Details of the Target

General Information of Target

Target ID LDTP11116
Target Name 45 kDa calcium-binding protein (SDF4)
Gene Name SDF4
Gene ID 51150
Synonyms
CAB45; 45 kDa calcium-binding protein; Cab45; Stromal cell-derived factor 4; SDF-4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAIVQTLPVPLEPAPEAATAPQAPVMGSVSSLISGRPCPGGPAPPRHHGPPGPTFFRQQD
GLLRGGYEAQEPLCPAVPPRKAVPVTSFTYINEDFRTESPPSPSSDVEDAREQRAHNAHL
RGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLT
QLFGGPASSSSSSSSSSAADKPLAFSGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTT
SSPGGHLPSHGSGRGALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRA
SPDSSSCGERSPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEE
RQRHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLER
RCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALRE
ARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREP
PVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGER
LAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAPCIC
LEEITATEI
Target Bioclass
Transporter and channel
Family
CREC family
Subcellular location
Cytoplasm; Golgi apparatus lumen
Function May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.; Isoform 5 may be involved in the exocytosis of zymogens by pancreatic acini.
Uniprot ID
Q9BRK5
HGNC ID
HGNC:24188

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		20.43  LDD0318  [1]
STPyne
 Probe Info  		K102(5.00); K121(4.31); K165(8.33); K170(10.00)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K121(1.36)  LDD3494  [3]
5E-2FA
 Probe Info  		H172(0.00); H134(0.00); H61(0.00)  LDD2235  [4]
m-APA
 Probe Info  		H156(0.00); H172(0.00); H333(0.00); H332(0.00)  LDD2231  [4]
SF
 Probe Info  		N.A.  LDD0028  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
PAL-AfBPP Probe
Click To Hide/Show 59 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		15.78  LDD1713  [7]
C004
 Probe Info  		9.71  LDD1714  [7]
C017
 Probe Info  		7.52  LDD1725  [7]
C022
 Probe Info  		12.21  LDD1728  [7]
C040
 Probe Info  		11.79  LDD1740  [7]
C041
 Probe Info  		10.93  LDD1741  [7]
C052
 Probe Info  		5.70  LDD1750  [7]
C053
 Probe Info  		4.92  LDD1751  [7]
C055
 Probe Info  		17.03  LDD1752  [7]
C056
 Probe Info  		17.63  LDD1753  [7]
C063
 Probe Info  		13.27  LDD1760  [7]
C070
 Probe Info  		9.25  LDD1766  [7]
C087
 Probe Info  		21.26  LDD1779  [7]
C106
 Probe Info  		35.26  LDD1793  [7]
C107
 Probe Info  		7.36  LDD1794  [7]
C108
 Probe Info  		12.73  LDD1795  [7]
C112
 Probe Info  		27.86  LDD1799  [7]
C145
 Probe Info  		8.69  LDD1827  [7]
C147
 Probe Info  		6.59  LDD1829  [7]
C160
 Probe Info  		7.01  LDD1840  [7]
C161
 Probe Info  		11.88  LDD1841  [7]
C165
 Probe Info  		14.22  LDD1845  [7]
C178
 Probe Info  		15.14  LDD1857  [7]
C187
 Probe Info  		20.39  LDD1865  [7]
C191
 Probe Info  		12.55  LDD1868  [7]
C193
 Probe Info  		5.39  LDD1869  [7]
C218
 Probe Info  		11.24  LDD1892  [7]
C220
 Probe Info  		12.13  LDD1894  [7]
C226
 Probe Info  		6.06  LDD1899  [7]
C228
 Probe Info  		17.15  LDD1901  [7]
C232
 Probe Info  		55.33  LDD1905  [7]
C243
 Probe Info  		12.38  LDD1916  [7]
C244
 Probe Info  		20.53  LDD1917  [7]
C246
 Probe Info  		14.83  LDD1919  [7]
C249
 Probe Info  		21.56  LDD1922  [7]
C284
 Probe Info  		27.47  LDD1954  [7]
C296
 Probe Info  		12.21  LDD1966  [7]
C305
 Probe Info  		11.96  LDD1974  [7]
C310
 Probe Info  		16.45  LDD1977  [7]
C338
 Probe Info  		11.55  LDD2001  [7]
C355
 Probe Info  		26.91  LDD2016  [7]
C356
 Probe Info  		8.22  LDD2017  [7]
C361
 Probe Info  		18.00  LDD2022  [7]
C362
 Probe Info  		49.87  LDD2023  [7]
C363
 Probe Info  		23.75  LDD2024  [7]
C364
 Probe Info  		21.11  LDD2025  [7]
C366
 Probe Info  		6.06  LDD2027  [7]
C367
 Probe Info  		6.06  LDD2028  [7]
C383
 Probe Info  		11.55  LDD2042  [7]
C388
 Probe Info  		48.50  LDD2047  [7]
C403
 Probe Info  		24.42  LDD2061  [7]
C407
 Probe Info  		16.00  LDD2064  [7]
FFF probe11
 Probe Info  		20.00  LDD0471  [8]
FFF probe12
 Probe Info  		20.00  LDD0473  [8]
FFF probe13
 Probe Info  		20.00  LDD0475  [8]
FFF probe2
 Probe Info  		20.00  LDD0463  [8]
FFF probe3
 Probe Info  		20.00  LDD0464  [8]
FFF probe6
 Probe Info  		20.00  LDD0467  [8]
FFF probe9
 Probe Info  		20.00  LDD0470  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0107  IAA HeLa H134(0.00); H78(0.00); H359(0.00)  LDD0221  [6]
 LDCM0109  NEM HeLa H134(0.00); H72(0.00); H359(0.00)  LDD0223  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-6 (CASP6) Peptidase C14A family P55212
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.