Details of the Target

General Information of Target

Target ID LDTP06977
Target Name GPI ethanolamine phosphate transferase 2 (PIGG)
Gene Name PIGG
Gene ID 54872
Synonyms
GPI7; GPI ethanolamine phosphate transferase 2; EC 2.-.-.-; GPI7 homolog; hGPI7; Phosphatidylinositol-glycan biosynthesis class G protein; PIG-G
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLGSGTFATCCVAIEVLGIAVFLRGFFPAPVRSSARAEHGAEPPAPEPSAGASSNWTTL
PPPLFSKVVIVLIDALRDDFVFGSKGVKFMPYTTYLVEKGASHSFVAEAKPPTVTMPRIK
ALMTGSLPGFVDVIRNLNSPALLEDSVIRQAKAAGKRIVFYGDETWVKLFPKHFVEYDGT
TSFFVSDYTEVDNNVTRHLDKVLKRGDWDILILHYLGLDHIGHISGPNSPLIGQKLSEMD
SVLMKIHTSLQSKERETPLPNLLVLCGDHGMSETGSHGASSTEEVNTPLILISSAFERKP
GDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLLFPVVEGRPMREQLRFLHLNTVQLSK
LLQENVPSYEKDPGFEQFKMSERLHGNWIRLYLEEKHSEVLFNLGSKVLRQYLDALKTLS
LSLSAQVAQYDIYSMMVGTVVVLEVLTLLLLSVPQALRRKAELEVPLSSPGFSLLFYLVI
LVLSAVHVIVCTSAESSCYFCGLSWLAAGGVMVLASALLCVIVSVLTNVLVGGNTPRKNP
MHPSSRWSELDLLILLGTAGHVLSLGASSFVEEEHQTWYFLVNTLCLALSQETYRNYFLG
DDGEPPCGLCVEQGHDGATAAWQDGPGCDVLERDKGHGSPSTSEVLRGREKWMVLASPWL
ILACCRLLRSLNQTGVQWAHRPDLGHWLTSSDHKAELSVLAALSLLVVFVLVQRGCSPVS
KAALALGLLGVYCYRAAIGSVRFPWRPDSKDISKGIIEARFVYVFVLGILFTGTKDLLKS
QVIAADFKLKTVGLWEIYSGLVLLAALLFRPHNLPVLAFSLLIQTLMTKFIWKPLRHDAA
EITVMHYWFGQAFFYFQGNSNNIATVDISAGFVGLDTYVEIPAVLLTAFGTYAGPVLWAS
HLVHFLSSETRSGSALSHACFCYALICSIPVFTYIVLVTSLRYHLFIWSVFSPKLLYEGM
HLLITAAVCVFFTAMDQTRLTQS
Target Bioclass
Enzyme
Family
PIGG/PIGN/PIGO family, PIGG subfamily
Subcellular location
Endoplasmic reticulum membrane
Function Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.
Uniprot ID
Q5H8A4
Ensemble ID
ENST00000310340.9
HGNC ID
HGNC:25985

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.V513M .
CMK SNV: p.P744S .
CORL88 SNV: p.H637R .
HCT15 SNV: p.H615Y .
Ishikawa (Heraklio) 02 ER Deletion: p.R649AfsTer12 .
KMRC1 SNV: p.L945Ter .
LNCaP clone FGC SNV: p.T447A .
MFE319 SNV: p.H904R .
RKO SNV: p.A737V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K152(1.85)  LDD0277  [1]
DA-P3
 Probe Info  		4.03  LDD0179  [2]
DBIA
 Probe Info  		C607(0.91)  LDD0813  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
AOyne
 Probe Info  		15.00  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		5.66  LDD1725  [6]
C053
 Probe Info  		5.21  LDD1751  [6]
C055
 Probe Info  		12.91  LDD1752  [6]
C056
 Probe Info  		20.25  LDD1753  [6]
C070
 Probe Info  		11.00  LDD1766  [6]
C072
 Probe Info  		7.73  LDD1768  [6]
C091
 Probe Info  		20.82  LDD1782  [6]
C092
 Probe Info  		30.06  LDD1783  [6]
C094
 Probe Info  		57.28  LDD1785  [6]
C106
 Probe Info  		18.51  LDD1793  [6]
C108
 Probe Info  		8.06  LDD1795  [6]
C153
 Probe Info  		18.00  LDD1834  [6]
C169
 Probe Info  		24.76  LDD1849  [6]
C187
 Probe Info  		15.56  LDD1865  [6]
C201
 Probe Info  		47.84  LDD1877  [6]
C206
 Probe Info  		22.47  LDD1881  [6]
C225
 Probe Info  		5.28  LDD1898  [6]
C228
 Probe Info  		25.81  LDD1901  [6]
C293
 Probe Info  		28.64  LDD1963  [6]
C296
 Probe Info  		12.64  LDD1966  [6]
C343
 Probe Info  		17.51  LDD2005  [6]
C348
 Probe Info  		14.83  LDD2009  [6]
C349
 Probe Info  		18.00  LDD2010  [6]
C350
 Probe Info  		48.50  LDD2011  [6]
C353
 Probe Info  		6.32  LDD2014  [6]
C390
 Probe Info  		29.86  LDD2049  [6]
OEA-DA
 Probe Info  		20.00  LDD0046  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C607(0.91)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C610(1.85)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C610(0.98)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C610(1.12)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C610(1.06)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C610(1.02)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C610(1.43)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C610(1.01)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C610(0.88)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C610(1.11)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C610(1.25)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C607(0.81)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C610(0.94)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C610(0.98)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C610(1.03)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C610(1.03)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C610(1.39)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C610(1.12)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C610(1.11)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C610(1.21)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C610(1.17)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C610(1.11)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C607(0.66)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C610(1.68)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C610(0.74)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C610(0.94)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C610(1.13)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C610(0.83)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C610(0.92)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C610(0.97)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C610(0.87)  LDD0843  [3]
 LDCM0259  AC14 HEK-293T C607(0.94)  LDD0857  [3]
 LDCM0263  AC143 HEK-293T C607(0.98)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C607(1.07)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C607(1.00)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C607(1.16)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C607(0.78)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C607(0.75)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C607(1.34)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C607(1.21)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C607(0.98)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C607(1.07)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C607(0.94)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C607(0.79)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C607(0.99)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C607(0.90)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C607(1.44)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C607(0.89)  LDD2165  [3]
 LDCM0283  AC23 HEK-293T C716(0.96)  LDD1522  [8]
 LDCM0285  AC25 HEK-293T C610(1.59)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C610(1.16)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C610(1.34)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C610(1.24)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C610(1.01)  LDD0887  [3]
 LDCM0291  AC30 HEK-293T C610(1.73)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C610(1.43)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C610(1.51)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C610(1.33)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C610(1.71)  LDD0893  [3]
 LDCM0300  AC39 HEK-293T C716(1.07)  LDD1539  [8]
 LDCM0308  AC46 HEK-293T C607(0.66); C610(0.66)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C607(0.96); C610(0.96)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C607(0.79); C610(0.79)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C607(1.00); C610(1.00)  LDD0909  [3]
 LDCM0313  AC50 HEK-293T C607(0.98); C610(0.98)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C607(1.09); C610(1.09)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C607(1.22); C610(1.22)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C607(1.34); C610(1.34)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C607(0.84); C610(0.84)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C607(0.93); C610(0.93)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C607(0.73); C610(0.73)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C610(1.62)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C610(1.57)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C610(1.12)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C607(0.49)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C610(1.07)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C610(0.94)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C610(1.03)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C610(0.96)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C610(0.96)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C610(1.05)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C610(1.24)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C610(1.04)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C607(1.16)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C607(1.42)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C607(0.66)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C607(1.38)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C607(1.01)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C607(1.13)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C607(1.01)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C607(1.15)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C607(1.17)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C607(1.26)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C607(1.34)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C607(1.28)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C607(1.04)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C607(0.73)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C607(1.33)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C607(1.24)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C607(1.53)  LDD0946  [3]
 LDCM0349  AC83 HEK-293T C610(0.58)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C610(0.64)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C610(0.86)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C610(0.82)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C610(0.76)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C610(0.59)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C610(0.71)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C610(0.87)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C610(0.51)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C610(0.66)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C610(0.44)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C610(0.49)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C610(0.64)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C610(0.42)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C610(0.74)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C610(0.99)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C610(1.20)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C607(0.73)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C607(0.88)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C607(0.82)  LDD0873  [3]
 LDCM0370  CL101 HEK-293T C607(0.99)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C607(0.80)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C607(0.89)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C607(0.82)  LDD0971  [3]
 LDCM0379  CL11 HEK-293T C716(1.22)  LDD1583  [8]
 LDCM0382  CL112 HEK-293T C610(1.75)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C610(1.72)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C610(1.21)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C610(1.55)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C610(1.44)  LDD0984  [3]
 LDCM0392  CL121 HEK-293T C607(0.85); C610(0.85)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C607(0.75); C610(0.75)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C607(1.00); C610(1.00)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C607(0.90); C610(0.90)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C610(1.04)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C610(1.09)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C610(0.95)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C610(1.50)  LDD0997  [3]
 LDCM0411  CL23 HEK-293T C716(1.11)  LDD1615  [8]
 LDCM0420  CL31 HEK-293T C610(1.01)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C610(0.83)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C610(0.99)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C610(0.68)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C610(1.29)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C610(0.88)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C610(0.82)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C610(0.84)  LDD1026  [3]
 LDCM0430  CL40 HEK-293T C610(0.84)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C610(0.70)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C610(0.74)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C610(0.60)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C610(0.95)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C610(0.77)  LDD1033  [3]
 LDCM0437  CL47 HEK-293T C716(1.34)  LDD1641  [8]
 LDCM0450  CL59 HEK-293T C716(1.46)  LDD1653  [8]
 LDCM0453  CL61 HEK-293T C610(2.04)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C610(1.07)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C610(1.47)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C610(1.39)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C610(1.43)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C610(1.09)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C610(1.76)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C610(0.96)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C610(1.14)  LDD1059  [3]
 LDCM0463  CL70 HEK-293T C610(1.07)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C610(0.91)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C610(1.53)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C610(0.88)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C610(1.32)  LDD1065  [3]
 LDCM0477  CL83 HEK-293T C716(1.36)  LDD1680  [8]
 LDCM0490  CL95 HEK-293T C716(1.59)  LDD1693  [8]
 LDCM0027  Dopamine HEK-293T 4.03  LDD0179  [2]
 LDCM0468  Fragment33 HEK-293T C610(0.80)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C610(0.49)  LDD1025  [3]
 LDCM0022  KB02 HEK-293T C716(1.17)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C716(1.07)  LDD1497  [8]
 LDCM0024  KB05 HEK-293T C716(1.00)  LDD1502  [8]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402