Details of the Target

General Information of Target

Target ID LDTP13802
Target Name DNA replication complex GINS protein PSF2 (GINS2)
Gene Name GINS2
Gene ID 51659
Synonyms
PSF2; DNA replication complex GINS protein PSF2; GINS complex subunit 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQYKGTMREAGRAMHLLKKRERQREQMEVLKQRIAEETILKSQVDKRFSAHYDAVEAEL
KSSTVGLVTLNDMKARQEALVRERERQLAKRQHLEEQRLQQERQREQEQRRERKRKISCL
SFALDDLDDQADAAEARRAGNLGKNPDVDTSFLPDRDREEEENRLREELRQEWEAQREKV
KDEEMEVTFSYWDGSGHRRTVRVRKGNTVQQFLKKALQGLRKDFLELRSAGVEQLMFIKE
DLILPHYHTFYDFIIARARGKSGPLFSFDVHDDVRLLSDATMEKDESHAGKVVLRSWYEK
NKHIFPASRWEAYDPEKKWDKYTIR
Target Bioclass
Other
Family
GINS2/PSF2 family
Subcellular location
Nucleus
Function
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
Uniprot ID
Q9Y248
Ensemble ID
ENST00000253462.8
HGNC ID
HGNC:24575

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBP2
 Probe Info  		3.36  LDD0323  [1]
5E-2FA
 Probe Info  		N.A.  LDD2235  [2]
m-APA
 Probe Info  		N.A.  LDD2231  [2]
PAL-AfBPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C007
 Probe Info  		7.94  LDD1716  [3]
C022
 Probe Info  		9.38  LDD1728  [3]
C026
 Probe Info  		7.89  LDD1732  [3]
C040
 Probe Info  		10.56  LDD1740  [3]
C053
 Probe Info  		6.41  LDD1751  [3]
C056
 Probe Info  		18.77  LDD1753  [3]
C134
 Probe Info  		26.35  LDD1816  [3]
C147
 Probe Info  		6.87  LDD1829  [3]
C161
 Probe Info  		16.91  LDD1841  [3]
C201
 Probe Info  		32.45  LDD1877  [3]
C206
 Probe Info  		19.03  LDD1881  [3]
C219
 Probe Info  		16.11  LDD1893  [3]
C220
 Probe Info  		16.91  LDD1894  [3]
C226
 Probe Info  		8.40  LDD1899  [3]
C228
 Probe Info  		28.25  LDD1901  [3]
C231
 Probe Info  		14.72  LDD1904  [3]
C282
 Probe Info  		30.06  LDD1952  [3]
C285
 Probe Info  		46.21  LDD1955  [3]
C287
 Probe Info  		8.75  LDD1957  [3]
C289
 Probe Info  		32.67  LDD1959  [3]
C356
 Probe Info  		10.27  LDD2017  [3]
C357
 Probe Info  		10.78  LDD2018  [3]
C362
 Probe Info  		63.12  LDD2023  [3]
C364
 Probe Info  		68.59  LDD2025  [3]
C366
 Probe Info  		21.86  LDD2027  [3]
C388
 Probe Info  		50.21  LDD2047  [3]
C390
 Probe Info  		44.32  LDD2049  [3]
C429
 Probe Info  		12.13  LDD2084  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase Chk2 (CHEK2) CAMK Ser/Thr protein kinase family O96017
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA replication complex GINS protein SLD5 (GINS4) GINS4/SLD5 family Q9BRT9
Mini-chromosome maintenance complex-binding protein (MCMBP) MCMBP family Q9BTE3

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587