Details of the Target

General Information of Target

Target ID LDTP12959
Target Name NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13)
Gene Name NDUFA13
Gene ID 51079
Synonyms
GRIM19; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; Cell death regulatory protein GRIM-19; Complex I-B16.6; CI-B16.6; Gene associated with retinoic and interferon-induced mortality 19 protein; GRIM-19; Gene associated with retinoic and IFN-induced mortality 19 protein; NADH-ubiquinone oxidoreductase B16.6 subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRV
LRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPMTDPTMLTDMMKGNVTNVLP
MILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLR
SIYSLILGQDNAADQSRMMQEQMTGAAMAMPADTNKAFKTEWEALELTDHQWALDDVEEE
LMAKDLHFEGMFKKELQTSIF
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Complex I NDUFA13 subunit family
Subcellular location
Mitochondrion inner membrane
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
TTD ID
T82391
Uniprot ID
Q9P0J0
DrugMap ID
TTRU1NG
Ensemble ID
ENST00000507754.9
HGNC ID
HGNC:17194
ChEMBL ID
CHEMBL4105781

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1B SNV: p.G46W .
JURKAT SNV: p.S34N .
SNU1 SNV: p.A2T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K22(1.45)  LDD0277  [1]
Acrolein
 Probe Info  		N.A.  LDD0223  [2]
Ox-W18
 Probe Info  		N.A.  LDD2175  [3]
PAL-AfBPP Probe
Click To Hide/Show 77 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		14.03  LDD1713  [4]
C004
 Probe Info  		7.21  LDD1714  [4]
C022
 Probe Info  		14.12  LDD1728  [4]
C039
 Probe Info  		5.03  LDD1739  [4]
C040
 Probe Info  		30.70  LDD1740  [4]
C041
 Probe Info  		10.20  LDD1741  [4]
C049
 Probe Info  		5.86  LDD1747  [4]
C052
 Probe Info  		5.94  LDD1750  [4]
C053
 Probe Info  		14.62  LDD1751  [4]
C055
 Probe Info  		13.55  LDD1752  [4]
C056
 Probe Info  		16.91  LDD1753  [4]
C063
 Probe Info  		11.47  LDD1760  [4]
C070
 Probe Info  		8.57  LDD1766  [4]
C091
 Probe Info  		13.00  LDD1782  [4]
C092
 Probe Info  		27.86  LDD1783  [4]
C094
 Probe Info  		62.25  LDD1785  [4]
C095
 Probe Info  		7.84  LDD1786  [4]
C100
 Probe Info  		18.51  LDD1789  [4]
C106
 Probe Info  		34.78  LDD1793  [4]
C107
 Probe Info  		8.63  LDD1794  [4]
C108
 Probe Info  		11.88  LDD1795  [4]
C112
 Probe Info  		23.92  LDD1799  [4]
C134
 Probe Info  		40.79  LDD1816  [4]
C135
 Probe Info  		11.00  LDD1817  [4]
C139
 Probe Info  		14.32  LDD1821  [4]
C141
 Probe Info  		10.48  LDD1823  [4]
C143
 Probe Info  		26.72  LDD1825  [4]
C153
 Probe Info  		19.03  LDD1834  [4]
C169
 Probe Info  		21.56  LDD1849  [4]
C177
 Probe Info  		8.75  LDD1856  [4]
C178
 Probe Info  		40.50  LDD1857  [4]
C186
 Probe Info  		10.63  LDD1864  [4]
C201
 Probe Info  		30.91  LDD1877  [4]
C206
 Probe Info  		15.89  LDD1881  [4]
C218
 Probe Info  		22.32  LDD1892  [4]
C220
 Probe Info  		20.39  LDD1894  [4]
C225
 Probe Info  		5.62  LDD1898  [4]
C228
 Probe Info  		17.63  LDD1901  [4]
C229
 Probe Info  		7.21  LDD1902  [4]
C231
 Probe Info  		36.25  LDD1904  [4]
C232
 Probe Info  		64.45  LDD1905  [4]
C233
 Probe Info  		11.16  LDD1906  [4]
C234
 Probe Info  		6.82  LDD1907  [4]
C235
 Probe Info  		55.33  LDD1908  [4]
C243
 Probe Info  		13.36  LDD1916  [4]
C244
 Probe Info  		50.56  LDD1917  [4]
C246
 Probe Info  		16.91  LDD1919  [4]
C249
 Probe Info  		12.73  LDD1922  [4]
C265
 Probe Info  		26.17  LDD1936  [4]
C273
 Probe Info  		5.74  LDD1943  [4]
C277
 Probe Info  		9.13  LDD1947  [4]
C278
 Probe Info  		61.82  LDD1948  [4]
C282
 Probe Info  		14.52  LDD1952  [4]
C293
 Probe Info  		19.03  LDD1963  [4]
C299
 Probe Info  		7.16  LDD1968  [4]
C310
 Probe Info  		7.67  LDD1977  [4]
C326
 Probe Info  		7.41  LDD1990  [4]
C343
 Probe Info  		13.09  LDD2005  [4]
C348
 Probe Info  		12.73  LDD2009  [4]
C349
 Probe Info  		26.17  LDD2010  [4]
C350
 Probe Info  		99.73  LDD2011  [4]
C353
 Probe Info  		6.63  LDD2014  [4]
C354
 Probe Info  		7.89  LDD2015  [4]
C362
 Probe Info  		54.57  LDD2023  [4]
C388
 Probe Info  		45.89  LDD2047  [4]
C390
 Probe Info  		43.11  LDD2049  [4]
C403
 Probe Info  		27.47  LDD2061  [4]
C405
 Probe Info  		5.39  LDD2063  [4]
C407
 Probe Info  		34.54  LDD2064  [4]
C409
 Probe Info  		7.46  LDD2066  [4]
C419
 Probe Info  		11.63  LDD2074  [4]
C429
 Probe Info  		11.00  LDD2084  [4]
C431
 Probe Info  		32.45  LDD2086  [4]
FFF probe11
 Probe Info  		20.00  LDD0471  [5]
FFF probe13
 Probe Info  		20.00  LDD0475  [5]
FFF probe14
 Probe Info  		18.26  LDD0477  [5]
OEA-DA
 Probe Info  		19.14  LDD0046  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine protease HTRA2, mitochondrial (HTRA2) Peptidase S1C family O43464
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) . Q9HC29

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Flurpiridaz F 18 Small molecular drug D0U1VZ

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
6 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570