Details of the Target

General Information of Target

Target ID LDTP08904
Target Name Protein jagunal homolog 1 (JAGN1)
Gene Name JAGN1
Gene ID 84522
Synonyms
Protein jagunal homolog 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASRAGPRAAGTDGSDFQHRERVAMHYQMSVTLKYEIKKLIYVHLVIWLLLVAKMSVGHL
RLLSHDQVAMPYQWEYPYLLSILPSLLGLLSFPRNNISYLVLSMISMGLFSIAPLIYGSM
EMFPAAQQLYRHGKAYRFLFGFSAVSIMYLVLVLAVQVHAWQLYYSKKLLDSWFTSTQEK
KHK
Target Bioclass
Other
Family
Jagunal family
Subcellular location
Endoplasmic reticulum membrane
Function
Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils.
Uniprot ID
Q8N5M9
Ensemble ID
ENST00000647897.1
HGNC ID
HGNC:26926

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		6.65  LDD0066  [1]
D5yne
 Probe Info  		1.58  LDD0055  [2]
ATP probe
 Probe Info  		K180(0.00); K181(0.00)  LDD0199  [3]
NHS
 Probe Info  		K168(0.00); K180(0.00)  LDD0010  [4]
STPyne
 Probe Info  		N.A.  LDD0009  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [5]
PAL-AfBPP Probe
Click To Hide/Show 80 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		7.78  LDD1728  [6]
C027
 Probe Info  		5.28  LDD1733  [6]
C040
 Probe Info  		19.29  LDD1740  [6]
C041
 Probe Info  		6.23  LDD1741  [6]
C049
 Probe Info  		5.98  LDD1747  [6]
C053
 Probe Info  		5.86  LDD1751  [6]
C055
 Probe Info  		37.53  LDD1752  [6]
C056
 Probe Info  		47.18  LDD1753  [6]
C063
 Probe Info  		20.97  LDD1760  [6]
C070
 Probe Info  		12.04  LDD1766  [6]
C072
 Probe Info  		10.27  LDD1768  [6]
C091
 Probe Info  		19.97  LDD1782  [6]
C092
 Probe Info  		34.54  LDD1783  [6]
C094
 Probe Info  		67.65  LDD1785  [6]
C095
 Probe Info  		5.78  LDD1786  [6]
C100
 Probe Info  		5.35  LDD1789  [6]
C106
 Probe Info  		25.11  LDD1793  [6]
C107
 Probe Info  		8.88  LDD1794  [6]
C108
 Probe Info  		9.19  LDD1795  [6]
C112
 Probe Info  		38.85  LDD1799  [6]
C129
 Probe Info  		5.86  LDD1811  [6]
C134
 Probe Info  		33.59  LDD1816  [6]
C135
 Probe Info  		10.93  LDD1817  [6]
C159
 Probe Info  		9.06  LDD1839  [6]
C160
 Probe Info  		13.18  LDD1840  [6]
C161
 Probe Info  		13.74  LDD1841  [6]
C169
 Probe Info  		24.76  LDD1849  [6]
C201
 Probe Info  		56.49  LDD1877  [6]
C206
 Probe Info  		29.45  LDD1881  [6]
C210
 Probe Info  		40.50  LDD1884  [6]
C218
 Probe Info  		16.00  LDD1892  [6]
C220
 Probe Info  		43.71  LDD1894  [6]
C225
 Probe Info  		5.50  LDD1898  [6]
C226
 Probe Info  		5.58  LDD1899  [6]
C228
 Probe Info  		29.86  LDD1901  [6]
C231
 Probe Info  		29.45  LDD1904  [6]
C233
 Probe Info  		9.06  LDD1906  [6]
C234
 Probe Info  		6.45  LDD1907  [6]
C235
 Probe Info  		33.36  LDD1908  [6]
C238
 Probe Info  		13.83  LDD1911  [6]
C243
 Probe Info  		17.63  LDD1916  [6]
C244
 Probe Info  		15.45  LDD1917  [6]
C246
 Probe Info  		25.63  LDD1919  [6]
C249
 Probe Info  		12.13  LDD1922  [6]
C264
 Probe Info  		16.91  LDD1935  [6]
C278
 Probe Info  		63.56  LDD1948  [6]
C280
 Probe Info  		9.92  LDD1950  [6]
C282
 Probe Info  		21.41  LDD1952  [6]
C285
 Probe Info  		22.47  LDD1955  [6]
C287
 Probe Info  		11.00  LDD1957  [6]
C288
 Probe Info  		8.75  LDD1958  [6]
C289
 Probe Info  		52.35  LDD1959  [6]
C293
 Probe Info  		22.63  LDD1963  [6]
C296
 Probe Info  		12.91  LDD1966  [6]
C299
 Probe Info  		16.45  LDD1968  [6]
C314
 Probe Info  		11.24  LDD1981  [6]
C343
 Probe Info  		26.72  LDD2005  [6]
C348
 Probe Info  		12.30  LDD2009  [6]
C349
 Probe Info  		22.78  LDD2010  [6]
C350
 Probe Info  		67.65  LDD2011  [6]
C355
 Probe Info  		22.16  LDD2016  [6]
C362
 Probe Info  		54.57  LDD2023  [6]
C363
 Probe Info  		16.91  LDD2024  [6]
C364
 Probe Info  		15.14  LDD2025  [6]
C366
 Probe Info  		6.28  LDD2027  [6]
C376
 Probe Info  		6.50  LDD2036  [6]
C382
 Probe Info  		9.32  LDD2041  [6]
C388
 Probe Info  		76.11  LDD2047  [6]
C390
 Probe Info  		34.30  LDD2049  [6]
C399
 Probe Info  		7.01  LDD2058  [6]
C403
 Probe Info  		18.38  LDD2061  [6]
C407
 Probe Info  		19.97  LDD2064  [6]
C429
 Probe Info  		15.03  LDD2084  [6]
C431
 Probe Info  		22.78  LDD2086  [6]
FFF probe11
 Probe Info  		20.00  LDD0471  [7]
FFF probe13
 Probe Info  		20.00  LDD0475  [7]
FFF probe2
 Probe Info  		20.00  LDD0463  [7]
FFF probe3
 Probe Info  		20.00  LDD0464  [7]
STS-2
 Probe Info  		N.A.  LDD0138  [8]
OEA-DA
 Probe Info  		14.89  LDD0046  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0095  DC-LC3IN-D5 HeLa 1.58  LDD0055  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q9NRZ5
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) CDP-alcohol phosphatidyltransferase class-I family O14735
rRNA methyltransferase 3, mitochondrial (MRM3) RNA methyltransferase TrmH family Q9HC36
Protein-S-isoprenylcysteine O-methyltransferase (ICMT) Isoprenylcysteine carboxyl methyltransferase family O60725
Cytochrome P450 4F2 (CYP4F2) Cytochrome P450 family P78329
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
Stearoyl-CoA desaturase (SCD) Fatty acid desaturase type 1 family O00767
Heme oxygenase 1 (HMOX1) Heme oxygenase family P09601
Phospholipid phosphatase 2 (PLPP2) PA-phosphatase related phosphoesterase family O43688
Inactive ubiquitin thioesterase OTULINL (OTULINL) Peptidase C65 family Q9NUU6
Squalene synthase (FDFT1) Phytoene/squalene synthase family P37268
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Very-long-chain enoyl-CoA reductase (TECR) Steroid 5-alpha reductase family Q9NZ01
GTPase IMAP family member 1 (GIMAP1) AIG1/Toc34/Toc159-like paraseptin GTPase family Q8WWP7
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
Ubiquitin-conjugating enzyme E2 J1 (UBE2J1) Ubiquitin-conjugating enzyme family Q9Y385
Ceramide synthase 4 (CERS4) . Q9HA82
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) . Q14318
Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) . Q9NTJ5
Transporter and channel
Click To Hide/Show 25 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stomatin-like protein 3 (STOML3) Band 7/mec-2 family Q8TAV4
Calcium homeostasis modulator protein 6 (CALHM6) CALHM family Q5R3K3
Claudin-7 (CLDN7) Claudin family O95471
Cytochrome c oxidase assembly protein COX20, mitochondrial (COX20) COX20 family Q5RI15
FXYD domain-containing ion transport regulator 6 (FXYD6) FXYD family Q9H0Q3
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) NIP3 family Q12983
Potassium voltage-gated channel subfamily A member 1 (KCNA1) Potassium channel family Q09470
Small integral membrane protein 1 (SMIM1) SMIM1 family B2RUZ4
Vesicle-associated membrane protein 2 (VAMP2) Synaptobrevin family P63027
Syntaxin-1A (STX1A) Syntaxin family Q16623
Syntaxin-3 (STX3) Syntaxin family Q13277
Syntaxin-5 (STX5) Syntaxin family Q13190
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) Tim17/Tim22/Tim23 family O14925
Transmembrane protein 106C (TMEM106C) TMEM106 family Q9BVX2
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transmembrane protein 242 (TMEM242) TMEM242 family Q9NWH2
Vesicle-associated membrane protein-associated protein A (VAPA) VAMP-associated protein (VAP) (TC 9.B.17) family Q9P0L0
Vesicle-associated membrane protein-associated protein B/C (VAPB) VAMP-associated protein (VAP) (TC 9.B.17) family O95292
Vesicle transport through interaction with t-SNAREs homolog 1B (VTI1B) VTI1 family Q9UEU0
Barttin (BSND) . Q8WZ55
Transmembrane protein 100 (TMEM100) . Q9NV29
Transmembrane protein 199 (TMEM199) . Q8N511
Transmembrane protein 65 (TMEM65) . Q6PI78
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 37-like 1 (GPR37L1) G-protein coupled receptor 1 family O60883
Lysophosphatidic acid receptor 3 (LPAR3) G-protein coupled receptor 1 family Q9UBY5
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctional adhesion molecule A (F11R) Immunoglobulin superfamily Q9Y624
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
Killer cell immunoglobulin-like receptor 3DL3 (KIR3DL3) Immunoglobulin superfamily Q8N743
High affinity immunoglobulin gamma Fc receptor I (FCGR1A) Immunoglobulin superfamily P12314
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Fc receptor-like protein 4 (FCRL4) . Q96PJ5
SLAM family member 6 (SLAMF6) . Q96DU3
V-set and immunoglobulin domain-containing protein 4 (VSIG4) . Q9Y279
Cytokine and receptor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-C motif chemokine 4-like (CCL4L1; CCL4L2) Intercrine beta (chemokine CC) family Q8NHW4
Tumor necrosis factor ligand superfamily member 14 (TNFSF14) Tumor necrosis factor family O43557
Interleukin-3 receptor subunit alpha (IL3RA) Type I cytokine receptor family P26951
Interferon gamma receptor 2 (IFNGR2) Type II cytokine receptor family P38484
Tumor necrosis factor receptor superfamily member 27 (EDA2R) . Q9HAV5
Other
Click To Hide/Show 38 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 13 (BCL2L13) Bcl-2 family Q9BXK5
BET1 homolog (BET1) BET1 family O15155
Gap junction beta-5 protein (GJB5) Connexin family O95377
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
Ergosterol biosynthetic protein 28 homolog (ERG28) ERG28 family Q9UKR5
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Mitochondrial fission 1 protein (FIS1) FIS1 family Q9Y3D6
Golgi membrane protein 1 (GOLM1) GOLM family Q8NBJ4
Golgi SNAP receptor complex member 2 (GOSR2) GOSR2 family O14653
Translation initiation factor IF-3, mitochondrial (MTIF3) IF-3 family Q9H2K0
Ninjurin-2 (NINJ2) Ninjurin family Q9NZG7
Stress-associated endoplasmic reticulum protein 1 (SERP1) RAMP4 family Q9Y6X1
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Vesicle transport protein SEC20 (BNIP1) SEC20 family Q12981
Small cell adhesion glycoprotein (SMAGP) SMAGP family Q0VAQ4
Small integral membrane protein 19 (SMIM19) SMIM19 family Q96E16
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183
Vesicle-trafficking protein SEC22b (SEC22B) Synaptobrevin family O75396
Syntaxin-7 (STX7) Syntaxin family O15400
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Bone morphogenetic protein 10 (BMP10) TGF-beta family O95393
Transmembrane protein 120B (TMEM120B) TMEM120 family A0PK00
Transmembrane protein 243 (TMEM243) TMEM243 family Q9BU79
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
Vesicle transport protein USE1 (USE1) USE1 family Q9NZ43
Immediate early response 3-interacting protein 1 (IER3IP1) YOS1 family Q9Y5U9
C-type lectin domain family 4 member D (CLEC4D) . Q8WXI8
C-type lectin domain family 7 member A (CLEC7A) . Q9BXN2
Cell growth regulator with RING finger domain protein 1 (CGRRF1) . Q99675
DnaJ homolog subfamily C member 30, mitochondrial (DNAJC30) . Q96LL9
FERM domain-containing protein 3 (FRMD3) . A2A2Y4
Fibronectin type III domain-containing protein 9 (FNDC9) . Q8TBE3
LEM domain-containing protein 1 (LEMD1) . Q68G75
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113
Protein KASH5 (KASH5) . Q8N6L0
Transmembrane protein 207 (TMEM207) . Q6UWW9
Transmembrane protein 52B (TMEM52B) . Q4KMG9

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew Chem Int Ed Engl. 2021 Dec 6;60(50):26105-26114. doi: 10.1002/anie.202109464. Epub 2021 Nov 5.
Mass spectrometry data entry: PXD026874
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
8 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
9 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570