Details of the Target

General Information of Target

Target ID LDTP01494
Target Name Protein YIF1A (YIF1A)
Gene Name YIF1A
Gene ID 10897
Synonyms
54TM; HYIF1P; YIF1; Protein YIF1A; 54TMp; YIP1-interacting factor homolog A
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAYHSGYGAHGSKHRARAAPDPPPLFDDTSGGYSSQPGGYPATGADVAFSVNHLLGDPMA
NVAMAYGSSIASHGKDMVHKELHRFVSVSKLKYFFAVDTAYVAKKLGLLVFPYTHQNWEV
QYSRDAPLPPRQDLNAPDLYIPTMAFITYVLLAGMALGIQKRFSPEVLGLCASTALVWVV
MEVLALLLGLYLATVRSDLSTFHLLAYSGYKYVGMILSVLTGLLFGSDGYYVALAWTSSA
LMYFIVRSLRTAALGPDSMGGPVPRQRLQLYLTLGAAAFQPLIIYWLTFHLVR
Target Bioclass
Other
Family
YIF1 family
Subcellular location
Endoplasmic reticulum membrane
Function Possible role in transport between endoplasmic reticulum and Golgi.
Uniprot ID
O95070
Ensemble ID
ENST00000376901.9
HGNC ID
HGNC:16688

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
SF
 Probe Info  		Y7(0.00); Y3(0.00)  LDD0028  [3]
AOyne
 Probe Info  		10.10  LDD0443  [4]
PAL-AfBPP Probe
Click To Hide/Show 85 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		9.06  LDD1725  [5]
C027
 Probe Info  		6.73  LDD1733  [5]
C040
 Probe Info  		18.00  LDD1740  [5]
C053
 Probe Info  		6.06  LDD1751  [5]
C055
 Probe Info  		25.99  LDD1752  [5]
C056
 Probe Info  		43.71  LDD1753  [5]
C063
 Probe Info  		14.32  LDD1760  [5]
C070
 Probe Info  		11.39  LDD1766  [5]
C072
 Probe Info  		9.78  LDD1768  [5]
C087
 Probe Info  		7.73  LDD1779  [5]
C091
 Probe Info  		17.03  LDD1782  [5]
C092
 Probe Info  		37.27  LDD1783  [5]
C094
 Probe Info  		45.57  LDD1785  [5]
C095
 Probe Info  		8.28  LDD1786  [5]
C100
 Probe Info  		9.19  LDD1789  [5]
C106
 Probe Info  		35.26  LDD1793  [5]
C107
 Probe Info  		7.36  LDD1794  [5]
C108
 Probe Info  		10.34  LDD1795  [5]
C112
 Probe Info  		41.64  LDD1799  [5]
C129
 Probe Info  		5.50  LDD1811  [5]
C134
 Probe Info  		35.02  LDD1816  [5]
C135
 Probe Info  		9.51  LDD1817  [5]
C143
 Probe Info  		15.03  LDD1825  [5]
C153
 Probe Info  		15.67  LDD1834  [5]
C159
 Probe Info  		10.27  LDD1839  [5]
C160
 Probe Info  		9.25  LDD1840  [5]
C161
 Probe Info  		21.56  LDD1841  [5]
C178
 Probe Info  		18.00  LDD1857  [5]
C186
 Probe Info  		12.21  LDD1864  [5]
C201
 Probe Info  		99.73  LDD1877  [5]
C206
 Probe Info  		33.59  LDD1881  [5]
C207
 Probe Info  		18.64  LDD1882  [5]
C210
 Probe Info  		89.26  LDD1884  [5]
C211
 Probe Info  		8.06  LDD1885  [5]
C213
 Probe Info  		15.56  LDD1887  [5]
C214
 Probe Info  		6.15  LDD1888  [5]
C218
 Probe Info  		11.79  LDD1892  [5]
C220
 Probe Info  		16.91  LDD1894  [5]
C225
 Probe Info  		5.06  LDD1898  [5]
C228
 Probe Info  		30.06  LDD1901  [5]
C229
 Probe Info  		16.56  LDD1902  [5]
C231
 Probe Info  		69.55  LDD1904  [5]
C232
 Probe Info  		96.34  LDD1905  [5]
C233
 Probe Info  		20.97  LDD1906  [5]
C234
 Probe Info  		14.32  LDD1907  [5]
C235
 Probe Info  		70.52  LDD1908  [5]
C238
 Probe Info  		12.21  LDD1911  [5]
C246
 Probe Info  		18.51  LDD1919  [5]
C252
 Probe Info  		10.78  LDD1925  [5]
C264
 Probe Info  		17.39  LDD1935  [5]
C278
 Probe Info  		65.80  LDD1948  [5]
C282
 Probe Info  		18.64  LDD1952  [5]
C284
 Probe Info  		20.97  LDD1954  [5]
C285
 Probe Info  		22.63  LDD1955  [5]
C287
 Probe Info  		8.75  LDD1957  [5]
C289
 Probe Info  		37.53  LDD1959  [5]
C293
 Probe Info  		30.91  LDD1963  [5]
C296
 Probe Info  		21.26  LDD1966  [5]
C310
 Probe Info  		9.32  LDD1977  [5]
C314
 Probe Info  		12.64  LDD1981  [5]
C343
 Probe Info  		16.34  LDD2005  [5]
C348
 Probe Info  		9.92  LDD2009  [5]
C349
 Probe Info  		20.68  LDD2010  [5]
C350
 Probe Info  		53.82  LDD2011  [5]
C355
 Probe Info  		28.44  LDD2016  [5]
C356
 Probe Info  		8.88  LDD2017  [5]
C357
 Probe Info  		5.17  LDD2018  [5]
C362
 Probe Info  		61.39  LDD2023  [5]
C363
 Probe Info  		15.45  LDD2024  [5]
C364
 Probe Info  		18.00  LDD2025  [5]
C366
 Probe Info  		8.57  LDD2027  [5]
C367
 Probe Info  		5.54  LDD2028  [5]
C373
 Probe Info  		5.24  LDD2033  [5]
C376
 Probe Info  		6.50  LDD2036  [5]
C382
 Probe Info  		9.85  LDD2041  [5]
C388
 Probe Info  		68.59  LDD2047  [5]
C390
 Probe Info  		30.91  LDD2049  [5]
C399
 Probe Info  		6.96  LDD2058  [5]
C403
 Probe Info  		26.72  LDD2061  [5]
C407
 Probe Info  		14.62  LDD2064  [5]
C429
 Probe Info  		11.63  LDD2084  [5]
C431
 Probe Info  		16.91  LDD2086  [5]
FFF probe11
 Probe Info  		20.00  LDD0471  [6]
FFF probe14
 Probe Info  		20.00  LDD0477  [6]
OEA-DA
 Probe Info  		20.00  LDD0046  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Polyamine-transporting ATPase 13A2 (ATP13A2) Cation transport ATPase (P-type) (TC 3.A.3) family Q9NQ11
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF) Cyclophilin-type PPIase family P30405
Palmitoyltransferase ZDHHC16 (ZDHHC16) DHHC palmitoyltransferase family Q969W1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Prostaglandin E synthase (PTGES) MAPEG family O14684
MYG1 exonuclease (MYG1) MYG1 family Q9HB07
SEC23-interacting protein (SEC23IP) PA-PLA1 family Q9Y6Y8
Caspase-6 (CASP6) Peptidase C14A family P55212
Tyrosine-protein phosphatase non-receptor type 9 (PTPN9) Protein-tyrosine phosphatase family P43378
E3 ubiquitin-protein ligase RNF144A (RNF144A) RBR family P50876
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Methylsterol monooxygenase 1 (MSMO1) Sterol desaturase family Q15800
Lanosterol synthase (LSS) Terpene cyclase/mutase family P48449
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) . Q12982
Ceramide synthase 2 (CERS2) . Q96G23
E3 ubiquitin-protein ligase MARCHF5 (MARCHF5) . Q9NX47
Josephin-2 (JOSD2) . Q8TAC2
Transporter and channel
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Gap junction alpha-8 protein (GJA8) Connexin family P48165
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Huntingtin (HTT) Huntingtin family P42858
ER membrane protein complex subunit 5 (MMGT1) Membrane magnesium transporter (TC 1.A.67) family Q8N4V1
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Sodium channel subunit beta-4 (SCN4B) Sodium channel auxiliary subunit SCN4B family Q8IWT1
Sorting nexin-10 (SNX10) Sorting nexin family Q9Y5X0
Sorting nexin-11 (SNX11) Sorting nexin family Q9Y5W9
Sorting nexin-2 (SNX2) Sorting nexin family O60749
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transmembrane protein 17 (TMEM17) TMEM17 family Q86X19
Vesicle-associated membrane protein-associated protein A (VAPA) VAMP-associated protein (VAP) (TC 9.B.17) family Q9P0L0
Vesicle-associated membrane protein-associated protein B/C (VAPB) VAMP-associated protein (VAP) (TC 9.B.17) family O95292
Protrudin (ZFYVE27) . Q5T4F4
Syntenin-1 (SDCBP) . O00560
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transmembrane protein 139 (TMEM139) . Q8IV31
Wolframin (WFS1) . O76024
GPCR
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
G-protein coupled receptor 42 (GPR42) G-protein coupled receptor 1 family O15529
Prosaposin receptor GPR37 (GPR37) G-protein coupled receptor 1 family O15354
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein A-V (APOA5) Apolipoprotein A1/A4/E family Q6Q788
CB1 cannabinoid receptor-interacting protein 1 (CNRIP1) CNRIP family Q96F85
Cystatin-M (CST6) Cystatin family Q15828
Receptor expression-enhancing protein 2 (REEP2) DP1 family Q9BRK0
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
Progranulin (GRN) Granulin family P28799
Transcription termination factor 3, mitochondrial (MTERF3) MTERF family Q96E29
Putative ribosome-binding factor A, mitochondrial (RBFA) RbfA family Q8N0V3
Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1) Tim17/Tim22/Tim23 family Q9NPL8
Transmembrane protein 248 (TMEM248) TMEM248 family Q9NWD8
Vacuolar ATPase assembly integral membrane protein VMA21 (VMA21) VMA21 family Q3ZAQ7
Protein YIPF4 (YIPF4) YIP1 family Q9BSR8
Protein YIPF5 (YIPF5) YIP1 family Q969M3
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
Protein ENL (MLLT1) . Q03111
Transmembrane protein 225B (TMEM225B) . P0DP42
WD repeat and FYVE domain-containing protein 2 (WDFY2) . Q96P53
Zinc finger FYVE domain-containing protein 21 (ZFYVE21) . Q9BQ24

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
7 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570