Details of the Target

General Information of Target

Target ID LDTP10357
Target Name RUS family member 1 (RUSF1)
Gene Name RUSF1
Gene ID 64755
Synonyms
C16orf58; RUS family member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGAGPRGAGPARRRGAGGPPSPLLPSLLLLLLLWMLPDTVAPQELNPRGRNVCRAPGSQ
VPTCCAGWRQQGDECGIAVCEGNSTCSENEVCVRPGECRCRHGYFGANCDTKCPRQFWGP
DCKELCSCHPHGQCEDVTGQCTCHARRWGARCEHACQCQHGTCHPRSGACRCEPGWWGAQ
CASACYCSATSRCDPQTGACLCHAGWWGRSCNNQCACNSSPCEQQSGRCQCRERTFGARC
DRYCQCFRGRCHPVDGTCACEPGYRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEG
RCLTCEPGWNGTKCDQPCATGFYGEGCSHRCPPCRDGHACNHVTGKCTRCNAGWIGDRCE
TKCSNGTYGEDCAFVCADCGSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLHGADCAQACS
CHEDTCDPVTGACHLETNQRKGVMGAGALLVLLVCLLLSLLGCCCACRGKDPTRRPRPRR
ELSLGRKKAPHRLCGRFSRISMKLPRIPLRRQKLPKVVVAHHDLDNTLNCSFLEPPSGLE
QPSPSWSSRASFSSFDTTDEGPVYCVPHEEAPAESRDPEVPTVPAEAPAPSPVPLTTPAS
AEEAIPLPASSDSERSASSVEGPGGALYARVARREARPARARGEIGGLSLSPSPERRKPP
PPDPATKPKVSWIHGKHSAAAAGRAPSPPPPGSEAAPSPSKRKRTPSDKSAHTVEHGSPR
TRDPTPRPPGLPEEATALAAPSPPRARARGRGPGLLEPTDAGGPPRSAPEAASMLAAELR
GKTRSLGRAEVALGAQGPREKPAPPQKAKRSVPPASPARAPPATETPGPEKAATDLPAPE
TPRKKTPIQKPPRKKSREAAGELGRAGAPTL
Target Bioclass
Other
Family
RUS1 family
Subcellular location
Membrane
Uniprot ID
Q96GQ5
Ensemble ID
ENST00000327237.7
HGNC ID
HGNC:25848

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.D139N DBIA    Probe Info 
COLO678 SNV: p.D3G DBIA    Probe Info 
HEC1 SNV: p.K153N DBIA    Probe Info 
HUH7 SNV: p.T210N .
IGROV1 SNV: p.G61W DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		7.84  LDD0402  [1]
HDSF-alk
 Probe Info  		2.38  LDD0197  [2]
FBP2
 Probe Info  		10.87  LDD0317  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
YN-4
 Probe Info  		100.00  LDD0445  [4]
STPyne
 Probe Info  		K297(10.00); K433(5.56)  LDD0277  [5]
Curcusone 37
 Probe Info  		3.96  LDD0188  [6]
Johansson_61
 Probe Info  		_(5.43)  LDD1485  [7]
YY4-yne
 Probe Info  		2.66  LDD0400  [8]
HPAP
 Probe Info  		3.10  LDD0062  [9]
DBIA
 Probe Info  		C201(6.62)  LDD0209  [10]
IPM
 Probe Info  		C201(2.30)  LDD1701  [11]
Acrolein
 Probe Info  		N.A.  LDD0227  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [13]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
VSF
 Probe Info  		N.A.  LDD0007  [15]
AOyne
 Probe Info  		10.40  LDD0443  [16]
PAL-AfBPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		12.38  LDD1740  [17]
C056
 Probe Info  		21.86  LDD1753  [17]
C091
 Probe Info  		11.00  LDD1782  [17]
C095
 Probe Info  		6.11  LDD1786  [17]
C100
 Probe Info  		5.10  LDD1789  [17]
C169
 Probe Info  		24.93  LDD1849  [17]
C177
 Probe Info  		7.94  LDD1856  [17]
C178
 Probe Info  		17.51  LDD1857  [17]
C218
 Probe Info  		27.67  LDD1892  [17]
C219
 Probe Info  		7.41  LDD1893  [17]
C220
 Probe Info  		23.10  LDD1894  [17]
C231
 Probe Info  		17.51  LDD1904  [17]
C233
 Probe Info  		10.85  LDD1906  [17]
C234
 Probe Info  		8.00  LDD1907  [17]
C235
 Probe Info  		32.45  LDD1908  [17]
C243
 Probe Info  		11.00  LDD1916  [17]
C246
 Probe Info  		13.18  LDD1919  [17]
C252
 Probe Info  		9.65  LDD1925  [17]
C285
 Probe Info  		49.87  LDD1955  [17]
C287
 Probe Info  		18.00  LDD1957  [17]
C288
 Probe Info  		8.82  LDD1958  [17]
C289
 Probe Info  		47.18  LDD1959  [17]
C299
 Probe Info  		7.57  LDD1968  [17]
FFF probe11
 Probe Info  		20.00  LDD0471  [18]
FFF probe14
 Probe Info  		20.00  LDD0477  [18]
FFF probe2
 Probe Info  		20.00  LDD0463  [18]
A-DA
 Probe Info  		2.93  LDD0145  [19]
OEA-DA
 Probe Info  		6.53  LDD0046  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C201(1.02)  LDD0531  [21]
 LDCM0215  AC10 HCT 116 C201(1.05)  LDD0532  [21]
 LDCM0216  AC100 HCT 116 C201(0.71)  LDD0533  [21]
 LDCM0217  AC101 HCT 116 C201(0.77)  LDD0534  [21]
 LDCM0218  AC102 HCT 116 C201(0.72)  LDD0535  [21]
 LDCM0219  AC103 HCT 116 C201(0.72)  LDD0536  [21]
 LDCM0220  AC104 HCT 116 C201(0.68)  LDD0537  [21]
 LDCM0221  AC105 HCT 116 C201(0.81)  LDD0538  [21]
 LDCM0222  AC106 HCT 116 C201(0.77)  LDD0539  [21]
 LDCM0223  AC107 HCT 116 C201(0.71)  LDD0540  [21]
 LDCM0224  AC108 HCT 116 C201(0.83)  LDD0541  [21]
 LDCM0225  AC109 HCT 116 C201(0.99)  LDD0542  [21]
 LDCM0226  AC11 HCT 116 C201(0.98)  LDD0543  [21]
 LDCM0227  AC110 HCT 116 C201(0.82)  LDD0544  [21]
 LDCM0228  AC111 HCT 116 C201(0.69)  LDD0545  [21]
 LDCM0229  AC112 HCT 116 C201(0.67)  LDD0546  [21]
 LDCM0230  AC113 HCT 116 C201(1.10)  LDD0547  [21]
 LDCM0231  AC114 HCT 116 C201(1.06)  LDD0548  [21]
 LDCM0232  AC115 HCT 116 C201(0.95)  LDD0549  [21]
 LDCM0233  AC116 HCT 116 C201(0.85)  LDD0550  [21]
 LDCM0234  AC117 HCT 116 C201(1.08)  LDD0551  [21]
 LDCM0235  AC118 HCT 116 C201(1.06)  LDD0552  [21]
 LDCM0236  AC119 HCT 116 C201(1.05)  LDD0553  [21]
 LDCM0237  AC12 HCT 116 C201(0.98)  LDD0554  [21]
 LDCM0238  AC120 HCT 116 C201(0.95)  LDD0555  [21]
 LDCM0239  AC121 HCT 116 C201(0.98)  LDD0556  [21]
 LDCM0240  AC122 HCT 116 C201(0.68)  LDD0557  [21]
 LDCM0241  AC123 HCT 116 C201(1.15)  LDD0558  [21]
 LDCM0242  AC124 HCT 116 C201(0.98)  LDD0559  [21]
 LDCM0243  AC125 HCT 116 C201(0.74)  LDD0560  [21]
 LDCM0244  AC126 HCT 116 C201(1.20)  LDD0561  [21]
 LDCM0245  AC127 HCT 116 C201(0.87)  LDD0562  [21]
 LDCM0246  AC128 HCT 116 C201(1.12)  LDD0563  [21]
 LDCM0247  AC129 HCT 116 C201(1.14)  LDD0564  [21]
 LDCM0249  AC130 HCT 116 C201(1.15)  LDD0566  [21]
 LDCM0250  AC131 HCT 116 C201(1.09)  LDD0567  [21]
 LDCM0251  AC132 HCT 116 C201(1.18)  LDD0568  [21]
 LDCM0252  AC133 HCT 116 C201(1.19)  LDD0569  [21]
 LDCM0253  AC134 HCT 116 C201(1.21)  LDD0570  [21]
 LDCM0254  AC135 HCT 116 C201(1.13)  LDD0571  [21]
 LDCM0255  AC136 HCT 116 C201(1.17)  LDD0572  [21]
 LDCM0256  AC137 HCT 116 C201(1.10)  LDD0573  [21]
 LDCM0257  AC138 HCT 116 C201(1.29)  LDD0574  [21]
 LDCM0258  AC139 HCT 116 C201(1.28)  LDD0575  [21]
 LDCM0259  AC14 HCT 116 C201(0.94)  LDD0576  [21]
 LDCM0260  AC140 HCT 116 C201(1.40)  LDD0577  [21]
 LDCM0261  AC141 HCT 116 C201(1.24)  LDD0578  [21]
 LDCM0262  AC142 HCT 116 C201(1.26)  LDD0579  [21]
 LDCM0263  AC143 HCT 116 C201(1.00)  LDD0580  [21]
 LDCM0264  AC144 HCT 116 C201(1.01)  LDD0581  [21]
 LDCM0265  AC145 HCT 116 C201(1.03)  LDD0582  [21]
 LDCM0266  AC146 HCT 116 C201(0.93)  LDD0583  [21]
 LDCM0267  AC147 HCT 116 C201(1.09)  LDD0584  [21]
 LDCM0268  AC148 HCT 116 C201(1.04)  LDD0585  [21]
 LDCM0269  AC149 HCT 116 C201(0.98)  LDD0586  [21]
 LDCM0270  AC15 HCT 116 C201(1.02)  LDD0587  [21]
 LDCM0271  AC150 HCT 116 C201(1.07)  LDD0588  [21]
 LDCM0272  AC151 HCT 116 C201(0.94)  LDD0589  [21]
 LDCM0273  AC152 HCT 116 C201(0.92)  LDD0590  [21]
 LDCM0274  AC153 HCT 116 C201(1.04)  LDD0591  [21]
 LDCM0621  AC154 HCT 116 C201(0.97)  LDD2158  [21]
 LDCM0622  AC155 HCT 116 C201(0.94)  LDD2159  [21]
 LDCM0623  AC156 HCT 116 C201(0.97)  LDD2160  [21]
 LDCM0624  AC157 HCT 116 C201(0.94)  LDD2161  [21]
 LDCM0276  AC17 HEK-293T C201(0.83); C357(1.07)  LDD1515  [22]
 LDCM0277  AC18 HEK-293T C201(0.93); C357(0.88)  LDD1516  [22]
 LDCM0278  AC19 HEK-293T C201(0.81); C357(0.86)  LDD1517  [22]
 LDCM0279  AC2 HCT 116 C201(1.17)  LDD0596  [21]
 LDCM0280  AC20 HEK-293T C201(1.00); C357(0.93)  LDD1519  [22]
 LDCM0281  AC21 HEK-293T C201(0.95); C357(0.87)  LDD1520  [22]
 LDCM0282  AC22 HEK-293T C201(0.88); C357(1.05)  LDD1521  [22]
 LDCM0283  AC23 HEK-293T C201(1.17); C357(0.88)  LDD1522  [22]
 LDCM0284  AC24 HEK-293T C201(0.92); C357(1.04)  LDD1523  [22]
 LDCM0285  AC25 HCT 116 C201(1.28)  LDD0602  [21]
 LDCM0286  AC26 HCT 116 C201(0.97)  LDD0603  [21]
 LDCM0287  AC27 HCT 116 C201(1.18)  LDD0604  [21]
 LDCM0288  AC28 HCT 116 C201(1.13)  LDD0605  [21]
 LDCM0289  AC29 HCT 116 C201(1.43)  LDD0606  [21]
 LDCM0290  AC3 HCT 116 C201(1.26)  LDD0607  [21]
 LDCM0291  AC30 HCT 116 C201(1.02)  LDD0608  [21]
 LDCM0292  AC31 HCT 116 C201(1.10)  LDD0609  [21]
 LDCM0293  AC32 HCT 116 C201(1.40)  LDD0610  [21]
 LDCM0294  AC33 HCT 116 C201(1.06)  LDD0611  [21]
 LDCM0295  AC34 HCT 116 C201(1.02)  LDD0612  [21]
 LDCM0296  AC35 HCT 116 C201(0.89)  LDD0613  [21]
 LDCM0297  AC36 HCT 116 C201(0.91)  LDD0614  [21]
 LDCM0298  AC37 HCT 116 C201(0.96)  LDD0615  [21]
 LDCM0299  AC38 HCT 116 C201(1.04)  LDD0616  [21]
 LDCM0300  AC39 HCT 116 C201(1.01)  LDD0617  [21]
 LDCM0301  AC4 HCT 116 C201(1.16)  LDD0618  [21]
 LDCM0302  AC40 HCT 116 C201(1.19)  LDD0619  [21]
 LDCM0303  AC41 HCT 116 C201(1.07)  LDD0620  [21]
 LDCM0304  AC42 HCT 116 C201(1.13)  LDD0621  [21]
 LDCM0305  AC43 HCT 116 C201(1.02)  LDD0622  [21]
 LDCM0306  AC44 HCT 116 C201(1.08)  LDD0623  [21]
 LDCM0307  AC45 HCT 116 C201(1.06)  LDD0624  [21]
 LDCM0308  AC46 HCT 116 C201(1.00)  LDD0625  [21]
 LDCM0309  AC47 HCT 116 C201(1.10)  LDD0626  [21]
 LDCM0310  AC48 HCT 116 C201(1.12)  LDD0627  [21]
 LDCM0311  AC49 HCT 116 C201(1.14)  LDD0628  [21]
 LDCM0312  AC5 HCT 116 C201(1.16)  LDD0629  [21]
 LDCM0313  AC50 HCT 116 C201(1.15)  LDD0630  [21]
 LDCM0314  AC51 HCT 116 C201(0.97)  LDD0631  [21]
 LDCM0315  AC52 HCT 116 C201(1.11)  LDD0632  [21]
 LDCM0316  AC53 HCT 116 C201(1.06)  LDD0633  [21]
 LDCM0317  AC54 HCT 116 C201(0.99)  LDD0634  [21]
 LDCM0318  AC55 HCT 116 C201(1.36)  LDD0635  [21]
 LDCM0319  AC56 HCT 116 C201(1.30)  LDD0636  [21]
 LDCM0320  AC57 HEK-293T C201(0.89); C357(1.01)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C201(0.98); C357(0.96)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C201(1.00); C357(1.03)  LDD1561  [22]
 LDCM0323  AC6 HCT 116 C201(0.96)  LDD0640  [21]
 LDCM0324  AC60 HEK-293T C201(0.95); C357(1.09)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C201(0.95); C357(0.96)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C201(1.05); C357(1.07)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C201(1.11); C357(1.08)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C201(0.86); C357(1.16)  LDD1567  [22]
 LDCM0334  AC7 HCT 116 C201(1.13)  LDD0651  [21]
 LDCM0345  AC8 HCT 116 C201(1.06)  LDD0662  [21]
 LDCM0349  AC83 HCT 116 C201(0.92)  LDD0666  [21]
 LDCM0350  AC84 HCT 116 C201(0.92)  LDD0667  [21]
 LDCM0351  AC85 HCT 116 C201(0.86)  LDD0668  [21]
 LDCM0352  AC86 HCT 116 C201(1.26)  LDD0669  [21]
 LDCM0353  AC87 HCT 116 C201(1.52)  LDD0670  [21]
 LDCM0354  AC88 HCT 116 C201(1.11)  LDD0671  [21]
 LDCM0355  AC89 HCT 116 C201(1.17)  LDD0672  [21]
 LDCM0357  AC90 HCT 116 C201(0.93)  LDD0674  [21]
 LDCM0358  AC91 HCT 116 C201(1.01)  LDD0675  [21]
 LDCM0359  AC92 HCT 116 C201(1.04)  LDD0676  [21]
 LDCM0360  AC93 HCT 116 C201(0.93)  LDD0677  [21]
 LDCM0361  AC94 HCT 116 C201(0.71)  LDD0678  [21]
 LDCM0362  AC95 HCT 116 C201(0.97)  LDD0679  [21]
 LDCM0363  AC96 HCT 116 C201(1.18)  LDD0680  [21]
 LDCM0364  AC97 HCT 116 C201(0.98)  LDD0681  [21]
 LDCM0365  AC98 HCT 116 C201(0.81)  LDD0682  [21]
 LDCM0366  AC99 HCT 116 C201(0.83)  LDD0683  [21]
 LDCM0248  AKOS034007472 HCT 116 C201(1.21)  LDD0565  [21]
 LDCM0356  AKOS034007680 HCT 116 C201(0.95)  LDD0673  [21]
 LDCM0275  AKOS034007705 HCT 116 C201(1.30)  LDD0592  [21]
 LDCM0156  Aniline NCI-H1299 11.34  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C201(1.01)  LDD0684  [21]
 LDCM0368  CL10 HCT 116 C201(1.07)  LDD0685  [21]
 LDCM0369  CL100 HCT 116 C201(1.13)  LDD0686  [21]
 LDCM0370  CL101 HCT 116 C201(1.05)  LDD0687  [21]
 LDCM0371  CL102 HCT 116 C201(0.92)  LDD0688  [21]
 LDCM0372  CL103 HCT 116 C201(0.98)  LDD0689  [21]
 LDCM0373  CL104 HCT 116 C201(0.99)  LDD0690  [21]
 LDCM0374  CL105 HEK-293T C201(0.99); C357(1.01)  LDD1578  [22]
 LDCM0375  CL106 HEK-293T C201(1.00); C357(0.98)  LDD1579  [22]
 LDCM0376  CL107 HEK-293T C201(0.82); C357(0.97)  LDD1580  [22]
 LDCM0377  CL108 HEK-293T C201(1.05); C357(0.85)  LDD1581  [22]
 LDCM0378  CL109 HEK-293T C201(0.98); C357(0.95)  LDD1582  [22]
 LDCM0379  CL11 HCT 116 C201(1.28)  LDD0696  [21]
 LDCM0380  CL110 HEK-293T C201(1.22); C357(0.82)  LDD1584  [22]
 LDCM0381  CL111 HEK-293T C201(1.10); C357(0.96)  LDD1585  [22]
 LDCM0382  CL112 HCT 116 C201(1.06)  LDD0699  [21]
 LDCM0383  CL113 HCT 116 C201(0.96)  LDD0700  [21]
 LDCM0384  CL114 HCT 116 C201(1.43)  LDD0701  [21]
 LDCM0385  CL115 HCT 116 C201(1.26)  LDD0702  [21]
 LDCM0386  CL116 HCT 116 C201(1.21)  LDD0703  [21]
 LDCM0387  CL117 HCT 116 C201(1.28)  LDD0704  [21]
 LDCM0388  CL118 HCT 116 C201(1.17)  LDD0705  [21]
 LDCM0389  CL119 HCT 116 C201(1.12)  LDD0706  [21]
 LDCM0390  CL12 HCT 116 C201(1.59)  LDD0707  [21]
 LDCM0391  CL120 HCT 116 C201(1.17)  LDD0708  [21]
 LDCM0392  CL121 HCT 116 C201(0.98)  LDD0709  [21]
 LDCM0393  CL122 HCT 116 C201(1.05)  LDD0710  [21]
 LDCM0394  CL123 HCT 116 C201(1.07)  LDD0711  [21]
 LDCM0395  CL124 HCT 116 C201(1.10)  LDD0712  [21]
 LDCM0396  CL125 HEK-293T C201(1.06); C357(1.15)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C201(0.99); C357(0.81)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C201(0.78); C357(0.96)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C201(1.05); C357(1.11)  LDD1603  [22]
 LDCM0400  CL13 HCT 116 C201(1.25)  LDD0717  [21]
 LDCM0401  CL14 HCT 116 C201(1.08)  LDD0718  [21]
 LDCM0402  CL15 HCT 116 C201(1.10)  LDD0719  [21]
 LDCM0403  CL16 HCT 116 C201(1.04)  LDD0720  [21]
 LDCM0404  CL17 HCT 116 C201(1.07)  LDD0721  [21]
 LDCM0405  CL18 HCT 116 C201(1.09)  LDD0722  [21]
 LDCM0406  CL19 HCT 116 C201(1.07)  LDD0723  [21]
 LDCM0407  CL2 HCT 116 C201(1.03)  LDD0724  [21]
 LDCM0408  CL20 HCT 116 C201(0.99)  LDD0725  [21]
 LDCM0409  CL21 HCT 116 C201(1.14)  LDD0726  [21]
 LDCM0410  CL22 HCT 116 C201(1.13)  LDD0727  [21]
 LDCM0411  CL23 HCT 116 C201(1.02)  LDD0728  [21]
 LDCM0412  CL24 HCT 116 C201(1.00)  LDD0729  [21]
 LDCM0413  CL25 HCT 116 C201(1.13)  LDD0730  [21]
 LDCM0414  CL26 HCT 116 C201(0.96)  LDD0731  [21]
 LDCM0415  CL27 HCT 116 C201(1.08)  LDD0732  [21]
 LDCM0416  CL28 HCT 116 C201(1.12)  LDD0733  [21]
 LDCM0417  CL29 HCT 116 C201(1.02)  LDD0734  [21]
 LDCM0418  CL3 HCT 116 C201(1.15)  LDD0735  [21]
 LDCM0419  CL30 HCT 116 C201(0.99)  LDD0736  [21]
 LDCM0420  CL31 HCT 116 C201(0.88)  LDD0737  [21]
 LDCM0421  CL32 HCT 116 C201(0.82)  LDD0738  [21]
 LDCM0422  CL33 HCT 116 C201(0.86)  LDD0739  [21]
 LDCM0423  CL34 HCT 116 C201(1.02)  LDD0740  [21]
 LDCM0424  CL35 HCT 116 C201(0.92)  LDD0741  [21]
 LDCM0425  CL36 HCT 116 C201(1.00)  LDD0742  [21]
 LDCM0426  CL37 HCT 116 C201(0.90)  LDD0743  [21]
 LDCM0428  CL39 HCT 116 C201(0.90)  LDD0745  [21]
 LDCM0429  CL4 HCT 116 C201(0.96)  LDD0746  [21]
 LDCM0430  CL40 HCT 116 C201(0.85)  LDD0747  [21]
 LDCM0431  CL41 HCT 116 C201(0.90)  LDD0748  [21]
 LDCM0432  CL42 HCT 116 C201(0.98)  LDD0749  [21]
 LDCM0433  CL43 HCT 116 C201(0.96)  LDD0750  [21]
 LDCM0434  CL44 HCT 116 C201(0.91)  LDD0751  [21]
 LDCM0435  CL45 HCT 116 C201(0.90)  LDD0752  [21]
 LDCM0436  CL46 HCT 116 C201(0.95)  LDD0753  [21]
 LDCM0437  CL47 HCT 116 C201(1.19)  LDD0754  [21]
 LDCM0438  CL48 HCT 116 C201(0.96)  LDD0755  [21]
 LDCM0439  CL49 HCT 116 C201(1.00)  LDD0756  [21]
 LDCM0440  CL5 HCT 116 C201(1.18)  LDD0757  [21]
 LDCM0441  CL50 HCT 116 C201(1.03)  LDD0758  [21]
 LDCM0442  CL51 HCT 116 C201(1.11)  LDD0759  [21]
 LDCM0443  CL52 HCT 116 C201(1.16)  LDD0760  [21]
 LDCM0444  CL53 HCT 116 C201(0.93)  LDD0761  [21]
 LDCM0445  CL54 HCT 116 C201(0.96)  LDD0762  [21]
 LDCM0446  CL55 HCT 116 C201(0.99)  LDD0763  [21]
 LDCM0447  CL56 HCT 116 C201(1.07)  LDD0764  [21]
 LDCM0448  CL57 HCT 116 C201(1.02)  LDD0765  [21]
 LDCM0449  CL58 HCT 116 C201(1.11)  LDD0766  [21]
 LDCM0450  CL59 HCT 116 C201(1.03)  LDD0767  [21]
 LDCM0451  CL6 HCT 116 C201(1.11)  LDD0768  [21]
 LDCM0452  CL60 HCT 116 C201(1.03)  LDD0769  [21]
 LDCM0453  CL61 HCT 116 C201(1.01)  LDD0770  [21]
 LDCM0454  CL62 HCT 116 C201(1.07)  LDD0771  [21]
 LDCM0455  CL63 HCT 116 C201(1.15)  LDD0772  [21]
 LDCM0456  CL64 HCT 116 C201(0.92)  LDD0773  [21]
 LDCM0457  CL65 HCT 116 C201(1.32)  LDD0774  [21]
 LDCM0458  CL66 HCT 116 C201(1.44)  LDD0775  [21]
 LDCM0459  CL67 HCT 116 C201(1.07)  LDD0776  [21]
 LDCM0460  CL68 HCT 116 C201(1.25)  LDD0777  [21]
 LDCM0461  CL69 HCT 116 C201(0.90)  LDD0778  [21]
 LDCM0462  CL7 HCT 116 C201(1.20)  LDD0779  [21]
 LDCM0463  CL70 HCT 116 C201(1.17)  LDD0780  [21]
 LDCM0464  CL71 HCT 116 C201(1.10)  LDD0781  [21]
 LDCM0465  CL72 HCT 116 C201(0.91)  LDD0782  [21]
 LDCM0466  CL73 HCT 116 C201(1.10)  LDD0783  [21]
 LDCM0467  CL74 HCT 116 C201(1.00)  LDD0784  [21]
 LDCM0469  CL76 HCT 116 C201(1.00)  LDD0786  [21]
 LDCM0470  CL77 HCT 116 C201(0.97)  LDD0787  [21]
 LDCM0471  CL78 HCT 116 C201(1.20)  LDD0788  [21]
 LDCM0472  CL79 HCT 116 C201(1.27)  LDD0789  [21]
 LDCM0473  CL8 HCT 116 C201(1.19)  LDD0790  [21]
 LDCM0474  CL80 HCT 116 C201(1.06)  LDD0791  [21]
 LDCM0475  CL81 HCT 116 C201(1.18)  LDD0792  [21]
 LDCM0476  CL82 HCT 116 C201(1.36)  LDD0793  [21]
 LDCM0477  CL83 HCT 116 C201(1.40)  LDD0794  [21]
 LDCM0478  CL84 HCT 116 C201(1.58)  LDD0795  [21]
 LDCM0479  CL85 HCT 116 C201(1.18)  LDD0796  [21]
 LDCM0480  CL86 HCT 116 C201(1.05)  LDD0797  [21]
 LDCM0481  CL87 HCT 116 C201(1.29)  LDD0798  [21]
 LDCM0482  CL88 HCT 116 C201(1.50)  LDD0799  [21]
 LDCM0483  CL89 HCT 116 C201(1.73)  LDD0800  [21]
 LDCM0484  CL9 HCT 116 C201(1.11)  LDD0801  [21]
 LDCM0485  CL90 HCT 116 C201(1.06)  LDD0802  [21]
 LDCM0486  CL91 HCT 116 C201(1.14)  LDD0803  [21]
 LDCM0487  CL92 HCT 116 C201(0.94)  LDD0804  [21]
 LDCM0488  CL93 HCT 116 C201(1.01)  LDD0805  [21]
 LDCM0489  CL94 HCT 116 C201(0.91)  LDD0806  [21]
 LDCM0490  CL95 HCT 116 C201(1.08)  LDD0807  [21]
 LDCM0491  CL96 HCT 116 C201(1.19)  LDD0808  [21]
 LDCM0492  CL97 HCT 116 C201(1.23)  LDD0809  [21]
 LDCM0493  CL98 HCT 116 C201(1.13)  LDD0810  [21]
 LDCM0494  CL99 HCT 116 C201(1.24)  LDD0811  [21]
 LDCM0033  Curcusone1d MCF-7 3.96  LDD0188  [6]
 LDCM0495  E2913 HEK-293T C201(0.84); C357(0.99)  LDD1698  [22]
 LDCM0625  F8 Ramos C201(1.10)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C201(3.61)  LDD2189  [23]
 LDCM0574  Fragment12 Ramos C201(1.89)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C201(1.24)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C201(2.18)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C201(2.61)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C201(1.18)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C201(1.05)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C201(0.96)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C201(1.02)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C201(1.38)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C201(1.52)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C201(1.28)  LDD2201  [23]
 LDCM0468  Fragment33 HCT 116 C201(1.10)  LDD0785  [21]
 LDCM0596  Fragment38 Ramos C201(2.18)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C201(2.07)  LDD2184  [23]
 LDCM0427  Fragment51 HCT 116 C201(0.95)  LDD0744  [21]
 LDCM0610  Fragment52 Ramos C201(2.31)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C201(1.25)  LDD2205  [23]
 LDCM0616  Fragment61 Jurkat _(12.69)  LDD1489  [7]
 LDCM0615  Fragment63-R Jurkat _(8.31)  LDD1487  [7]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [7]
 LDCM0569  Fragment7 Jurkat _(5.43)  LDD1485  [7]
 LDCM0022  KB02 HEK-293T C357(1.05)  LDD1492  [22]
 LDCM0023  KB03 Jurkat C201(6.62)  LDD0209  [10]
 LDCM0024  KB05 HMCB C201(5.80)  LDD3312  [24]
 LDCM0109  NEM HeLa N.A.  LDD0227  [12]
 LDCM0628  OTUB2-COV-1 HEK-293T C12(0.07)  LDD2207  [25]
 LDCM0014  Panhematin HEK-293T 3.10  LDD0062  [9]
 LDCM0084  Ro 48-8071 A-549 2.93  LDD0145  [19]
 LDCM0154  YY4 T cell 2.66  LDD0400  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7) 3-beta-HSD family Q9H2F3
Palmitoyltransferase ZDHHC15 (ZDHHC15) DHHC palmitoyltransferase family Q96MV8
Diacylglycerol O-acyltransferase 2-like protein 6 (DGAT2L6) Diacylglycerol acyltransferase family Q6ZPD8
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Serine protease HTRA2, mitochondrial (HTRA2) Peptidase S1C family O43464
E3 ubiquitin-protein ligase RNF5 (RNF5) RNF5 family Q99942
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Dehydrogenase/reductase SDR family member on chromosome X (DHRSX) Short-chain dehydrogenases/reductases (SDR) family Q8N5I4
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) . Q9Y680
Transporter and channel
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q8IWU4
Gap junction alpha-8 protein (GJA8) Connexin family P48165
Membrane-associated progesterone receptor component 2 (PGRMC2) Cytochrome b5 family O15173
Novel acetylcholine receptor chaperone (TMEM35A) DoxX family Q53FP2
Huntingtin (HTT) Huntingtin family P42858
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
ER membrane protein complex subunit 5 (MMGT1) Membrane magnesium transporter (TC 1.A.67) family Q8N4V1
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Membrane-spanning 4-domains subfamily A member 4A (MS4A4A) MS4A family Q96JQ5
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Solute carrier family 35 member E3 (SLC35E3) TPT transporter family Q7Z769
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3) BZIP family Q68CJ9
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
G-protein coupled receptor 42 (GPR42) G-protein coupled receptor 1 family O15529
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Programmed cell death 1 ligand 2 (PDCD1LG2) BTN/MOG family Q9BQ51
Poliovirus receptor (PVR) Nectin family P15151
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon gamma receptor 1 (IFNGR1) Type II cytokine receptor family P15260
Interleukin-10 receptor subunit alpha (IL10RA) Type II cytokine receptor family Q13651
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL6IP6) ARL6IP6 family Q8N6S5
CDGSH iron-sulfur domain-containing protein 2 (CISD2) CISD protein family Q8N5K1
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Integrin alpha-M (ITGAM) Integrin alpha chain family P11215
Peripherin (PRPH) Intermediate filament family P41219
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Sideroflexin-3 (SFXN3) Sideroflexin family Q9BWM7
Transmembrane protein 248 (TMEM248) TMEM248 family Q9NWD8
Zinc finger CCHC domain-containing protein 12 (ZCCHC12) ZCCHC12 family Q6PEW1
Bcl-2-interacting killer (BIK) . Q13323
Outer dense fiber protein 4 (ODF4) . Q2M2E3
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
Sperm-associated antigen 4 protein (SPAG4) . Q9NPE6
Testis-expressed protein 29 (TEX29) . Q8N6K0
Uncharacterized protein C5orf46 (C5orf46) . Q6UWT4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
7 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
8 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
9 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
10 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
11 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
20 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
21 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
25 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.