Details of the Target

General Information of Target

Target ID LDTP06142
Target Name Squalene monooxygenase (SQLE)
Gene Name SQLE
Gene ID 6713
Synonyms
ERG1; Squalene monooxygenase; EC 1.14.14.17; Squalene epoxidase; SE
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWTFLGIATFTYFYKKFGDFITLANREVLLCVLVFLSLGLVLSYRCRHRNGGLLGRQQSG
SQFALFSDILSGLPFIGFFWAKSPPESENKEQLEARRRRKGTNISETSLIGTAACTSTSS
QNDPEVIIVGAGVLGSALAAVLSRDGRKVTVIERDLKEPDRIVGEFLQPGGYHVLKDLGL
GDTVEGLDAQVVNGYMIHDQESKSEVQIPYPLSENNQVQSGRAFHHGRFIMSLRKAAMAE
PNAKFIEGVVLQLLEEDDVVMGVQYKDKETGDIKELHAPLTVVADGLFSKFRKSLVSNKV
SVSSHFVGFLMKNAPQFKANHAELILANPSPVLIYQISSSETRVLVDIRGEMPRNLREYM
VEKIYPQIPDHLKEPFLEATDNSHLRSMPASFLPPSSVKKRGVLLLGDAYNMRHPLTGGG
MTVAFKDIKLWRKLLKGIPDLYDDAAIFEAKKSFYWARKTSHSFVVNILAQALYELFSAT
DDSLHQLRKACFLYFKLGGECVAGPVGLLSVLSPNPLVLIGHFFAVAIYAVYFCFKSEPW
ITKPRALLSSGAVLYKACSVIFPLIYSEMKYMVH
Target Type
Successful
Target Bioclass
Enzyme
Family
Squalene monooxygenase family
Subcellular location
Microsome membrane
Function Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
TTD ID
T93344
Uniprot ID
Q14534
DrugMap ID
TTE14XG
Ensemble ID
ENST00000265896.10
HGNC ID
HGNC:11279
ChEMBL ID
CHEMBL3592

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.45  LDD0402  [1]
DA-P2
 Probe Info  		4.27  LDD0348  [2]
YN-4
 Probe Info  		100.00  LDD0445  [3]
Johansson_61
 Probe Info  		_(4.18)  LDD1487  [4]
DA-P3
 Probe Info  		23.43  LDD0180  [2]
HPAP
 Probe Info  		4.42  LDD0062  [5]
DBIA
 Probe Info  		C491(0.91)  LDD0531  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 68 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		8.11  LDD1714  [12]
C022
 Probe Info  		7.46  LDD1728  [12]
C027
 Probe Info  		6.92  LDD1733  [12]
C040
 Probe Info  		19.43  LDD1740  [12]
C041
 Probe Info  		6.32  LDD1741  [12]
C055
 Probe Info  		11.63  LDD1752  [12]
C056
 Probe Info  		23.75  LDD1753  [12]
C063
 Probe Info  		12.82  LDD1760  [12]
C070
 Probe Info  		8.75  LDD1766  [12]
C091
 Probe Info  		28.64  LDD1782  [12]
C092
 Probe Info  		43.11  LDD1783  [12]
C094
 Probe Info  		61.39  LDD1785  [12]
C095
 Probe Info  		5.13  LDD1786  [12]
C100
 Probe Info  		6.92  LDD1789  [12]
C106
 Probe Info  		20.53  LDD1793  [12]
C107
 Probe Info  		5.70  LDD1794  [12]
C108
 Probe Info  		8.22  LDD1795  [12]
C112
 Probe Info  		28.44  LDD1799  [12]
C134
 Probe Info  		26.17  LDD1816  [12]
C153
 Probe Info  		20.39  LDD1834  [12]
C163
 Probe Info  		6.02  LDD1843  [12]
C169
 Probe Info  		26.54  LDD1849  [12]
C178
 Probe Info  		18.25  LDD1857  [12]
C198
 Probe Info  		11.88  LDD1874  [12]
C201
 Probe Info  		34.78  LDD1877  [12]
C218
 Probe Info  		18.90  LDD1892  [12]
C219
 Probe Info  		6.23  LDD1893  [12]
C220
 Probe Info  		21.26  LDD1894  [12]
C228
 Probe Info  		18.64  LDD1901  [12]
C231
 Probe Info  		17.88  LDD1904  [12]
C235
 Probe Info  		23.43  LDD1908  [12]
C238
 Probe Info  		11.08  LDD1911  [12]
C246
 Probe Info  		16.34  LDD1919  [12]
C251
 Probe Info  		36.25  LDD1924  [12]
C252
 Probe Info  		9.45  LDD1925  [12]
C264
 Probe Info  		18.13  LDD1935  [12]
C285
 Probe Info  		20.97  LDD1955  [12]
C287
 Probe Info  		8.94  LDD1957  [12]
C289
 Probe Info  		33.13  LDD1959  [12]
C293
 Probe Info  		23.26  LDD1963  [12]
C296
 Probe Info  		16.11  LDD1966  [12]
C299
 Probe Info  		6.68  LDD1968  [12]
C310
 Probe Info  		9.78  LDD1977  [12]
C339
 Probe Info  		5.39  LDD2002  [12]
C343
 Probe Info  		18.38  LDD2005  [12]
C348
 Probe Info  		13.45  LDD2009  [12]
C349
 Probe Info  		29.45  LDD2010  [12]
C350
 Probe Info  		66.26  LDD2011  [12]
C355
 Probe Info  		29.45  LDD2016  [12]
C356
 Probe Info  		9.58  LDD2017  [12]
C357
 Probe Info  		5.58  LDD2018  [12]
C362
 Probe Info  		31.56  LDD2023  [12]
C376
 Probe Info  		6.45  LDD2036  [12]
C378
 Probe Info  		6.02  LDD2037  [12]
C382
 Probe Info  		10.56  LDD2041  [12]
C388
 Probe Info  		56.10  LDD2047  [12]
C390
 Probe Info  		38.05  LDD2049  [12]
C403
 Probe Info  		21.26  LDD2061  [12]
C407
 Probe Info  		16.34  LDD2064  [12]
C431
 Probe Info  		20.68  LDD2086  [12]
FFF probe11
 Probe Info  		20.00  LDD0471  [13]
FFF probe13
 Probe Info  		20.00  LDD0475  [13]
FFF probe14
 Probe Info  		20.00  LDD0477  [13]
FFF probe2
 Probe Info  		20.00  LDD0463  [13]
FFF probe3
 Probe Info  		20.00  LDD0464  [13]
JN0003
 Probe Info  		20.00  LDD0469  [13]
A-DA
 Probe Info  		2.29  LDD0143  [14]
OEA-DA
 Probe Info  		12.75  LDD0046  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C491(0.91)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C491(0.96)  LDD0532  [6]
 LDCM0216  AC100 HEK-293T C491(1.09)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C491(1.04)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C491(0.90)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C491(1.17)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C491(0.95)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C491(1.06)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C491(0.91)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C491(0.92)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C491(0.94)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C491(0.97)  LDD0823  [6]
 LDCM0226  AC11 HCT 116 C491(0.94)  LDD0543  [6]
 LDCM0227  AC110 HEK-293T C491(1.12)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C491(0.97)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C491(0.92)  LDD0827  [6]
 LDCM0237  AC12 HCT 116 C491(0.99)  LDD0554  [6]
 LDCM0246  AC128 HEK-293T C491(0.91)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C491(0.78)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C491(0.92)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C491(1.10)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C491(0.73)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C491(1.07)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C491(0.89)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C491(1.02)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C491(0.95)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C491(0.84)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C491(0.94)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C491(0.87)  LDD0856  [6]
 LDCM0259  AC14 HCT 116 C491(0.96)  LDD0576  [6]
 LDCM0260  AC140 HEK-293T C491(0.84)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C491(0.82)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C491(0.88)  LDD0860  [6]
 LDCM0263  AC143 HCT 116 C491(0.98)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C491(0.93)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C491(1.01)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C491(1.01)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C491(0.96)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C491(1.01)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C491(0.95)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C491(1.02)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C491(1.02)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C491(1.01)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C491(1.12)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C491(1.14)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C491(1.11)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C491(1.11)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C491(0.97)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C491(1.07)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C491(1.32)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C491(1.22)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C491(1.26)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C491(0.98)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C491(1.10)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C491(1.14)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C491(1.16)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C491(1.22)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C491(1.14)  LDD0601  [6]
 LDCM0285  AC25 HEK-293T C491(0.89); C558(0.87)  LDD1524  [16]
 LDCM0286  AC26 HEK-293T C491(0.97)  LDD1525  [16]
 LDCM0287  AC27 HEK-293T C491(1.05)  LDD1526  [16]
 LDCM0288  AC28 HEK-293T C491(0.74)  LDD1527  [16]
 LDCM0289  AC29 HEK-293T C491(1.03); C558(0.96)  LDD1528  [16]
 LDCM0290  AC3 HCT 116 C491(1.14)  LDD0607  [6]
 LDCM0291  AC30 HEK-293T C491(0.89)  LDD1530  [16]
 LDCM0292  AC31 HEK-293T C491(0.93)  LDD1531  [16]
 LDCM0293  AC32 HEK-293T C491(0.97); C558(0.97)  LDD1532  [16]
 LDCM0294  AC33 HEK-293T C491(0.82); C558(0.90)  LDD1533  [16]
 LDCM0295  AC34 HEK-293T C491(0.92)  LDD1534  [16]
 LDCM0296  AC35 HEK-293T C491(1.12)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C491(0.69)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C491(0.98); C558(1.09)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C491(1.03)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C491(0.90)  LDD1539  [16]
 LDCM0301  AC4 HCT 116 C491(1.21)  LDD0618  [6]
 LDCM0302  AC40 HEK-293T C491(0.89); C558(0.91)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C491(0.83); C558(0.97)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C491(0.79)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C491(0.95)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C491(0.82)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C491(0.88); C558(1.03)  LDD1546  [16]
 LDCM0308  AC46 HEK-293T C491(0.81)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C491(0.85)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C491(0.99); C558(1.02)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C491(0.83); C558(1.00)  LDD1550  [16]
 LDCM0312  AC5 HCT 116 C491(1.13)  LDD0629  [6]
 LDCM0313  AC50 HEK-293T C491(0.88)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C491(0.95)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C491(0.75)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C491(0.94); C558(1.23)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C491(0.79)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C491(0.91)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C491(0.92); C558(1.05)  LDD1558  [16]
 LDCM0320  AC57 HCT 116 C491(1.13)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C491(1.26)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C491(1.10)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C491(0.94)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C491(1.05)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C491(1.07)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C491(0.96)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C491(0.98)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C491(1.12)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C491(1.08)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C491(1.06)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C491(1.20)  LDD0648  [6]
 LDCM0334  AC7 HCT 116 C491(0.95)  LDD0651  [6]
 LDCM0345  AC8 HCT 116 C491(0.94)  LDD0662  [6]
 LDCM0349  AC83 HCT 116 C491(0.85)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C491(0.84)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C491(0.87)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C491(0.92)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C491(0.97)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C491(0.95)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C491(0.87)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C491(0.86)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C491(0.84)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C491(0.92)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C491(0.95)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C491(0.99)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C491(0.88)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C491(1.00)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C491(0.83)  LDD0681  [6]
 LDCM0365  AC98 HEK-293T C491(1.08)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C491(0.94)  LDD0964  [6]
 LDCM0248  AKOS034007472 HCT 116 C491(1.03)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C491(0.94)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C491(0.99)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 12.97  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C491(0.87)  LDD2171  [6]
 LDCM0083  Avasimibe A-549 2.29  LDD0143  [14]
 LDCM0367  CL1 HCT 116 C491(0.95)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C491(0.98)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C491(0.92)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C491(0.95)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C491(1.04)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C491(0.97)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C491(1.04)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C491(1.59)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C491(1.49)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C491(1.37)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C491(1.42)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C491(1.16)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C491(1.07)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C491(1.22)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C491(1.24)  LDD0698  [6]
 LDCM0382  CL112 HEK-293T C491(0.89)  LDD1586  [16]
 LDCM0383  CL113 HEK-293T C491(0.80)  LDD1587  [16]
 LDCM0384  CL114 HEK-293T C491(0.96)  LDD1588  [16]
 LDCM0385  CL115 HEK-293T C491(0.93)  LDD1589  [16]
 LDCM0386  CL116 HEK-293T C491(0.93)  LDD1590  [16]
 LDCM0387  CL117 HEK-293T C491(0.79)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C491(0.94)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C491(1.02)  LDD1593  [16]
 LDCM0390  CL12 HCT 116 C491(0.93)  LDD0707  [6]
 LDCM0391  CL120 HEK-293T C491(0.93)  LDD1595  [16]
 LDCM0392  CL121 HEK-293T C491(0.83)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C491(0.93)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C491(1.09)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C491(0.94)  LDD1599  [16]
 LDCM0396  CL125 HCT 116 C491(1.01)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C491(1.08)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C491(1.08)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C491(1.09)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C491(1.08)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C491(0.98)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C491(1.05)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C491(0.96)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C491(1.00)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C491(0.95)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C491(1.10)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C491(0.82)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C491(0.98)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C491(1.06)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C491(1.01)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C491(0.99)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C491(1.01)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C491(0.85)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C491(0.85)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C491(1.01)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C491(0.87)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C491(0.93)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C491(0.86)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C491(0.89)  LDD0736  [6]
 LDCM0420  CL31 HEK-293T C491(0.98)  LDD1624  [16]
 LDCM0421  CL32 HCT 116 C491(1.00)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C491(0.88)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C491(0.98)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C491(0.93)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C491(1.17)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C491(0.99)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C491(0.98)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C491(1.02)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C491(0.88)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C491(0.96)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C491(1.23)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C491(1.06)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C491(0.90)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C491(0.95)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C491(0.89)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C491(1.03)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C491(0.97)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C491(1.14)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C491(1.03)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C491(0.98)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C491(0.93)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C491(0.97)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C491(1.14)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C491(1.02)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C491(1.05)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C491(1.06)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C491(1.10)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C491(1.04)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C491(1.08)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C491(1.04)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C491(1.05)  LDD0769  [6]
 LDCM0453  CL61 HEK-293T C491(0.84)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C491(0.88)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C491(0.98)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C491(0.99)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C491(0.68); C558(1.02)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C491(0.90)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C491(0.98)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C491(0.73)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C491(0.95); C558(1.20)  LDD1664  [16]
 LDCM0462  CL7 HCT 116 C491(1.15)  LDD0779  [6]
 LDCM0463  CL70 HEK-293T C491(0.96)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C491(0.97)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C491(0.99); C558(1.22)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C491(1.01)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C491(1.00)  LDD1670  [16]
 LDCM0469  CL76 HEK-293T C491(0.95)  LDD1672  [16]
 LDCM0470  CL77 HEK-293T C491(0.89); C558(0.97)  LDD1673  [16]
 LDCM0471  CL78 HEK-293T C491(1.05)  LDD1674  [16]
 LDCM0472  CL79 HEK-293T C491(0.95)  LDD1675  [16]
 LDCM0473  CL8 HCT 116 C491(1.09)  LDD0790  [6]
 LDCM0474  CL80 HEK-293T C491(0.74)  LDD1677  [16]
 LDCM0475  CL81 HEK-293T C491(0.89); C558(1.12)  LDD1678  [16]
 LDCM0476  CL82 HEK-293T C491(0.95)  LDD1679  [16]
 LDCM0477  CL83 HEK-293T C491(1.01)  LDD1680  [16]
 LDCM0478  CL84 HEK-293T C491(0.94); C558(1.19)  LDD1681  [16]
 LDCM0479  CL85 HEK-293T C491(0.83)  LDD1682  [16]
 LDCM0480  CL86 HEK-293T C491(1.13)  LDD1683  [16]
 LDCM0481  CL87 HEK-293T C491(1.09)  LDD1684  [16]
 LDCM0482  CL88 HEK-293T C491(1.04)  LDD1685  [16]
 LDCM0483  CL89 HEK-293T C491(0.85); C558(1.18)  LDD1686  [16]
 LDCM0484  CL9 HCT 116 C491(1.18)  LDD0801  [6]
 LDCM0485  CL90 HEK-293T C491(1.10)  LDD1688  [16]
 LDCM0486  CL91 HCT 116 C491(0.91)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C491(0.88)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C491(1.02)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C491(0.87)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C491(0.99)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C491(1.02)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C491(1.04)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C491(0.88)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C491(0.94)  LDD0811  [6]
 LDCM0185  Compound 17 HEK-293T 10.31  LDD0512  [13]
 LDCM0191  Compound 21 HEK-293T 9.13  LDD0508  [13]
 LDCM0190  Compound 34 HEK-293T 13.25  LDD0510  [13]
 LDCM0192  Compound 35 HEK-293T 10.75  LDD0509  [13]
 LDCM0193  Compound 36 HEK-293T 6.51  LDD0511  [13]
 LDCM0028  Dobutamine HEK-293T 23.43  LDD0180  [2]
 LDCM0495  E2913 HEK-293T C491(0.88)  LDD1698  [16]
 LDCM0625  F8 Ramos C558(0.89)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C558(0.85)  LDD2189  [17]
 LDCM0573  Fragment11 Ramos C558(2.28)  LDD2190  [17]
 LDCM0574  Fragment12 Ramos C558(1.05)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C558(1.05)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C558(1.91)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C558(0.91)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C558(0.96)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C558(0.95)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C558(0.99)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C558(0.68)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C558(1.25)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C558(1.37)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C558(0.75)  LDD2201  [17]
 LDCM0468  Fragment33 HEK-293T C491(1.00)  LDD1671  [16]
 LDCM0596  Fragment38 Ramos C558(1.25)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C558(0.63)  LDD2184  [17]
 LDCM0427  Fragment51 HCT 116 C491(0.96)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C558(1.39)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C558(1.07)  LDD2205  [17]
 LDCM0615  Fragment63-R Jurkat _(4.18)  LDD1487  [4]
 LDCM0569  Fragment7 Ramos C558(0.58)  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C558(1.04)  LDD2188  [17]
 LDCM0022  KB02 HEK-293T C558(0.93); C491(0.97)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C558(0.97); C491(0.94)  LDD1497  [16]
 LDCM0024  KB05 NCI-N87 C491(4.24)  LDD3364  [18]
 LDCM0032  Oleacein HEK-293T 4.14  LDD0184  [2]
 LDCM0014  Panhematin HEK-293T 4.42  LDD0062  [5]
 LDCM0029  Quercetin HEK-293T 27.26  LDD0181  [2]
 LDCM0084  Ro 48-8071 A-549 3.30  LDD0145  [14]
 LDCM0021  THZ1 HCT 116 C491(0.87)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Butenafine Small molecular drug DB01091
Naftifine Small molecular drug D00HPK
Terbinafine Small molecular drug DB00857
Tolnaftate Small molecular drug D02NTO
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Epigallocatechin Gallate Small molecular drug D0U2BH
Investigative
Click To Hide/Show 27 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1(Beta)-o-galloylpedunculagin Small molecular drug D0F9KV
1,2,3,4,6-penta-o-galloyl-beta-d-glucose Small molecular drug D00QDR
1,2,6-tri-o-galloyl-beta-d-glucose Small molecular drug D07WLU
Chebulinic Acid Small molecular drug D0Z9YK
Corilagin Small molecular drug D03SPJ
Ellagic Acid Small molecular drug D0A1CM
Ellagic Acid Small molecular drug DB08846
Ethylgallate Small molecular drug D06CPD
Eugeniin Small molecular drug D0K2XJ
Furosin Small molecular drug D0G3SL
Geraniin Small molecular drug D0C6QS
Green Tea Small molecular drug D0L1XR
Mallotinic Acid Small molecular drug D05UWZ
Mallotusinic Acid Small molecular drug D0QN6H
N-cetylgallate Small molecular drug D01VEP
N-dodecylgallate Small molecular drug D0VS1V
Octyl_gallate Small molecular drug D02ZSX
Pedunculagin Small molecular drug D0Z2TG
Procyanidin B-2 3,3'-di-o-gallate Small molecular drug D06YCQ
Tellurium Small molecular drug D0A1QJ
Theasinensin A Small molecular drug D0T0XY
Thiocarbamate Small molecular drug D0F3KP
Trisnorsqualene Alcohol Small molecular drug D0Z9PB
Trisnorsqualene Cyclopropylamine Small molecular drug D0J1DW
Trisnorsqualene Difluoromethylidene Small molecular drug D03RKP
Allylamines . D0F9RE
Sanguiin H-6 . D0J1QQ
Discontinued
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fr-194738 Small molecular drug D04DMO
Nb-598 Small molecular drug D0I3XW
Sdz-87-469 Small molecular drug D06MUZ

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
5 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
15 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840