Details of the Target

General Information of Target

Target ID LDTP04227
Target Name Guided entry of tail-anchored proteins factor CAMLG (CAMLG)
Gene Name CAMLG
Gene ID 819
Synonyms
CAML; GET2; Guided entry of tail-anchored proteins factor CAMLG; Calcium signal-modulating cyclophilin ligand
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESMAVATDGGERPGVPAGSGLSASQRRAELRRRKLLMNSEQRINRIMGFHRPGSGAEEE
SQTKSKQQDSDKLNSLSVPSVSKRVVLGDSVSTGTTDQQGGVAEVKGTQLGDKLDSFIKP
PECSSDVNLELRQRNRGDLTADSVQRGSRHGLEQYLSRFEEAMKLRKQLISEKPSQEDGN
TTEEFDSFRIFRLVGCALLALGVRAFVCKYLSIFAPFLTLQLAYMGLYKYFPKSEKKIKT
TVLTAALLLSGIPAEVINRSMDTYSKMGEVFTDLCVYFFTFIFCHELLDYWGSEVP
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Subcellular location
Endoplasmic reticulum membrane
Function
Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.
TTD ID
T07601
Uniprot ID
P49069
DrugMap ID
TTATDGJ
Ensemble ID
ENST00000297156.4
HGNC ID
HGNC:1471

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.99  LDD0402  [1]
DA-P2
 Probe Info  		7.84  LDD0348  [2]
HRP
 Probe Info  		6.99  LDD0347  [2]
TG42
 Probe Info  		6.12  LDD0043  [3]
C-Sul
 Probe Info  		2.82  LDD0066  [4]
IPM
 Probe Info  		N.A.  LDD0241  [5]
DBIA
 Probe Info  		C123(2.24)  LDD3312  [6]
DA-P3
 Probe Info  		14.73  LDD0179  [2]
Alkyne-RA190
 Probe Info  		4.32  LDD0300  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
PAL-AfBPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		10.56  LDD1740  [11]
C053
 Probe Info  		6.06  LDD1751  [11]
C063
 Probe Info  		21.71  LDD1760  [11]
C134
 Probe Info  		30.27  LDD1816  [11]
C169
 Probe Info  		28.05  LDD1849  [11]
C264
 Probe Info  		16.56  LDD1935  [11]
C314
 Probe Info  		65.80  LDD1981  [11]
C338
 Probe Info  		12.13  LDD2001  [11]
C339
 Probe Info  		7.16  LDD2002  [11]
C349
 Probe Info  		14.12  LDD2010  [11]
C350
 Probe Info  		59.30  LDD2011  [11]
C363
 Probe Info  		24.59  LDD2024  [11]
C383
 Probe Info  		11.16  LDD2042  [11]
C388
 Probe Info  		62.68  LDD2047  [11]
OEA-DA
 Probe Info  		6.32  LDD0046  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C123(0.92); C196(0.94)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C196(0.92)  LDD0813  [14]
 LDCM0216  AC100 HEK-293T C196(1.27)  LDD0814  [14]
 LDCM0217  AC101 HEK-293T C196(1.20)  LDD0815  [14]
 LDCM0218  AC102 HEK-293T C196(1.16)  LDD0816  [14]
 LDCM0219  AC103 HEK-293T C196(1.40)  LDD0817  [14]
 LDCM0220  AC104 HEK-293T C196(1.29)  LDD0818  [14]
 LDCM0221  AC105 HEK-293T C196(1.35)  LDD0819  [14]
 LDCM0222  AC106 HEK-293T C196(0.88)  LDD0820  [14]
 LDCM0223  AC107 HEK-293T C196(1.02)  LDD0821  [14]
 LDCM0224  AC108 HEK-293T C196(0.97)  LDD0822  [14]
 LDCM0225  AC109 HEK-293T C196(1.33)  LDD0823  [14]
 LDCM0226  AC11 HEK-293T C196(0.88)  LDD0824  [14]
 LDCM0227  AC110 HEK-293T C196(1.35)  LDD0825  [14]
 LDCM0228  AC111 HEK-293T C196(1.52)  LDD0826  [14]
 LDCM0229  AC112 HEK-293T C196(1.51)  LDD0827  [14]
 LDCM0230  AC113 HEK-293T C196(0.83)  LDD0828  [14]
 LDCM0231  AC114 HEK-293T C196(0.64)  LDD0829  [14]
 LDCM0232  AC115 HEK-293T C196(0.81)  LDD0830  [14]
 LDCM0233  AC116 HEK-293T C196(0.77)  LDD0831  [14]
 LDCM0234  AC117 HEK-293T C196(0.72)  LDD0832  [14]
 LDCM0235  AC118 HEK-293T C196(0.95)  LDD0833  [14]
 LDCM0236  AC119 HEK-293T C196(0.81)  LDD0834  [14]
 LDCM0237  AC12 HEK-293T C196(0.96)  LDD0835  [14]
 LDCM0238  AC120 HEK-293T C196(0.94)  LDD0836  [14]
 LDCM0239  AC121 HEK-293T C196(1.00)  LDD0837  [14]
 LDCM0240  AC122 HEK-293T C196(1.25)  LDD0838  [14]
 LDCM0241  AC123 HEK-293T C196(1.07)  LDD0839  [14]
 LDCM0242  AC124 HEK-293T C196(0.90)  LDD0840  [14]
 LDCM0243  AC125 HEK-293T C196(1.21)  LDD0841  [14]
 LDCM0244  AC126 HEK-293T C196(1.25)  LDD0842  [14]
 LDCM0245  AC127 HEK-293T C196(1.53)  LDD0843  [14]
 LDCM0259  AC14 HEK-293T C196(1.00)  LDD0857  [14]
 LDCM0270  AC15 HEK-293T C196(1.16)  LDD0868  [14]
 LDCM0276  AC17 HEK-293T C123(0.93); C196(0.91)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C123(0.97); C196(1.10)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C123(1.00); C196(0.78)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C123(0.99); C196(1.02)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C123(0.99); C196(0.97)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C123(1.03); C196(0.95)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C123(1.06); C196(1.00)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C123(1.01); C196(1.02)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C123(0.93); C196(1.03)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C123(0.97); C196(0.91)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C123(0.96); C196(1.03)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C123(1.02); C196(0.86)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C123(1.04); C196(0.95)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C123(1.02); C196(0.99)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C123(1.07); C196(0.99)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C123(1.14); C196(0.98)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C123(1.05); C196(0.92)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C123(1.00); C196(0.98)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C123(0.89); C196(0.96)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C123(0.96); C196(1.06)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C123(1.00); C196(0.93)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C123(1.03); C196(0.95)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C123(0.98); C196(0.97)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C123(0.99); C196(1.06)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C123(0.92); C196(0.97)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C123(1.16); C196(0.93)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C123(0.99); C196(1.12)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C123(0.91); C196(0.88)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C123(1.11); C196(0.95)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C123(0.96); C196(0.91)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C123(1.01); C196(0.91)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C123(0.99); C196(1.00)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C196(1.54)  LDD0906  [14]
 LDCM0309  AC47 HEK-293T C196(1.45)  LDD0907  [14]
 LDCM0310  AC48 HEK-293T C196(1.42)  LDD0908  [14]
 LDCM0311  AC49 HEK-293T C196(1.26)  LDD0909  [14]
 LDCM0312  AC5 HEK-293T C123(1.08); C196(1.02)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C196(1.23)  LDD0911  [14]
 LDCM0314  AC51 HEK-293T C196(1.94)  LDD0912  [14]
 LDCM0315  AC52 HEK-293T C196(1.61)  LDD0913  [14]
 LDCM0316  AC53 HEK-293T C196(1.46)  LDD0914  [14]
 LDCM0317  AC54 HEK-293T C196(1.70)  LDD0915  [14]
 LDCM0318  AC55 HEK-293T C196(1.34)  LDD0916  [14]
 LDCM0319  AC56 HEK-293T C196(1.36)  LDD0917  [14]
 LDCM0320  AC57 HEK-293T C123(0.95); C196(1.05)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C123(1.01); C196(1.03)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C123(0.99); C196(1.08)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C196(0.60)  LDD0921  [14]
 LDCM0324  AC60 HEK-293T C123(1.04); C196(1.09)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C123(1.06); C196(1.05)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C123(1.21); C196(1.06)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C123(1.07); C196(1.04)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C123(1.03); C196(1.18)  LDD1567  [13]
 LDCM0332  AC68 HEK-293T C196(1.02)  LDD0930  [14]
 LDCM0333  AC69 HEK-293T C196(0.86)  LDD0931  [14]
 LDCM0334  AC7 HEK-293T C196(1.01)  LDD0932  [14]
 LDCM0335  AC70 HEK-293T C196(1.00)  LDD0933  [14]
 LDCM0336  AC71 HEK-293T C196(0.92)  LDD0934  [14]
 LDCM0337  AC72 HEK-293T C196(1.16)  LDD0935  [14]
 LDCM0338  AC73 HEK-293T C196(1.14)  LDD0936  [14]
 LDCM0339  AC74 HEK-293T C196(0.89)  LDD0937  [14]
 LDCM0340  AC75 HEK-293T C196(0.92)  LDD0938  [14]
 LDCM0341  AC76 HEK-293T C196(0.92)  LDD0939  [14]
 LDCM0342  AC77 HEK-293T C196(1.04)  LDD0940  [14]
 LDCM0343  AC78 HEK-293T C196(1.31)  LDD0941  [14]
 LDCM0344  AC79 HEK-293T C196(0.86)  LDD0942  [14]
 LDCM0345  AC8 HEK-293T C196(0.93)  LDD0943  [14]
 LDCM0346  AC80 HEK-293T C196(0.83)  LDD0944  [14]
 LDCM0347  AC81 HEK-293T C196(0.88)  LDD0945  [14]
 LDCM0348  AC82 HEK-293T C196(0.94)  LDD0946  [14]
 LDCM0365  AC98 HEK-293T C196(0.85)  LDD0963  [14]
 LDCM0366  AC99 HEK-293T C196(1.08)  LDD0964  [14]
 LDCM0248  AKOS034007472 HEK-293T C196(0.97)  LDD0846  [14]
 LDCM0356  AKOS034007680 HEK-293T C196(1.13)  LDD0954  [14]
 LDCM0275  AKOS034007705 HEK-293T C196(0.94)  LDD0873  [14]
 LDCM0156  Aniline NCI-H1299 12.50  LDD0403  [1]
 LDCM0087  Capsaicin HEK-293T 6.94  LDD0185  [2]
 LDCM0367  CL1 HEK-293T C123(0.96); C196(1.03)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C123(0.35); C196(1.53)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C123(1.09); C196(0.92)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C196(0.89)  LDD0968  [14]
 LDCM0371  CL102 HEK-293T C196(1.03)  LDD0969  [14]
 LDCM0372  CL103 HEK-293T C196(1.01)  LDD0970  [14]
 LDCM0373  CL104 HEK-293T C196(0.76)  LDD0971  [14]
 LDCM0374  CL105 HEK-293T C123(0.99); C196(0.95)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C123(1.11); C196(0.91)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C123(1.12); C196(1.04)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C123(1.01); C196(0.96)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C123(1.02); C196(1.03)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C123(0.66); C196(1.13)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C123(1.01); C196(0.74)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C123(0.95); C196(1.01)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C123(1.01); C196(0.92)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C123(0.96); C196(0.91)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C123(1.09); C196(1.01)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C123(0.98); C196(0.93)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C123(1.02); C196(0.95)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C123(0.94); C196(0.97)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C123(1.07); C196(0.89)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C123(1.06); C196(1.10)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C123(0.93); C196(1.12)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C123(1.09); C196(0.97)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C196(1.49)  LDD0990  [14]
 LDCM0393  CL122 HEK-293T C196(1.20)  LDD0991  [14]
 LDCM0394  CL123 HEK-293T C196(1.39)  LDD0992  [14]
 LDCM0395  CL124 HEK-293T C196(1.15)  LDD0993  [14]
 LDCM0396  CL125 HEK-293T C123(1.06); C196(1.19)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C123(1.20); C196(0.98)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C123(1.10); C196(1.19)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C123(1.15); C196(0.90)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C123(0.98); C196(1.05)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C123(1.13); C196(0.90)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C123(0.88); C196(1.00)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C123(0.99); C196(0.91)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C123(0.86); C196(1.21)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C123(0.88); C196(1.06)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C123(0.95); C196(0.90)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C123(1.09); C196(0.90)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C123(1.02); C196(0.99)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C123(0.92); C196(1.23)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C123(0.38); C196(1.15)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C123(0.63); C196(1.01)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C123(0.92); C196(1.11)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C123(1.01); C196(1.32)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C123(1.17); C196(0.91)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C123(1.00); C196(1.02)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C123(0.95); C196(1.03)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C123(0.79); C196(0.97)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C123(0.91); C196(1.05)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C123(0.94); C196(1.04)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C123(0.95); C196(0.93)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C123(0.93); C196(0.96)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C123(0.81); C196(1.62)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C123(0.34); C196(1.12)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C123(0.55); C196(1.04)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C123(0.77); C196(1.12)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C123(1.01); C196(1.02)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C123(1.01); C196(1.05)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C123(1.12); C196(1.11)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C123(1.06); C196(0.89)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C123(0.94); C196(0.96)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C123(1.01); C196(1.02)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C123(0.87); C196(0.84)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C123(0.95); C196(0.90)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C123(0.96); C196(1.09)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C123(0.37); C196(1.11)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C123(0.60); C196(1.03)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C123(0.89); C196(1.14)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C123(1.04); C196(1.12)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C123(0.88); C196(1.01)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C123(1.06); C196(0.93)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C123(1.02); C196(0.90)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C123(0.88); C196(1.04)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C123(0.80); C196(1.41)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C123(0.90); C196(0.90)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C123(1.01); C196(0.96)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C123(0.89); C196(1.12)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C123(0.36); C196(1.19)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C123(0.62); C196(0.98)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C123(0.85); C196(1.33)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C123(0.91); C196(1.18)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C196(0.79)  LDD1051  [14]
 LDCM0454  CL62 HEK-293T C196(0.88)  LDD1052  [14]
 LDCM0455  CL63 HEK-293T C196(0.73)  LDD1053  [14]
 LDCM0456  CL64 HEK-293T C196(0.91)  LDD1054  [14]
 LDCM0457  CL65 HEK-293T C196(0.94)  LDD1055  [14]
 LDCM0458  CL66 HEK-293T C196(1.13)  LDD1056  [14]
 LDCM0459  CL67 HEK-293T C196(1.17)  LDD1057  [14]
 LDCM0460  CL68 HEK-293T C196(1.21)  LDD1058  [14]
 LDCM0461  CL69 HEK-293T C196(1.22)  LDD1059  [14]
 LDCM0462  CL7 HEK-293T C123(0.91); C196(1.03)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C196(1.25)  LDD1061  [14]
 LDCM0464  CL71 HEK-293T C196(1.36)  LDD1062  [14]
 LDCM0465  CL72 HEK-293T C196(1.09)  LDD1063  [14]
 LDCM0466  CL73 HEK-293T C196(1.61)  LDD1064  [14]
 LDCM0467  CL74 HEK-293T C196(1.84)  LDD1065  [14]
 LDCM0469  CL76 HEK-293T C123(0.97); C196(1.11)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C123(0.89); C196(1.04)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C123(0.94); C196(1.03)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C123(0.95); C196(0.93)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C123(0.77); C196(2.28)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C123(0.88); C196(1.00)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C123(0.90); C196(0.98)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C123(0.48); C196(0.99)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C123(0.69); C196(1.08)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C123(0.86); C196(1.16)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C123(1.11); C196(1.18)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C123(1.08); C196(0.96)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C123(1.16); C196(0.98)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C123(1.03); C196(1.02)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C123(1.00); C196(0.99)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C123(0.95); C196(1.15)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C123(0.76); C196(1.35)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C123(0.92); C196(0.97)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C123(0.92); C196(1.12)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C123(0.89); C196(1.19)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C123(0.61); C196(1.11)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C123(0.78); C196(1.20)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C123(0.86); C196(1.34)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C123(1.09); C196(1.12)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C123(1.07); C196(0.92)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C123(1.03); C196(1.12)  LDD1697  [13]
 LDCM0028  Dobutamine HEK-293T 5.09  LDD0180  [2]
 LDCM0027  Dopamine HEK-293T 14.73  LDD0179  [2]
 LDCM0495  E2913 HEK-293T C123(0.99); C196(1.10)  LDD1698  [13]
 LDCM0573  Fragment11 Ramos C123(1.40)  LDD2190  [15]
 LDCM0576  Fragment14 Ramos C123(1.97)  LDD2193  [15]
 LDCM0468  Fragment33 HEK-293T C196(1.31)  LDD1066  [14]
 LDCM0566  Fragment4 Ramos C123(0.44)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C123(1.05); C196(0.90)  LDD1631  [13]
 LDCM0569  Fragment7 Ramos C123(0.41)  LDD2186  [15]
 LDCM0022  KB02 HEK-293T C123(1.01); C196(0.93)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C123(1.01); C196(0.96)  LDD1497  [13]
 LDCM0024  KB05 HMCB C123(2.24)  LDD3312  [6]
 LDCM0029  Quercetin HEK-293T 7.37  LDD0181  [2]
 LDCM0131  RA190 MM1.R 4.32  LDD0300  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
ATPase GET3 (GET3) ArsA ATPase family O43681
Ethanolamine kinase 1 (ETNK1) Choline/ethanolamine kinase family Q9HBU6
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Thioredoxin domain-containing protein 12 (TXNDC12) . O95881
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Membrane-associated progesterone receptor component 1 (PGRMC1) Cytochrome b5 family O00264
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) OST1 family P04843
Potassium voltage-gated channel subfamily A member 2 (KCNA2) Potassium channel family P16389
Potassium voltage-gated channel subfamily E member 4 (KCNE4) Potassium channel KCNE family Q8WWG9
Guided entry of tail-anchored proteins factor 1 (GET1) WRB/GET1 family O00258
Adiponectin (ADIPOQ) . Q15848
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctional adhesion molecule A (F11R) Immunoglobulin superfamily Q9Y624
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neutrophil gelatinase-associated lipocalin (LCN2) Lipocalin family P80188
Radiation-inducible immediate-early gene IEX-1 (IER3) IER3 family P46695
OCIA domain-containing protein 1 (OCIAD1) OCIAD1 family Q9NX40
Brorin (VWC2) . Q2TAL6
Fibrocystin (PKHD1) . P08F94
Pre-B-cell leukemia transcription factor-interacting protein 1 (PBXIP1) . Q96AQ6

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cyclosporine Protein/peptide DB00091
Voclosporin Small molecular drug DB11693
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alisporivir Protein/peptide D0CE0O
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Scy-635 Small molecular drug D02EEJ
Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Scy-641 . D0TP7T
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
D-43787 Small molecular drug D00CEG

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
3 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578