Details of the Target

General Information of Target

Target ID LDTP16006
Target Name Optic atrophy 3 protein (OPA3)
Gene Name OPA3
Gene ID 80207
Synonyms
Optic atrophy 3 protein
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDTPLRRSRRLGGLRPESPESLTSVSRTRRALVEFESNPEETREPGSPPSVQRAGLGSPE
RPPKTSPGSPRLQQGAGLESPQGQPEPGAASPQRQQDLHLESPQRQPEYSPESPRCQPKP
SEEAPKCSQDQGVLASELAQNKEELTPGAPQHQLPPVPGSPEPYPGQQAPGPEPSQPLLE
LTPRAPGSPRGQHEPSKPPPAGETVTGGFGAKKRKGSSSQAPASKKLNKEELPVIPKGKP
KSGRVWKDRSKKRFSQMLQDKPLRTSWQRKMKERQERKLAKDFARHLEEEKERRRQEKKQ
RRAENLKRRLENERKAEVVQVIRNPAKLKRAKKKQLRSIEKRDTLALLQKQPPQQPAAKI
Target Bioclass
Other
Family
OPA3 family
Subcellular location
Mitochondrion
Function May play some role in mitochondrial processes.
Uniprot ID
Q9H6K4
Ensemble ID
ENST00000263275.5
HGNC ID
HGNC:8142

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.W51L DBIA    Probe Info 
HUPT4 SNV: p.A106S DBIA    Probe Info 
NCIH1155 SNV: p.R116C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.71  LDD0402  [1]
STPyne
 Probe Info  		K21(0.82)  LDD0277  [2]
BTD
 Probe Info  		C164(0.64)  LDD2109  [3]
AHL-Pu-1
 Probe Info  		C164(2.45)  LDD0170  [4]
DBIA
 Probe Info  		C164(1.21)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
Compound 11
 Probe Info  		N.A.  LDD2213  [9]
IPM
 Probe Info  		N.A.  LDD0005  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
W1
 Probe Info  		N.A.  LDD0236  [11]
AOyne
 Probe Info  		14.90  LDD0443  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 110 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C039
 Probe Info  		4.99  LDD1739  [14]
C040
 Probe Info  		22.47  LDD1740  [14]
C041
 Probe Info  		11.24  LDD1741  [14]
C049
 Probe Info  		6.96  LDD1747  [14]
C053
 Probe Info  		4.96  LDD1751  [14]
C055
 Probe Info  		24.59  LDD1752  [14]
C056
 Probe Info  		41.64  LDD1753  [14]
C060
 Probe Info  		4.99  LDD1757  [14]
C063
 Probe Info  		32.22  LDD1760  [14]
C082
 Probe Info  		5.78  LDD1774  [14]
C087
 Probe Info  		7.94  LDD1779  [14]
C091
 Probe Info  		30.91  LDD1782  [14]
C092
 Probe Info  		35.75  LDD1783  [14]
C094
 Probe Info  		41.36  LDD1785  [14]
C095
 Probe Info  		5.24  LDD1786  [14]
C106
 Probe Info  		32.22  LDD1793  [14]
C107
 Probe Info  		8.34  LDD1794  [14]
C108
 Probe Info  		13.45  LDD1795  [14]
C112
 Probe Info  		62.68  LDD1799  [14]
C130
 Probe Info  		9.25  LDD1812  [14]
C141
 Probe Info  		18.00  LDD1823  [14]
C143
 Probe Info  		32.45  LDD1825  [14]
C153
 Probe Info  		35.02  LDD1834  [14]
C159
 Probe Info  		16.34  LDD1839  [14]
C160
 Probe Info  		11.47  LDD1840  [14]
C161
 Probe Info  		21.41  LDD1841  [14]
C163
 Probe Info  		5.98  LDD1843  [14]
C169
 Probe Info  		91.14  LDD1849  [14]
C170
 Probe Info  		12.13  LDD1850  [14]
C172
 Probe Info  		5.54  LDD1852  [14]
C173
 Probe Info  		8.63  LDD1853  [14]
C174
 Probe Info  		9.06  LDD1854  [14]
C177
 Probe Info  		12.30  LDD1856  [14]
C178
 Probe Info  		52.71  LDD1857  [14]
C186
 Probe Info  		10.34  LDD1864  [14]
C187
 Probe Info  		20.39  LDD1865  [14]
C194
 Probe Info  		10.27  LDD1870  [14]
C198
 Probe Info  		10.63  LDD1874  [14]
C201
 Probe Info  		57.28  LDD1877  [14]
C206
 Probe Info  		28.84  LDD1881  [14]
C210
 Probe Info  		55.72  LDD1884  [14]
C213
 Probe Info  		18.51  LDD1887  [14]
C218
 Probe Info  		29.86  LDD1892  [14]
C219
 Probe Info  		10.20  LDD1893  [14]
C220
 Probe Info  		32.90  LDD1894  [14]
C225
 Probe Info  		10.56  LDD1898  [14]
C226
 Probe Info  		8.17  LDD1899  [14]
C228
 Probe Info  		39.67  LDD1901  [14]
C229
 Probe Info  		12.30  LDD1902  [14]
C231
 Probe Info  		50.91  LDD1904  [14]
C232
 Probe Info  		77.17  LDD1905  [14]
C233
 Probe Info  		19.29  LDD1906  [14]
C234
 Probe Info  		18.00  LDD1907  [14]
C235
 Probe Info  		63.12  LDD1908  [14]
C238
 Probe Info  		35.02  LDD1911  [14]
C239
 Probe Info  		5.35  LDD1912  [14]
C240
 Probe Info  		15.89  LDD1913  [14]
C243
 Probe Info  		33.13  LDD1916  [14]
C244
 Probe Info  		25.11  LDD1917  [14]
C246
 Probe Info  		53.08  LDD1919  [14]
C249
 Probe Info  		22.63  LDD1922  [14]
C252
 Probe Info  		21.11  LDD1925  [14]
C264
 Probe Info  		35.75  LDD1935  [14]
C265
 Probe Info  		18.00  LDD1936  [14]
C270
 Probe Info  		8.69  LDD1940  [14]
C277
 Probe Info  		8.57  LDD1947  [14]
C278
 Probe Info  		69.55  LDD1948  [14]
C280
 Probe Info  		9.65  LDD1950  [14]
C282
 Probe Info  		26.17  LDD1952  [14]
C284
 Probe Info  		26.17  LDD1954  [14]
C285
 Probe Info  		99.73  LDD1955  [14]
C286
 Probe Info  		15.45  LDD1956  [14]
C287
 Probe Info  		79.34  LDD1957  [14]
C288
 Probe Info  		34.54  LDD1958  [14]
C289
 Probe Info  		99.73  LDD1959  [14]
C290
 Probe Info  		17.03  LDD1960  [14]
C293
 Probe Info  		25.28  LDD1963  [14]
C296
 Probe Info  		16.68  LDD1966  [14]
C314
 Probe Info  		12.73  LDD1981  [14]
C326
 Probe Info  		8.75  LDD1990  [14]
C339
 Probe Info  		6.82  LDD2002  [14]
C343
 Probe Info  		31.34  LDD2005  [14]
C355
 Probe Info  		29.04  LDD2016  [14]
C356
 Probe Info  		11.16  LDD2017  [14]
C357
 Probe Info  		5.58  LDD2018  [14]
C362
 Probe Info  		99.73  LDD2023  [14]
C363
 Probe Info  		57.68  LDD2024  [14]
C364
 Probe Info  		49.87  LDD2025  [14]
C366
 Probe Info  		18.51  LDD2027  [14]
C367
 Probe Info  		9.51  LDD2028  [14]
C376
 Probe Info  		21.41  LDD2036  [14]
C378
 Probe Info  		10.06  LDD2037  [14]
C380
 Probe Info  		5.70  LDD2039  [14]
C382
 Probe Info  		24.59  LDD2041  [14]
C383
 Probe Info  		19.03  LDD2042  [14]
C386
 Probe Info  		12.82  LDD2045  [14]
C388
 Probe Info  		77.71  LDD2047  [14]
C390
 Probe Info  		88.03  LDD2049  [14]
C391
 Probe Info  		17.27  LDD2050  [14]
C399
 Probe Info  		8.75  LDD2058  [14]
C403
 Probe Info  		20.82  LDD2061  [14]
C429
 Probe Info  		23.59  LDD2084  [14]
C431
 Probe Info  		34.06  LDD2086  [14]
FFF probe11
 Probe Info  		20.00  LDD0471  [15]
FFF probe13
 Probe Info  		20.00  LDD0475  [15]
FFF probe14
 Probe Info  		20.00  LDD0477  [15]
FFF probe2
 Probe Info  		20.00  LDD0463  [15]
FFF probe3
 Probe Info  		20.00  LDD0464  [15]
JN0003
 Probe Info  		20.00  LDD0469  [15]
OEA-DA
 Probe Info  		20.00  LDD0046  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C164(2.45)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C164(4.84)  LDD0171  [4]
 LDCM0214  AC1 HCT 116 C164(1.01)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C164(1.37)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C164(0.80)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C164(0.98)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C164(0.75)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C164(0.90)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C164(0.90)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C164(0.81)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C164(0.93)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C164(0.93)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C164(0.80)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C164(0.91)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C164(1.24)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C164(1.02)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C164(0.92)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C164(1.21)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C164(0.72)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C164(0.79)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C164(0.84)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C164(0.77)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C164(0.80)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C164(0.75)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C164(1.04)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C164(1.05)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C164(0.75)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C164(0.71)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C164(0.73)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C164(0.84)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C164(0.81)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C164(0.80)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C164(0.89)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C164(0.85)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C164(1.02)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C164(1.07)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C164(1.27)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C164(1.36)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C164(1.46)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C164(1.71)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C164(1.11)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C164(1.11)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C164(1.19)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C164(1.82)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C164(1.43)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C164(1.24)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C164(1.05)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C164(1.61)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C164(1.50)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C164(1.23)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C164(0.67)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C164(0.76)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C164(0.50)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C164(0.52)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C164(0.88)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C164(0.49)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C164(0.57)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C164(1.20)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C164(0.49)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C164(0.46)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C164(0.54)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C164(0.42)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C164(0.52)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C164(0.52)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C164(0.57)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C164(0.71)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C164(0.76)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C164(0.83)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C164(0.79)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C164(0.82)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C164(0.74)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C164(0.72)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C164(0.73)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C164(0.71)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C164(0.74)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C164(1.14)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C164(1.27)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C164(1.28)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C164(1.32)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C164(1.28)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C164(1.03)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C164(1.16)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C164(1.11)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C164(1.62)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C164(1.69)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C164(1.65)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C164(0.84)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C164(0.86)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C164(0.86)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C164(0.84)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C164(0.86)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C164(1.11)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C164(0.97)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C164(0.91)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C164(1.08)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C164(1.04)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C164(0.97)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C164(1.00)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C164(1.76)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C164(1.14)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C164(1.03)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C164(0.62)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C164(1.26)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C164(0.99)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C164(0.76)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C164(0.87)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C164(0.83)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C164(0.97)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C164(0.77)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C164(0.88)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C164(1.51)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C164(1.06)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C164(1.14)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C164(1.21)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C164(1.35)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C164(1.19)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C164(1.35)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C164(1.20)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C164(1.15)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C164(1.26)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C164(1.13)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C164(1.03)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C164(1.11)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C164(0.81)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C164(1.42)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C164(0.83)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C164(0.97)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C164(1.03)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C164(0.90)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C164(1.42)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C164(1.18)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C164(0.90)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C164(0.88)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C164(0.71)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C164(0.86)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C164(1.26)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C164(0.97)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C164(1.29)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C164(1.61)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C164(1.17)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C164(1.35)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C164(1.20)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C164(1.35)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C164(1.50)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C164(1.20)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C164(1.30)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C164(1.89)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C164(1.35)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C164(1.52)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C164(1.59)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C164(1.48)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C164(1.34)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C164(1.21)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C164(1.70)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C164(1.02)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C164(0.92)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C164(1.06)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C164(1.09)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C164(1.47)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C164(1.21)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0367  CL1 HCT 116 C164(1.07)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C164(1.11)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C164(0.74)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C164(1.15)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C164(1.05)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C164(1.06)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C164(1.00)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C164(0.86)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C164(0.96)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C164(0.97)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C164(1.05)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C164(0.81)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C164(0.99)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C164(0.85)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C164(0.75)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C164(1.07)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C164(1.31)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C164(1.08)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C164(1.16)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C164(1.69)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C164(1.10)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C164(0.92)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C164(0.97)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C164(0.95)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C164(0.91)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C164(0.76)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C164(0.79)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C164(0.99)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C164(0.72)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C164(1.71)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C164(0.91)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C164(1.38)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C164(1.20)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C164(1.08)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C164(1.09)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C164(1.13)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C164(0.94)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C164(1.15)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C164(1.06)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C164(1.07)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C164(1.33)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C164(1.03)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C164(1.47)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C164(2.00)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C164(1.02)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C164(1.33)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C164(1.55)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C164(1.12)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C164(1.08)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C164(1.26)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C164(1.13)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C164(0.92)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C164(1.20)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C164(0.90)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C164(1.12)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C164(0.98)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C164(0.97)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C164(1.00)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C164(0.65)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C164(1.03)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C164(0.97)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C164(1.07)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C164(0.96)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C164(0.83)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C164(0.76)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C164(1.03)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C164(1.12)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C164(1.00)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C164(1.41)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C164(1.35)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C164(1.30)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C164(1.19)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C164(1.18)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C164(1.13)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C164(1.28)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C164(1.34)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C164(0.93)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C164(1.02)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C164(0.94)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C164(1.03)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C164(0.98)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C164(0.94)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C164(1.17)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C164(1.21)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C164(1.31)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C164(0.93)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C164(1.03)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C164(1.24)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C164(0.90)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C164(0.92)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C164(0.95)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C164(0.91)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C164(1.10)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C164(1.17)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C164(1.24)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C164(1.00)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C164(1.14)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C164(1.02)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C164(1.05)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C164(0.93)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C164(1.06)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C164(1.00)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C164(1.08)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C164(1.25)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C164(1.16)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C164(0.94)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C164(1.19)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C164(1.30)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C164(1.50)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C164(1.63)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C164(1.03)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C164(1.01)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C164(0.99)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C164(1.19)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C164(1.53)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C164(1.35)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C164(0.81)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C164(0.99)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C164(1.09)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C164(0.82)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C164(0.59)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C164(0.68)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C164(0.87)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C164(0.81)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C164(0.94)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C164(0.90)  LDD0811  [5]
 LDCM0185  Compound 17 HEK-293T 9.30  LDD0512  [15]
 LDCM0191  Compound 21 HEK-293T 12.66  LDD0508  [15]
 LDCM0190  Compound 34 HEK-293T 11.63  LDD0510  [15]
 LDCM0192  Compound 35 HEK-293T 6.41  LDD0509  [15]
 LDCM0193  Compound 36 HEK-293T 8.51  LDD0511  [15]
 LDCM0495  E2913 HEK-293T C164(0.93); C42(1.18)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C164(2.64)  LDD1702  [3]
 LDCM0625  F8 Ramos C164(1.39); C42(1.05)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C164(1.61); C42(0.83)  LDD2189  [18]
 LDCM0574  Fragment12 Ramos C164(1.76); C42(0.76)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C164(1.12); C42(0.60)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C164(3.23); C42(2.74)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C164(1.78); C42(1.45)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C164(1.16); C42(0.65)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C164(1.93); C42(1.20)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C164(0.89); C42(0.75)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C164(0.86); C42(0.90)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C164(1.16); C42(0.87)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C164(1.49); C42(0.81)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C164(1.36); C42(1.00)  LDD2201  [18]
 LDCM0468  Fragment33 HCT 116 C164(1.04)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C164(1.65)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C164(1.44); C42(0.77)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C164(0.72)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C164(1.28)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C164(1.42); C42(0.69)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C164(1.82); C42(0.73)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C164(2.16); C42(0.92)  LDD2188  [18]
 LDCM0022  KB02 HEK-293T C164(0.97); C42(0.95)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C164(1.00); C42(1.05)  LDD1497  [17]
 LDCM0024  KB05 G361 C164(4.17)  LDD3311  [19]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C164(0.64)  LDD2109  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C164(1.26)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C164(1.35)  LDD2127  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C164(0.40)  LDD2143  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C164(1.01)  LDD2206  [20]
 LDCM0628  OTUB2-COV-1 HEK-293T C164(0.63)  LDD2207  [20]

References

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2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.