Details of the Target

General Information of Target

Target ID LDTP00729
Target Name Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1)
Gene Name GPAA1
Gene ID 8733
Synonyms
GAA1; Glycosylphosphatidylinositol anchor attachment 1 protein; GPI anchor attachment protein 1; GAA1 protein homolog; hGAA1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLLSDPVRRRALARLVLRLNAPLCVLSYVAGIAWFLALVFPPLTQRTYMSENAMGSTMV
EEQFAGGDRARAFARDFAAHRKKSGALPVAWLERTMRSVGLEVYTQSFSRKLPFPDETHE
RYMVSGTNVYGILRAPRAASTESLVLTVPCGSDSTNSQAVGLLLALAAHFRGQIYWAKDI
VFLVTEHDLLGTEAWLEAYHDVNVTGMQSSPLQGRAGAIQAAVALELSSDVVTSLDVAVE
GLNGQLPNLDLLNLFQTFCQKGGLLCTLQGKLQPEDWTSLDGPLQGLQTLLLMVLRQASG
RPHGSHGLFLRYRVEALTLRGINSFRQYKYDLVAVGKALEGMFRKLNHLLERLHQSFFLY
LLPGLSRFVSIGLYMPAVGFLLLVLGLKALELWMQLHEAGMGLEEPGGAPGPSVPLPPSQ
GVGLASLVAPLLISQAMGLALYVLPVLGQHVATQHFPVAEAEAVVLTLLAIYAAGLALPH
NTHRVVSTQAPDRGWMALKLVALIYLALQLGCIALTNFSLGFLLATTMVPTAALAKPHGP
RTLYAALLVLTSPAATLLGSLFLWRELQEAPLSLAEGWQLFLAALAQGVLEHHTYGALLF
PLLSLGLYPCWLLFWNVLFWK
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum membrane
Function
Component of the GPI transamidase complex, necessary for transfer of GPI to proteins. Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate.
Uniprot ID
O43292
Ensemble ID
ENST00000355091.9
HGNC ID
HGNC:4446

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH1155 SNV: p.R541W .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y122(6.24)  LDD0260  [1]
STPyne
 Probe Info  		K83(4.97)  LDD0277  [2]
BTD
 Probe Info  		C266(1.13)  LDD2101  [3]
IPM
 Probe Info  		C266(6.61)  LDD1701  [3]
DBIA
 Probe Info  		C266(1.25)  LDD0531  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
PAL-AfBPP Probe
Click To Hide/Show 36 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.63  LDD1714  [8]
C040
 Probe Info  		12.47  LDD1740  [8]
C055
 Probe Info  		14.83  LDD1752  [8]
C091
 Probe Info  		17.27  LDD1782  [8]
C092
 Probe Info  		21.56  LDD1783  [8]
C094
 Probe Info  		33.13  LDD1785  [8]
C095
 Probe Info  		5.98  LDD1786  [8]
C106
 Probe Info  		20.25  LDD1793  [8]
C112
 Probe Info  		39.12  LDD1799  [8]
C153
 Probe Info  		18.90  LDD1834  [8]
C169
 Probe Info  		27.86  LDD1849  [8]
C218
 Probe Info  		11.96  LDD1892  [8]
C220
 Probe Info  		12.91  LDD1894  [8]
C231
 Probe Info  		22.16  LDD1904  [8]
C232
 Probe Info  		38.85  LDD1905  [8]
C233
 Probe Info  		9.65  LDD1906  [8]
C234
 Probe Info  		5.74  LDD1907  [8]
C235
 Probe Info  		27.67  LDD1908  [8]
C246
 Probe Info  		15.78  LDD1919  [8]
C277
 Probe Info  		8.11  LDD1947  [8]
C285
 Probe Info  		26.17  LDD1955  [8]
C287
 Probe Info  		15.35  LDD1957  [8]
C288
 Probe Info  		7.41  LDD1958  [8]
C289
 Probe Info  		43.71  LDD1959  [8]
C314
 Probe Info  		12.73  LDD1981  [8]
C339
 Probe Info  		5.10  LDD2002  [8]
C349
 Probe Info  		10.41  LDD2010  [8]
C350
 Probe Info  		26.35  LDD2011  [8]
C388
 Probe Info  		54.95  LDD2047  [8]
C407
 Probe Info  		13.09  LDD2064  [8]
FFF probe11
 Probe Info  		20.00  LDD0471  [9]
FFF probe14
 Probe Info  		20.00  LDD0477  [9]
FFF probe3
 Probe Info  		20.00  LDD0464  [9]
A-DA
 Probe Info  		2.36  LDD0145  [10]
Alk-rapa
 Probe Info  		4.36  LDD0213  [11]
OEA-DA
 Probe Info  		19.81  LDD0046  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C266(1.54)  LDD2117  [3]
 LDCM0214  AC1 HCT 116 C266(1.25)  LDD0531  [4]
 LDCM0215  AC10 HEK-293T C266(0.99); C150(1.15)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C266(1.01); C150(0.83)  LDD1509  [13]
 LDCM0230  AC113 HCT 116 C266(1.02)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C266(1.24)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C266(1.11)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C266(1.27)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C266(1.03)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C266(1.24)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C266(1.18)  LDD0553  [4]
 LDCM0237  AC12 HEK-293T C266(1.04)  LDD1510  [13]
 LDCM0238  AC120 HCT 116 C266(1.35)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C266(0.90)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C266(1.35)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C266(0.77)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C266(1.07)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C266(1.50)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C266(1.44)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C266(1.24)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C266(1.26)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C266(1.29)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C266(1.08)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C266(1.09)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C266(1.08)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C266(1.26)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C266(1.07)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C266(1.14)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C266(0.96)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C266(0.99)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C266(0.90)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C266(1.02)  LDD0575  [4]
 LDCM0259  AC14 HEK-293T C266(1.06)  LDD1512  [13]
 LDCM0260  AC140 HCT 116 C266(0.97)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C266(0.94)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C266(1.05)  LDD0579  [4]
 LDCM0270  AC15 HEK-293T C266(0.99)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C266(1.09)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C266(1.06); C150(1.05)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C266(1.19); C150(0.95)  LDD1517  [13]
 LDCM0279  AC2 HCT 116 C266(1.21)  LDD0596  [4]
 LDCM0280  AC20 HEK-293T C266(1.02)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C266(1.00)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C266(1.02)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C266(0.97)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C266(0.86)  LDD1523  [13]
 LDCM0285  AC25 HCT 116 C266(1.07)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C266(1.04)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C266(1.24)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C266(1.28)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C266(1.01)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C266(1.28)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C266(1.05)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C266(1.37)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C266(1.04)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C266(0.99)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C266(0.80)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C266(1.07)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C266(1.04)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C266(0.93)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C266(0.92)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C266(1.20)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C266(1.47)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C266(0.89)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C266(0.70)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C266(0.63)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C266(0.72)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C266(0.68)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C266(0.71)  LDD0624  [4]
 LDCM0308  AC46 HEK-293T C266(1.04)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C266(1.00)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C266(0.87)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C266(1.01)  LDD1550  [13]
 LDCM0312  AC5 HCT 116 C266(1.47)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C266(0.94); C150(1.01)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C266(0.98); C150(1.03)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C266(1.05)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C266(0.99)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C266(1.00)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C266(0.97)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C266(1.01)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C266(1.10)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C266(0.97); C150(1.17)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C266(1.02); C150(1.07)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C266(1.08)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C266(1.04)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C266(1.07)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C266(0.98)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C266(1.10)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C266(0.93)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C266(1.02)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C266(0.91)  LDD1569  [13]
 LDCM0349  AC83 HCT 116 C266(0.93)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C266(0.98)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C266(1.07)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C266(0.96)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C266(0.98)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C266(1.12)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C266(1.08)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C266(1.21)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C266(1.04)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C266(0.92)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C266(1.06)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C266(1.23)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C266(1.01)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C266(0.91)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C266(1.05)  LDD0681  [4]
 LDCM0248  AKOS034007472 HEK-293T C266(1.00)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C266(1.07)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C266(0.99)  LDD1514  [13]
 LDCM0367  CL1 HCT 116 C266(1.11)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C266(1.13)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C266(1.17)  LDD0686  [4]
 LDCM0370  CL101 HEK-293T C266(1.03)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C266(1.28); C150(1.06)  LDD1575  [13]
 LDCM0373  CL104 HEK-293T C266(1.06); C150(1.05)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C266(1.09)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C266(1.09); C150(1.50)  LDD1579  [13]
 LDCM0377  CL108 HEK-293T C266(1.02); C150(1.32)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C266(0.95)  LDD1582  [13]
 LDCM0379  CL11 HCT 116 C266(1.29)  LDD0696  [4]
 LDCM0380  CL110 HEK-293T C266(1.28); C150(0.99)  LDD1584  [13]
 LDCM0382  CL112 HCT 116 C266(1.41)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C266(1.09)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C266(1.06)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C266(0.81)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C266(0.87)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C266(0.84)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C266(1.11)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C266(0.95)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C266(1.15)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C266(0.84)  LDD0708  [4]
 LDCM0392  CL121 HEK-293T C266(0.96)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C266(1.09); C150(1.05)  LDD1597  [13]
 LDCM0395  CL124 HEK-293T C266(1.06); C150(1.16)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C266(1.00)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C266(1.22); C150(1.03)  LDD1601  [13]
 LDCM0399  CL128 HEK-293T C266(1.01); C150(1.09)  LDD1603  [13]
 LDCM0400  CL13 HCT 116 C266(1.10)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C266(1.14)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C266(1.25)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C266(1.31)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C266(1.04)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C266(1.10)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C266(0.97)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C266(1.03)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C266(1.08)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C266(0.83)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C266(1.11)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C266(1.23)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C266(1.72)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C266(1.36)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C266(1.39)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C266(1.48)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C266(1.49)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C266(1.87)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C266(1.05)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C266(1.62)  LDD0736  [4]
 LDCM0420  CL31 HEK-293T C266(1.19); C150(0.84)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C266(1.07)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C266(2.04)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C266(1.17)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C266(1.13)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C266(1.22)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C266(0.91)  LDD1630  [13]
 LDCM0429  CL4 HCT 116 C266(1.01)  LDD0746  [4]
 LDCM0430  CL40 HEK-293T C266(1.04); C150(1.34)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C266(1.16)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C266(0.99); C150(1.14)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C266(1.20); C150(1.02)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C266(1.14)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C266(1.36)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C266(1.27)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C266(1.27)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C266(1.12)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C266(1.00)  LDD1643  [13]
 LDCM0440  CL5 HCT 116 C266(1.13)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C266(1.22); C150(1.15)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C266(1.19); C150(1.00)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C266(1.26)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C266(1.37); C150(1.53)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C266(1.12); C150(1.21)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C266(1.11)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C266(1.47)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C266(1.33)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C266(1.23)  LDD1653  [13]
 LDCM0451  CL6 HCT 116 C266(1.11)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C266(1.13)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C266(0.93)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C266(1.09); C150(1.16)  LDD1657  [13]
 LDCM0456  CL64 HEK-293T C266(1.26); C150(0.99)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C266(1.12)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C266(1.09); C150(1.17)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C266(1.02); C150(1.19)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C266(1.17)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C266(1.17)  LDD1664  [13]
 LDCM0462  CL7 HCT 116 C266(1.35)  LDD0779  [4]
 LDCM0463  CL70 HEK-293T C266(1.16)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C266(1.17)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C266(0.99)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C266(1.02)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C266(1.03); C150(1.04)  LDD1670  [13]
 LDCM0469  CL76 HCT 116 C266(0.92)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C266(1.08)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C266(0.83)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C266(1.07)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C266(1.09)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C266(0.99)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C266(0.94)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C266(1.12)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C266(0.85)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C266(1.01)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C266(0.88)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C266(0.84)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C266(0.99)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C266(0.89)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C266(0.93)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C266(1.20)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C266(1.03)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C266(1.21)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C266(1.30)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C266(1.40)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C266(1.42)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C266(1.45)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C266(1.41)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C266(1.30)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C266(1.14)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C266(1.22)  LDD0811  [4]
 LDCM0427  Fragment51 HEK-293T C266(1.05); C150(1.49)  LDD1631  [13]
 LDCM0022  KB02 HEK-293T C266(0.96)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C266(1.01)  LDD1497  [13]
 LDCM0024  KB05 MEWO C266(1.43)  LDD3319  [14]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C266(1.13)  LDD2101  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C266(1.30)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C266(1.03)  LDD2109  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C266(0.90)  LDD2127  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C266(0.94)  LDD2135  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C266(0.61)  LDD2140  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C266(0.79)  LDD2148  [3]
 LDCM0090  Rapamycin JHH-7 4.36  LDD0213  [11]
 LDCM0084  Ro 48-8071 A-549 2.36  LDD0145  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase B (PPIB) Cyclophilin-type PPIase family P23284
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
GPI-anchor transamidase (PIGK) Peptidase C13 family Q92643
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GPI transamidase component PIG-T (PIGT) PIGT family Q969N2

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
11 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
12 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840