Details of the Target

General Information of Target

Target ID LDTP06721
Target Name GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (ALG11)
Gene Name ALG11
Gene ID 440138
Synonyms
GT8; GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; EC 2.4.1.131; Asparagine-linked glycosylation protein 11 homolog; Glycolipid 2-alpha-mannosyltransferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAGERSWCLCKLLRFFYSLFFPGLIVCGTLCVCLVIVLWGIRLLLQRKKKLVSTSKNGK
NQMVIAFFHPYCNAGGGGERVLWCALRALQKKYPEAVYVVYTGDVNVNGQQILEGAFRRF
NIRLIHPVQFVFLRKRYLVEDSLYPHFTLLGQSLGSIFLGWEALMQCVPDVYIDSMGYAF
TLPLFKYIGGCQVGSYVHYPTISTDMLSVVKNQNIGFNNAAFITRNPFLSKVKLIYYYLF
AFIYGLVGSCSDVVMVNSSWTLNHILSLWKVGNCTNIVYPPCDVQTFLDIPLHEKKMTPG
HLLVSVGQFRPEKNHPLQIRAFAKLLNKKMVESPPSLKLVLIGGCRNKDDELRVNQLRRL
SEDLGVQEYVEFKINIPFDELKNYLSEATIGLHTMWNEHFGIGVVECMAAGTIILAHNSG
GPKLDIVVPHEGDITGFLAESEEDYAETIAHILSMSAEKRLQIRKSARASVSRFSDQEFE
VTFLSSVEKLFK
Target Bioclass
Enzyme
Family
Glycosyltransferase group 1 family, Glycosyltransferase 4 subfamily
Subcellular location
Endoplasmic reticulum
Function
Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain.
Uniprot ID
Q2TAA5
Ensemble ID
ENST00000521508.2
HGNC ID
HGNC:32456

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CHEMBL5175495
 Probe Info  		6.02  LDD0196  [1]
BTD
 Probe Info  		C345(0.82)  LDD2123  [2]
Johansson_61
 Probe Info  		_(11.75)  LDD1485  [3]
Acrolein
 Probe Info  		N.A.  LDD0222  [4]
DBIA
 Probe Info  		C345(0.97); C84(1.02)  LDD0531  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [7]
IPM
 Probe Info  		N.A.  LDD0147  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
PAL-AfBPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		5.46  LDD1714  [9]
C022
 Probe Info  		7.11  LDD1728  [9]
C040
 Probe Info  		6.73  LDD1740  [9]
C091
 Probe Info  		10.27  LDD1782  [9]
C094
 Probe Info  		24.59  LDD1785  [9]
C095
 Probe Info  		5.24  LDD1786  [9]
C134
 Probe Info  		21.71  LDD1816  [9]
C158
 Probe Info  		9.00  LDD1838  [9]
C169
 Probe Info  		20.97  LDD1849  [9]
C183
 Probe Info  		5.03  LDD1861  [9]
C186
 Probe Info  		9.45  LDD1864  [9]
C214
 Probe Info  		5.70  LDD1888  [9]
C218
 Probe Info  		14.42  LDD1892  [9]
C220
 Probe Info  		11.79  LDD1894  [9]
C251
 Probe Info  		29.04  LDD1924  [9]
C264
 Probe Info  		19.29  LDD1935  [9]
C310
 Probe Info  		7.62  LDD1977  [9]
C349
 Probe Info  		9.45  LDD2010  [9]
C388
 Probe Info  		37.53  LDD2047  [9]
C403
 Probe Info  		14.03  LDD2061  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C345(0.97); C84(1.02)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C274(0.48); C282(0.48); C345(0.99); C84(0.92)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C274(0.31); C282(0.31); C345(1.04); C84(0.90)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C274(0.42); C282(0.42); C345(1.11); C84(0.85)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C274(0.61); C282(0.61); C345(1.08); C84(0.86)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C274(0.19); C282(0.19); C345(0.95); C84(0.80)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C274(0.28); C282(0.28); C345(1.02); C84(0.97)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C274(0.29); C282(0.29); C345(1.09); C84(0.83)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C274(0.20); C282(0.20); C345(1.15); C84(0.70)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C274(0.29); C282(0.31); C345(0.99); C84(0.78)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C274(0.22); C282(0.34); C345(1.09); C84(0.90)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C274(0.34); C282(0.33); C345(1.37); C84(0.96)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C274(0.45); C282(0.45); C345(1.12); C84(1.01)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C274(0.30); C282(0.27); C345(0.99); C84(0.98)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C274(0.30); C282(0.25); C345(1.03); C84(0.97)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C274(0.29); C282(0.27); C345(1.19); C84(0.90)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C345(1.07)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C345(1.01)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C345(1.02)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C345(0.97)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C345(0.98)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C345(1.03)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C345(0.98)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C274(0.60); C282(0.60); C345(1.21); C84(0.85)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C345(1.03)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C345(1.06)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C345(1.05)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C345(1.17)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C345(1.09)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C345(1.09)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C345(1.09)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C345(1.15)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C274(0.38); C282(0.38); C345(0.72); C84(1.54)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C274(0.85); C282(0.85); C345(1.12); C84(1.27)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C274(0.46); C282(0.46); C345(0.83); C84(1.28)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C274(1.05); C282(1.05); C345(1.16); C84(1.56)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C274(1.50); C282(1.50); C345(1.18); C84(1.20)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C274(0.49); C282(0.49); C345(0.86); C84(1.36)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C274(0.54); C282(0.54); C345(0.93); C84(1.36)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C274(0.54); C282(0.54); C345(0.85); C84(1.30)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C274(0.56); C282(0.56); C345(1.03); C84(1.09)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C274(0.75); C282(0.75); C345(1.08); C84(1.11)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C274(0.59); C282(0.59); C345(0.92); C84(1.03)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C274(0.67); C282(0.67); C345(1.05); C84(1.09)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C274(0.41); C282(0.41); C345(1.09); C84(0.80)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C274(0.61); C282(0.61); C345(0.90); C84(1.17)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C274(0.75); C282(0.75); C345(1.10); C84(1.15)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C274(1.00); C282(1.00); C345(1.06); C84(0.99)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C274(0.54); C282(0.54); C345(1.02); C84(0.96)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C274(0.33); C282(0.33); C84(0.56); C345(0.91)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C274(0.54); C282(0.54); C84(0.77); C345(0.99)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C274(0.31); C282(0.31); C84(0.54); C345(0.91)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C274(0.28); C282(0.28); C84(0.40); C345(0.89)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C274(0.14); C282(0.14); C84(0.22); C345(0.73)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C274(0.22); C282(0.22); C84(0.40); C345(0.80)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C274(0.52); C282(0.52); C345(1.01); C84(1.03)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C274(0.32); C282(0.32); C84(1.04); C345(1.11)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C84(0.92); C345(1.02); C274(1.17); C282(1.17)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C274(0.28); C282(0.28); C84(0.45); C345(0.82)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C274(0.11); C282(0.11); C84(0.21); C345(0.71)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C274(0.33); C282(0.33); C345(1.02); C84(0.51)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C274(0.41); C282(0.41); C345(0.90); C84(0.69)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C274(0.77); C282(0.77); C345(1.01); C84(0.89)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C274(0.49); C282(0.49); C345(0.89); C84(1.10)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C84(0.95); C345(0.98)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C84(0.47); C345(0.98)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C345(0.97); C84(1.11)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C84(0.77); C345(0.97)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C345(1.11); C84(1.31)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C84(0.82); C345(0.96)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C84(1.00); C345(1.03)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C84(0.92); C345(0.94)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C345(1.01); C84(1.07)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C345(0.95); C84(0.96)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C84(0.74); C345(1.01)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C84(0.79); C345(1.07)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C84(0.73); C345(1.07)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C84(0.74); C345(0.89)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C84(0.91); C345(1.06)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C84(0.75); C345(0.93)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C84(0.66); C345(0.94)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C84(0.56); C345(0.95)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C84(0.72); C345(0.98)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C84(0.64); C345(0.90)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C345(1.08); C84(1.17); C274(2.14); C282(2.14)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C345(1.17); C84(1.29); C274(2.31); C282(2.31)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C345(1.08); C84(1.13); C274(2.00); C282(2.00)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C274(1.04); C282(1.04); C345(1.07); C84(1.27)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C274(0.95); C282(0.95); C345(1.04); C84(1.05)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C84(0.99); C345(1.05)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C345(0.82); C84(0.85); C274(0.94); C282(0.94)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C84(0.99); C345(1.19); C274(2.01); C282(2.01)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C84(0.94); C345(1.08); C274(1.18); C282(1.18)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C84(0.86); C345(1.01); C274(1.36); C282(1.36)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C84(0.90); C345(0.97); C274(1.03); C282(1.03)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C84(0.68); C274(0.81); C282(0.81); C345(0.92)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C345(0.80); C84(0.92)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C345(0.84); C84(0.85)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C84(0.70); C345(0.76)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C84(0.60); C345(0.66)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C84(1.11); C345(1.13)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C84(0.68); C345(0.74)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C345(0.95); C84(1.10)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C345(0.97); C84(1.07)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C84(0.70); C345(0.77)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C84(0.74); C345(0.86)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C84(0.69); C345(0.71)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C84(0.60); C345(0.67)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C274(0.55); C282(0.55); C84(0.67); C345(0.89)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C274(0.49); C282(0.49); C84(0.63); C345(0.88)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C274(0.53); C282(0.53); C84(0.65); C345(0.90)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C274(0.52); C282(0.52); C345(1.00); C84(1.01)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C274(0.54); C282(0.54); C84(0.80); C345(0.87)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C274(0.49); C282(0.49); C84(0.57); C345(0.78)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C274(0.48); C282(0.48); C84(0.63); C345(0.82)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C274(0.47); C282(0.47); C84(0.69); C345(0.97)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C274(0.49); C282(0.49); C84(0.69); C345(0.87)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C84(0.71); C274(0.76); C282(0.76); C345(1.02)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C274(0.65); C282(0.65); C84(0.76); C345(0.97)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C274(0.35); C282(0.35); C84(0.56); C345(0.69)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C84(0.61); C345(0.81)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C84(0.61); C345(0.73)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C274(0.65); C282(0.65); C345(1.04); C84(1.18)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C84(0.45); C345(0.66)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C84(0.87); C345(1.05)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C84(0.64); C345(0.79)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C84(0.43); C345(0.66)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C84(0.56); C345(0.66)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C84(0.46); C345(0.62)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C84(0.56); C345(0.78)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C84(0.49); C345(0.77)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C84(0.66); C345(0.92)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C84(0.74); C345(1.07)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C274(0.66); C282(0.66); C84(0.80); C345(0.94)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C84(0.72); C345(0.76)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C84(0.71); C345(1.04)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C84(0.49); C345(0.72)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C84(0.27); C345(0.66)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C84(0.26); C345(0.71)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C84(0.38); C345(0.91)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C84(0.57); C345(1.11)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C84(0.60); C345(0.95)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C84(0.68); C345(1.10)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C84(0.38); C345(0.80)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C345(1.11); C84(1.13)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C84(0.28); C345(0.66)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C84(0.30); C345(0.76)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C84(0.68); C345(1.05)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C84(0.56); C345(0.98)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C84(0.46); C345(0.82)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C84(0.34); C345(0.94)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C84(0.45); C345(0.80)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C274(0.10); C282(0.10); C84(0.92); C345(1.12)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C274(0.43); C282(0.43); C84(0.83); C345(0.99)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C274(0.82); C282(0.82); C345(1.12); C84(0.74)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C274(0.53); C282(0.53); C84(1.00); C345(1.07)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C274(0.19); C282(0.19); C84(0.89); C345(1.03)  LDD0592  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0367  CL1 HCT 116 C345(0.95); C84(1.01); C274(1.23); C282(1.23)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C274(0.49); C282(0.49); C84(0.53); C345(0.87)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C345(1.04); C84(1.05)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C274(0.48); C282(0.48); C84(0.85); C345(1.01)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C274(0.56); C282(0.56); C84(0.80); C345(1.07)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C274(0.71); C282(0.71); C345(1.07); C84(1.12)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C274(0.62); C282(0.62); C84(0.77); C345(1.17)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C84(0.67); C345(1.03)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C84(0.41); C345(0.92)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C84(0.49); C345(0.96)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C84(0.46); C345(0.92)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C84(0.84); C345(1.09)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C274(0.34); C282(0.34); C84(0.44); C345(0.78)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C84(0.63); C345(0.95)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C84(0.83); C345(1.00)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C84(0.85); C345(0.91)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C84(0.65); C345(0.96)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C84(0.73); C345(0.95)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C84(0.81); C345(0.95)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C84(0.79); C345(0.99)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C274(0.55); C282(0.55); C345(0.75); C84(0.83)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C84(0.90); C345(1.02); C274(1.17); C282(1.17)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C84(0.87); C345(0.90); C274(0.93); C282(0.93)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C274(0.35); C282(0.35); C84(0.45); C345(0.84)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C84(0.93); C345(1.12); C274(1.31); C282(1.31)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C84(0.69); C345(0.80)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C84(0.80); C345(0.82)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C84(0.63); C345(0.70)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C84(0.65); C345(0.70)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C345(1.04); C274(1.11); C282(1.11); C84(1.17)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C345(1.04); C274(1.06); C282(1.06); C84(1.68)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C84(0.87); C274(0.97); C282(0.97); C345(1.10)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C274(0.53); C282(0.53); C84(0.73); C345(0.89)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C274(0.48); C282(0.48); C84(0.55); C345(0.89)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C274(0.88); C282(0.88); C345(1.01); C84(1.13)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C274(0.48); C282(0.48); C84(0.62); C345(0.85)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C274(0.72); C282(0.72); C84(0.77); C345(0.90)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C274(0.66); C282(0.66); C345(0.86); C84(1.16)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C274(0.36); C282(0.36); C345(0.74); C84(0.93)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C274(0.69); C282(0.69); C345(0.87); C84(1.13)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C274(1.03); C282(1.03); C84(1.08); C345(1.12)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C274(0.44); C282(0.44); C345(0.75); C84(0.97)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C274(0.35); C282(0.35); C345(0.77); C84(1.12)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C274(0.25); C282(0.25); C345(0.65); C84(1.16)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C274(0.58); C282(0.58); C345(0.84); C84(0.96)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C274(0.30); C282(0.30); C345(0.61); C84(0.81)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C274(0.38); C282(0.38); C345(0.70); C84(0.81)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C274(0.72); C282(0.72); C345(0.80); C84(0.73)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C274(0.70); C282(0.70); C345(0.89); C84(1.00)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C274(0.46); C282(0.46); C345(0.76); C84(0.83)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C274(0.48); C282(0.48); C345(0.77); C84(0.85)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C274(1.00); C282(1.00); C345(1.01); C84(0.96)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C274(0.71); C282(0.71); C345(0.87); C84(0.91)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C345(0.90); C84(0.89)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C345(0.95); C84(0.66)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C345(0.89); C84(0.69)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C345(0.90); C84(0.58)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C345(0.87); C84(0.65)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C345(0.91); C84(0.67)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C345(0.94); C84(0.61)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C345(0.94); C84(0.66)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C274(0.92); C282(0.92); C345(1.04); C84(1.14)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C345(0.87); C84(0.69)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C345(0.94); C84(0.75)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C345(0.92); C84(0.61)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C345(0.93); C84(0.66)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C345(0.94); C84(0.65)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C345(0.99); C84(0.61)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C345(1.26); C84(0.91)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C345(1.18); C84(0.95)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C345(1.18); C84(0.98)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C345(1.11); C84(1.01)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C274(0.75); C282(0.75); C345(1.11); C84(0.83)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C345(1.14); C84(0.92)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C345(1.13); C84(0.86)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C345(1.08); C84(0.87)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C345(1.05); C84(1.04)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C345(1.02); C84(0.88)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C345(1.14); C84(1.22)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C345(1.13); C84(0.94)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C345(1.12); C84(1.32)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C345(1.18); C84(1.01)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C345(1.20); C84(1.02)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C274(0.52); C282(0.52); C345(0.84); C84(0.61)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C345(1.20); C84(0.94)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C274(0.77); C282(0.77); C345(1.11); C84(0.83)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C274(0.81); C282(0.81); C345(1.09); C84(0.85)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C274(0.73); C282(0.73); C345(1.06); C84(0.74)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C274(0.63); C282(0.63); C345(0.94); C84(0.91)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C274(0.85); C282(0.85); C345(1.05); C84(0.88)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C274(0.38); C282(0.38); C345(0.98); C84(0.87)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C274(0.57); C282(0.57); C345(0.93); C84(0.86)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C274(0.48); C282(0.48); C345(0.85); C84(0.64)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C274(0.38); C282(0.38); C345(0.81); C84(0.74)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C274(0.47); C282(0.47); C345(0.96); C84(0.72)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C274(0.51); C282(0.51); C345(0.76); C84(0.73)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C274(0.66); C282(0.66); C345(0.99); C84(0.84)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C274(0.91); C282(0.91); C345(1.00); C84(0.67)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C274(0.61); C282(0.61); C345(0.87); C84(0.86)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C274(0.58); C282(0.58); C345(0.92); C84(0.77)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C274(0.66); C282(0.66); C345(1.16); C84(0.89)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C274(0.78); C282(0.78); C345(1.13); C84(0.96)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C274(0.95); C282(0.95); C345(0.91); C84(1.17)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C274(0.44); C282(0.44); C345(1.14); C84(0.94)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C274(0.33); C282(0.33); C345(0.78); C84(0.43)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C274(0.54); C282(0.54); C345(1.15); C84(0.90)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C274(0.82); C282(0.82); C345(1.41); C84(1.00)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C274(0.34); C282(0.34); C345(1.28); C84(0.88)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C274(0.38); C282(0.38); C345(1.13); C84(0.89)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C274(0.31); C282(0.31); C345(1.06); C84(0.75)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C274(0.75); C282(0.75); C345(1.11); C84(0.97)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C274(1.03); C282(1.03); C345(1.35); C84(1.13)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C274(0.80); C282(0.80); C345(1.51); C84(0.93)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C274(0.53); C282(0.53); C345(1.31); C84(0.94)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C274(0.33); C282(0.33); C345(1.24); C84(0.83)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C274(0.60); C282(0.60); C345(1.05); C84(0.87)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C274(2.58); C282(2.58); C345(1.21); C84(1.17)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C345(0.96); C84(0.88)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C345(1.08); C84(1.38)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C345(1.00); C84(1.52)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C345(0.93); C84(1.80)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C345(0.96); C84(0.97)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C345(1.06); C84(0.96)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C345(0.90); C84(0.89)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C345(0.98); C84(0.80)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C345(1.06); C84(0.90)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C345(1.07); C72(1.01); C274(1.01); C282(0.98)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C345(6.04); C84(4.23)  LDD1702  [2]
 LDCM0625  F8 Ramos C84(0.99); C345(0.88); C72(0.65)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C84(0.75); C345(0.99)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C84(0.30); C345(0.32)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C84(0.87); C345(1.16)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C84(0.68); C345(0.97)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C84(1.19); C345(1.05); C72(1.05)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C84(1.28); C345(1.27)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C84(0.69); C345(0.97)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C84(0.70); C345(0.78)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C84(0.70); C345(1.02)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C84(0.70); C345(0.75); C72(1.39)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C84(0.92); C345(0.97)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C84(0.63); C345(0.91)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C84(0.69); C345(0.75)  LDD2201  [11]
 LDCM0468  Fragment33 HCT 116 C274(0.68); C282(0.68); C345(1.19); C84(0.84)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C84(0.69); C345(0.80)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C84(1.14); C345(1.26); C72(0.57)  LDD2184  [11]
 LDCM0427  Fragment51 HCT 116 C345(0.89); C84(0.64)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C84(0.71); C345(1.15)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C84(0.78); C345(1.05)  LDD2205  [11]
 LDCM0616  Fragment61 Jurkat _(15.38)  LDD1489  [3]
 LDCM0615  Fragment63-R Jurkat _(16.85)  LDD1487  [3]
 LDCM0569  Fragment7 Jurkat _(11.75)  LDD1485  [3]
 LDCM0571  Fragment9 Ramos C84(1.42); C345(1.28)  LDD2188  [11]
 LDCM0022  KB02 HEK-293T C345(0.99); C84(0.88); C274(1.01); C72(0.87)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C345(0.91); C84(0.82); C274(1.00); C72(1.04)  LDD1497  [10]
 LDCM0024  KB05 COLO792 C345(2.16)  LDD3310  [12]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C345(0.82)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C345(1.02)  LDD2125  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C345(1.35)  LDD2129  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C345(1.40)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C345(1.11)  LDD2136  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C345(0.84)  LDD2146  [2]

References

1 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840