Details of the Target

General Information of Target

Target ID LDTP04565
Target Name Methionine aminopeptidase 1 (METAP1)
Gene Name METAP1
Gene ID 23173
Synonyms
KIAA0094; Methionine aminopeptidase 1; MAP 1; MetAP 1; EC 3.4.11.18; Peptidase M 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Peptidase M24A family, Methionine aminopeptidase type 1 subfamily
Subcellular location
Cytoplasm
Function
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.
TTD ID
T42337
Uniprot ID
P53582
DrugMap ID
TT1L79K
Ensemble ID
ENST00000296411.11
HGNC ID
HGNC:15789
ChEMBL ID
CHEMBL2474

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y291(20.00)  LDD0260  [1]
BTD
 Probe Info  		C292(1.09)  LDD2093  [2]
HHS-475
 Probe Info  		Y309(1.17)  LDD0264  [3]
HHS-465
 Probe Info  		Y309(6.68)  LDD2237  [4]
DBIA
 Probe Info  		C22(1.18); C25(1.18); C36(1.08); C40(1.08)  LDD0078  [5]
5E-2FA
 Probe Info  		N.A.  LDD2235  [6]
ATP probe
 Probe Info  		K311(0.00); K313(0.00)  LDD0199  [7]
m-APA
 Probe Info  		N.A.  LDD2231  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C174(0.00); C255(0.00); C179(0.00); C368(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C331(0.00); C9(0.00); C368(0.00)  LDD0032  [9]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [10]
Lodoacetamide azide
 Probe Info  		C174(0.00); C255(0.00); C179(0.00); C368(0.00)  LDD0037  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
IPM
 Probe Info  		C36(0.00); C40(0.00)  LDD0005  [12]
SF
 Probe Info  		N.A.  LDD0028  [13]
Phosphinate-6
 Probe Info  		C9(0.00); C292(0.00); C14(0.00); C25(0.00)  LDD0018  [14]
Acrolein
 Probe Info  		C292(0.00); C14(0.00); C202(0.00); C368(0.00)  LDD0217  [15]
Crotonaldehyde
 Probe Info  		C292(0.00); C14(0.00)  LDD0219  [15]
Methacrolein
 Probe Info  		C292(0.00); C194(0.00); C14(0.00)  LDD0218  [15]
W1
 Probe Info  		C9(0.00); C14(0.00); C22(0.00); C25(0.00)  LDD0236  [16]
NAIA_5
 Probe Info  		C174(0.00); C255(0.00); C143(0.00); C368(0.00)  LDD2223  [17]
HHS-482
 Probe Info  		Y309(1.19)  LDD2239  [4]
PAL-AfBPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C056
 Probe Info  		17.63  LDD1753  [18]
C095
 Probe Info  		5.50  LDD1786  [18]
C099
 Probe Info  		5.70  LDD1788  [18]
C166
 Probe Info  		6.54  LDD1846  [18]
C187
 Probe Info  		99.73  LDD1865  [18]
C206
 Probe Info  		20.68  LDD1881  [18]
C210
 Probe Info  		55.33  LDD1884  [18]
C211
 Probe Info  		8.34  LDD1885  [18]
C212
 Probe Info  		8.34  LDD1886  [18]
C213
 Probe Info  		17.75  LDD1887  [18]
C231
 Probe Info  		15.35  LDD1904  [18]
C243
 Probe Info  		19.97  LDD1916  [18]
C278
 Probe Info  		48.50  LDD1948  [18]
C280
 Probe Info  		11.88  LDD1950  [18]
C282
 Probe Info  		14.83  LDD1952  [18]
C304
 Probe Info  		5.39  LDD1973  [18]
C362
 Probe Info  		48.50  LDD2023  [18]
C407
 Probe Info  		11.88  LDD2064  [18]
C408
 Probe Info  		6.06  LDD2065  [18]
C409
 Probe Info  		4.99  LDD2066  [18]
C429
 Probe Info  		13.74  LDD2084  [18]
VE-P
 Probe Info  		N.A.  LDD0396  [19]
OEA-DA
 Probe Info  		11.70  LDD0046  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C292(0.69)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C292(0.99)  LDD2152  [2]
 LDCM0214  AC1 HCT 116 C179(0.93); C14(1.09); C193(1.10); C194(1.43)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C179(0.79); C14(1.27); C193(0.80); C194(0.81)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C179(0.72); C14(1.05); C193(0.68); C194(1.05)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C179(0.63); C14(1.04); C193(0.84); C194(0.82)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C179(0.66); C14(1.10); C193(1.12); C194(0.87)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C179(0.35); C14(1.49); C193(0.78); C194(0.69)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C179(0.51); C14(1.05); C193(1.37); C194(0.86)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C179(0.43); C14(1.20); C193(0.81); C194(0.73)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C179(0.38); C14(1.35); C193(1.04); C194(0.74)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C179(0.41); C14(1.21); C193(0.82); C194(0.83)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C179(0.56); C14(1.07); C193(0.59); C194(0.79)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C179(0.95); C14(0.99); C193(1.26); C194(0.78)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C179(0.75); C14(1.28); C193(0.78); C194(0.80)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C179(0.62); C14(1.04); C193(0.79); C194(0.71)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C179(0.70); C14(1.03); C193(0.93); C194(0.73)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C179(0.51); C14(1.14); C193(1.02); C194(0.71)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C179(1.22); C14(1.00); C193(1.11); C194(1.18)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C179(1.06); C14(1.14); C193(1.27); C194(1.05)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C179(1.09); C14(1.30); C193(1.05); C194(1.07)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C179(1.08); C14(1.28); C193(1.32); C194(1.19)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C179(1.08); C14(1.19); C193(1.11); C194(1.19)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C179(1.14); C14(1.05); C193(1.10); C194(1.16)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C179(1.00); C14(1.25); C193(1.20); C194(1.16)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C179(1.05); C14(1.10); C193(0.90); C194(1.27)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C179(1.35); C14(1.11); C193(1.34); C194(1.15)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C179(1.23); C14(1.08); C193(1.09); C194(1.19)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C179(1.13); C14(1.18); C193(1.36); C194(1.12)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C179(1.41); C14(1.16); C193(0.94); C194(1.31)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C179(1.10); C14(1.01); C193(1.24); C194(1.15)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C179(1.10); C14(1.14); C193(1.52); C194(1.15)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C179(1.17); C14(1.32); C193(1.08); C194(1.03)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C179(1.20); C14(1.37); C193(1.14); C194(1.14)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C179(0.83); C14(1.12); C193(1.19); C194(1.21)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C179(1.26); C14(0.97); C193(1.10); C194(1.12)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C179(0.90); C14(1.18); C193(1.00); C194(1.26)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C179(1.39); C14(0.85); C193(1.36); C194(1.28)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C179(1.27); C14(0.96); C193(1.13); C194(1.32)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C179(0.99); C14(1.05); C193(1.27); C194(1.29)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C179(0.79); C14(1.13); C193(1.14); C194(1.57)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C179(0.81); C14(1.08); C193(1.09); C194(1.28)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C179(0.97); C14(1.12); C193(1.17); C194(1.32)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C179(1.11); C14(1.04); C193(1.12); C194(1.11)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C179(0.80); C14(1.30); C193(0.70); C194(0.95)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C179(0.78); C14(1.16); C193(0.87); C194(1.27)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C179(0.97); C14(1.04); C193(1.05); C194(1.00)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C179(0.62); C14(1.29); C193(0.68); C194(1.01)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C179(0.76); C14(1.22); C193(0.65); C194(0.93)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C179(1.15); C14(0.97); C193(1.05); C194(1.32)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C179(0.99); C22(1.02); C9(1.04); C40(1.06)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C179(0.68); C194(0.88); C202(0.90); C25(0.96)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C22(0.81); C25(0.90); C179(0.94); C193(1.03)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C179(0.86); C22(0.92); C25(0.93); C193(1.16)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C179(0.66); C194(0.69); C202(0.70); C22(0.81)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C179(0.55); C202(0.61); C194(0.65); C193(0.65)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C179(0.59); C202(0.80); C194(0.84); C22(0.90)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C193(0.68); C194(0.70); C202(0.72); C179(0.84)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C22(0.82); C25(0.93); C179(1.01); C40(1.06)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C22(0.81); C25(0.95); C179(1.02); C14(1.04)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C179(0.60); C194(0.79); C202(0.81); C22(0.83)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C179(0.56); C202(0.64); C193(0.68); C194(0.72)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C179(0.78); C14(1.29); C193(1.00); C194(1.00)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C179(0.78); C14(1.33); C193(1.03); C194(1.08)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C179(1.02); C14(0.98); C193(0.91); C194(1.24)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C179(1.16); C14(1.06); C193(0.99); C194(1.40)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C368(0.88); C25(0.95); C22(0.96); C36(1.02)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C368(0.38); C193(0.69); C179(0.70); C194(0.74)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C179(0.94); C25(0.98); C193(1.02); C9(1.04)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C179(0.85); C40(0.92); C9(0.93); C25(1.07)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C368(0.96); C25(1.04); C22(1.09); C14(1.09)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C368(0.85); C202(0.94); C194(0.96); C193(0.98)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C179(0.99); C14(1.00); C368(1.02); C202(1.02)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C193(0.79); C368(0.81); C202(0.88); C194(0.89)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C368(0.76); C9(0.87); C25(0.92); C14(0.93)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C202(1.00); C193(1.01); C36(1.04); C194(1.04)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C202(0.83); C194(0.83); C193(0.84); C179(0.91)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C202(0.81); C193(0.84); C194(0.84); C179(1.10)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C194(0.74); C202(0.80); C193(0.83); C179(0.97)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C194(0.64); C193(0.76); C202(0.77); C179(0.87)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C179(0.80); C9(0.84); C40(0.93); C14(1.00)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C194(0.75); C193(0.81); C202(0.82); C179(0.82)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C194(0.90); C179(0.90); C202(0.92); C193(0.93)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C194(0.54); C193(0.61); C202(0.63); C179(1.14)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C193(0.65); C202(0.67); C194(0.69); C179(0.99)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C202(0.65); C193(0.68); C194(0.75); C179(1.12)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C9(0.83); C22(0.86); C25(0.86); C14(1.18)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C9(0.89); C40(0.90); C36(0.95); C25(1.02)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C25(0.92); C22(0.94); C9(0.97); C14(0.99)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C9(0.87); C40(0.99); C36(1.08); C22(1.10)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C179(0.91); C40(0.97); C9(1.02); C202(1.06)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C179(0.73); C25(0.85); C9(0.86); C22(0.96)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C193(0.65); C202(0.73); C194(0.79); C179(0.80)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C22(0.99); C25(1.00); C9(1.11); C179(1.18)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C193(0.88); C202(0.94); C179(0.94); C9(1.00)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C40(0.98); C36(1.09); C22(1.14); C9(1.16)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C202(0.84); C193(0.86); C194(0.92); C179(0.93)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C193(0.60); C202(0.68); C194(0.73); C179(0.77)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C179(0.78); C193(0.91); C194(1.12); C36(1.12)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C179(0.85); C193(0.92); C194(0.94); C36(1.05)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C193(0.82); C179(0.84); C36(1.07); C40(1.13)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C194(0.65); C193(0.82); C202(0.94); C179(1.13)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C179(0.69); C9(0.86); C25(0.91); C40(1.00)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C194(0.70); C202(0.90); C193(0.95); C179(0.98)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C193(0.87); C179(1.04); C36(1.04); C9(1.08)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C193(0.91); C194(1.03); C179(1.04); C202(1.07)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C194(0.85); C179(1.02); C9(1.03); C193(1.03)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C194(0.69); C193(0.84); C202(0.84); C179(0.95)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C194(0.68); C202(0.85); C179(0.90); C193(1.01)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C194(0.67); C202(0.77); C193(0.86); C179(0.88)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C179(0.78); C22(0.87); C194(0.91); C193(1.09)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C179(0.76); C22(0.86); C194(0.88); C193(1.05)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C179(0.72); C22(0.91); C194(0.97); C193(1.10)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C193(0.74); C202(0.77); C194(0.82); C179(0.82)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C194(0.85); C22(0.90); C179(0.94); C193(1.01)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C14(0.83); C194(0.93); C22(0.97); C193(1.01)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C179(0.77); C22(0.94); C194(1.02); C14(1.11)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C179(0.84); C22(0.95); C40(1.06); C14(1.11)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C179(0.78); C22(0.93); C14(1.09); C193(1.30)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C179(0.73); C194(0.94); C14(0.96); C193(1.05)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C179(0.82); C194(0.86); C22(0.92); C193(0.94)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C179(0.65); C14(0.85); C193(0.94); C202(0.94)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C368(0.28); C179(0.62); C9(0.87); C194(1.03)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C368(0.36); C179(0.73); C9(0.84); C193(0.93)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C179(0.80); C202(1.03); C193(1.04); C40(1.04)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C368(0.13); C179(0.43); C193(0.81); C194(0.96)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C368(0.72); C9(0.79); C40(0.90); C193(0.97)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C368(0.22); C179(0.51); C193(0.86); C194(0.91)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C368(0.15); C179(0.43); C193(0.86); C194(0.90)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C368(0.15); C179(0.45); C9(0.95); C193(0.99)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C368(0.13); C179(0.47); C193(0.85); C194(1.00)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C368(0.16); C179(0.46); C9(1.04); C194(1.04)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C368(0.21); C179(0.60); C194(0.92); C202(0.92)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C194(0.86); C202(0.86); C368(0.88); C193(0.98)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C368(0.28); C179(0.65); C9(0.90); C194(0.93)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C193(0.79); C202(0.80); C194(0.84); C179(0.91)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C368(0.24); C179(0.49); C194(1.04); C202(1.04)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C368(0.69); C194(1.00); C202(1.00); C9(1.00)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C368(0.12); C179(0.38); C194(0.97); C202(0.97)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C179(0.41); C40(1.07); C36(1.11); C193(1.13)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C179(0.43); C193(1.07); C194(1.12); C202(1.16)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C179(0.69); C36(1.09); C193(1.09); C202(1.10)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C179(0.50); C36(0.96); C40(1.00); C9(1.16)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C179(0.59); C40(0.82); C36(0.84); C193(1.00)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C179(0.73); C36(0.96); C40(0.97); C193(1.08)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C179(0.41); C36(1.02); C40(1.04); C193(1.06)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C179(0.70); C40(0.83); C36(0.84); C25(1.00)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C179(0.45); C202(1.05); C194(1.09); C193(1.11)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C179(0.35); C40(1.03); C36(1.05); C194(1.08)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C179(0.63); C40(0.94); C36(1.00); C193(1.05)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C40(0.90); C36(0.99); C194(1.06); C202(1.06)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C179(0.68); C40(0.95); C36(1.01); C25(1.10)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C179(0.61); C40(1.01); C194(1.07); C36(1.08)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C179(0.46); C40(0.99); C36(1.03); C193(1.14)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C368(0.10); C179(0.26); C194(0.52); C202(0.52)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C179(0.56); C193(0.70); C368(0.70); C194(0.84)  LDD0683  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C193(0.78)  LDD2113  [2]
 LDCM0248  AKOS034007472 HCT 116 C179(0.92); C14(1.06); C193(0.93); C194(0.95)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C193(0.78); C194(0.79); C202(0.79); C179(0.81)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C193(0.39); C202(0.39); C194(0.42); C179(0.54)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C22(1.18); C25(1.18); C36(1.08); C40(1.08)  LDD0078  [5]
 LDCM0102  BDHI 8 Jurkat C179(4.74)  LDD0204  [21]
 LDCM0200  BPK-25 T cell C292(9.04)  LDD0516  [22]
 LDCM0108  Chloroacetamide HeLa C255(0.00); C174(0.00); C292(0.00); C14(0.00)  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C292(1.13)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C202(0.76); C179(0.84); C193(0.86); C194(0.97)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C179(0.49); C202(0.92); C193(0.94); C40(1.09)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C179(0.73); C9(0.95); C25(1.02); C202(1.05)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C202(0.79); C193(0.81); C194(0.83); C179(0.96)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C25(0.87); C202(0.88); C179(0.89); C194(0.90)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C179(0.85); C14(0.90); C36(0.92); C9(0.98)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C179(0.92); C22(0.95); C193(0.97); C202(0.98)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C368(0.46); C179(0.75); C194(0.92); C202(0.94)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C368(0.45); C179(0.61); C194(0.66); C193(0.67)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C368(0.24); C193(0.55); C179(0.56); C194(0.60)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C368(0.18); C179(0.48); C193(0.53); C194(0.53)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C368(0.53); C179(0.69); C202(0.89); C194(0.90)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C179(0.35); C202(0.83); C193(0.85); C194(1.13)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C368(0.48); C179(0.61); C194(0.66); C193(0.68)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C179(0.77); C368(0.80); C194(0.96); C202(0.97)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C179(0.86); C202(0.93); C22(0.93); C25(0.93)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C194(0.60); C202(0.60); C193(0.63); C179(0.88)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C179(0.70); C36(1.13); C194(1.14); C40(1.20)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C194(0.70); C193(0.74); C202(0.77); C179(1.00)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C194(0.84); C202(0.86); C193(0.88); C179(1.04)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C193(0.44); C202(0.51); C194(0.55); C179(0.63)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C179(0.98); C9(1.00); C193(1.04); C202(1.04)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C193(0.76); C202(0.84); C194(0.88); C179(0.91)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C179(0.37); C202(1.02); C193(1.09); C40(1.31)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C179(0.95); C25(0.98); C22(0.98); C9(1.10)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C202(0.60); C194(0.77); C179(0.89); C193(0.96)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C179(0.84); C193(0.93); C9(1.18); C14(1.20)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C179(0.52); C194(0.63); C193(0.71); C202(0.79)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C194(0.76); C202(0.84); C193(0.89); C179(0.92)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C194(0.78); C193(0.91); C202(0.91); C25(0.92)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C194(0.69); C193(0.84); C202(0.84); C22(0.93)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C194(0.89); C14(0.96); C40(0.98); C25(1.00)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C179(0.70); C14(0.87); C22(0.91); C193(0.96)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C179(0.74); C202(1.19); C194(1.22); C40(1.22)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C179(0.75); C202(0.94); C193(0.99); C22(1.07)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C179(0.67); C194(0.67); C193(0.73); C202(0.73)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C194(0.73); C202(0.73); C368(0.76); C179(0.81)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C368(0.70); C179(0.87); C36(0.88); C194(0.89)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C36(0.82); C194(1.07); C202(1.07); C368(1.12)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C36(0.88); C179(0.97); C194(1.02); C202(1.02)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C40(0.93); C202(0.99); C14(0.99); C9(1.02)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C368(0.36); C179(0.74); C36(0.95); C194(0.97)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C368(0.19); C179(0.44); C194(0.90); C202(0.90)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C368(0.22); C179(0.60); C194(0.90); C202(0.90)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C368(0.44); C179(0.78); C36(1.03); C194(1.16)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C368(0.27); C179(0.60); C194(0.87); C202(0.87)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C179(0.55); C14(1.45); C194(0.91); C202(0.91)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C179(0.64); C14(1.42); C194(1.08); C202(1.08)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C179(0.79); C14(1.26); C194(1.03); C202(1.03)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C179(0.66); C14(1.53); C194(0.79); C202(0.79)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C179(0.81); C14(1.38); C194(1.07); C202(1.07)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C179(1.07); C14(0.97); C193(1.07); C194(0.89)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C179(0.94); C14(1.21); C194(1.21); C202(1.21)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C179(0.95); C14(1.22); C194(0.74); C202(0.79)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C179(1.08); C14(1.24); C194(0.71); C202(0.85)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C179(0.77); C14(1.25); C194(0.89); C202(1.03)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C179(0.72); C14(1.25); C194(0.89); C202(0.93)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C179(0.51); C14(1.32); C194(0.90); C202(0.93)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C179(0.90); C14(1.22); C194(0.88); C202(0.84)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C179(0.49); C14(1.39); C194(0.95); C202(0.92)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C179(0.51); C14(1.54); C194(0.90); C202(1.01)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C179(0.95); C14(0.99); C193(1.18); C194(1.08)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C179(0.51); C14(1.62); C194(0.59); C202(0.66)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C179(0.82); C14(1.28); C194(0.90); C202(0.90)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C179(0.51); C14(1.85); C194(1.00); C202(0.94)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C179(0.59); C14(1.51); C194(0.93); C202(0.91)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C179(0.66); C14(1.46); C194(0.67); C202(0.85)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C179(0.60); C14(1.54); C194(0.70); C202(0.88)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C179(0.78); C14(1.01); C193(0.98); C194(0.89)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C179(0.87); C14(1.07); C193(0.89); C194(0.81)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C179(0.90); C14(1.05); C193(1.02); C194(1.03)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C179(0.96); C14(1.00); C193(1.09); C194(1.05)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C179(0.89); C14(1.10); C193(1.20); C194(1.20)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C179(0.96); C14(1.16); C193(1.06); C194(1.03)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C179(0.85); C14(0.99); C193(0.95); C194(0.94)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C179(0.91); C14(1.09); C193(1.08); C194(1.03)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C179(0.99); C14(0.99); C193(1.14); C194(1.05)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C179(0.87); C14(1.24); C193(0.90); C194(0.83)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C179(1.12); C14(1.11); C193(1.08); C194(0.99)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C179(1.04); C14(1.07); C193(0.97); C194(0.90)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C179(0.91); C14(1.06); C193(0.93); C194(0.86)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C179(1.10); C14(0.95); C193(1.01); C194(0.90)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C179(0.99); C14(1.09); C193(1.19); C194(1.05)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C179(1.21); C14(1.09); C193(1.04); C194(0.96)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C179(0.84); C14(0.98); C193(0.98); C194(0.98)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C179(1.09); C14(0.93); C193(0.96); C194(1.01)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C179(0.88); C14(1.00); C193(0.96); C194(0.92)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C179(0.73); C14(1.28); C193(0.91); C194(0.94)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C179(0.62); C14(0.96); C193(0.58); C194(0.63)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C179(0.96); C14(0.99); C193(1.04); C194(1.23)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C179(0.48); C14(1.11); C193(0.46); C194(0.50)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C179(0.77); C14(1.16); C193(0.59); C194(0.61)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C179(0.86); C14(1.44); C193(0.93); C194(0.89)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C179(1.17); C14(1.29); C193(0.97); C194(0.94)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C179(0.57); C14(1.12); C193(1.01); C194(0.97)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C179(1.04); C14(1.10); C193(1.20); C194(1.29)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C179(0.73); C14(1.05); C193(0.76); C194(0.74)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C179(1.07); C14(0.81); C193(0.92); C194(1.00)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C179(0.98); C14(0.92); C193(0.77); C194(0.82)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C179(0.89); C14(0.98); C193(0.81); C194(0.85)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C179(0.96); C14(1.14); C193(0.97); C194(0.84)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C179(1.00); C14(1.06); C193(0.72); C194(0.73)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C179(0.68); C14(1.18); C193(0.86); C194(0.78)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C179(0.52); C14(1.37); C193(0.69); C194(0.67)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C179(0.36); C14(1.15); C193(0.95); C194(1.12)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C179(1.02); C14(1.17); C193(1.06); C194(0.92)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C179(0.77); C14(1.33); C193(0.83); C194(0.76)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C179(0.47); C14(1.59); C193(0.52); C194(0.61)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C179(0.47); C14(1.59); C193(0.56); C194(0.60)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C179(0.45); C14(1.73); C193(0.57); C194(0.57)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C179(0.83); C14(1.38); C193(0.70); C194(0.73)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C179(1.01); C14(1.21); C193(0.93); C194(0.86)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C179(0.65); C14(1.66); C193(0.66); C194(0.61)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C179(0.59); C14(1.32); C193(0.71); C194(0.75)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C179(0.46); C14(1.81); C193(0.61); C194(0.62)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C179(0.63); C14(1.14); C193(0.72); C194(0.69)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C179(0.74); C14(1.04); C193(0.94); C194(0.82)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C179(0.80); C14(1.12); C193(1.13); C194(1.16)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C179(0.73); C14(1.17); C193(0.94); C194(1.09)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C179(0.90); C14(1.07); C193(1.04); C194(1.18)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C179(0.70); C14(1.34); C193(0.97); C194(1.00)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C179(0.64); C14(1.16); C193(1.16); C194(1.11)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C179(0.76); C14(0.91); C193(1.21); C194(1.19)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C179(0.71); C14(0.93); C193(1.14); C194(1.02)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C179(0.66); C14(1.30); C193(1.01); C194(1.02)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C179(0.71); C14(1.13); C193(1.21); C194(1.15)  LDD0811  [5]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C36, C40, C41(5.64)  LDD0526  [22]
 LDCM0495  E2913 HEK-293T C292(1.17); C36(1.07); C255(1.09); C179(1.18)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C22(1.24); C25(1.07)  LDD1702  [2]
 LDCM0625  F8 Ramos 0.86  LDD2187  [24]
 LDCM0572  Fragment10 Ramos 1.53  LDD2189  [24]
 LDCM0573  Fragment11 Ramos 2.26  LDD2190  [24]
 LDCM0574  Fragment12 Ramos 0.43  LDD2191  [24]
 LDCM0575  Fragment13 Ramos 1.27  LDD2192  [24]
 LDCM0576  Fragment14 Ramos 1.12  LDD2193  [24]
 LDCM0579  Fragment20 Ramos 0.64  LDD2194  [24]
 LDCM0580  Fragment21 Ramos 0.51  LDD2195  [24]
 LDCM0582  Fragment23 Ramos 0.66  LDD2196  [24]
 LDCM0578  Fragment27 Ramos 0.50  LDD2197  [24]
 LDCM0586  Fragment28 Ramos 1.21  LDD2198  [24]
 LDCM0588  Fragment30 Ramos 0.29  LDD2199  [24]
 LDCM0589  Fragment31 Ramos 1.04  LDD2200  [24]
 LDCM0468  Fragment33 HCT 116 C179(0.74); C14(1.07); C193(0.81); C194(0.86)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos 1.04  LDD2203  [24]
 LDCM0566  Fragment4 Ramos 1.86  LDD2184  [24]
 LDCM0427  Fragment51 HCT 116 C179(0.57); C14(1.52); C194(0.70); C202(0.66)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos 0.40  LDD2204  [24]
 LDCM0614  Fragment56 Ramos 0.41  LDD2205  [24]
 LDCM0569  Fragment7 Ramos 1.65  LDD2186  [24]
 LDCM0571  Fragment9 Ramos 1.93  LDD2188  [24]
 LDCM0116  HHS-0101 DM93 Y309(1.17)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y309(0.68)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y309(1.12)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y309(0.77)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y309(1.22)  LDD0268  [3]
 LDCM0107  IAA HeLa C292(0.00); C194(0.00); H294(0.00)  LDD0221  [15]
 LDCM0022  KB02 HCT 116 C292(1.74); C36(2.63); C14(1.85); C22(1.59)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C292(1.46); C36(1.38); C14(1.58); C22(1.76)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C292(20.00); C36(1.95); C14(1.68); C22(1.67)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [15]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C292(1.09)  LDD2093  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C292(0.66)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C292(1.02)  LDD2111  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C292(1.12)  LDD2119  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C292(1.19)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C292(0.84)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C292(1.02)  LDD2129  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C25(0.96)  LDD2140  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C292(1.49)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C292(0.70)  LDD2146  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C194(0.89)  LDD2148  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C40(0.95); C14(0.90)  LDD2206  [25]
 LDCM0628  OTUB2-COV-1 HEK-293T C22(2.22); C40(1.13); C9(0.24)  LDD2207  [25]
 LDCM0131  RA190 MM1.R C36(1.28); C40(1.28); C22(1.27); C25(1.27)  LDD0304  [26]
 LDCM0021  THZ1 HCT 116 C36(1.15); C40(1.15); C292(1.05); C14(1.14)  LDD2173  [5]
 LDCM0112  W16 Hep-G2 C14(1.58)  LDD0239  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Glutaredoxin-3 (GLRX3) . O76003
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86
Puratrophin-1 (PLEKHG4) . Q58EX7

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ovalicin Small molecular drug DB04324
Pmid23634668c14 Small molecular drug D0Z7RB
3-[(22-dimethylpropanoyl)Amino]-n-13-thiazol-2-ylpyridine-2-carboxamide . DB07903
5-chloro-6-methyl-n-(2-phenylethyl)-2-pyridin-2-ylpyrimidin-4-amine . DB07901
Tert-butyl {2-[(13-thiazol-2-ylamino)Carbonyl]Pyridin-3-yl}Carbamate . DB07902

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
20 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
21 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
22 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
26 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.