Details of the Target

General Information of Target

Target ID LDTP17410
Target Name Cytochrome P450 20A1 (CYP20A1)
Gene Name CYP20A1
Gene ID 57404
Synonyms
Cytochrome P450 20A1; EC 1.14.-.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLGAKPHWLPGPLHSPGLPLVLVLLALGAGWAQEGSEPVLLEGECLVVCEPGRAAAGGPG
GAALGEAPPGRVAFAAVRSHHHEPAGETGNGTSGAIYFDQVLVNEGGGFDRASGSFVAPV
RGVYSFRFHVVKVYNRQTVQVSLMLNTWPVISAFANDPDVTREAATSSVLLPLDPGDRVS
LRLRRGNLLGGWKYSSFSGFLIFPL
Target Bioclass
Enzyme
Family
Cytochrome P450 family
Subcellular location
Membrane
Uniprot ID
Q6UW02
Ensemble ID
ENST00000356079.9
HGNC ID
HGNC:20576

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 Insertion: p.S274FfsTer23 .
HEC1B Insertion: p.S274FfsTer23 .
KMRC1 SNV: p.Y127C .
SKMEL24 SNV: p.E119Ter .
SW756 SNV: p.E332K .
UACC257 SNV: p.F209I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C326(1.52)  LDD2125  [1]
IPM
 Probe Info  		C409(2.60); C326(0.81)  LDD1702  [1]
DBIA
 Probe Info  		C326(0.80); C331(0.80)  LDD0533  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [3]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
PAL-AfBPP Probe
Click To Hide/Show 103 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ILS-1 PP
 Probe Info  		2.40  LDD0417  [6]
C017
 Probe Info  		12.64  LDD1725  [7]
C022
 Probe Info  		17.51  LDD1728  [7]
C039
 Probe Info  		6.45  LDD1739  [7]
C040
 Probe Info  		29.24  LDD1740  [7]
C041
 Probe Info  		7.26  LDD1741  [7]
C049
 Probe Info  		4.96  LDD1747  [7]
C052
 Probe Info  		7.84  LDD1750  [7]
C053
 Probe Info  		7.31  LDD1751  [7]
C055
 Probe Info  		31.12  LDD1752  [7]
C056
 Probe Info  		60.13  LDD1753  [7]
C063
 Probe Info  		23.75  LDD1760  [7]
C070
 Probe Info  		11.08  LDD1766  [7]
C072
 Probe Info  		19.97  LDD1768  [7]
C091
 Probe Info  		19.43  LDD1782  [7]
C092
 Probe Info  		45.57  LDD1783  [7]
C094
 Probe Info  		42.52  LDD1785  [7]
C095
 Probe Info  		7.06  LDD1786  [7]
C106
 Probe Info  		63.56  LDD1793  [7]
C107
 Probe Info  		8.75  LDD1794  [7]
C108
 Probe Info  		18.77  LDD1795  [7]
C112
 Probe Info  		81.57  LDD1799  [7]
C134
 Probe Info  		51.27  LDD1816  [7]
C135
 Probe Info  		15.89  LDD1817  [7]
C139
 Probe Info  		16.56  LDD1821  [7]
C140
 Probe Info  		8.40  LDD1822  [7]
C141
 Probe Info  		16.56  LDD1823  [7]
C143
 Probe Info  		45.89  LDD1825  [7]
C147
 Probe Info  		7.94  LDD1829  [7]
C153
 Probe Info  		23.26  LDD1834  [7]
C159
 Probe Info  		15.03  LDD1839  [7]
C160
 Probe Info  		15.24  LDD1840  [7]
C161
 Probe Info  		64.45  LDD1841  [7]
C163
 Probe Info  		5.82  LDD1843  [7]
C166
 Probe Info  		9.25  LDD1846  [7]
C169
 Probe Info  		83.29  LDD1849  [7]
C173
 Probe Info  		5.58  LDD1853  [7]
C174
 Probe Info  		4.96  LDD1854  [7]
C178
 Probe Info  		23.92  LDD1857  [7]
C187
 Probe Info  		25.99  LDD1865  [7]
C191
 Probe Info  		14.03  LDD1868  [7]
C194
 Probe Info  		15.03  LDD1870  [7]
C196
 Probe Info  		21.71  LDD1872  [7]
C198
 Probe Info  		13.55  LDD1874  [7]
C201
 Probe Info  		99.73  LDD1877  [7]
C206
 Probe Info  		37.01  LDD1881  [7]
C210
 Probe Info  		82.14  LDD1884  [7]
C211
 Probe Info  		9.71  LDD1885  [7]
C213
 Probe Info  		15.78  LDD1887  [7]
C218
 Probe Info  		21.41  LDD1892  [7]
C220
 Probe Info  		19.70  LDD1894  [7]
C225
 Probe Info  		8.63  LDD1898  [7]
C226
 Probe Info  		8.69  LDD1899  [7]
C228
 Probe Info  		47.84  LDD1901  [7]
C229
 Probe Info  		7.73  LDD1902  [7]
C231
 Probe Info  		19.03  LDD1904  [7]
C232
 Probe Info  		43.11  LDD1905  [7]
C233
 Probe Info  		14.83  LDD1906  [7]
C235
 Probe Info  		19.43  LDD1908  [7]
C238
 Probe Info  		19.03  LDD1911  [7]
C240
 Probe Info  		12.30  LDD1913  [7]
C243
 Probe Info  		20.53  LDD1916  [7]
C246
 Probe Info  		25.63  LDD1919  [7]
C252
 Probe Info  		13.36  LDD1925  [7]
C264
 Probe Info  		17.27  LDD1935  [7]
C278
 Probe Info  		54.57  LDD1948  [7]
C282
 Probe Info  		22.16  LDD1952  [7]
C285
 Probe Info  		20.97  LDD1955  [7]
C287
 Probe Info  		9.19  LDD1957  [7]
C288
 Probe Info  		7.11  LDD1958  [7]
C289
 Probe Info  		58.08  LDD1959  [7]
C293
 Probe Info  		43.41  LDD1963  [7]
C299
 Probe Info  		9.71  LDD1968  [7]
C305
 Probe Info  		13.74  LDD1974  [7]
C313
 Probe Info  		17.75  LDD1980  [7]
C314
 Probe Info  		13.27  LDD1981  [7]
C317
 Probe Info  		6.06  LDD1983  [7]
C322
 Probe Info  		10.41  LDD1988  [7]
C326
 Probe Info  		8.17  LDD1990  [7]
C343
 Probe Info  		19.56  LDD2005  [7]
C348
 Probe Info  		22.01  LDD2009  [7]
C349
 Probe Info  		15.78  LDD2010  [7]
C350
 Probe Info  		73.01  LDD2011  [7]
C355
 Probe Info  		41.07  LDD2016  [7]
C356
 Probe Info  		11.24  LDD2017  [7]
C357
 Probe Info  		6.36  LDD2018  [7]
C362
 Probe Info  		91.77  LDD2023  [7]
C364
 Probe Info  		20.82  LDD2025  [7]
C366
 Probe Info  		11.24  LDD2027  [7]
C367
 Probe Info  		6.02  LDD2028  [7]
C383
 Probe Info  		10.93  LDD2042  [7]
C388
 Probe Info  		99.73  LDD2047  [7]
C390
 Probe Info  		99.73  LDD2049  [7]
C391
 Probe Info  		21.56  LDD2050  [7]
C399
 Probe Info  		7.73  LDD2058  [7]
C403
 Probe Info  		36.50  LDD2061  [7]
C407
 Probe Info  		28.64  LDD2064  [7]
C429
 Probe Info  		54.19  LDD2084  [7]
C431
 Probe Info  		58.08  LDD2086  [7]
FFF probe14
 Probe Info  		20.00  LDD0477  [8]
FFF probe3
 Probe Info  		20.00  LDD0464  [8]
FFF probe4
 Probe Info  		20.00  LDD0466  [8]
OEA-DA
 Probe Info  		20.00  LDD0046  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C326(1.07); C331(1.04)  LDD0812  [2]
 LDCM0215  AC10 PaTu 8988t C326(0.49); C331(0.49)  LDD1094  [2]
 LDCM0216  AC100 HCT 116 C326(0.80); C331(0.80)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C326(0.52); C331(0.52)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C326(0.65); C331(0.65)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C326(0.64); C331(0.64)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C326(0.80); C331(0.80)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C326(0.57); C331(0.57)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C326(0.69); C331(0.69)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C326(0.65); C331(0.79)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C326(1.28); C331(0.58)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C326(0.96); C331(0.53)  LDD0542  [2]
 LDCM0226  AC11 PaTu 8988t C326(0.70); C331(0.70)  LDD1105  [2]
 LDCM0227  AC110 HCT 116 C326(0.72); C331(0.83)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C326(0.99); C331(0.57)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C326(0.62); C331(0.64)  LDD0546  [2]
 LDCM0230  AC113 HEK-293T C326(1.01); C331(1.01)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C326(1.39); C331(1.39)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C326(0.97); C331(0.97)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C326(1.55); C331(1.55)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C326(1.49); C331(1.49)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C326(1.55); C331(1.55)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C326(1.48); C331(1.48)  LDD0834  [2]
 LDCM0237  AC12 PaTu 8988t C326(0.85); C331(0.85)  LDD1116  [2]
 LDCM0238  AC120 HEK-293T C326(1.26); C331(1.26)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C326(0.76); C331(0.76)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C326(0.88); C331(0.88)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C326(1.28); C331(1.28)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C326(1.02); C331(1.02)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C326(1.08); C331(1.08)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C326(0.96); C331(0.96)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C326(1.18); C331(1.18)  LDD0843  [2]
 LDCM0246  AC128 HCT 116 C326(1.09); C331(1.09)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C326(0.95); C331(0.95)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C326(0.91); C331(0.91)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C326(0.99); C331(0.99)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C326(0.82); C331(0.82)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C326(0.93); C331(0.93)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C326(0.88); C331(0.88)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C326(0.87); C331(0.87)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C326(0.80); C331(0.80)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C326(0.70); C331(0.70)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C326(0.77); C331(0.77)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C326(0.67); C331(0.67)  LDD0575  [2]
 LDCM0259  AC14 PaTu 8988t C326(0.72); C331(0.72)  LDD1138  [2]
 LDCM0260  AC140 HCT 116 C326(0.75); C331(0.75)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C326(0.79); C331(0.79)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C326(0.83); C331(0.83)  LDD0579  [2]
 LDCM0263  AC143 PaTu 8988t C409(1.34); C285(0.78); C290(0.78); C326(1.00)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C409(0.81); C285(0.82); C290(0.82); C326(1.12)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C409(0.88); C285(0.84); C290(0.84); C326(1.06)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C409(0.74); C285(1.46); C290(1.46); C326(0.95)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C409(2.25); C285(1.02); C290(1.02); C326(1.08)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C409(1.18); C285(0.82); C290(0.82); C326(0.93)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C409(0.92); C285(0.87); C290(0.87); C326(1.11)  LDD1148  [2]
 LDCM0270  AC15 PaTu 8988t C326(0.62); C331(0.62)  LDD1149  [2]
 LDCM0271  AC150 PaTu 8988t C409(1.45); C285(0.91); C290(0.91); C326(1.10)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C409(1.48); C285(0.93); C290(0.93); C326(1.24)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C409(1.18); C285(1.00); C290(1.00); C326(1.25)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C409(1.20); C285(0.84); C290(0.84); C326(0.97)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C409(0.97); C285(0.97); C290(0.97); C326(1.07)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C409(1.42); C285(0.84); C290(0.84); C326(0.97)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C409(1.56); C285(0.88); C290(0.88); C326(1.22)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C409(1.16); C285(1.04); C290(1.04); C326(1.00)  LDD2169  [2]
 LDCM0276  AC17 HEK-293T C326(0.71); C331(0.71)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C326(0.62); C331(0.62)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C326(0.72); C331(0.72)  LDD0876  [2]
 LDCM0279  AC2 HEK-293T C326(0.69); C331(1.01)  LDD0877  [2]
 LDCM0280  AC20 HEK-293T C326(0.61); C331(0.61)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C326(0.57); C331(0.57)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C326(0.63); C331(0.63)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C326(0.54); C331(0.54)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C326(0.59); C331(0.59)  LDD0882  [2]
 LDCM0285  AC25 HCT 116 C326(1.28); C331(1.28)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C326(0.98); C331(0.98)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C326(1.11); C331(1.11)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C326(0.92); C331(0.92)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C326(1.13); C331(1.13)  LDD0606  [2]
 LDCM0290  AC3 HEK-293T C326(1.27); C331(1.27)  LDD0888  [2]
 LDCM0291  AC30 HCT 116 C326(1.27); C331(1.27)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C326(0.99); C331(0.99)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C326(0.99); C331(0.99)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C326(1.03); C331(1.03)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C326(1.10); C331(1.10)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C326(1.08); C331(1.08)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C326(0.88); C331(0.88)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C326(1.34); C331(1.34)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C326(1.07); C331(1.07)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C326(0.91); C331(0.91)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C326(0.91); C331(1.05)  LDD0899  [2]
 LDCM0302  AC40 HCT 116 C326(1.17); C331(1.17)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C326(0.92); C331(0.92)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C326(0.88); C331(0.88)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C326(0.83); C331(0.83)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C326(1.11); C331(1.11)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C326(1.21); C331(1.21)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C326(0.97); C331(0.97)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C326(0.62); C331(0.62)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C326(0.80); C331(0.80)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C326(0.78); C331(0.78)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C326(1.01); C331(1.10)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C326(0.80); C331(0.80)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C326(0.63); C331(0.63)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C326(0.74); C331(0.74)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C326(0.75); C331(0.75)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C326(0.63); C331(0.63)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C326(0.53); C331(0.53)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C326(0.87); C331(0.87)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C409(1.04)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C409(1.19); C285(0.97)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C409(1.10); C331(1.23)  LDD1561  [10]
 LDCM0323  AC6 PaTu 8988t C326(0.97); C331(0.97)  LDD1202  [2]
 LDCM0324  AC60 HEK-293T C409(0.93); C331(1.12)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C409(1.09)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C409(1.14)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C409(1.11); C331(1.22); C285(1.23)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C409(1.11)  LDD1567  [10]
 LDCM0332  AC68 HCT 116 C326(0.78); C331(0.78)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C326(0.81); C331(0.81)  LDD0650  [2]
 LDCM0334  AC7 PaTu 8988t C326(1.22); C331(1.22)  LDD1213  [2]
 LDCM0335  AC70 HCT 116 C326(0.94); C331(0.94)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C326(1.30); C331(1.30)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C326(0.92); C331(0.92)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C326(0.83); C331(0.83)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C326(0.88); C331(0.88)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C326(0.74); C331(0.74)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C326(1.34); C331(1.34)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C326(1.29); C331(1.29)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C326(0.82); C331(0.82)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C326(1.25); C331(1.25)  LDD0661  [2]
 LDCM0345  AC8 PaTu 8988t C326(0.82); C331(0.82)  LDD1224  [2]
 LDCM0346  AC80 HCT 116 C326(0.86); C331(0.86)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C326(0.88); C331(0.88)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C326(0.89); C331(0.89)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C326(0.90); C331(0.90)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C326(0.95); C331(0.95)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C326(0.86); C331(0.86)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C326(0.89); C331(0.89)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C326(0.98); C331(0.98)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C326(0.77); C331(0.77)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C326(0.87); C331(0.87)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C326(0.74); C331(0.74)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C326(0.88); C331(0.88)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C326(0.85); C331(0.85)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C326(0.89); C331(0.89)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C326(1.19); C331(1.19)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C326(0.98); C331(0.98)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C326(1.07); C331(1.07)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C326(0.88); C331(0.88)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C326(0.35); C331(0.35)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C326(0.90); C331(0.90)  LDD0683  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C326(0.64); C331(0.64)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C326(0.75); C331(0.75)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C326(0.65); C331(0.65)  LDD1154  [2]
 LDCM0367  CL1 PaTu 8988t C285(1.15); C290(1.15)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C285(0.79); C290(0.79)  LDD1247  [2]
 LDCM0369  CL100 HEK-293T C326(1.38); C331(1.28)  LDD0967  [2]
 LDCM0370  CL101 PaTu 8988t C326(0.90); C331(0.90)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C326(1.03); C331(1.03)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C326(0.64); C331(0.64)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C326(0.74); C331(0.74)  LDD1252  [2]
 LDCM0374  CL105 HEK-293T C326(0.63); C331(0.63)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C326(0.56); C331(0.56)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C326(0.60); C331(0.60)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C326(0.64); C331(0.64)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C326(0.65); C331(0.65)  LDD0976  [2]
 LDCM0379  CL11 PaTu 8988t C285(0.95); C290(0.95)  LDD1258  [2]
 LDCM0380  CL110 HEK-293T C326(0.55); C331(0.55)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C326(0.65); C331(0.65)  LDD0979  [2]
 LDCM0382  CL112 HCT 116 C326(0.98); C331(0.98)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C326(1.07); C331(1.07)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C326(1.12); C331(1.12)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C326(1.14); C331(1.14)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C326(1.06); C331(1.06)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C326(0.98); C331(0.98)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C326(0.70); C331(0.70)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C326(0.79); C331(0.79)  LDD0706  [2]
 LDCM0390  CL12 PaTu 8988t C285(0.93); C290(0.93)  LDD1269  [2]
 LDCM0391  CL120 HCT 116 C326(0.72); C331(0.72)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C326(0.57); C331(0.57)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C326(0.83); C331(0.83)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C326(0.63); C331(0.63)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C326(0.74); C331(0.74)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C409(1.07)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C409(1.19); C285(1.32)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C409(1.18)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C331(1.09)  LDD1603  [10]
 LDCM0400  CL13 PaTu 8988t C285(0.71); C290(0.71)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C285(0.76); C290(0.76)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C285(0.78); C290(0.78)  LDD1281  [2]
 LDCM0403  CL16 HCT 116 C326(1.28); C331(1.28)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C326(0.86); C331(0.86)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C326(0.50); C331(0.50)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C326(0.93); C331(0.93)  LDD0723  [2]
 LDCM0407  CL2 PaTu 8988t C285(0.93); C290(0.93)  LDD1286  [2]
 LDCM0408  CL20 HCT 116 C326(0.96); C331(0.96)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C326(0.52); C331(0.52)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C326(0.55); C331(0.55)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C326(0.78); C331(0.78)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C326(0.64); C331(0.64)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C326(0.69); C331(0.69)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C326(0.82); C331(0.82)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C326(0.71); C331(0.71)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C326(0.65); C331(0.65)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C326(0.68); C331(0.68)  LDD0734  [2]
 LDCM0418  CL3 PaTu 8988t C285(0.57); C290(0.57)  LDD1297  [2]
 LDCM0419  CL30 HCT 116 C326(0.80); C331(0.80)  LDD0736  [2]
 LDCM0420  CL31 HEK-293T C326(1.05); C331(1.05)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C326(1.05); C331(1.05)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C326(0.85); C331(0.85)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C326(1.35); C331(1.35)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C326(1.11); C331(1.11)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C326(0.82); C331(0.82)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C326(0.83); C331(0.83)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C326(0.83); C331(0.83)  LDD1026  [2]
 LDCM0429  CL4 PaTu 8988t C285(0.67); C290(0.67)  LDD1308  [2]
 LDCM0430  CL40 HEK-293T C326(0.98); C331(0.98)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C326(0.88); C331(0.88)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C326(1.28); C331(1.28)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C326(1.27); C331(1.27)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C326(1.06); C331(1.06)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C326(1.04); C331(1.04)  LDD1033  [2]
 LDCM0436  CL46 HCT 116 C326(1.07); C331(1.07)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C326(0.95); C331(0.95)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C326(0.92); C331(0.92)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C326(0.91); C331(0.91)  LDD0756  [2]
 LDCM0440  CL5 PaTu 8988t C285(0.82); C290(0.82)  LDD1319  [2]
 LDCM0441  CL50 HCT 116 C326(0.88); C331(0.88)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C326(0.82); C331(0.82)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C326(0.85); C331(0.85)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C326(0.87); C331(0.87)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C326(0.80); C331(0.80)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C326(0.89); C331(0.89)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C326(0.89); C331(0.89)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C326(0.87); C331(0.87)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C326(0.76); C331(0.76)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C326(0.84); C331(0.84)  LDD0767  [2]
 LDCM0451  CL6 PaTu 8988t C285(0.90); C290(0.90)  LDD1330  [2]
 LDCM0452  CL60 HCT 116 C326(0.79); C331(0.79)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C326(1.05); C331(1.05)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C326(0.72); C331(0.72)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C326(1.40); C331(1.40)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C326(0.68); C331(0.68)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C326(0.87); C331(0.87)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C326(0.92); C331(0.92)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C326(0.91); C331(0.91)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C326(1.01); C331(1.01)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C326(1.11); C331(1.11)  LDD1059  [2]
 LDCM0462  CL7 PaTu 8988t C285(0.90); C290(0.90)  LDD1341  [2]
 LDCM0463  CL70 HEK-293T C326(1.33); C331(1.33)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C326(1.20); C331(1.20)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C326(1.01); C331(1.01)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C326(0.78); C331(0.78)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C326(0.98); C331(0.98)  LDD1065  [2]
 LDCM0469  CL76 HCT 116 C326(1.05); C331(1.05)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C326(1.14); C331(1.14)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C326(0.97); C331(0.97)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C326(1.05); C331(1.05)  LDD0789  [2]
 LDCM0473  CL8 PaTu 8988t C285(0.60); C290(0.60)  LDD1352  [2]
 LDCM0474  CL80 HCT 116 C326(0.97); C331(0.97)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C326(1.22); C331(1.22)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C326(1.49); C331(1.49)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C326(1.77); C331(1.77)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C326(1.22); C331(1.22)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C326(0.92); C331(0.92)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C326(1.16); C331(1.16)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C326(1.24); C331(1.24)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C326(1.24); C331(1.24)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C326(1.16); C331(1.16)  LDD0800  [2]
 LDCM0484  CL9 PaTu 8988t C285(0.80); C290(0.80)  LDD1363  [2]
 LDCM0485  CL90 HCT 116 C326(1.32); C331(1.32)  LDD0802  [2]
 LDCM0486  CL91 HEK-293T C326(1.00); C331(1.01)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C326(0.71); C331(0.87)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C326(0.80); C331(0.98)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C326(0.62); C331(0.76)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C326(0.49); C331(0.76)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C326(0.91); C331(0.95)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C326(0.70); C331(0.87)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C326(0.71); C331(1.07)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C326(0.75); C331(0.92)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C409(1.11)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C409(2.60); C326(0.81)  LDD1702  [1]
 LDCM0468  Fragment33 HEK-293T C326(1.00); C331(1.00)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C326(1.20); C331(1.20)  LDD1025  [2]
 LDCM0022  KB02 HEK-293T C409(1.04); C290(1.02); C331(0.96)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C409(0.99); C290(1.07); C331(0.95)  LDD1497  [10]
 LDCM0024  KB05 OVCAR-3 C409(1.23)  LDD3365  [11]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C326(1.52)  LDD2125  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3.
Mass spectrometry data entry: PXD014175
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
9 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840