Details of the Target

General Information of Target

Target ID LDTP11259
Target Name Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12)
Gene Name ALG12
Gene ID 79087
Synonyms
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; EC 2.4.1.260; Asparagine-linked glycosylation protein 12 homolog; hALG12; Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase; Mannosyltransferase ALG12 homolog; Membrane protein SB87
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLP
LDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMK
LSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLL
AQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLK
DSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELE
ELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEG
THLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKP
GTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
Target Bioclass
Enzyme
Family
Glycosyltransferase 22 family
Subcellular location
Endoplasmic reticulum membrane
Function Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.
Uniprot ID
Q9BV10
Ensemble ID
ENST00000330817.11
HGNC ID
HGNC:19358

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C328(1.26)  LDD0547  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
PAL-AfBPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		15.24  LDD1728  [3]
C040
 Probe Info  		23.26  LDD1740  [3]
C041
 Probe Info  		5.78  LDD1741  [3]
C056
 Probe Info  		27.86  LDD1753  [3]
C063
 Probe Info  		9.78  LDD1760  [3]
C092
 Probe Info  		21.56  LDD1783  [3]
C094
 Probe Info  		29.45  LDD1785  [3]
C095
 Probe Info  		5.86  LDD1786  [3]
C153
 Probe Info  		15.56  LDD1834  [3]
C187
 Probe Info  		20.11  LDD1865  [3]
C218
 Probe Info  		13.64  LDD1892  [3]
C219
 Probe Info  		6.36  LDD1893  [3]
C220
 Probe Info  		19.70  LDD1894  [3]
C225
 Probe Info  		4.99  LDD1898  [3]
C226
 Probe Info  		10.93  LDD1899  [3]
C228
 Probe Info  		22.16  LDD1901  [3]
C231
 Probe Info  		13.93  LDD1904  [3]
C233
 Probe Info  		9.99  LDD1906  [3]
C264
 Probe Info  		16.45  LDD1935  [3]
C280
 Probe Info  		23.75  LDD1950  [3]
C288
 Probe Info  		8.51  LDD1958  [3]
C289
 Probe Info  		32.45  LDD1959  [3]
C293
 Probe Info  		26.72  LDD1963  [3]
C307
 Probe Info  		5.62  LDD1975  [3]
C310
 Probe Info  		11.96  LDD1977  [3]
C390
 Probe Info  		22.78  LDD2049  [3]
C419
 Probe Info  		8.88  LDD2074  [3]
FFF probe11
 Probe Info  		20.00  LDD0471  [4]
FFF probe15
 Probe Info  		20.00  LDD0478  [4]
JN0003
 Probe Info  		20.00  LDD0469  [4]
OEA-DA
 Probe Info  		16.87  LDD0046  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C328(0.92)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C274(1.03)  LDD1508  [6]
 LDCM0216  AC100 HEK-293T C328(1.12)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C328(0.94)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C328(1.07)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C328(1.19)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C328(1.04)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C328(0.93)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C328(0.76)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C328(1.03)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C328(0.89)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C328(0.89)  LDD0823  [1]
 LDCM0226  AC11 HEK-293T C328(0.97)  LDD1509  [6]
 LDCM0227  AC110 HEK-293T C328(1.23)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C328(1.58)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C328(1.33)  LDD0827  [1]
 LDCM0230  AC113 HCT 116 C328(1.26)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C328(0.99)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C328(0.94)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C328(1.02)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C328(1.01)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C328(1.05)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C328(1.02)  LDD0553  [1]
 LDCM0237  AC12 HEK-293T C328(0.91)  LDD1510  [6]
 LDCM0238  AC120 HCT 116 C328(1.05)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C328(0.97)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C328(1.11)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C328(0.91)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C328(0.89)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C328(1.17)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C328(1.08)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C328(0.91)  LDD0562  [1]
 LDCM0246  AC128 HEK-293T C328(1.01)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C328(1.10)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C328(1.08)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C328(1.01)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C328(0.99)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C328(1.26)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C328(1.19)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C328(1.09)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C328(1.15)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C328(1.41)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C328(1.65)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C328(1.50)  LDD0856  [1]
 LDCM0260  AC140 HEK-293T C328(1.37)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C328(1.58)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C328(1.30)  LDD0860  [1]
 LDCM0263  AC143 HEK-293T C328(1.29)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C328(1.39)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C328(1.53)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C328(1.40)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C328(1.59)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C328(1.43)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C328(1.13)  LDD0867  [1]
 LDCM0270  AC15 HEK-293T C328(1.00); C274(0.95)  LDD1513  [6]
 LDCM0271  AC150 HEK-293T C328(1.34)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C328(1.30)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C328(1.23)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C328(1.22)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C328(1.20)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C328(1.35)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C328(1.55)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C328(1.79)  LDD2165  [1]
 LDCM0276  AC17 HEK-293T C328(1.32)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C328(1.10)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C328(1.10)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C274(0.94)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C328(1.31)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C328(1.16)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C328(1.41)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C328(1.48)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C328(1.18)  LDD0882  [1]
 LDCM0285  AC25 HCT 116 C328(1.23)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C328(1.09)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C328(0.88)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C328(1.10)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C328(0.74)  LDD0606  [1]
 LDCM0290  AC3 HEK-293T C328(0.86)  LDD1529  [6]
 LDCM0291  AC30 HCT 116 C328(0.66)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C328(0.80)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C328(0.71)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C328(1.15)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C328(0.97)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C328(1.36)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C328(1.08)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C328(1.69)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C328(0.95)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C328(0.90)  LDD0617  [1]
 LDCM0301  AC4 HEK-293T C328(0.95)  LDD1540  [6]
 LDCM0302  AC40 HCT 116 C328(1.09)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C328(0.98)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C328(1.03)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C328(1.32)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C328(1.38)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C328(1.50)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C328(1.05)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C328(1.19)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C328(1.12)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C328(1.09)  LDD0909  [1]
 LDCM0312  AC5 HEK-293T C328(1.20); C274(0.89)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C328(1.17)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C328(1.27)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C328(1.19)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C328(1.10)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C328(1.23)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C328(1.08)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C328(1.15)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C328(1.01)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C328(0.97)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C328(0.98)  LDD0920  [1]
 LDCM0324  AC60 HEK-293T C328(0.88)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C328(1.28)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C328(1.08)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C328(1.14)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C328(1.00)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C328(1.25)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C328(0.99)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C328(1.18)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C328(1.13)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C328(1.13)  LDD0931  [1]
 LDCM0334  AC7 HEK-293T C328(1.05); C274(1.15)  LDD1568  [6]
 LDCM0335  AC70 HEK-293T C328(1.29)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C328(1.15)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C328(1.16)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C328(1.22)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C328(1.20)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C328(1.37)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C328(1.18)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C328(1.25)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C328(1.38)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C328(1.20)  LDD0942  [1]
 LDCM0345  AC8 HEK-293T C328(0.99); C274(1.14)  LDD1569  [6]
 LDCM0346  AC80 HEK-293T C328(1.35)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C328(1.22)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C328(1.73)  LDD0946  [1]
 LDCM0349  AC83 HEK-293T C328(0.94)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C328(1.29)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C328(1.15)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C328(1.11)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C328(1.16)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C328(1.36)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C328(1.33)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C328(1.24)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C328(1.24)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C328(1.18)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C328(1.15)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C328(1.37)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C328(1.26)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C328(1.45)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C328(2.27)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C328(0.89)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C328(0.85)  LDD0964  [1]
 LDCM0248  AKOS034007472 HEK-293T C328(1.17); C274(0.99)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C328(0.90)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C328(0.94); C274(1.02)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C328(1.07); C274(1.06)  LDD1571  [6]
 LDCM0369  CL100 HEK-293T C328(1.00); C274(1.20)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C328(1.08); C274(0.99)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C328(1.18)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C328(1.01)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C328(1.07); C274(1.04)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C328(1.14)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C328(1.11)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C328(1.05)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C328(1.26)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C328(1.24)  LDD0976  [1]
 LDCM0379  CL11 HEK-293T C328(2.22); C274(1.29)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C328(1.31)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C328(1.00)  LDD0979  [1]
 LDCM0382  CL112 HCT 116 C328(0.93)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C328(0.62)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C328(0.61)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C328(0.83)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C328(0.91)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C328(0.96)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C328(0.99)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C328(1.05)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C328(1.07); C274(1.40)  LDD1594  [6]
 LDCM0391  CL120 HCT 116 C328(1.02)  LDD0708  [1]
 LDCM0392  CL121 HEK-293T C328(1.21)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C328(1.13)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C328(1.06)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C328(1.13)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C328(1.07)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C328(1.09)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C328(1.01)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C328(0.93)  LDD0997  [1]
 LDCM0400  CL13 HEK-293T C328(1.00); C274(1.05)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C328(0.95)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C328(1.23)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C328(0.99); C274(1.03)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C328(1.42)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C274(0.98)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C328(1.52)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C328(1.06)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C328(1.15)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C328(2.68); C274(0.92)  LDD1613  [6]
 LDCM0411  CL23 HEK-293T C328(1.94); C274(1.37)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C328(1.16); C274(1.22)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C328(1.22); C274(1.09)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C328(0.96)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C328(1.06)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C328(0.95); C274(1.04)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C328(0.92)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C328(1.10)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C274(0.87)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C328(1.18)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C328(1.16)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C328(1.23)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C328(1.21)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C328(1.28)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C328(1.20)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C328(1.21)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C328(1.86)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C328(1.13); C274(1.28)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C328(1.21)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C328(1.61)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C328(1.65)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C328(1.77)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C328(1.21)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C328(1.72)  LDD1033  [1]
 LDCM0437  CL47 HEK-293T C328(1.26); C274(1.46)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C328(0.92); C274(1.36)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C328(1.06); C274(0.95)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C328(0.88)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C328(1.25)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C328(1.16); C274(1.00)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C328(1.31)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C274(1.00)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C328(1.60)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C328(1.10)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C328(2.72); C274(0.93)  LDD1651  [6]
 LDCM0450  CL59 HEK-293T C328(1.27); C274(1.18)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C274(1.14)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C328(1.06); C274(1.00)  LDD1655  [6]
 LDCM0453  CL61 HCT 116 C328(0.84)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C328(0.78)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C328(0.69)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C328(0.62)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C328(0.82)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C328(0.49)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C328(0.63)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C328(0.47)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C328(0.59)  LDD0778  [1]
 LDCM0462  CL7 HEK-293T C328(1.98)  LDD1665  [6]
 LDCM0463  CL70 HCT 116 C328(0.56)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C328(0.60)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C328(0.94)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C328(0.64)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C328(0.63)  LDD0784  [1]
 LDCM0469  CL76 HEK-293T C328(1.08); C274(0.97)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C328(0.90)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C274(0.88)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C328(1.22)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C328(1.39)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C328(1.13)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C328(1.43); C274(0.90)  LDD1678  [6]
 LDCM0477  CL83 HEK-293T C328(1.99); C274(1.34)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C328(1.07); C274(1.06)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C328(1.12); C274(1.10)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C328(0.99)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C328(1.07)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C328(0.96); C274(0.96)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C328(0.59)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C328(1.69); C274(0.85)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C274(0.94)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C328(1.36)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C328(1.17)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C328(2.27); C274(1.04)  LDD1691  [6]
 LDCM0490  CL95 HEK-293T C328(1.94); C274(1.10)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C328(1.13); C274(1.13)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C328(1.13); C274(0.98)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C328(0.90)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C328(0.99)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C328(1.01)  LDD1698  [6]
 LDCM0468  Fragment33 HCT 116 C328(0.61)  LDD0785  [1]
 LDCM0427  Fragment51 HEK-293T C328(1.27)  LDD1025  [1]
 LDCM0022  KB02 A2058 C274(1.68)  LDD2253  [7]
 LDCM0023  KB03 A2058 C274(2.46)  LDD2670  [7]
 LDCM0024  KB05 COLO792 C274(2.00)  LDD3310  [7]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
4 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
5 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840