Details of the Target

General Information of Target

Target ID LDTP07368
Target Name Tetratricopeptide repeat protein 19, mitochondrial (TTC19)
Gene Name TTC19
Gene ID 54902
Synonyms
Tetratricopeptide repeat protein 19, mitochondrial; TPR repeat protein 19
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFRLLSWSLGRGFLRAAGRRCRGCSARLLPGLAGGPGPEVQVPPSRVAPHGRGPGLLPLL
AALAWFSRPAAAEEEEQQGADGAAAEDGADEAEAEIIQLLKRAKLSIMKDEPEEAELILH
DALRLAYQTDNKKAITYTYDLMANLAFIRGQLENAEQLFKATMSYLLGGGMKQEDNAIIE
ISLKLASIYAAQNRQEFAVAGYEFCISTLEEKIEREKELAEDIMSVEEKANTHLLLGMCL
DACARYLLFSKQPSQAQRMYEKALQISEEIQGERHPQTIVLMSDLATTLDAQGRFDEAYI
YMQRASDLARQINHPELHMVLSNLAAVLMHRERYTQAKEIYQEALKQAKLKKDEISVQHI
REELAELSKKSRPLTNSVKL
Target Bioclass
Other
Family
TTC19 family
Subcellular location
Mitochondrion inner membrane
Function
Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1. Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation of UQCRFS1 into the complex III and whose presence is detrimental for its catalytic activity.
Uniprot ID
Q6DKK2
Ensemble ID
ENST00000261647.10
HGNC ID
HGNC:26006

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K251(0.93)  LDD0277  [1]
Probe 1
 Probe Info  		Y127(40.06); Y189(15.53)  LDD3495  [2]
DBIA
 Probe Info  		C239(1.07); C243(1.07)  LDD0531  [3]
NHS
 Probe Info  		K346(0.00); K338(0.00)  LDD0010  [4]
AOyne
 Probe Info  		5.90  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 95 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		8.22  LDD1711  [6]
C004
 Probe Info  		9.58  LDD1714  [6]
C010
 Probe Info  		5.86  LDD1719  [6]
C027
 Probe Info  		5.24  LDD1733  [6]
C039
 Probe Info  		6.73  LDD1739  [6]
C040
 Probe Info  		9.13  LDD1740  [6]
C041
 Probe Info  		8.22  LDD1741  [6]
C053
 Probe Info  		7.31  LDD1751  [6]
C055
 Probe Info  		18.13  LDD1752  [6]
C056
 Probe Info  		18.51  LDD1753  [6]
C063
 Probe Info  		17.63  LDD1760  [6]
C087
 Probe Info  		12.38  LDD1779  [6]
C091
 Probe Info  		15.14  LDD1782  [6]
C092
 Probe Info  		23.75  LDD1783  [6]
C106
 Probe Info  		25.28  LDD1793  [6]
C108
 Probe Info  		10.34  LDD1795  [6]
C112
 Probe Info  		23.75  LDD1799  [6]
C130
 Probe Info  		6.63  LDD1812  [6]
C141
 Probe Info  		9.71  LDD1823  [6]
C143
 Probe Info  		12.30  LDD1825  [6]
C145
 Probe Info  		9.32  LDD1827  [6]
C147
 Probe Info  		10.06  LDD1829  [6]
C153
 Probe Info  		25.28  LDD1834  [6]
C158
 Probe Info  		10.70  LDD1838  [6]
C159
 Probe Info  		8.88  LDD1839  [6]
C160
 Probe Info  		11.24  LDD1840  [6]
C161
 Probe Info  		15.24  LDD1841  [6]
C165
 Probe Info  		24.42  LDD1845  [6]
C178
 Probe Info  		23.10  LDD1857  [6]
C186
 Probe Info  		10.13  LDD1864  [6]
C187
 Probe Info  		25.46  LDD1865  [6]
C191
 Probe Info  		28.25  LDD1868  [6]
C193
 Probe Info  		7.31  LDD1869  [6]
C194
 Probe Info  		10.70  LDD1870  [6]
C196
 Probe Info  		9.99  LDD1872  [6]
C197
 Probe Info  		5.24  LDD1873  [6]
C198
 Probe Info  		11.63  LDD1874  [6]
C210
 Probe Info  		55.72  LDD1884  [6]
C213
 Probe Info  		23.43  LDD1887  [6]
C228
 Probe Info  		15.56  LDD1901  [6]
C232
 Probe Info  		35.02  LDD1905  [6]
C238
 Probe Info  		11.00  LDD1911  [6]
C244
 Probe Info  		14.62  LDD1917  [6]
C249
 Probe Info  		24.08  LDD1922  [6]
C265
 Probe Info  		17.15  LDD1936  [6]
C270
 Probe Info  		8.94  LDD1940  [6]
C277
 Probe Info  		12.73  LDD1947  [6]
C280
 Probe Info  		9.13  LDD1950  [6]
C284
 Probe Info  		26.91  LDD1954  [6]
C293
 Probe Info  		20.39  LDD1963  [6]
C296
 Probe Info  		14.42  LDD1966  [6]
C303
 Probe Info  		4.99  LDD1972  [6]
C305
 Probe Info  		13.27  LDD1974  [6]
C310
 Probe Info  		8.51  LDD1977  [6]
C313
 Probe Info  		16.45  LDD1980  [6]
C314
 Probe Info  		16.34  LDD1981  [6]
C322
 Probe Info  		6.02  LDD1988  [6]
C338
 Probe Info  		21.71  LDD2001  [6]
C343
 Probe Info  		17.63  LDD2005  [6]
C348
 Probe Info  		13.00  LDD2009  [6]
C349
 Probe Info  		10.20  LDD2010  [6]
C350
 Probe Info  		32.45  LDD2011  [6]
C353
 Probe Info  		7.16  LDD2014  [6]
C354
 Probe Info  		7.94  LDD2015  [6]
C355
 Probe Info  		32.67  LDD2016  [6]
C356
 Probe Info  		10.56  LDD2017  [6]
C357
 Probe Info  		5.50  LDD2018  [6]
C361
 Probe Info  		19.97  LDD2022  [6]
C362
 Probe Info  		33.13  LDD2023  [6]
C363
 Probe Info  		22.47  LDD2024  [6]
C364
 Probe Info  		23.92  LDD2025  [6]
C367
 Probe Info  		6.36  LDD2028  [6]
C376
 Probe Info  		8.17  LDD2036  [6]
C382
 Probe Info  		8.82  LDD2041  [6]
C383
 Probe Info  		12.30  LDD2042  [6]
C386
 Probe Info  		6.82  LDD2045  [6]
C388
 Probe Info  		37.79  LDD2047  [6]
C390
 Probe Info  		21.41  LDD2049  [6]
C391
 Probe Info  		14.52  LDD2050  [6]
C403
 Probe Info  		17.63  LDD2061  [6]
C407
 Probe Info  		11.00  LDD2064  [6]
C413
 Probe Info  		17.27  LDD2069  [6]
C420
 Probe Info  		16.80  LDD2075  [6]
C424
 Probe Info  		7.78  LDD2079  [6]
C429
 Probe Info  		16.80  LDD2084  [6]
C431
 Probe Info  		27.10  LDD2086  [6]
C433
 Probe Info  		6.15  LDD2088  [6]
FFF probe11
 Probe Info  		20.00  LDD0471  [7]
FFF probe13
 Probe Info  		20.00  LDD0475  [7]
FFF probe14
 Probe Info  		20.00  LDD0477  [7]
FFF probe2
 Probe Info  		20.00  LDD0463  [7]
FFF probe3
 Probe Info  		20.00  LDD0464  [7]
FFF probe6
 Probe Info  		20.00  LDD0467  [7]
JN0003
 Probe Info  		20.00  LDD0469  [7]
VE-P
 Probe Info  		N.A.  LDD0396  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C239(1.07); C243(1.07)  LDD0531  [3]
 LDCM0215  AC10 HEK-293T C205(1.02)  LDD1508  [9]
 LDCM0276  AC17 HCT 116 C239(0.54); C243(0.54)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C239(0.57); C243(0.57)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C239(0.58); C243(0.58)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C239(0.84); C243(0.84)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C239(0.63); C243(0.63)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C239(0.58); C243(0.58)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C239(0.65); C243(0.65)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C239(0.63); C243(0.63)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C239(0.80); C243(0.80)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C239(0.84); C243(0.84)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C239(0.69); C243(0.69)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C239(0.81); C243(0.81)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C239(0.65); C243(0.65)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C239(0.66); C243(0.66)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C239(1.23); C243(1.23)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C239(0.72); C243(0.72)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C239(0.66); C243(0.66)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C239(0.62); C243(0.62)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C239(0.60); C243(0.60)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C239(0.57); C243(0.57)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C239(1.34); C243(1.34)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C239(1.26); C243(1.26)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C239(1.13); C243(1.13)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C239(1.16); C243(1.16)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C239(0.97); C243(0.97)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C239(0.85); C243(0.85)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C239(0.88); C243(0.88)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C239(1.12); C243(1.12)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C239(1.17); C243(1.17)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C239(1.15); C243(1.15)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C239(0.96); C243(0.96)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C239(0.93); C243(0.93)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C239(0.97); C243(0.97)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C239(0.85); C243(0.85)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C239(1.19); C243(1.19)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C239(0.73); C243(0.73)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C239(1.03); C243(1.03)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C239(0.77); C243(0.77)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C239(1.54); C243(1.54)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C239(0.94); C243(0.94)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C239(0.83); C243(0.83)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C239(0.93); C243(0.93)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C239(0.72); C243(0.72)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C239(0.82); C243(0.82)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C239(0.35); C243(0.35)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C239(0.35); C243(0.35)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C239(0.33); C243(0.33)  LDD0639  [3]
 LDCM0324  AC60 HCT 116 C239(0.38); C243(0.38)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C239(0.47); C243(0.47)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C239(0.36); C243(0.36)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C239(0.36); C243(0.36)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C239(0.35); C243(0.35)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C239(0.39); C243(0.39)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C239(0.42); C243(0.42)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C239(0.29); C243(0.29)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C239(0.89); C243(0.89)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C239(0.78); C243(0.78)  LDD0650  [3]
 LDCM0335  AC70 HCT 116 C239(0.54); C243(0.54)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C239(0.90); C243(0.90)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C239(0.66); C243(0.66)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C239(0.59); C243(0.59)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C239(0.64); C243(0.64)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C239(0.71); C243(0.71)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C239(0.62); C243(0.62)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C239(0.59); C243(0.59)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C239(0.97); C243(0.97)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C239(0.75); C243(0.75)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C205(0.92)  LDD1569  [9]
 LDCM0346  AC80 HCT 116 C239(0.72); C243(0.72)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C239(0.98); C243(0.98)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C239(0.66); C243(0.66)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C239(0.44); C243(0.44)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C239(0.44); C243(0.44)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C239(0.62); C243(0.62)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C239(0.65); C243(0.65)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C239(0.87); C243(0.87)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C239(0.66); C243(0.66)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C239(0.58); C243(0.58)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C239(0.88); C243(0.88)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C239(0.37); C243(0.37)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C239(0.46); C243(0.46)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C239(0.58); C243(0.58)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C239(0.67); C243(0.67)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C239(1.23); C243(1.23)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C239(0.71); C243(0.71)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C239(0.42); C243(0.42)  LDD0681  [3]
 LDCM0356  AKOS034007680 HEK-293T C205(1.10)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C205(1.04)  LDD1514  [9]
 LDCM0369  CL100 HCT 116 C239(0.75); C243(0.75)  LDD0686  [3]
 LDCM0371  CL102 HEK-293T C205(1.00)  LDD1575  [9]
 LDCM0373  CL104 HEK-293T C205(1.02)  LDD1577  [9]
 LDCM0374  CL105 HCT 116 C239(0.50); C243(0.50)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C239(0.39); C243(0.39)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C239(0.39); C243(0.39)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C239(0.35); C243(0.35)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C239(0.50); C243(0.50)  LDD0695  [3]
 LDCM0380  CL110 HCT 116 C239(0.43); C243(0.43)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C239(0.55); C243(0.55)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C239(0.92); C243(0.92)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C239(0.57); C243(0.57)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C239(0.65); C243(0.65)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C239(0.75); C243(0.75)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C239(0.77); C243(0.77)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C239(0.97); C243(0.97)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C239(1.02); C243(1.02)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C239(0.89); C243(0.89)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C205(1.42)  LDD1594  [9]
 LDCM0391  CL120 HCT 116 C239(0.95); C243(0.95)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C239(4.47); C243(4.47)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C239(0.96); C243(0.96)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C239(0.82); C243(0.82)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C239(0.77); C243(0.77)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C239(0.54); C243(0.54)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C239(0.54); C243(0.54)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C239(0.60); C243(0.60)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C239(0.37); C243(0.37)  LDD0716  [3]
 LDCM0401  CL14 HEK-293T C205(0.92)  LDD1605  [9]
 LDCM0403  CL16 HCT 116 C239(0.89); C243(0.89)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C239(0.93); C243(0.93)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C239(0.98); C243(0.98)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C239(0.82); C243(0.82)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C205(0.96)  LDD1611  [9]
 LDCM0408  CL20 HCT 116 C239(0.62); C243(0.62)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C239(0.58); C243(0.58)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C239(0.60); C243(0.60)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C239(0.58); C243(0.58)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C239(0.54); C243(0.54)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C239(0.56); C243(0.56)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C239(0.68); C243(0.68)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C239(0.65); C243(0.65)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C239(0.69); C243(0.69)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C239(0.66); C243(0.66)  LDD0734  [3]
 LDCM0419  CL30 HCT 116 C239(0.74); C243(0.74)  LDD0736  [3]
 LDCM0425  CL36 HEK-293T C205(0.85)  LDD1629  [9]
 LDCM0429  CL4 HEK-293T C205(1.03)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C205(1.02)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C205(0.96)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C205(1.49)  LDD1636  [9]
 LDCM0438  CL48 HEK-293T C205(1.17)  LDD1642  [9]
 LDCM0440  CL5 HEK-293T C205(1.52)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C205(0.91)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C205(1.14)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C205(1.07)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C205(0.87)  LDD1648  [9]
 LDCM0451  CL6 HEK-293T C205(1.26)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C205(1.29)  LDD1655  [9]
 LDCM0454  CL62 HEK-293T C205(1.01)  LDD1657  [9]
 LDCM0456  CL64 HEK-293T C205(1.07)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C205(1.05)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C205(0.92)  LDD1661  [9]
 LDCM0465  CL72 HEK-293T C205(1.08)  LDD1668  [9]
 LDCM0467  CL74 HEK-293T C205(0.89)  LDD1670  [9]
 LDCM0469  CL76 HCT 116 C239(0.85); C243(0.85)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C239(0.74); C243(0.74)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C239(0.81); C243(0.81)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C239(0.68); C243(0.68)  LDD0789  [3]
 LDCM0474  CL80 HCT 116 C239(0.98); C243(0.98)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C239(0.75); C243(0.75)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C239(0.59); C243(0.59)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C239(0.59); C243(0.59)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C239(0.59); C243(0.59)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C239(0.67); C243(0.67)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C239(0.89); C243(0.89)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C239(0.67); C243(0.67)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C239(0.63); C243(0.63)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C239(0.68); C243(0.68)  LDD0800  [3]
 LDCM0485  CL90 HCT 116 C239(0.99); C243(0.99)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C239(1.17); C243(1.17)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C239(0.81); C243(0.81)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C239(0.84); C243(0.84)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C239(0.66); C243(0.66)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C239(0.73); C243(0.73)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C239(0.85); C243(0.85)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C239(1.02); C243(1.02)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C239(0.96); C243(0.96)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C239(0.91); C243(0.91)  LDD0811  [3]
 LDCM0427  Fragment51 HEK-293T C205(0.79)  LDD1631  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fumarate hydratase, mitochondrial (FH) Class-II fumarase/aspartase family P07954
Alanine--glyoxylate aminotransferase (AGXT) Class-V pyridoxal-phosphate-dependent aminotransferase family P21549
Cytochrome c oxidase assembly factor 6 homolog (COA6) Cytochrome c oxidase subunit 6B family Q5JTJ3
Nucleoside diphosphate kinase, mitochondrial (NME4) NDK family O00746
Serine protease HTRA2, mitochondrial (HTRA2) Peptidase S1C family O43464
Adenine phosphoribosyltransferase (APRT) Purine/pyrimidine phosphoribosyltransferase family P07741
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 4E transporter (EIF4ENIF1) 4E-T/EIF4E-T family Q9NRA8
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Protein shisa-6 (SHISA6) Shisa family Q6ZSJ9
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Doublesex- and mab-3-related transcription factor 3 (DMRT3) DMRT family Q9NQL9
Zinc finger protein 688 (ZNF688) Krueppel C2H2-type zinc-finger protein family P0C7X2
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Proto-oncogene c-Rel (REL) . Q04864
T-box transcription factor TBX2 (TBX2) . Q13207
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Matrix remodeling-associated protein 8 (MXRA8) . Q9BRK3
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Retinol-binding protein 1 (RBP1) Fatty-acid binding protein (FABP) family P09455
Protein FAM136A (FAM136A) FAM136 family Q96C01
Protein FAM217B (FAM217B) FAM217 family Q9NTX9
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
LIM domain-binding protein 2 (LDB2) LDB family O43679
Promotilin (MLN) Motilin family P12872
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
Nonsense-mediated mRNA decay factor SMG9 (SMG9) SMG9 family Q9H0W8
AP-4 complex accessory subunit RUSC1 (RUSC1) . Q9BVN2
Ciliary microtubule inner protein 1 (CIMIP1) . Q9H1P6
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
Interactor of HORMAD1 protein 1 (IHO1) . Q8IYA8
Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) . Q96JM7
Proline-rich protein 35 (PRR35) . P0CG20
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
Telethonin (TCAP) . O15273

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
8 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402