Details of the Target

General Information of Target

Target ID LDTP11318
Target Name ADP-ribose pyrophosphatase, mitochondrial (NUDT9)
Gene Name NUDT9
Gene ID 53343
Synonyms
NUDT10; ADP-ribose pyrophosphatase, mitochondrial; EC 3.6.1.13; ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; Adenosine diphosphoribose pyrophosphatase; ADPR-PPase; Nucleoside diphosphate-linked moiety X motif 9; Nudix motif 9
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSERKVLNKYYPPDFDPSKIPKLKLPKDRQYVVRLMAPFNMRCKTCGEYIYKGKKFNARK
ETVQNEVYLGLPIFRFYIKCTRCLAEITFKTDPENTDYTMEHGATRNFQAEKLLEEEEKR
VQKEREDEELNNPMKVLENRTKDSKLEMEVLENLQELKDLNQRQAHVDFEAMLRQHRLSE
EERRRQQQEEDEQETAALLEEARKRRLLEDSDSEDEAAPSPLQPALRPNPTAILDEAPKP
KRKVEVWEQSVGSLGSRPPLSRLVVVKKAKADPDCSNGQPQAAPTPGAPQNRKEANPTPL
TPGASSLSQLGAYLDSDDSNGSN
Target Bioclass
Enzyme
Family
Nudix hydrolase family, NudF subfamily
Subcellular location
Mitochondrion
Function Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate.
Uniprot ID
Q9BW91
Ensemble ID
ENST00000302174.9
HGNC ID
HGNC:8056
ChEMBL ID
CHEMBL4105984

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO679 SNV: p.N185K .
HEC1 SNV: p.M51I DBIA    Probe Info 
NCIH2172 SNV: p.V80F .
OVK18 SNV: p.S192F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C347(3.29)  LDD0169  [2]
HHS-482
 Probe Info  		Y321(0.80)  LDD0285  [3]
HHS-475
 Probe Info  		Y321(1.81)  LDD0264  [4]
HHS-465
 Probe Info  		Y321(10.00)  LDD2237  [5]
DBIA
 Probe Info  		C207(1.36)  LDD0080  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C347(0.00); C207(0.00)  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0025  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
1d-yne
 Probe Info  		N.A.  LDD0356  [11]
NHS
 Probe Info  		N.A.  LDD0010  [12]
SF
 Probe Info  		N.A.  LDD0028  [13]
STPyne
 Probe Info  		N.A.  LDD0009  [12]
Phosphinate-6
 Probe Info  		C207(0.00); C29(0.00); C347(0.00)  LDD0018  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C053
 Probe Info  		5.06  LDD1751  [17]
C106
 Probe Info  		16.56  LDD1793  [17]
C220
 Probe Info  		21.71  LDD1894  [17]
C228
 Probe Info  		20.11  LDD1901  [17]
C277
 Probe Info  		9.58  LDD1947  [17]
C278
 Probe Info  		62.68  LDD1948  [17]
C280
 Probe Info  		9.92  LDD1950  [17]
C282
 Probe Info  		98.36  LDD1952  [17]
C284
 Probe Info  		37.27  LDD1954  [17]
C357
 Probe Info  		5.94  LDD2018  [17]
C376
 Probe Info  		8.28  LDD2036  [17]
C388
 Probe Info  		52.35  LDD2047  [17]
FFF probe13
 Probe Info  		20.00  LDD0476  [18]
FFF probe14
 Probe Info  		20.00  LDD0477  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C347(3.29)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C347(1.15); C207(0.88)  LDD1507  [19]
 LDCM0215  AC10 HCT 116 C207(0.96)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C207(1.07)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C207(1.02)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C207(1.00)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C207(1.06)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C207(1.17)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C207(1.32)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C207(1.12)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C207(1.37)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C207(1.23)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C207(1.29)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C207(1.56)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C207(1.27)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C207(1.33)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C207(1.25)  LDD0546  [6]
 LDCM0237  AC12 HCT 116 C207(1.76)  LDD0554  [6]
 LDCM0246  AC128 HCT 116 C207(1.17)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C207(1.25)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C207(1.59)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C207(1.38)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C207(1.35)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C207(1.39)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C207(1.27)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C207(1.82)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C207(1.87)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C207(1.46)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C207(1.23)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C207(1.60)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C207(1.43)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C207(1.40)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C207(1.41)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C207(1.32)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C207(1.32)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C207(0.90)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C207(0.99)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C207(1.05)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C207(1.25)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C207(0.93)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C207(0.91)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C207(1.72)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C207(0.95)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C207(1.06)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C207(0.98)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C207(0.89)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C207(1.13)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C207(1.02)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C207(0.97)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C207(1.00)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C207(1.22)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C207(1.01)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C207(1.10)  LDD0595  [6]
 LDCM0279  AC2 HEK-293T C347(0.96); C207(1.07)  LDD1518  [19]
 LDCM0280  AC20 HCT 116 C207(1.33)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C207(1.22)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C207(1.48)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C207(1.09)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C207(1.37)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C207(1.39)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C207(0.88)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C207(1.28)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C207(0.69)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C207(0.70)  LDD0606  [6]
 LDCM0290  AC3 HEK-293T C347(0.97); C207(0.96)  LDD1529  [19]
 LDCM0291  AC30 HCT 116 C207(0.61)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C207(1.23)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C207(1.21)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C207(0.63)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C207(0.63)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C207(1.19)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C207(1.35)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C207(1.24)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C207(1.09)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C207(1.11)  LDD0617  [6]
 LDCM0301  AC4 HEK-293T C347(1.04); C207(0.95)  LDD1540  [19]
 LDCM0302  AC40 HCT 116 C207(0.88)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C207(1.48)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C207(1.08)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C207(1.11)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C207(0.83)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C207(0.99)  LDD0624  [6]
 LDCM0308  AC46 HEK-293T C207(1.00)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C347(1.00); C207(1.01)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C347(0.99); C207(1.00)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C347(0.95); C207(0.91)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C207(1.09)  LDD1551  [19]
 LDCM0313  AC50 HEK-293T C347(0.96); C207(1.00)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C347(1.02); C207(1.02)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C347(0.96); C207(0.84)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C207(1.05)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C207(0.97)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C347(0.97); C207(0.98)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C347(1.00); C207(1.01)  LDD1558  [19]
 LDCM0320  AC57 HCT 116 C207(1.00)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C207(0.83)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C207(0.89)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C207(0.99)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C207(0.75)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C207(1.32)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C207(1.17)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C207(0.81)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C207(0.76)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C207(1.14)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C207(1.17)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C207(1.17)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C207(0.64)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C207(0.60)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C207(1.07)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C207(0.85)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C207(0.57)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C207(0.71)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C207(0.93)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C207(0.80)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C207(0.71)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C207(0.78)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C207(0.73)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C207(0.85)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C207(0.87)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C207(1.23)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C207(0.96)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C207(0.68)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C207(0.86)  LDD0665  [6]
 LDCM0365  AC98 HCT 116 C207(1.22)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C207(1.26)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C207(1.46)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C207(1.04)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C207(1.70)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 14.71  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C347(1.02)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C207(1.17)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C207(0.91)  LDD0685  [6]
 LDCM0369  CL100 HEK-293T C347(1.25); C207(0.97)  LDD1573  [19]
 LDCM0370  CL101 HCT 116 C207(1.20)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C207(1.16)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C207(1.69)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C207(1.93)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C207(1.05)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C207(0.72)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C207(1.00)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C207(1.39)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C207(1.08)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C207(0.91)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C207(0.71)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C207(0.83)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C207(0.90)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C207(1.08)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C207(1.06)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C207(0.85)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C207(0.72)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C207(0.74)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C207(1.06)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C207(1.40)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C207(1.13)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C207(1.26)  LDD0708  [6]
 LDCM0392  CL121 HEK-293T C347(0.89); C207(1.00)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C347(1.01); C207(0.95)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C347(1.02); C207(0.92)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C347(0.93); C207(0.94)  LDD1599  [19]
 LDCM0396  CL125 HCT 116 C207(0.95)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C207(1.04)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C207(1.00)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C207(0.92)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C207(1.13)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C207(1.03)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C207(0.98)  LDD0719  [6]
 LDCM0403  CL16 HEK-293T C347(1.11); C207(1.05)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C347(1.03); C207(0.91)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C347(0.93); C207(1.01)  LDD1609  [19]
 LDCM0406  CL19 HEK-293T C347(0.94); C207(0.97)  LDD1610  [19]
 LDCM0407  CL2 HCT 116 C207(1.17)  LDD0724  [6]
 LDCM0408  CL20 HEK-293T C347(1.03); C207(0.99)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C207(0.98)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C207(1.25)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C347(1.15); C207(1.09)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C347(1.00); C207(1.08)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C347(0.89); C207(0.97)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C347(0.96); C207(1.05)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C347(0.95); C207(0.91)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C347(0.98); C207(0.97)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C347(1.13); C207(0.96)  LDD1621  [19]
 LDCM0418  CL3 HCT 116 C207(0.92)  LDD0735  [6]
 LDCM0419  CL30 HEK-293T C347(0.94); C207(1.04)  LDD1623  [19]
 LDCM0420  CL31 HCT 116 C207(0.92)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C207(0.82)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C207(1.08)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C207(0.98)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C207(0.99)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C207(0.91)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C207(0.70)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C207(0.67)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C207(1.05)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C207(0.70)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C207(0.78)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C207(0.75)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C207(0.97)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C207(0.92)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C207(0.78)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C207(1.05)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C207(0.99)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C207(0.88)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C207(1.08)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C207(1.18)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C207(1.05)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C207(1.03)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C207(1.61)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C207(0.80)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C207(0.71)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C207(1.09)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C207(0.80)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C207(1.16)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C207(1.23)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C207(1.19)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C207(1.29)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C207(1.43)  LDD0769  [6]
 LDCM0453  CL61 HEK-293T C347(1.00); C207(1.13)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C347(1.01); C207(1.02)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C347(1.03); C207(1.02)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C347(0.87); C207(0.96)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C347(1.13); C207(0.98)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C347(0.89); C207(0.96)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C347(1.05); C207(0.98)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C347(1.03); C207(0.93)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C207(1.04)  LDD1664  [19]
 LDCM0462  CL7 HCT 116 C207(1.27)  LDD0779  [6]
 LDCM0463  CL70 HEK-293T C207(1.15)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C347(1.18); C207(1.04)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C347(1.09); C207(1.06)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C347(0.93); C207(1.00)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C347(1.03); C207(1.00)  LDD1670  [19]
 LDCM0469  CL76 HCT 116 C207(0.95)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C207(0.78)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C207(1.09)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C207(0.97)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C207(1.06)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C207(1.24)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C207(1.05)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C207(0.87)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C207(0.71)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C207(0.85)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C207(0.86)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C207(0.88)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C207(0.94)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C207(1.07)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C207(1.32)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C207(1.28)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C207(1.08)  LDD0802  [6]
 LDCM0486  CL91 HEK-293T C347(0.93); C207(0.86)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C347(1.04); C207(0.92)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C207(1.04)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C207(1.03)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C347(1.09); C207(0.86)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C347(0.95); C207(0.91)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C347(0.94); C207(0.95)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C347(0.96); C207(1.00)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C347(0.98); C207(0.95)  LDD1697  [19]
 LDCM0634  CY-0357 Hep-G2 C347(0.42)  LDD2228  [10]
 LDCM0495  E2913 HEK-293T C347(1.04); C207(1.00)  LDD1698  [19]
 LDCM0625  F8 Ramos C207(1.25)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C347(0.66)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C207(1.15)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C347(0.58); C207(1.21)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C347(1.00); C207(1.03)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C347(0.50); C207(0.87)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C347(0.44); C207(0.95)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C347(0.71); C207(0.80)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C347(0.71); C207(0.97)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C347(0.84); C207(0.72)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C347(0.72); C207(0.29)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C347(1.40); C207(1.23)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C347(0.66); C207(0.82)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C347(0.61)  LDD2201  [20]
 LDCM0468  Fragment33 HEK-293T C347(0.93); C207(0.97)  LDD1671  [19]
 LDCM0596  Fragment38 Ramos C347(0.54); C207(0.60)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C207(0.81)  LDD2184  [20]
 LDCM0427  Fragment51 HCT 116 C207(0.55)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C347(1.31); C207(0.65)  LDD2204  [20]
 LDCM0614  Fragment56 Ramos C347(1.71); C207(0.86)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C207(0.75)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C347(0.59); C207(0.72)  LDD2188  [20]
 LDCM0116  HHS-0101 DM93 Y321(1.81)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y321(1.17)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y321(0.76)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y321(0.84)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y321(1.50)  LDD0268  [4]
 LDCM0123  JWB131 DM93 Y321(0.80)  LDD0285  [3]
 LDCM0124  JWB142 DM93 Y321(0.72)  LDD0286  [3]
 LDCM0125  JWB146 DM93 Y321(0.88)  LDD0287  [3]
 LDCM0126  JWB150 DM93 Y321(2.67)  LDD0288  [3]
 LDCM0127  JWB152 DM93 Y321(1.74)  LDD0289  [3]
 LDCM0128  JWB198 DM93 Y321(0.59)  LDD0290  [3]
 LDCM0129  JWB202 DM93 Y321(0.36)  LDD0291  [3]
 LDCM0130  JWB211 DM93 Y321(0.97)  LDD0292  [3]
 LDCM0022  KB02 HCT 116 C207(1.36)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C207(1.28)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C207(1.29)  LDD0082  [6]
 LDCM0109  NEM HeLa N.A.  LDD0227  [15]
 LDCM0131  RA190 MM1.R C347(1.15)  LDD0304  [21]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Beta-d-glucose Small molecular drug DB02379
Beta-d-ribose-5-phosphate . DB04352

References

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2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.