Details of the Target

General Information of Target

Target ID LDTP14276
Target Name NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9)
Gene Name NDUFB9
Gene ID 4715
Synonyms
LYRM3; UQOR22; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; Complex I-B22; CI-B22; LYR motif-containing protein 3; NADH-ubiquinone oxidoreductase B22 subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERFRLEKKLPGPDEEAVVDLGKTSSTVNTKFEKEELESHRAVYIGVHVPFSKESRRRHR
HRGHKHHHRRRKDKESDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELC
YRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRA
STLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKK
HSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLGHLLPSSRAGTPAGSRCT
TPVPTPQNSPPSSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHPPEEDLEAALK
GEEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMR
KIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQ
YHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKS
VPSQEKRKIPVFHNGSTPTLGETPKEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDF
KDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQ
PLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYIT
RFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLA
QWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSS
FLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGW
IISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGV
MLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMG
LSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLW
KVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPE
SKKKKEDDKKKKEKEEAERMLQDDDDTVHLPFEGGSLLQIPVKALKYSPDKPVSVKISFE
DEPRKKYVDAETSL
Target Bioclass
Enzyme
Family
Complex I LYR family
Subcellular location
Mitochondrion inner membrane
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
TTD ID
T01465
Uniprot ID
Q9Y6M9
DrugMap ID
TTBYJ39
Ensemble ID
ENST00000276689.8
HGNC ID
HGNC:7704
ChEMBL ID
CHEMBL2363065

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y73(8.40)  LDD0260  [1]
STPyne
 Probe Info  		K59(0.86)  LDD0277  [2]
Probe 1
 Probe Info  		Y73(47.93)  LDD3495  [3]
m-APA
 Probe Info  		11.55  LDD0403  [4]
BTD
 Probe Info  		C31(1.12)  LDD2104  [5]
Curcusone 37
 Probe Info  		3.99  LDD0188  [6]
DBIA
 Probe Info  		C42(2.32); C31(1.37)  LDD0080  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C103(0.00); C31(0.00); C42(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C31(0.00); C103(0.00)  LDD0037  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
Compound 11
 Probe Info  		N.A.  LDD2213  [12]
IPM
 Probe Info  		N.A.  LDD0005  [13]
SF
 Probe Info  		N.A.  LDD0028  [14]
Phosphinate-6
 Probe Info  		C96(0.00); C103(0.00); C42(0.00)  LDD0018  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
Crotonaldehyde
 Probe Info  		C42(0.00); C31(0.00)  LDD0219  [16]
W1
 Probe Info  		N.A.  LDD0236  [17]
AOyne
 Probe Info  		15.00  LDD0443  [18]
NAIA_5
 Probe Info  		C31(0.00); C42(0.00)  LDD2223  [19]
TER-AC
 Probe Info  		N.A.  LDD0426  [20]
TPP-AC
 Probe Info  		N.A.  LDD0427  [20]
PAL-AfBPP Probe
Click To Hide/Show 71 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		6.06  LDD1725  [21]
C040
 Probe Info  		29.04  LDD1740  [21]
C049
 Probe Info  		5.90  LDD1747  [21]
C053
 Probe Info  		5.62  LDD1751  [21]
C055
 Probe Info  		15.89  LDD1752  [21]
C056
 Probe Info  		24.76  LDD1753  [21]
C063
 Probe Info  		9.92  LDD1760  [21]
C064
 Probe Info  		8.28  LDD1761  [21]
C070
 Probe Info  		8.82  LDD1766  [21]
C072
 Probe Info  		7.41  LDD1768  [21]
C082
 Probe Info  		7.57  LDD1774  [21]
C091
 Probe Info  		22.47  LDD1782  [21]
C092
 Probe Info  		31.34  LDD1783  [21]
C095
 Probe Info  		12.13  LDD1786  [21]
C112
 Probe Info  		27.28  LDD1799  [21]
C134
 Probe Info  		45.25  LDD1816  [21]
C158
 Probe Info  		12.38  LDD1838  [21]
C159
 Probe Info  		15.89  LDD1839  [21]
C160
 Probe Info  		10.56  LDD1840  [21]
C161
 Probe Info  		23.75  LDD1841  [21]
C169
 Probe Info  		57.68  LDD1849  [21]
C201
 Probe Info  		60.55  LDD1877  [21]
C206
 Probe Info  		24.08  LDD1881  [21]
C210
 Probe Info  		99.73  LDD1884  [21]
C213
 Probe Info  		20.97  LDD1887  [21]
C218
 Probe Info  		47.84  LDD1892  [21]
C219
 Probe Info  		5.66  LDD1893  [21]
C220
 Probe Info  		15.45  LDD1894  [21]
C228
 Probe Info  		15.14  LDD1901  [21]
C231
 Probe Info  		24.93  LDD1904  [21]
C233
 Probe Info  		8.82  LDD1906  [21]
C235
 Probe Info  		34.54  LDD1908  [21]
C238
 Probe Info  		16.80  LDD1911  [21]
C239
 Probe Info  		6.87  LDD1912  [21]
C246
 Probe Info  		28.84  LDD1919  [21]
C252
 Probe Info  		9.19  LDD1925  [21]
C265
 Probe Info  		25.28  LDD1936  [21]
C278
 Probe Info  		63.56  LDD1948  [21]
C282
 Probe Info  		18.13  LDD1952  [21]
C287
 Probe Info  		23.92  LDD1957  [21]
C289
 Probe Info  		77.71  LDD1959  [21]
C304
 Probe Info  		5.39  LDD1973  [21]
C310
 Probe Info  		10.56  LDD1977  [21]
C322
 Probe Info  		6.59  LDD1988  [21]
C338
 Probe Info  		12.04  LDD2001  [21]
C343
 Probe Info  		11.71  LDD2005  [21]
C349
 Probe Info  		44.94  LDD2010  [21]
C350
 Probe Info  		22.32  LDD2011  [21]
C353
 Probe Info  		5.94  LDD2014  [21]
C356
 Probe Info  		12.30  LDD2017  [21]
C362
 Probe Info  		27.28  LDD2023  [21]
C366
 Probe Info  		8.88  LDD2027  [21]
C367
 Probe Info  		6.87  LDD2028  [21]
C382
 Probe Info  		10.85  LDD2041  [21]
C388
 Probe Info  		99.73  LDD2047  [21]
C390
 Probe Info  		67.65  LDD2049  [21]
C403
 Probe Info  		15.78  LDD2061  [21]
C407
 Probe Info  		18.77  LDD2064  [21]
C413
 Probe Info  		41.36  LDD2069  [21]
C419
 Probe Info  		11.63  LDD2074  [21]
C423
 Probe Info  		11.08  LDD2078  [21]
C424
 Probe Info  		9.38  LDD2079  [21]
C429
 Probe Info  		15.56  LDD2084  [21]
C431
 Probe Info  		15.56  LDD2086  [21]
FFF probe11
 Probe Info  		20.00  LDD0471  [22]
FFF probe13
 Probe Info  		20.00  LDD0475  [22]
FFF probe14
 Probe Info  		20.00  LDD0477  [22]
FFF probe15
 Probe Info  		14.21  LDD0478  [22]
FFF probe2
 Probe Info  		20.00  LDD0463  [22]
FFF probe3
 Probe Info  		20.00  LDD0464  [22]
FFF probe4
 Probe Info  		12.61  LDD0466  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C31(1.04); C42(1.05)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C31(0.72); C42(1.29)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C103(1.00); C31(0.78); C42(1.15)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C103(0.89); C31(0.85); C42(1.20)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C103(1.11); C31(0.92); C42(1.14)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C103(1.14); C31(0.87); C42(1.60)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C103(1.32); C31(0.80); C42(1.47)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C103(1.06); C31(0.82); C42(1.35)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C103(1.03); C31(0.86); C42(1.35)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C103(1.24); C31(0.89); C42(1.46)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C103(0.84); C31(0.82); C42(0.93)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C103(0.90); C31(0.82); C42(0.95)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C31(0.75); C42(1.31)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C103(0.87); C31(0.88); C42(0.99)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C103(0.80); C31(0.79); C42(1.06)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C103(1.07); C31(0.93); C42(1.20)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C103(1.05); C31(0.98); C42(1.00)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C103(1.04); C31(1.02); C42(1.24)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C103(1.16); C31(1.14); C42(1.53)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C103(1.22); C31(1.10); C42(1.47)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C103(1.26); C31(1.00); C42(1.24)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C103(1.10); C31(0.96); C42(1.12)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C103(1.30); C31(1.06); C42(1.19)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C31(0.78); C42(1.09)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C103(1.53); C31(0.99); C42(1.40)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C103(1.06); C31(0.98); C42(1.09)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C103(1.00); C31(1.06); C42(1.13)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C103(1.07); C31(0.97); C42(1.10)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C103(1.05); C31(0.89); C42(1.10)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C103(1.08); C31(1.12); C42(1.15)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C103(1.21); C31(0.92); C42(1.29)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C103(1.14); C31(0.94); C42(1.27)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C103(1.06); C42(1.07)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C103(0.70); C42(1.10)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C103(0.83); C42(1.17)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C103(0.75); C42(1.28)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C103(0.74); C42(1.19)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C103(0.77); C42(1.17)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C103(0.89); C42(1.42)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C103(0.88); C42(1.17)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C103(1.00); C42(1.25)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C103(0.89); C42(1.29)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C103(0.81); C42(1.64)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C103(0.79); C42(1.53)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C31(0.67); C42(1.17)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C103(0.79); C42(1.61)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C103(0.81); C42(1.59)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C103(0.68); C42(1.26)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C103(1.11); C42(1.18); C31(1.18)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C31(1.25); C103(1.31); C42(1.72)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C103(1.06); C31(1.10); C42(1.31)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C31(1.13); C103(1.34); C42(1.65)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C31(1.18); C103(1.44); C42(1.72)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C31(1.16); C103(1.55); C42(2.67)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C31(1.16); C103(1.25); C42(1.72)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C31(0.83); C42(1.33)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C31(1.04); C103(1.10); C42(1.19)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C103(1.14); C31(1.15); C42(1.16)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C31(1.14); C103(1.59); C42(1.88)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C31(1.30); C103(1.55); C42(3.20)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C103(1.31); C31(1.03); C42(1.64)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C103(1.45); C31(1.07); C42(1.52)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C103(1.07); C31(1.11); C42(1.14)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C103(0.90); C31(0.98); C42(1.10)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C42(1.03); C31(1.05)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C31(0.86); C42(1.42)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C31(0.90); C42(1.10)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C42(1.07); C31(1.27)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C31(0.88); C42(1.06)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C31(0.93); C42(1.02)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C31(0.98); C42(1.00)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C31(0.91); C42(1.04)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C42(0.94); C31(0.96)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C31(0.89); C42(1.06)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C31(1.05); C42(1.48)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C31(1.10); C42(1.39)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C31(1.14); C42(1.62)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C31(1.22); C42(1.37)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C42(1.01); C31(1.27)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C31(1.14); C42(1.28)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C31(1.16); C42(1.60)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C31(1.16); C42(1.81)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C31(1.08); C42(1.69)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C31(1.18); C42(1.93)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C42(0.88)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C42(0.87)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C42(0.89)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C42(0.91)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C42(0.96)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C31(1.22); C42(1.29)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C42(1.22)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C42(0.98)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C42(1.08)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C42(1.05)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C42(1.10)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C42(1.10)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C42(1.08); C31(1.12)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C31(1.00); C42(1.07)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C42(1.03); C31(1.23)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C31(0.89); C42(1.44)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C31(1.25); C42(1.38)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C31(0.96); C42(1.46)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C31(0.98); C42(1.04)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C31(1.02); C42(1.18)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C31(0.92); C42(1.14)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C31(1.03); C42(1.20)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C31(0.66); C42(1.29)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C31(1.08); C42(1.85)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C31(0.96); C42(1.75)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C31(0.93); C42(1.58)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C31(1.14); C42(2.12)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C31(0.90); C42(1.30)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C31(1.09); C42(1.94)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C31(0.93); C42(1.46)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C31(1.06); C42(1.80)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C31(1.05); C42(1.68)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C31(1.07); C42(2.06)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C31(1.09); C42(2.02)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C31(1.00); C42(1.87)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C31(1.09); C42(2.31)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C31(0.95); C42(1.04)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C42(1.16); C31(1.22)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C31(0.92); C42(1.12)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C31(0.98); C42(1.42)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C42(0.99); C31(0.99)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C42(1.25); C31(1.26)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C31(1.10); C42(1.86)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C31(1.17); C42(1.61)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C31(1.18); C42(1.79)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C31(0.93); C42(1.29)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C31(1.02); C42(1.30)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C42(1.00); C31(1.14)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C31(1.04); C42(1.20)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C31(0.89); C42(1.34)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C31(1.08); C42(1.30)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C31(0.89); C42(0.98)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C31(0.68); C42(1.22)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C31(1.13); C42(2.15)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C31(1.10); C42(1.94)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C31(1.06); C42(1.47)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C31(1.00); C42(1.29)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C31(0.92); C42(1.12)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C31(0.97); C42(1.20)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C31(0.95); C42(1.57)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C42(0.95); C31(0.98)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C31(1.15); C42(2.29)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C31(1.05); C42(1.98)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C31(1.02); C42(1.38)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C31(1.04); C42(1.24)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C31(0.97); C42(1.13)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C31(1.08); C42(1.55)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C31(1.09); C42(1.77)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C31(0.79); C103(0.98); C42(1.91)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C31(0.91); C103(1.01); C42(1.04)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C31(0.73); C42(1.06)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C31(0.83); C42(1.19)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C31(0.85); C42(1.74)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 11.55  LDD0403  [4]
 LDCM0020  ARS-1620 HCC44 C42(1.15)  LDD2171  [7]
 LDCM0108  Chloroacetamide HeLa C42(0.00); C103(0.00); C31(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C31(4.77)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C31(1.01); C42(1.01)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C31(1.08); C42(1.40)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C42(1.21); C31(1.22)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C31(1.06); C42(1.25)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C42(1.09); C31(1.24)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C31(0.85); C42(1.05)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C31(0.91); C42(1.09)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C31(1.04); C42(1.37)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C31(0.84); C42(1.36)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C31(1.06); C42(1.35)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C31(1.09); C42(1.41)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C31(1.01); C42(1.34)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C31(1.13); C42(1.39)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C31(1.27); C42(1.57)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C31(1.10); C42(1.28)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C31(0.96); C42(1.18)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C31(1.24); C42(1.83)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C31(1.48); C42(1.73)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C31(1.10); C42(1.29)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C31(1.15); C42(1.57)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C42(1.33)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C42(1.13)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C42(1.17)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C31(1.19); C42(1.49)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C42(0.97)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C42(1.14); C31(1.15)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C31(1.05); C42(1.45)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C31(1.34); C42(1.95)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C31(1.14); C42(1.59)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C31(1.01); C42(1.14)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C31(1.14); C42(1.45)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C31(1.09); C42(1.35)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C31(0.95); C42(1.82)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C31(1.10); C42(1.14)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C31(1.03); C42(1.10)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C31(1.05); C42(1.06)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C42(0.97); C31(1.00)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C42(1.13); C31(1.22)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C31(1.08); C42(1.19)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C31(0.99); C42(1.18)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C31(0.93); C42(0.96)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C31(1.17); C42(1.29)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C31(1.23); C42(1.50)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C31(0.98); C42(1.70)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C31(0.80); C42(1.13)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C31(0.99); C42(1.33)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C31(0.84); C42(1.18)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C31(1.10); C42(1.34)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C31(1.02); C42(0.95)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C31(0.98); C42(1.12)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C31(1.09); C42(1.22)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C31(0.89); C42(0.94)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C31(0.84); C42(1.01)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C103(0.81); C31(0.97); C42(1.26)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C103(1.09); C31(0.97); C42(1.63)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C103(1.31); C31(1.06); C42(2.44)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C103(0.89); C31(1.02); C42(1.86)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C103(1.23); C31(0.96); C42(2.05)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C103(1.20); C31(0.94); C42(1.68)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C103(0.97); C31(0.92); C42(2.13)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C103(1.38); C31(0.93); C42(2.04)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C31(1.08); C42(1.05)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C103(1.07); C31(0.93); C42(2.06)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C103(1.02); C31(0.86); C42(1.90)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C103(1.80); C31(0.92); C42(2.56)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C103(1.27); C31(0.91); C42(2.25)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C103(1.06); C31(0.92); C42(1.91)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C103(1.09); C31(0.96); C42(1.72)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C31(1.02); C42(0.89)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C31(1.14); C42(0.92)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C31(1.11); C42(0.92)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C31(1.15); C42(0.90)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C31(0.98); C42(1.01)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C31(0.99); C42(0.87)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C31(1.11); C42(0.93)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C31(1.17); C42(0.91)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C31(1.12); C42(1.01)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C31(1.46); C42(0.98)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C31(1.06); C42(0.91)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C31(1.16); C42(0.98)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C31(1.15); C42(0.92)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C31(1.04); C42(0.86)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C31(1.20); C42(0.94)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C31(1.05); C42(1.13)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C31(1.19); C42(1.01)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C31(0.95); C42(1.06)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C31(1.03); C42(1.04)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C31(1.04); C42(1.25)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C31(1.13); C42(1.54)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C31(1.06); C42(1.19)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C31(1.16); C42(1.72)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C31(1.12); C42(1.50)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C31(1.15); C42(1.26)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C31(1.08); C42(1.24)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C31(1.23); C42(1.18)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C31(1.05); C42(1.28)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C31(1.05); C42(1.34)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C31(1.11); C42(1.22)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C31(1.07); C42(1.26)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C31(1.07); C42(1.36)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C42(1.20)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C42(1.08)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C42(1.21)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C42(1.52)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C31(1.19); C42(2.49)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C42(1.11)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C42(1.33)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C42(2.04)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C42(1.78)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C42(2.28)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C42(1.23)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C42(1.14)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C42(1.34)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C42(1.67)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C42(2.84)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C31(1.08); C42(1.14)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C42(1.19)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C31(0.92); C42(1.05)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C31(1.02); C42(1.26)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C31(1.02); C42(1.15)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C31(1.24); C42(1.48)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C31(1.17); C42(1.65)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C31(1.15); C42(1.24)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C31(1.22); C42(1.21)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C31(0.98); C42(1.31)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C31(1.14); C42(1.15)  LDD0811  [7]
 LDCM0033  Curcusone1d MCF-7 3.99  LDD0188  [6]
 LDCM0495  E2913 HEK-293T C31(1.00); C42(0.90)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C103(1.24); C42(1.21)  LDD1702  [5]
 LDCM0625  F8 Ramos C42(0.61); C31(0.78)  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C42(0.72); C31(0.56)  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C42(0.71); C31(14.26)  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C42(0.68); C31(0.46)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C42(1.14); C31(0.83)  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C42(0.63); C31(1.24)  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C42(0.82); C31(0.41)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C42(0.96); C31(0.62)  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C42(1.19); C31(0.86)  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C42(0.97); C31(1.00)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C42(0.74); C31(1.39)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C42(1.20); C31(0.86)  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C42(0.78); C31(0.79)  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C42(0.59); C31(0.44)  LDD2201  [24]
 LDCM0468  Fragment33 HCT 116 C31(1.05); C42(1.29)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C42(0.72); C31(0.89)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C42(0.73); C31(0.65)  LDD2184  [24]
 LDCM0427  Fragment51 HCT 116 C103(1.07); C31(1.13); C42(3.13)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C42(1.22); C31(1.03)  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C42(1.25); C31(0.90)  LDD2205  [24]
 LDCM0569  Fragment7 Ramos C42(0.75); C31(0.60)  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C42(0.60); C31(0.43)  LDD2188  [24]
 LDCM0022  KB02 HCT 116 C42(2.32); C31(1.37)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C42(2.38); C31(1.90)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C42(3.24); C31(2.61)  LDD0082  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C31(1.12)  LDD2104  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C31(1.31)  LDD2141  [5]
 LDCM0628  OTUB2-COV-1 HEK-293T C31(0.84)  LDD2207  [25]
 LDCM0021  THZ1 HCT 116 C42(1.15)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Melanoma-associated antigen 11 (MAGEA11) . P43364

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.