Details of the Target

General Information of Target

Target ID LDTP05066
Target Name Signal peptidase complex catalytic subunit SEC11A (SEC11A)
Gene Name SEC11A
Gene ID 23478
Synonyms
SEC11L1; SPC18; SPCS4A; Signal peptidase complex catalytic subunit SEC11A; EC 3.4.21.89; Endopeptidase SP18; Microsomal signal peptidase 18 kDa subunit; SPase 18 kDa subunit; SEC11 homolog A; SEC11-like protein 1; SPC18
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLSLDFLDDVRRMNKRQLYYQVLNFGMIVSSALMIWKGLMVITGSESPIVVVLSGSMEPA
FHRGDLLFLTNRVEDPIRVGEIVVFRIEGREIPIVHRVLKIHEKQNGHIKFLTKGDNNAV
DDRGLYKQGQHWLEKKDVVGRARGFVPYIGIVTILMNDYPKFKYAVLFLLGLFVLVHRE
Target Bioclass
Enzyme
Family
Peptidase S26B family
Subcellular location
Endoplasmic reticulum membrane
Function
Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
Uniprot ID
P67812
Ensemble ID
ENST00000268220.12
HGNC ID
HGNC:17718

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
OVK18 SNV: p.F6L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CHEMBL5175495
 Probe Info  		14.60  LDD0196  [1]
C-Sul
 Probe Info  		2.89  LDD0066  [2]
ONAyne
 Probe Info  		K100(1.37); K136(0.92)  LDD0274  [3]
STPyne
 Probe Info  		K100(7.34); K104(9.37); K110(4.22); K114(10.00)  LDD0277  [3]
Jackson_14
 Probe Info  		4.00  LDD0123  [4]
HPAP
 Probe Info  		4.30  LDD0062  [5]
Acrolein
 Probe Info  		N.A.  LDD0233  [6]
PAL-AfBPP Probe
Click To Hide/Show 136 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.96  LDD1714  [7]
C007
 Probe Info  		8.28  LDD1716  [7]
C010
 Probe Info  		5.24  LDD1719  [7]
C011
 Probe Info  		5.03  LDD1720  [7]
C017
 Probe Info  		6.96  LDD1725  [7]
C022
 Probe Info  		16.11  LDD1728  [7]
C027
 Probe Info  		13.09  LDD1733  [7]
C039
 Probe Info  		5.39  LDD1739  [7]
C040
 Probe Info  		51.27  LDD1740  [7]
C041
 Probe Info  		10.48  LDD1741  [7]
C053
 Probe Info  		7.46  LDD1751  [7]
C055
 Probe Info  		49.52  LDD1752  [7]
C056
 Probe Info  		99.73  LDD1753  [7]
C063
 Probe Info  		16.80  LDD1760  [7]
C067
 Probe Info  		6.45  LDD1763  [7]
C070
 Probe Info  		28.25  LDD1766  [7]
C072
 Probe Info  		18.38  LDD1768  [7]
C082
 Probe Info  		9.13  LDD1774  [7]
C085
 Probe Info  		5.82  LDD1777  [7]
C087
 Probe Info  		12.47  LDD1779  [7]
C088
 Probe Info  		6.77  LDD1780  [7]
C089
 Probe Info  		8.82  LDD1781  [7]
C091
 Probe Info  		99.73  LDD1782  [7]
C092
 Probe Info  		99.73  LDD1783  [7]
C094
 Probe Info  		99.73  LDD1785  [7]
C095
 Probe Info  		5.06  LDD1786  [7]
C100
 Probe Info  		10.06  LDD1789  [7]
C106
 Probe Info  		84.45  LDD1793  [7]
C107
 Probe Info  		27.10  LDD1794  [7]
C108
 Probe Info  		34.78  LDD1795  [7]
C112
 Probe Info  		99.73  LDD1799  [7]
C130
 Probe Info  		7.62  LDD1812  [7]
C134
 Probe Info  		54.95  LDD1816  [7]
C135
 Probe Info  		16.00  LDD1817  [7]
C139
 Probe Info  		19.03  LDD1821  [7]
C153
 Probe Info  		41.93  LDD1834  [7]
C159
 Probe Info  		14.12  LDD1839  [7]
C160
 Probe Info  		11.88  LDD1840  [7]
C161
 Probe Info  		18.13  LDD1841  [7]
C163
 Probe Info  		5.86  LDD1843  [7]
C165
 Probe Info  		14.72  LDD1845  [7]
C166
 Probe Info  		7.16  LDD1846  [7]
C169
 Probe Info  		56.49  LDD1849  [7]
C173
 Probe Info  		6.19  LDD1853  [7]
C178
 Probe Info  		15.03  LDD1857  [7]
C186
 Probe Info  		14.32  LDD1864  [7]
C187
 Probe Info  		42.22  LDD1865  [7]
C191
 Probe Info  		10.78  LDD1868  [7]
C193
 Probe Info  		6.15  LDD1869  [7]
C194
 Probe Info  		18.38  LDD1870  [7]
C196
 Probe Info  		14.72  LDD1872  [7]
C198
 Probe Info  		43.11  LDD1874  [7]
C201
 Probe Info  		36.00  LDD1877  [7]
C210
 Probe Info  		95.01  LDD1884  [7]
C218
 Probe Info  		30.06  LDD1892  [7]
C220
 Probe Info  		28.64  LDD1894  [7]
C222
 Probe Info  		6.68  LDD1896  [7]
C225
 Probe Info  		12.55  LDD1898  [7]
C226
 Probe Info  		16.80  LDD1899  [7]
C228
 Probe Info  		79.34  LDD1901  [7]
C229
 Probe Info  		13.18  LDD1902  [7]
C231
 Probe Info  		78.25  LDD1904  [7]
C232
 Probe Info  		99.73  LDD1905  [7]
C233
 Probe Info  		26.54  LDD1906  [7]
C234
 Probe Info  		39.12  LDD1907  [7]
C235
 Probe Info  		99.73  LDD1908  [7]
C238
 Probe Info  		24.08  LDD1911  [7]
C240
 Probe Info  		8.22  LDD1913  [7]
C243
 Probe Info  		21.11  LDD1916  [7]
C246
 Probe Info  		29.45  LDD1919  [7]
C249
 Probe Info  		14.42  LDD1922  [7]
C252
 Probe Info  		78.25  LDD1925  [7]
C264
 Probe Info  		36.00  LDD1935  [7]
C265
 Probe Info  		19.16  LDD1936  [7]
C266
 Probe Info  		7.57  LDD1937  [7]
C270
 Probe Info  		29.04  LDD1940  [7]
C273
 Probe Info  		11.55  LDD1943  [7]
C277
 Probe Info  		11.00  LDD1947  [7]
C278
 Probe Info  		95.67  LDD1948  [7]
C282
 Probe Info  		33.36  LDD1952  [7]
C284
 Probe Info  		36.50  LDD1954  [7]
C285
 Probe Info  		43.41  LDD1955  [7]
C287
 Probe Info  		15.14  LDD1957  [7]
C288
 Probe Info  		11.08  LDD1958  [7]
C289
 Probe Info  		79.89  LDD1959  [7]
C293
 Probe Info  		24.25  LDD1963  [7]
C296
 Probe Info  		24.08  LDD1966  [7]
C299
 Probe Info  		36.25  LDD1968  [7]
C305
 Probe Info  		14.42  LDD1974  [7]
C310
 Probe Info  		8.57  LDD1977  [7]
C313
 Probe Info  		14.52  LDD1980  [7]
C314
 Probe Info  		24.93  LDD1981  [7]
C322
 Probe Info  		24.08  LDD1988  [7]
C326
 Probe Info  		9.19  LDD1990  [7]
C338
 Probe Info  		14.93  LDD2001  [7]
C339
 Probe Info  		16.11  LDD2002  [7]
C343
 Probe Info  		19.97  LDD2005  [7]
C349
 Probe Info  		10.13  LDD2010  [7]
C350
 Probe Info  		29.24  LDD2011  [7]
C355
 Probe Info  		26.17  LDD2016  [7]
C356
 Probe Info  		8.88  LDD2017  [7]
C357
 Probe Info  		5.10  LDD2018  [7]
C361
 Probe Info  		19.03  LDD2022  [7]
C362
 Probe Info  		99.73  LDD2023  [7]
C363
 Probe Info  		33.82  LDD2024  [7]
C364
 Probe Info  		46.85  LDD2025  [7]
C366
 Probe Info  		14.42  LDD2027  [7]
C367
 Probe Info  		16.00  LDD2028  [7]
C373
 Probe Info  		17.27  LDD2033  [7]
C376
 Probe Info  		6.63  LDD2036  [7]
C378
 Probe Info  		6.06  LDD2037  [7]
C382
 Probe Info  		12.47  LDD2041  [7]
C383
 Probe Info  		12.38  LDD2042  [7]
C388
 Probe Info  		99.73  LDD2047  [7]
C397
 Probe Info  		9.78  LDD2056  [7]
C399
 Probe Info  		25.46  LDD2058  [7]
C403
 Probe Info  		76.11  LDD2061  [7]
C407
 Probe Info  		34.78  LDD2064  [7]
C409
 Probe Info  		8.75  LDD2066  [7]
C419
 Probe Info  		14.32  LDD2074  [7]
C420
 Probe Info  		12.73  LDD2075  [7]
C423
 Probe Info  		12.91  LDD2078  [7]
C424
 Probe Info  		7.62  LDD2079  [7]
C426
 Probe Info  		20.82  LDD2081  [7]
C431
 Probe Info  		16.80  LDD2086  [7]
FFF probe11
 Probe Info  		20.00  LDD0471  [8]
FFF probe13
 Probe Info  		20.00  LDD0475  [8]
FFF probe14
 Probe Info  		20.00  LDD0477  [8]
FFF probe2
 Probe Info  		20.00  LDD0463  [8]
FFF probe3
 Probe Info  		20.00  LDD0464  [8]
JN0003
 Probe Info  		20.00  LDD0469  [8]
A-DA
 Probe Info  		3.27  LDD0145  [9]
Alk-rapa
 Probe Info  		3.37  LDD0213  [10]
BD-F
 Probe Info  		P147(0.00); Y148(0.00); I149(0.00); D158(0.00)  LDD0024  [11]
LD-F
 Probe Info  		I149(0.00); Y148(0.00)  LDD0015  [11]
OEA-DA
 Probe Info  		8.64  LDD0046  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0233  [6]
 LDCM0014  Panhematin HEK-293T 4.30  LDD0062  [5]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 4.00  LDD0123  [4]
 LDCM0090  Rapamycin JHH-7 3.37  LDD0213  [10]
 LDCM0084  Ro 48-8071 A-549 3.27  LDD0145  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Signal peptidase complex subunit 3 (SPCS3) SPCS3 family P61009
Cholinesterase (BCHE) Type-B carboxylesterase/lipase family P06276

References

1 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
5 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
9 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
10 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
11 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
12 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570