Details of the Target

General Information of Target

Target ID LDTP00859
Target Name Synaptogyrin-2 (SYNGR2)
Gene Name SYNGR2
Gene ID 9144
Synonyms
Synaptogyrin-2; Cellugyrin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESGAYGAAKAGGSFDLRRFLTQPQVVARAVCLVFALIVFSCIYGEGYSNAHESKQMYCV
FNRNEDACRYGSAIGVLAFLASAFFLVVDAYFPQISNATDRKYLVIGDLLFSALWTFLWF
VGFCFLTNQWAVTNPKDVLVGADSVRAAITFSFFSIFSWGVLASLAYQRYKAGVDDFIQN
YVDPTPDPNTAYASYPGASVDNYQQPPFTQNAETTEGYQPPPVY
Target Bioclass
Other
Family
Synaptogyrin family
Subcellular location
Cytoplasmic vesicle membrane; Lipid droplet
Function
May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane.; (Microbial infection) May play a role in the assembly of cytoplasmic inclusion bodies required for SFTS phlebovirus replication.
Uniprot ID
O43760
Ensemble ID
ENST00000225777.8
HGNC ID
HGNC:11499

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KURAMOCHI SNV: p.D175E .
RT112 SNV: p.G160S .
SNU1196 SNV: p.G12D DBIA    Probe Info 
TE1 SNV: p.Y48C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		12.49  LDD0318  [1]
C-Sul
 Probe Info  		9.59  LDD0066  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
AZ-9
 Probe Info  		E2(1.04)  LDD2208  [4]
BTD
 Probe Info  		C59(0.52)  LDD2089  [5]
DBIA
 Probe Info  		C59(0.84)  LDD0531  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
NAIA_5
 Probe Info  		C42(0.00); C32(0.00); C68(0.00); C59(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 91 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		17.03  LDD1728  [10]
C026
 Probe Info  		5.13  LDD1732  [10]
C040
 Probe Info  		18.00  LDD1740  [10]
C041
 Probe Info  		7.62  LDD1741  [10]
C053
 Probe Info  		5.90  LDD1751  [10]
C055
 Probe Info  		21.26  LDD1752  [10]
C056
 Probe Info  		39.40  LDD1753  [10]
C063
 Probe Info  		14.22  LDD1760  [10]
C064
 Probe Info  		6.77  LDD1761  [10]
C070
 Probe Info  		8.69  LDD1766  [10]
C072
 Probe Info  		7.21  LDD1768  [10]
C095
 Probe Info  		7.78  LDD1786  [10]
C100
 Probe Info  		9.13  LDD1789  [10]
C106
 Probe Info  		16.45  LDD1793  [10]
C107
 Probe Info  		5.74  LDD1794  [10]
C112
 Probe Info  		60.97  LDD1799  [10]
C130
 Probe Info  		6.73  LDD1812  [10]
C134
 Probe Info  		40.50  LDD1816  [10]
C135
 Probe Info  		13.64  LDD1817  [10]
C139
 Probe Info  		13.18  LDD1821  [10]
C141
 Probe Info  		14.93  LDD1823  [10]
C143
 Probe Info  		31.34  LDD1825  [10]
C153
 Probe Info  		22.16  LDD1834  [10]
C159
 Probe Info  		14.52  LDD1839  [10]
C160
 Probe Info  		13.83  LDD1840  [10]
C161
 Probe Info  		25.46  LDD1841  [10]
C163
 Probe Info  		9.13  LDD1843  [10]
C165
 Probe Info  		12.55  LDD1845  [10]
C169
 Probe Info  		37.53  LDD1849  [10]
C170
 Probe Info  		7.73  LDD1850  [10]
C177
 Probe Info  		7.78  LDD1856  [10]
C178
 Probe Info  		33.59  LDD1857  [10]
C186
 Probe Info  		12.55  LDD1864  [10]
C194
 Probe Info  		11.08  LDD1870  [10]
C196
 Probe Info  		13.93  LDD1872  [10]
C198
 Probe Info  		15.35  LDD1874  [10]
C201
 Probe Info  		76.64  LDD1877  [10]
C206
 Probe Info  		24.08  LDD1881  [10]
C210
 Probe Info  		58.89  LDD1884  [10]
C213
 Probe Info  		14.42  LDD1887  [10]
C218
 Probe Info  		18.00  LDD1892  [10]
C219
 Probe Info  		6.92  LDD1893  [10]
C220
 Probe Info  		26.91  LDD1894  [10]
C225
 Probe Info  		4.99  LDD1898  [10]
C228
 Probe Info  		16.45  LDD1901  [10]
C231
 Probe Info  		58.49  LDD1904  [10]
C232
 Probe Info  		48.17  LDD1905  [10]
C233
 Probe Info  		14.83  LDD1906  [10]
C235
 Probe Info  		53.45  LDD1908  [10]
C238
 Probe Info  		11.39  LDD1911  [10]
C240
 Probe Info  		9.32  LDD1913  [10]
C243
 Probe Info  		18.51  LDD1916  [10]
C244
 Probe Info  		16.91  LDD1917  [10]
C246
 Probe Info  		45.25  LDD1919  [10]
C252
 Probe Info  		10.93  LDD1925  [10]
C277
 Probe Info  		13.74  LDD1947  [10]
C285
 Probe Info  		22.78  LDD1955  [10]
C287
 Probe Info  		13.55  LDD1957  [10]
C288
 Probe Info  		6.68  LDD1958  [10]
C289
 Probe Info  		44.32  LDD1959  [10]
C293
 Probe Info  		36.25  LDD1963  [10]
C296
 Probe Info  		33.13  LDD1966  [10]
C299
 Probe Info  		7.01  LDD1968  [10]
C305
 Probe Info  		11.63  LDD1974  [10]
C310
 Probe Info  		8.22  LDD1977  [10]
C314
 Probe Info  		14.42  LDD1981  [10]
C322
 Probe Info  		6.87  LDD1988  [10]
C326
 Probe Info  		9.71  LDD1990  [10]
C339
 Probe Info  		11.79  LDD2002  [10]
C343
 Probe Info  		22.78  LDD2005  [10]
C348
 Probe Info  		12.47  LDD2009  [10]
C349
 Probe Info  		17.03  LDD2010  [10]
C350
 Probe Info  		46.85  LDD2011  [10]
C355
 Probe Info  		47.50  LDD2016  [10]
C356
 Probe Info  		13.36  LDD2017  [10]
C357
 Probe Info  		6.87  LDD2018  [10]
C362
 Probe Info  		41.64  LDD2023  [10]
C363
 Probe Info  		17.03  LDD2024  [10]
C364
 Probe Info  		15.56  LDD2025  [10]
C366
 Probe Info  		6.11  LDD2027  [10]
C376
 Probe Info  		6.92  LDD2036  [10]
C382
 Probe Info  		9.71  LDD2041  [10]
C388
 Probe Info  		48.84  LDD2047  [10]
C390
 Probe Info  		31.34  LDD2049  [10]
C399
 Probe Info  		10.13  LDD2058  [10]
C403
 Probe Info  		29.45  LDD2061  [10]
C413
 Probe Info  		23.10  LDD2069  [10]
C426
 Probe Info  		15.03  LDD2081  [10]
C429
 Probe Info  		17.27  LDD2084  [10]
C431
 Probe Info  		21.71  LDD2086  [10]
STS-2
 Probe Info  		N.A.  LDD0138  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C59(0.76); C68(1.91)  LDD2142  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C59(0.79)  LDD2103  [5]
 LDCM0214  AC1 HCT 116 C59(0.84)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C59(1.27)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C59(0.81)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C59(0.81)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C59(0.72)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C59(0.81)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C59(0.76)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C59(0.67)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C59(0.70)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C59(0.63)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C59(0.61)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C59(0.93)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C59(1.08)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C59(0.86)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C59(0.99)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C59(0.74)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C59(0.99)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C59(1.12)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C59(1.08)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C59(0.93)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C59(0.74)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C59(0.81)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C59(0.77)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C59(1.06)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C59(1.61)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C59(1.51)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C59(0.98)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C59(1.77)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C59(1.26)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C59(1.38)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C59(1.09)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C59(0.98)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C59(1.16)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C59(1.22)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C59(1.26)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C59(1.48)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C59(0.84)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C59(1.11)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C59(1.33)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C59(1.12)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C59(1.02)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C59(0.93)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C59(1.54)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C59(1.01)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C59(1.04)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C59(1.00)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C59(1.35)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C59(0.91)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C59(1.05)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C59(0.95)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C59(1.04)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C59(0.94)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C59(0.89)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C59(1.01)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C59(0.87)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C59(1.22)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C59(1.60)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C59(1.01)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C59(1.03)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C59(0.95)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C59(0.93)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C59(1.08)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C59(0.96)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C59(1.59)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C59(0.84)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C59(0.95)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C59(0.93)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C59(1.00)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C59(0.70)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C59(0.76)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C59(0.99)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C59(0.84)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C59(0.94)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C59(1.31)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C59(0.71)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C59(0.85)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C59(0.92)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C59(0.82)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C59(1.03)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C59(0.90)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C59(0.89)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C59(0.64)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C59(1.03)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C59(1.73)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C59(1.29)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C59(1.07)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C59(0.98)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C59(0.86)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C59(0.73)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C59(1.03)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C59(0.88)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C59(0.91)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C59(0.95)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C59(0.92)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C59(1.08)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C59(0.94)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C59(1.00)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C59(0.84)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C59(0.60)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C59(0.95)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C59(1.21)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C59(1.29)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C59(1.05)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C59(1.04)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C59(1.13)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C59(1.28)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C59(0.90)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C59(0.97)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C59(1.25)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C59(0.98)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C59(0.71)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C59(1.10)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C59(1.24)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C59(0.68)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C59(0.94)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C59(0.81)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C59(0.83)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C59(0.66)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C59(0.60)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C59(0.58)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C59(0.91)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C59(0.97)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C59(1.05)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C59(0.78)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C59(1.01)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C59(1.06)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C59(0.96)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C59(0.98)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C59(0.91)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C59(0.96)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C59(0.96)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C59(0.89)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C59(0.95)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C59(1.12)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C59(1.03)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C59(0.95)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C59(0.79)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C59(0.77)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C59(0.64)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C59(0.54)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C59(0.83)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C59(0.62)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C59(0.75)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C59(0.55)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C59(0.60)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C59(0.59)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C59(0.65)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C59(0.65)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C59(0.66)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C59(0.61)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C59(0.62)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C59(0.65)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C59(0.67)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C59(0.70)  LDD0683  [6]
 LDCM0545  Acetamide MDA-MB-231 C59(0.60)  LDD2138  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C68(0.81)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C59(0.99)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C59(0.91)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C59(1.04)  LDD0592  [6]
 LDCM0498  BS-3668 MDA-MB-231 C59(0.64)  LDD2091  [5]
 LDCM0367  CL1 HCT 116 C59(0.80)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C59(0.64)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C59(0.80)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C59(1.19)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C59(1.21)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C59(1.22)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C59(1.25)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C59(0.88)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C59(0.98)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C59(0.95)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C59(0.98)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C59(0.80)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C59(0.69)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C59(0.89)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C59(1.00)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C59(1.20)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C59(0.98)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C59(1.40)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C59(1.40)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C59(1.52)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C59(0.84)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C59(1.00)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C59(0.92)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C59(0.61)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C59(0.76)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C59(1.08)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C59(0.86)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C59(0.95)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C59(0.98)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C59(0.81)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C59(0.80)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C59(0.84)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C59(0.71)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C59(0.87)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C59(0.81)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C59(0.94)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C59(0.79)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C59(0.60)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C59(0.77)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C59(0.82)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C59(0.80)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C59(0.87)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C59(0.75)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C59(0.98)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C59(0.99)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C59(0.73)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C59(0.65)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C59(0.86)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C59(0.71)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C59(0.73)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C59(0.71)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C59(0.81)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C59(0.91)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C59(0.98)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C59(1.06)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C59(0.89)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C59(0.91)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C59(1.31)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C59(1.22)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C59(1.14)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C59(1.02)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C59(0.94)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C59(1.29)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C59(1.29)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C59(1.19)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C59(1.38)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C59(1.13)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C59(0.81)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C59(1.04)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C59(0.89)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C59(1.14)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C59(1.19)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C59(0.89)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C59(1.08)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C59(1.10)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C59(0.98)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C59(1.01)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C59(0.93)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C59(1.05)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C59(0.92)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C59(0.90)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C59(0.95)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C59(0.99)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C59(0.82)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C59(1.13)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C59(1.30)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C59(1.01)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C59(1.07)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C59(1.28)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C59(1.43)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C59(1.33)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C59(1.15)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C59(1.19)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C59(1.08)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C59(0.73)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C59(1.09)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C59(1.18)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C59(1.34)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C59(1.40)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C59(1.89)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C59(1.29)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C59(1.59)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C59(1.16)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C59(1.12)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C59(0.67)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C59(1.35)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C59(1.28)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C59(1.22)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C59(1.14)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C59(1.06)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C59(1.08)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C59(1.20)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C59(0.94)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C59(1.26)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C59(1.11)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C59(0.83)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C59(1.38)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C59(0.86)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C59(0.87)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C59(0.93)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C59(0.80)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C59(0.76)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C59(0.88)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C59(1.01)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C59(0.89)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C59(1.03)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C59(1.16)  LDD1698  [12]
 LDCM0573  Fragment11 Ramos C59(0.49)  LDD2190  [13]
 LDCM0575  Fragment13 Ramos C59(1.01)  LDD2192  [13]
 LDCM0582  Fragment23 Ramos C59(0.51)  LDD2196  [13]
 LDCM0586  Fragment28 Ramos C59(1.16)  LDD2198  [13]
 LDCM0468  Fragment33 HCT 116 C59(1.19)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C59(1.33)  LDD2203  [13]
 LDCM0427  Fragment51 HCT 116 C59(1.19)  LDD0744  [6]
 LDCM0022  KB02 HEK-293T C59(0.96)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C59(1.09)  LDD1497  [12]
 LDCM0024  KB05 HMCB C59(2.58)  LDD3312  [14]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C59(0.56)  LDD2121  [5]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C59(0.52)  LDD2089  [5]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C59(1.48); C68(1.47)  LDD2090  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C59(1.18)  LDD2093  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C59(0.73)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C68(1.16)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C68(3.07)  LDD2100  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C59(1.31); C68(1.65)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C59(1.44)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C59(2.35); C68(4.07)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C59(0.80)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C59(0.84)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C59(0.90)  LDD2111  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C59(0.78); C68(0.53)  LDD2115  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C59(1.86)  LDD2119  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C59(1.01)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C59(0.87); C68(1.05)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C59(1.12)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C59(1.27)  LDD2129  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C59(0.63); C68(0.43)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C59(0.99)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C59(1.23)  LDD2136  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C59(0.86)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C59(0.63); C68(1.65)  LDD2141  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C59(1.59)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C59(0.98)  LDD2146  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C59(0.93); C68(0.51)  LDD2148  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C68(0.56)  LDD2150  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C59(1.83)  LDD2153  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Scavenger receptor class A member 3 (SCARA3) . Q6AZY7

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840