVVGYETSLKSCRLFN
PNDDGKEEPPTTLLWVQYYLAQHYDKIGQPSIALEYINTAIESTPTLIELFLVKAKIYKH
AGNIKEAARWMDEAQALDTADRFINSKCAKYMLKANLIKEAEEMCSKFTREGTSAVENLN
EMQCMWFQTECAQAYKAMNKFGEALKKCHEIERHFIEITDDQFDFHTYCMRKITLRSYVD
LLKLEDVLRQHPFYFKAARIAIEIYLKLHDNPLTDENKEHEADTANMSDKELKKLRNKQR
RAQKKAQIEEEKKNAEKEKQQRNQKKKKDDDDEEIGGPKEELIPEKLAKVETPLEEAIKF
LTPLKNLVKNKIETHLFAFEIYFRKEKFLLMLQSVKRAFAIDSSHPWLHECMIRLFNTAV
CESKDLSDTVRTVLKQEMNRLFGATNPKNFNETFLKRNSDSLPHRLSAAKMVYYLDPSSQ
KRAIELATTLDESLTNRNLQTCMEVLEALYDGSLGDCKEAAEIYRANCHKLFPYALAFMP
PGYEEDMKITVNGDSSAEAEELANEI
Target Bioclass
Other
Family
Bcl-2 family
Subcellular location
Nucleus; Mitochondrion membrane
Function May promote the activation of caspase-3 and apoptosis.
Uniprot ID
Q9BXK5
Ensemble ID
ENST00000317582.10
HGNC ID
HGNC:17164

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ETK1 SNV: p.S326F .
HCT116 SNV: p.I216V .
KPL1 Deletion: p.S5LfsTer40 .
MCF7 Deletion: p.S5LfsTer40 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C139(2.50)  LDD3383  [1]
5E-2FA
 Probe Info  		N.A.  LDD2235  [2]
m-APA
 Probe Info  		N.A.  LDD2231  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
PAL-AfBPP Probe
Click To Hide/Show 51 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.92  LDD1714  [7]
C007
 Probe Info  		5.70  LDD1716  [7]
C022
 Probe Info  		7.21  LDD1728  [7]
C040
 Probe Info  		13.83  LDD1740  [7]
C041
 Probe Info  		6.45  LDD1741  [7]
C056
 Probe Info  		25.46  LDD1753  [7]
C091
 Probe Info  		15.03  LDD1782  [7]
C092
 Probe Info  		26.17  LDD1783  [7]
C094
 Probe Info  		25.63  LDD1785  [7]
C095
 Probe Info  		5.86  LDD1786  [7]
C100
 Probe Info  		6.06  LDD1789  [7]
C112
 Probe Info  		29.45  LDD1799  [7]
C134
 Probe Info  		35.51  LDD1816  [7]
C135
 Probe Info  		9.85  LDD1817  [7]
C159
 Probe Info  		8.69  LDD1839  [7]
C160
 Probe Info  		7.84  LDD1840  [7]
C161
 Probe Info  		12.13  LDD1841  [7]
C210
 Probe Info  		68.12  LDD1884  [7]
C213
 Probe Info  		17.51  LDD1887  [7]
C218
 Probe Info  		13.00  LDD1892  [7]
C228
 Probe Info  		22.16  LDD1901  [7]
C231
 Probe Info  		20.97  LDD1904  [7]
C232
 Probe Info  		44.63  LDD1905  [7]
C233
 Probe Info  		9.25  LDD1906  [7]
C235
 Probe Info  		23.59  LDD1908  [7]
C238
 Probe Info  		14.52  LDD1911  [7]
C246
 Probe Info  		12.38  LDD1919  [7]
C264
 Probe Info  		19.16  LDD1935  [7]
C285
 Probe Info  		19.43  LDD1955  [7]
C289
 Probe Info  		43.11  LDD1959  [7]
C293
 Probe Info  		18.77  LDD1963  [7]
C299
 Probe Info  		5.94  LDD1968  [7]
C305
 Probe Info  		10.06  LDD1974  [7]
C310
 Probe Info  		8.82  LDD1977  [7]
C322
 Probe Info  		5.74  LDD1988  [7]
C343
 Probe Info  		12.04  LDD2005  [7]
C348
 Probe Info  		9.92  LDD2009  [7]
C349
 Probe Info  		15.24  LDD2010  [7]
C350
 Probe Info  		38.05  LDD2011  [7]
C355
 Probe Info  		25.99  LDD2016  [7]
C362
 Probe Info  		35.26  LDD2023  [7]
C388
 Probe Info  		68.12  LDD2047  [7]
C390
 Probe Info  		29.65  LDD2049  [7]
C403
 Probe Info  		14.03  LDD2061  [7]
C407
 Probe Info  		12.30  LDD2064  [7]
FFF probe11
 Probe Info  		20.00  LDD0471  [8]
FFF probe13
 Probe Info  		20.00  LDD0475  [8]
FFF probe14
 Probe Info  		14.70  LDD0477  [8]
FFF probe2
 Probe Info  		20.00  LDD0463  [8]
FFF probe3
 Probe Info  		20.00  LDD0465  [8]
VE-P
 Probe Info  		N.A.  LDD0396  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C139(0.99); C103(0.93)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C103(1.01)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C139(1.12)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C139(1.15)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C139(1.32); C103(1.01)  LDD1513  [10]
 LDCM0277  AC18 HEK-293T C139(0.97); C103(0.92)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C103(0.91)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C139(0.89); C103(0.99)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C139(0.99)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C139(1.09)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C139(1.08)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C139(1.00); C103(1.15)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C139(1.09); C103(1.00)  LDD1523  [10]
 LDCM0286  AC26 HEK-293T C139(1.03); C103(1.09)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C103(1.06)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C139(0.99)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C139(1.02)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C103(1.00)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C139(1.12)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C139(1.03); C103(0.94)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C139(1.00); C103(0.83)  LDD1532  [10]
 LDCM0295  AC34 HEK-293T C139(1.02); C103(1.03)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C103(1.07)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C139(0.97)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C139(1.06)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C139(1.05)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C139(1.04); C103(1.12)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C139(0.95)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C139(1.01); C103(1.03)  LDD1541  [10]
 LDCM0304  AC42 HEK-293T C139(0.94); C103(1.03)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C103(1.13)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C139(0.97)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C139(1.07)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C139(1.10)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C139(1.20); C103(0.94)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C139(0.96); C103(1.07)  LDD1549  [10]
 LDCM0312  AC5 HEK-293T C139(1.18)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C139(0.94); C103(1.01)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C103(1.00)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C139(1.04)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C139(1.11)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C139(1.13)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C139(1.09); C103(0.94)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C139(1.10); C103(1.02)  LDD1558  [10]
 LDCM0321  AC58 HEK-293T C139(0.99); C103(0.98)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C103(1.03)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C139(1.04)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C139(0.98)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C139(1.08)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C139(1.10)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C139(0.97); C103(1.05)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C139(1.02); C103(0.93)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C139(1.06); C103(1.01)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C139(1.04); C103(1.06)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C139(1.06)  LDD1511  [10]
 LDCM0275  AKOS034007705 HEK-293T C139(1.12); C103(1.04)  LDD1514  [10]
 LDCM0367  CL1 HEK-293T C139(1.19); C103(0.97)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C139(1.25)  LDD1572  [10]
 LDCM0370  CL101 HEK-293T C139(0.96); C103(0.90)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C139(1.23); C103(0.99)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C103(1.00)  LDD1576  [10]
 LDCM0374  CL105 HEK-293T C139(0.93); C103(0.91)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C139(1.12); C103(1.00)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C103(0.94)  LDD1580  [10]
 LDCM0378  CL109 HEK-293T C139(0.99); C103(0.99)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C139(1.30); C103(1.26)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C139(1.26); C103(1.03)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C103(1.11)  LDD1585  [10]
 LDCM0383  CL113 HEK-293T C139(1.08); C103(0.90)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C139(1.13); C103(0.99)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C103(1.05)  LDD1589  [10]
 LDCM0387  CL117 HEK-293T C139(0.98); C103(0.96)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C139(1.15); C103(1.01)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C103(1.03)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C139(1.15); C103(1.14)  LDD1594  [10]
 LDCM0392  CL121 HEK-293T C139(0.92); C103(0.92)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C139(1.22); C103(0.95)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C103(1.03)  LDD1598  [10]
 LDCM0396  CL125 HEK-293T C139(0.85); C103(0.85)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C139(1.05); C103(0.86)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C103(0.94)  LDD1602  [10]
 LDCM0400  CL13 HEK-293T C139(1.08); C103(0.88)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C139(1.17); C103(1.00)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C103(1.02)  LDD1606  [10]
 LDCM0405  CL18 HEK-293T C139(0.99); C103(1.20)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C103(1.14)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C139(1.16); C103(1.00)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C139(1.04)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C139(1.10)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C139(1.26)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C139(1.07); C103(1.36)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C139(1.16); C103(1.36)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C139(0.93); C103(0.97)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C139(1.17); C103(1.10)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C103(0.89)  LDD1619  [10]
 LDCM0418  CL3 HEK-293T C103(0.93)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C139(0.96); C103(1.08)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C103(1.07)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C139(1.13)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C139(1.32)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C139(1.12)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C139(1.10); C103(1.23)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C139(1.19); C103(1.29)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C139(0.95); C103(0.93)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C103(1.03)  LDD1632  [10]
 LDCM0432  CL42 HEK-293T C139(0.97); C103(1.01)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C103(0.96)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C139(1.09)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C139(1.08)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C139(1.12)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C139(1.26); C103(1.16)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C139(1.13); C103(1.14)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C139(1.11); C103(0.90)  LDD1643  [10]
 LDCM0441  CL50 HEK-293T C139(1.28); C103(1.07)  LDD1645  [10]
 LDCM0445  CL54 HEK-293T C139(1.18); C103(1.14)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C103(1.07)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C139(1.18)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C139(1.15)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C139(1.24)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C139(1.17); C103(1.19)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C139(1.05); C103(1.07)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C139(1.25); C103(1.22)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C139(0.94); C103(0.88)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C139(1.22); C103(1.08)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C103(1.04)  LDD1658  [10]
 LDCM0458  CL66 HEK-293T C139(1.10); C103(1.13)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C103(1.10)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C139(1.15)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C139(1.23)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C103(0.94)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C139(1.22)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C139(1.14); C103(1.20)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C139(1.15); C103(1.30)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C139(1.08); C103(0.86)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C139(0.97); C103(1.07)  LDD1670  [10]
 LDCM0471  CL78 HEK-293T C139(1.09); C103(1.13)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C103(1.08)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C139(1.17)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C139(0.98)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C139(1.14)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C139(1.10)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C139(1.07); C103(1.14)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C139(1.17); C103(1.08)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C139(0.94); C103(0.76)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C139(0.82); C103(0.75)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C103(0.85)  LDD1684  [10]
 LDCM0484  CL9 HEK-293T C139(1.22)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C139(1.18); C103(1.11)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C103(1.16)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C139(0.95)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C139(1.13)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C139(1.02)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C139(1.33); C103(1.23)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C139(0.93); C103(0.93)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C139(1.02); C103(0.88)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C139(0.93); C103(0.92)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C103(1.04)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C103(1.08)  LDD1698  [10]
 LDCM0573  Fragment11 Ramos C103(1.53)  LDD2190  [11]
 LDCM0468  Fragment33 HEK-293T C103(1.02)  LDD1671  [10]
 LDCM0566  Fragment4 Ramos C103(1.33)  LDD2184  [11]
 LDCM0427  Fragment51 HEK-293T C139(1.38); C103(1.04)  LDD1631  [10]
 LDCM0569  Fragment7 Ramos C103(0.74)  LDD2186  [11]
 LDCM0022  KB02 HEK-293T C139(0.98); C103(0.96)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C139(0.92); C103(0.95)  LDD1497  [10]
 LDCM0024  KB05 OVCAR-5 C139(2.50)  LDD3383  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2) Glycosyltransferase 2 family Q10471
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
Phospholipid phosphatase 4 (PLPP4) PA-phosphatase related phosphoesterase family Q5VZY2
Endoplasmic reticulum metallopeptidase 1 (ERMP1) Peptidase M28 family Q7Z2K6
Lysoplasmalogenase TMEM86A (TMEM86A) TMEM86 family Q8N2M4
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Transporter and channel
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q8IWU4
Myelin and lymphocyte protein (MAL) MAL family P21145
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972
Myelin proteolipid protein (PLP1) Myelin proteolipid protein family P60201
CMP-sialic acid transporter (SLC35A1) Nucleotide-sugar transporter family P78382
Cardiac phospholamban (PLN) Phospholamban family P26678
Solute carrier family 35 member G5 (SLC35G5) SLC35G solute transporter family Q96KT7
Small integral membrane protein 1 (SMIM1) SMIM1 family B2RUZ4
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Leukocyte surface antigen CD53 (CD53) Tetraspanin (TM4SF) family P19397
Transmembrane 6 superfamily member 2 (TM6SF2) TM6SF family Q9BZW4
Transmembrane protein 14C (TMEM14C) TMEM14 family Q9P0S9
Transmembrane protein 242 (TMEM242) TMEM242 family Q9NWH2
Sigma intracellular receptor 2 (TMEM97) TMEM97/sigma-2 receptor family Q5BJF2
Adiponectin (ADIPOQ) . Q15848
Transmembrane protein 128 (TMEM128) . Q5BJH2
Transmembrane protein 72 (TMEM72) . A0PK05
Wolframin (WFS1) . O76024
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysophosphatidic acid receptor 3 (LPAR3) G-protein coupled receptor 1 family Q9UBY5
Frizzled-7 (FZD7) G-protein coupled receptor Fz/Smo family O75084
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor (TNF) Tumor necrosis factor family P01375
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Beta-defensin 127 (DEFB127) Beta-defensin family Q9H1M4
Apolipoprotein D (APOD) Lipocalin family P05090
Ergosterol biosynthetic protein 28 homolog (ERG28) ERG28 family Q9UKR5
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
Gastrin (GAST) Gastrin/cholecystokinin family P01350
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Plasmolipin (PLLP) MAL family Q9Y342
Ninjurin-2 (NINJ2) Ninjurin family Q9NZG7
Syntaxin-12 (STX12) Syntaxin family Q86Y82
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Testican-1 (SPOCK1) . Q08629
Transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2) . Q71RG4
Transmembrane protein 254 (TMEM254) . Q8TBM7
Transmembrane protein 51 (TMEM51) . Q9NW97

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
9 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578