Details of the Target

General Information of Target

Target ID LDTP10020
Target Name Ras-related protein Rab-24 (RAB24)
Gene Name RAB24
Gene ID 53917
Synonyms
Ras-related protein Rab-24
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDYKSSLIQDGNPMENLEKQLICPICLEMFTKPVVILPCQHNLCRKCANDIFQAANPYWT
SRGSSVSMSGGRFRCPTCRHEVIMDRHGVYGLQRNLLVENIIDIYKQECSSRPLQKGSHP
MCKEHEDEKINIYCLTCEVPTCSMCKVFGIHKACEVAPLQSVFQGQKTELNNCISMLVAG
NDRVQTIITQLEDSRRVTKENSHQVKEELSQKFDTLYAILDEKKSELLQRITQEQEKKLS
FIEALIQQYQEQLDKSTKLVETAIQSLDEPGGATFLLTAKQLIKSIVEASKGCQLGKTEQ
GFENMDFFTLDLEHIADALRAIDFGTDEEEEEFIEEEDQEEEESTEGKEEGHQ
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rab family
Subcellular location
Cytoplasm, cytosol
Function May be involved in autophagy-related processes.
Uniprot ID
Q969Q5
Ensemble ID
ENST00000303251.11
HGNC ID
HGNC:9765

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K100(10.00)  LDD0277  [1]
HPAP
 Probe Info  		3.09  LDD0063  [2]
DBIA
 Probe Info  		C113(2.08); C118(2.08)  LDD0080  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
TFBX
 Probe Info  		C113(0.00); C87(0.00)  LDD0027  [5]
AOyne
 Probe Info  		12.40  LDD0443  [6]
PAL-AfBPP Probe
Click To Hide/Show 62 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		9.00  LDD1728  [7]
C040
 Probe Info  		13.36  LDD1740  [7]
C049
 Probe Info  		5.78  LDD1747  [7]
C055
 Probe Info  		20.82  LDD1752  [7]
C056
 Probe Info  		42.52  LDD1753  [7]
C070
 Probe Info  		9.85  LDD1766  [7]
C091
 Probe Info  		21.56  LDD1782  [7]
C092
 Probe Info  		33.82  LDD1783  [7]
C094
 Probe Info  		41.07  LDD1785  [7]
C095
 Probe Info  		6.06  LDD1786  [7]
C100
 Probe Info  		6.92  LDD1789  [7]
C106
 Probe Info  		24.93  LDD1793  [7]
C107
 Probe Info  		5.74  LDD1794  [7]
C112
 Probe Info  		29.65  LDD1799  [7]
C134
 Probe Info  		29.86  LDD1816  [7]
C143
 Probe Info  		15.89  LDD1825  [7]
C153
 Probe Info  		16.91  LDD1834  [7]
C159
 Probe Info  		10.85  LDD1839  [7]
C160
 Probe Info  		7.16  LDD1840  [7]
C161
 Probe Info  		14.03  LDD1841  [7]
C169
 Probe Info  		26.91  LDD1849  [7]
C196
 Probe Info  		11.88  LDD1872  [7]
C198
 Probe Info  		13.09  LDD1874  [7]
C201
 Probe Info  		36.00  LDD1877  [7]
C210
 Probe Info  		65.34  LDD1884  [7]
C218
 Probe Info  		19.03  LDD1892  [7]
C220
 Probe Info  		13.74  LDD1894  [7]
C225
 Probe Info  		5.13  LDD1898  [7]
C228
 Probe Info  		33.36  LDD1901  [7]
C231
 Probe Info  		21.26  LDD1904  [7]
C232
 Probe Info  		59.71  LDD1905  [7]
C234
 Probe Info  		5.46  LDD1907  [7]
C235
 Probe Info  		40.79  LDD1908  [7]
C238
 Probe Info  		15.56  LDD1911  [7]
C243
 Probe Info  		12.04  LDD1916  [7]
C246
 Probe Info  		19.03  LDD1919  [7]
C249
 Probe Info  		12.91  LDD1922  [7]
C252
 Probe Info  		10.34  LDD1925  [7]
C285
 Probe Info  		22.63  LDD1955  [7]
C287
 Probe Info  		11.47  LDD1957  [7]
C288
 Probe Info  		6.15  LDD1958  [7]
C289
 Probe Info  		95.01  LDD1959  [7]
C293
 Probe Info  		21.26  LDD1963  [7]
C296
 Probe Info  		13.45  LDD1966  [7]
C299
 Probe Info  		6.87  LDD1968  [7]
C310
 Probe Info  		7.67  LDD1977  [7]
C314
 Probe Info  		11.88  LDD1981  [7]
C339
 Probe Info  		5.28  LDD2002  [7]
C343
 Probe Info  		12.47  LDD2005  [7]
C349
 Probe Info  		11.71  LDD2010  [7]
C350
 Probe Info  		30.48  LDD2011  [7]
C355
 Probe Info  		28.64  LDD2016  [7]
C382
 Probe Info  		9.51  LDD2041  [7]
C388
 Probe Info  		82.14  LDD2047  [7]
C390
 Probe Info  		85.63  LDD2049  [7]
C391
 Probe Info  		12.38  LDD2050  [7]
C397
 Probe Info  		14.22  LDD2056  [7]
C399
 Probe Info  		13.64  LDD2058  [7]
C403
 Probe Info  		60.97  LDD2061  [7]
C407
 Probe Info  		16.80  LDD2064  [7]
FFF probe11
 Probe Info  		20.00  LDD0471  [8]
FFF probe3
 Probe Info  		20.00  LDD0464  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C87(1.11)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C87(1.05); C118(1.09)  LDD1508  [9]
 LDCM0237  AC12 HEK-293T C87(0.92)  LDD1510  [9]
 LDCM0276  AC17 HEK-293T C87(1.21)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C87(1.09); C118(1.05)  LDD1516  [9]
 LDCM0279  AC2 HEK-293T C87(1.17); C118(0.93)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C87(0.81)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C118(1.04)  LDD1520  [9]
 LDCM0284  AC24 HEK-293T C87(0.96)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C87(0.82)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C87(0.92); C118(0.98)  LDD1525  [9]
 LDCM0288  AC28 HEK-293T C87(0.87)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C118(1.04)  LDD1528  [9]
 LDCM0293  AC32 HEK-293T C87(1.02)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C87(0.98)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C87(1.00); C118(1.17)  LDD1534  [9]
 LDCM0297  AC36 HEK-293T C87(0.79)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C118(1.10)  LDD1537  [9]
 LDCM0301  AC4 HEK-293T C87(0.92)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C87(1.05)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C87(0.92)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C87(0.94); C118(0.99)  LDD1543  [9]
 LDCM0306  AC44 HEK-293T C87(0.80)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C118(0.95)  LDD1546  [9]
 LDCM0310  AC48 HEK-293T C87(1.18)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C87(0.90)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C118(0.93)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C87(1.00); C118(0.89)  LDD1552  [9]
 LDCM0315  AC52 HEK-293T C87(0.79)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C118(0.98)  LDD1555  [9]
 LDCM0319  AC56 HEK-293T C87(1.10)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C87(1.04)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C87(1.14); C118(1.04)  LDD1560  [9]
 LDCM0324  AC60 HEK-293T C87(1.05)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C118(1.03)  LDD1564  [9]
 LDCM0328  AC64 HEK-293T C87(0.82)  LDD1567  [9]
 LDCM0345  AC8 HEK-293T C87(1.25)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C118(0.98)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C87(1.20)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C87(0.93)  LDD1514  [9]
 LDCM0367  CL1 HEK-293T C87(1.18)  LDD1571  [9]
 LDCM0370  CL101 HEK-293T C87(1.05)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C87(1.05); C118(1.02)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C87(0.95)  LDD1576  [9]
 LDCM0374  CL105 HEK-293T C87(0.94)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C87(1.04); C118(1.01)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C87(1.05)  LDD1580  [9]
 LDCM0378  CL109 HEK-293T C87(1.17)  LDD1582  [9]
 LDCM0380  CL110 HEK-293T C87(0.94); C118(1.02)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C87(1.22)  LDD1585  [9]
 LDCM0383  CL113 HEK-293T C87(1.30)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C87(0.95); C118(1.06)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C87(1.06)  LDD1589  [9]
 LDCM0387  CL117 HEK-293T C87(1.02)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C87(1.01); C118(1.11)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C87(0.90)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C87(1.12)  LDD1594  [9]
 LDCM0392  CL121 HEK-293T C87(1.02)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C87(0.99); C118(0.98)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C87(1.06)  LDD1598  [9]
 LDCM0396  CL125 HEK-293T C87(1.07)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C87(1.01); C118(1.07)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C87(1.11)  LDD1602  [9]
 LDCM0400  CL13 HEK-293T C87(1.01)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C87(1.10); C118(1.00)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C87(0.93)  LDD1606  [9]
 LDCM0404  CL17 HEK-293T C87(1.29)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C87(1.25); C118(1.09)  LDD1609  [9]
 LDCM0407  CL2 HEK-293T C87(1.15); C118(0.98)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C87(1.08)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C118(1.23)  LDD1613  [9]
 LDCM0412  CL24 HEK-293T C87(1.19)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C87(1.22)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C87(0.84); C118(0.96)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C87(1.11)  LDD1619  [9]
 LDCM0417  CL29 HEK-293T C87(1.10)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C87(1.01)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C87(0.95); C118(1.08)  LDD1623  [9]
 LDCM0421  CL32 HEK-293T C87(1.01)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C118(1.20)  LDD1626  [9]
 LDCM0425  CL36 HEK-293T C87(1.41)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C87(1.07)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C87(0.96)  LDD1632  [9]
 LDCM0431  CL41 HEK-293T C87(0.85)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C87(0.89); C118(1.14)  LDD1636  [9]
 LDCM0434  CL44 HEK-293T C87(1.02)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C118(1.22)  LDD1639  [9]
 LDCM0438  CL48 HEK-293T C87(1.10)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C87(1.09)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C87(1.20)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C87(0.84); C118(1.09)  LDD1645  [9]
 LDCM0444  CL53 HEK-293T C87(1.15)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C87(0.93); C118(1.06)  LDD1648  [9]
 LDCM0447  CL56 HEK-293T C87(0.98)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C118(1.35)  LDD1651  [9]
 LDCM0451  CL6 HEK-293T C87(1.05); C118(1.30)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C87(1.11)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C87(1.18)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C87(1.06); C118(0.80)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C87(1.05)  LDD1658  [9]
 LDCM0457  CL65 HEK-293T C87(1.10)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C87(1.20); C118(1.13)  LDD1661  [9]
 LDCM0460  CL68 HEK-293T C87(0.93)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C118(1.27)  LDD1664  [9]
 LDCM0465  CL72 HEK-293T C87(1.26)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C87(1.03)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C87(0.98); C118(1.03)  LDD1670  [9]
 LDCM0470  CL77 HEK-293T C87(1.26)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C87(1.09); C118(1.14)  LDD1674  [9]
 LDCM0473  CL8 HEK-293T C87(0.93)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C87(1.10)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C118(1.06)  LDD1678  [9]
 LDCM0478  CL84 HEK-293T C87(1.78)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C87(1.00)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C87(1.01); C118(1.20)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C87(1.09)  LDD1684  [9]
 LDCM0483  CL89 HEK-293T C87(1.07)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C118(1.08)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C87(0.98); C118(0.99)  LDD1688  [9]
 LDCM0487  CL92 HEK-293T C87(1.00)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C118(1.13)  LDD1691  [9]
 LDCM0491  CL96 HEK-293T C87(0.99)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C87(0.94)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C87(1.06); C118(1.06)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C87(1.07)  LDD1697  [9]
 LDCM0191  Compound 21 HEK-293T 9.22  LDD0508  [8]
 LDCM0192  Compound 35 HEK-293T 6.10  LDD0509  [8]
 LDCM0193  Compound 36 HEK-293T 9.13  LDD0511  [8]
 LDCM0495  E2913 HEK-293T C87(0.98)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C87(1.13)  LDD1671  [9]
 LDCM0427  Fragment51 HEK-293T C87(1.15); C118(1.07)  LDD1631  [9]
 LDCM0022  KB02 HCT 116 C113(2.08); C118(2.08)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C113(3.06); C118(3.06)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C113(3.19); C118(3.19)  LDD0082  [3]
 LDCM0014  Panhematin K562 3.09  LDD0063  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guanidinoacetate N-methyltransferase (GAMT) RMT2 methyltransferase family Q14353

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402